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Circulation Journal : Official Journal... Mar 2002Genetic forms of human dilated cardiomyopathy (DCM) are briefly discussed, and a variety of animal models of genetic DCM are presented, some of which are caused by the... (Review)
Review
Genetic forms of human dilated cardiomyopathy (DCM) are briefly discussed, and a variety of animal models of genetic DCM are presented, some of which are caused by the gene mutations that also cause DCM in humans. The forms of DCM related to mutations or deletion of genes coding for extrasarcomeric or intrasarcomeric proteins, as well as to overexpression or knockout of genes in the beta-adrenergic signaling pathway, are included. Finally, novel approaches to treatment in experimental animal models are discussed, including double transgenesis and newer recombination methods, as well as in vivo somatic gene transfer which, based on initial experiments in animals, seems likely to find eventual application in human cardiac failure.
Topics: Animals; Animals, Genetically Modified; Cardiomyopathy, Dilated; Disease Models, Animal; Humans; Mice; Mice, Knockout; Mutation
PubMed: 11922267
DOI: 10.1253/circj.66.219 -
The New England Journal of Medicine Oct 1989
Topics: Cardiomyopathy, Dilated; Humans; Immunosuppression Therapy; Prednisone
PubMed: 2797069
DOI: 10.1056/NEJM198910193211609 -
JACC. Clinical Electrophysiology Jul 2023
Topics: Humans; Cardiomyopathy, Dilated; Prognosis; Arrhythmias, Cardiac
PubMed: 37438046
DOI: 10.1016/j.jacep.2023.01.005 -
Journal of the American College of... Jan 1988
Topics: Age Factors; Cardiomyopathy, Dilated; Child; Heart Transplantation; Humans; Prognosis
PubMed: 3275704
DOI: 10.1016/0735-1097(88)90180-5 -
Clinical Pediatrics Mar 2004
Topics: Adolescent; Cardiomyopathy, Dilated; Humans; Male
PubMed: 15024449
DOI: 10.1177/000992280404300216 -
Zhongguo Dang Dai Er Ke Za Zhi =... Oct 2023Dilated cardiomyopathy (DCM) is a significant contributor to heart failure and can lead to life-threatening cardiovascular events at any stage. RNA-binding motif protein... (Review)
Review
Dilated cardiomyopathy (DCM) is a significant contributor to heart failure and can lead to life-threatening cardiovascular events at any stage. RNA-binding motif protein 20 () gene mutation is known to be one of the causes of DCM. This mutation exhibits familial aggregation and is associated with arrhythmias, increasing the risk of sudden and early death. This article delves into the characteristics of the gene, highlighting its role in regulating alternative splicing of the gene and calcium/calmodulin-dependent protein kinase type II gene. Furthermore, the article provides a summary of treatment options available for DCM caused by gene mutations, aiming to enhance clinicians' understanding of the gene and provide new ideas for precision medicine treatment.
Topics: Humans; Alternative Splicing; Cardiomyopathy, Dilated; Heart Failure; Mutation
PubMed: 37905768
DOI: 10.7499/j.issn.1008-8830.2306087 -
Journal of Cardiovascular Medicine... Jul 2008Myocarditis is an inflammatory heart muscle disease, resulting from various etiologies, both noninfectious and infectious, which may be associated or not with cardiac... (Review)
Review
Myocarditis is an inflammatory heart muscle disease, resulting from various etiologies, both noninfectious and infectious, which may be associated or not with cardiac dysfunction. Its course is unpredictable: it may spontaneously resolve or evolve into dilated cardiomyopathy and heart failure. A possible connection between myocarditis and dilated cardiomyopathy has long been postulated, but the intimate mechanisms linking these two conditions are still poorly understood. Viral myocarditis could induce a dilated cardiomyopathy through viral persistence and/or by triggering an autoimmune process. Understanding the mechanisms underlying the relationship between myocarditis and dilated cardiomyopathy will help in identifying an effective strategy of treatment aimed to stop and prevent cardiac damage. Specifically, we need to (a) evaluate the potential role of autoantibodies in disease prevention and progression, and understand their importance as markers of disease progression; (b) clarify the role of immunoregulation in exacerbating the disease.
