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Heart (British Cardiac Society) Dec 2016
Review
Topics: Animals; Cardiomyopathy, Dilated; Genetic Markers; Genetic Predisposition to Disease; Humans; Molecular Diagnostic Techniques; Mutation; Phenotype; Predictive Value of Tests; Prognosis; Risk Factors
PubMed: 27634407
DOI: 10.1136/heartjnl-2015-308190 -
The Israel Medical Association Journal... Nov 2012
Review
Topics: Cardiomyopathy, Dilated; Disease Progression; Humans; Prognosis; Ventricular Remodeling
PubMed: 23240375
DOI: No ID Found -
Revue Medicale Suisse Dec 2022Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction in the absence of abnormal loading conditions and severe...
Dilated cardiomyopathy is defined by the presence of left ventricular dilatation and contractile dysfunction in the absence of abnormal loading conditions and severe coronary artery disease. Once dilated cardiomyopathy is discovered, a careful and detailed history with laboratory tests may reveal a potential toxic cause. In this article, we present the case of a patient with suspected toxic dilated cardiomyopathy, and then discuss the common causes and treatment of toxic dilated cardiomyopathy.
Topics: Humans; Cardiomyopathy, Dilated
PubMed: 36515479
DOI: 10.53738/REVMED.2022.18.808.2406 -
Cardiovascular & Hematological... 2023Dilated cardiomyopathy (DCM) is distinguished by ventricular chamber expansion, systolic dysfunction, and normal left ventricular (LV) wall thickness, and is mainly... (Review)
Review
Dilated cardiomyopathy (DCM) is distinguished by ventricular chamber expansion, systolic dysfunction, and normal left ventricular (LV) wall thickness, and is mainly caused due to genetic or environmental factors; however, its aetiology is undetermined in the majority of patients. The focus of this work is on pathogenesis, small animal models, as well as the herbal medicinal approach, and the most recent advances in imaging modalities for patients with dilated cardiomyopathy. Several small animal models have been proposed over the last few years to mimic various pathomechanisms that contribute to dilated cardiomyopathy. Surgical procedures, gene mutations, and drug therapies are all characteristic features of these models. The pros and cons, including heart failure stimulation of extensively established small animal models for dilated cardiomyopathy, are illustrated, as these models tend to procure key insights and contribute to the development of innovative treatment techniques for patients. Traditional medicinal plants used as treatment in these models are also discussed, along with contemporary developments in herbal therapies. In the last few decades, accurate diagnosis, proper recognition of the underlying disease, specific risk stratification, and forecasting of clinical outcome, have indeed improved the health of DCM patients. Cardiac magnetic resonance (CMR) is the bullion criterion for assessing ventricular volume and ejection fraction in a reliable and consistent direction. Other technologies, like strain analysis and 3D echocardiography, have enhanced this technique's predictive and therapeutic potential. Nuclear imaging potentially helps doctors pinpoint the causative factors of left ventricular dysfunction, as with cardiac sarcoidosis and amyloidosis.
Topics: Humans; Cardiomyopathy, Dilated; Stroke Volume; Heart; Heart Failure; Ventricular Dysfunction, Left; Multimodal Imaging
PubMed: 36734898
DOI: 10.2174/1871529X23666230123122808 -
Expert Review of Cardiovascular Therapy Jan 2019Dilated cardiomyopathy (DCM) is generally thought as a final common pathway of several conditions leading to the same clinical phenotype. Multiple imaging modalities... (Comparative Study)
Comparative Study Review
Dilated cardiomyopathy (DCM) is generally thought as a final common pathway of several conditions leading to the same clinical phenotype. Multiple imaging modalities play a fundamental role in recognizing the underlying pathological substrate in DCM. Areas covered: Echocardiography represents the first reliable and easily accessible diagnostic tool, allowing the identification of associated cardiac abnormalities, such as valve disease and highlighting features associated with an adverse prognosis. Recent advances in technology such as strain analysis and 3D-echocardiography have improved the diagnostic and prognostic capabilities of this technique. Cardiac magnetic resonance (CMR) is considered the gold standard for an accurate and reproducible assessment of ventricular volumes and ejection fraction. In addition, CMR allows us to perform tissue characterization that, through new sophisticated sequences, could be obtained even without gadolinium. Nuclear images could be useful to identify specific causes of left ventricular dysfunction, such as cardiac sarcoidosis and amyloidosis. Finally, endomyocardial biopsy is generally performed if acute myocarditis is suspected in high-risk patients. Expert commentary: Strengths and limitations are different for every method, but multiparametric evaluation of patients and family members could progressively improve current understanding of the disease. This is fundamental to specifically target therapy, allowing us to improve patients' prognosis.
Topics: Cardiac Imaging Techniques; Cardiomyopathy, Dilated; Heart; Humans
PubMed: 30457393
DOI: 10.1080/14779072.2019.1550719 -
International Journal of Cardiology Apr 2018Dilated cardiomyopathy is part of the spectrum of heart failure which is a syndrome with certain morphological and functional characteristics. Although significant... (Review)
Review
Dilated cardiomyopathy is part of the spectrum of heart failure which is a syndrome with certain morphological and functional characteristics. Although significant progress in the management of those patients has been achieved, seems that risk stratification and future treatments will be related to the specific pathological substrate.
Topics: Cardiomyopathy, Dilated; Electrocardiography; Humans; Ventricular Dysfunction, Left
PubMed: 29506734
DOI: 10.1016/j.ijcard.2018.01.002 -
JACC. Cardiovascular Imaging Jun 2022
Topics: Atrial Appendage; Cardiomyopathy, Dilated; Heart Atria; Humans; Predictive Value of Tests
PubMed: 35680210
DOI: 10.1016/j.jcmg.2022.02.009 -
Journal of Clinical Pathology Mar 2009Dilated cardiomyopathy (DCM) is a common cardiac diagnosis that may result as a consequence of a variety of pathologies. The differential diagnosis remains quite broad... (Review)
Review
Dilated cardiomyopathy (DCM) is a common cardiac diagnosis that may result as a consequence of a variety of pathologies. The differential diagnosis remains quite broad since many pathologies can present as DCM, and as a result the approach to diagnosis may, at times, be quite difficult. This review article discusses genetic and acquired causes of DCM, pathophysiology of myocardial damage, pathology, and diagnostic criteria. An approach to management is also included, in the hope of informing physicians of a clinical entity that afflicts a substantial number of people worldwide.
Topics: Adult; Angiotensin-Converting Enzyme Inhibitors; Cardiomyopathy, Dilated; Diagnostic Techniques, Cardiovascular; Female; Genetic Predisposition to Disease; Humans; Male; Middle Aged; Myocardium
PubMed: 19017683
DOI: 10.1136/jcp.2008.060731 -
Revista Chilena de Pediatria Dec 2020Pediatric cardiomyopathies are infrequent diseases of the cardiac muscle, with an annual inciden ce of 1.1 to 1.2 per 100,000 children. Dilated cardiomyopathy (DCM) is...
Pediatric cardiomyopathies are infrequent diseases of the cardiac muscle, with an annual inciden ce of 1.1 to 1.2 per 100,000 children. Dilated cardiomyopathy (DCM) is the predominant form, characterized by ventricular dilatation and systolic dysfunction. Etiologies are multiple, with at least 50%-70% of cases being idiopathic. When assessing a child with DCM, secondary potentially reversible causes must be ruled out. The main diagnostic tool is the echocardiogram which allows the identification of cardiac phenotype, to establish the degree of functional compromise, and res ponse to medical therapy. Prognosis is limited but more favorable in infants younger than 1 year at the onset, post myocarditis, or with a lesser degree of ventricular dysfunction. At least 20% of patients may recover ventricular function in the first 2 years after the onset and 40%-50% may die or need heart transplant in the first 5 years. Medical therapy is mainly based on adult experience with limited scientific evidence in children. Heart transplant is the therapy of choice in patients with end-stage disease, with excellent short- and medium-term survival. A significant proportion of patients may require stabilization on the waiting list, including the use of mechanical circulatory support as a bridge to transplantation. The purpose of this revision is to update the available infor mation on etiology, physiopathological mechanisms, prognostic factors, and management of DCM in children.
Topics: Age Factors; Cardiomyopathy, Dilated; Child; Child, Preschool; Echocardiography; Heart Transplantation; Humans; Infant; Prognosis; Waiting Lists
PubMed: 33861821
DOI: 10.32641/rchped.vi91i6.2851 -
Deutsche Medizinische Wochenschrift... Jan 1989
Review
Topics: Cardiomyopathy, Dilated; Heart Transplantation; Humans; Prognosis
PubMed: 2642803
DOI: 10.1055/s-2008-1066555