Topics: Animals; Autoimmunity; Cardiomyopathy, Dilated; Humans; Immunoglobulins, Intravenous; Immunologic Factors; Immunosorbent Techniques; Immunosuppressive Agents; Myocarditis
PubMed: 18545064
DOI: 10.2459/JCM.0b013e3282f3e9c2 -
Srpski Arhiv Za Celokupno Lekarstvo 2012Celiac disease is an inflammatory condition of the small intestinal mucosa induced by gluten consumption in genetically susceptible individuals, leading to a spectrum of... (Review)
Review
INTRODUCTION
Celiac disease is an inflammatory condition of the small intestinal mucosa induced by gluten consumption in genetically susceptible individuals, leading to a spectrum of gastrointestinal presentation. A number of autoimmune and other disorders are highly associated with celiac disease. Cardiomyopathy associated with celiac disease has been rarely reported in the literature.
CASE OUTLINE
We present a case of a 27-year-old male with one month history of diarrhea, weight loss, fatigue, dyspeptic symptoms, peripheral edema, and cardiac palpitations. After positive serological screening with immunoglobulin A anti-tissue transglutaminase antibody test, the diagnosis of celiac disease was confirmed with histopathology examination of duodenal biopsy specimen. Echocardiographic findings were consistent with acute myocarditis. After common causes of myocarditis had been excluded, probable celiac disease-associated autoimmune myocarditis was diagnosed. The patient was recommended to undergo a strict life-long gluten-free diet. IgA anti-transglutaminase antibodies, and anti-gliadin antibodies, were both significantly elevated during the 6-, 12- and 18-month follow-up. Low compliance to gluten-free diet in our patient led to progressive worsening of the left ventricular ejective fraction and other serious cardiac complications which warranted invasive cardiac interventions.
CONCLUSION
Dilated cardiomyopathy associated with celiac disease is a serious condition which requires multidisciplinary approach involving gastroenterologist and cardiologist. Compliance with gluten-free diet is mandatory if patients are to avoid progression of cardiomyopathy. Screening of patients with idiopathic dilated cardiomyopathy for celiac disease is advisable.
Topics: Adult; Cardiomyopathy, Dilated; Celiac Disease; Humans; Male
PubMed: 23289283
DOI: No ID Found -
Cardiology Journal 2010The clinical goals of risk stratification of sudden death are to identify subjects who are at high risk of, and eventually to reduce the incidence of, sudden death.... (Review)
Review
The clinical goals of risk stratification of sudden death are to identify subjects who are at high risk of, and eventually to reduce the incidence of, sudden death. Numerous studies have described risk stratification techniques for serious cardiac events in patients following myocardial infarction. However, relatively little information is available regarding nonischemic dilated cardiomyopathy. A number of diagnostic methods have been used for risk stratification of patients with nonischemic dilated cardiomyopathy, including presence of syncope, ambulatory electrocardiographic monitoring, programmed ventricular stimulation, QRS duration, QT interval dispersion, QT interval dynamicity, signal-averaged ECG, heart rate variability, heart rate turbulence, baroreflex sensitivity, heart rate recovery, exercise recovery ventricular ectopy, fragmented QRS and cardiac magnetic resonance imaging. In this review, existing data regarding risk stratification of sudden cardiac death in nonischemic dilated cardiomyopathy will be summarized and its implications in clinical practice will be reviewed.
Topics: Baroreflex; Cardiac Pacing, Artificial; Cardiomyopathy, Dilated; Death, Sudden, Cardiac; Electrocardiography; Electrocardiography, Ambulatory; Electrophysiologic Techniques, Cardiac; Heart Rate; Humans; Magnetic Resonance Imaging; Nonlinear Dynamics; Predictive Value of Tests; Prognosis; Risk Assessment; Risk Factors; Syncope; Time Factors
PubMed: 20535711
DOI: No ID Found -
European Journal of Heart Failure Jan 2024
Topics: Humans; Cardiomyopathy, Dilated; Coronary Artery Disease; Heart Failure; Coronary Angiography; Echocardiography
PubMed: 37994286
DOI: 10.1002/ejhf.3095