-
Journal of Psychopharmacology (Oxford,... Sep 2001We assessed the influence of dimenhydrinate, cinnarizine and transdermal scopolamine on the ability to perform simulated naval crew tasks. The effect of single doses of... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
We assessed the influence of dimenhydrinate, cinnarizine and transdermal scopolamine on the ability to perform simulated naval crew tasks. The effect of single doses of dimenhydrinate, 100 mg, cinnarizine, 50 mg, and one transdermal scopolamine patch on psychomotor performance was evaluated using a double-blind, placebo-controlled, randomized, crossover design in three separate studies. A total of 60 young naval crew (20 for dimenhydrinate, 15 for cinnarizine and 25 for transdermal scopolamine) underwent a battery of computerized and paper and pencil performance tests, and filled out a questionnaire on side-effects and well-being self-assessment. Dimenhydrinate significantly impaired decision reaction time and auditory digit span. Most of the subjects who took dimenhydrinate also reported a subjective decrease in well-being and general performance abilities. Cinnarizine and transdermal scopolamine did not affect performance abilities. Cinnarizine was free of significant side-effects. Dry mouth was the only significant side-effect of transdermal scopolamine. These findings could be explained by the well-known sedative properties of dimenhydrinate and not by a specific effect on any particular cognitive or motor function. Our results suggest that dimenhydrinate, 100 mg, adversely affects psychomotor function, whereas single doses of cinnarizine, 50 mg, and transdermal scopolamine appear to be free of side-effects on performance and seem to be a preferable anti-seasickness drug for use by a naval crew.
Topics: Administration, Cutaneous; Administration, Oral; Adolescent; Adult; Arousal; Attention; Cinnarizine; Cross-Over Studies; Dimenhydrinate; Dose-Response Relationship, Drug; Double-Blind Method; Drug Administration Schedule; Humans; Male; Mental Recall; Military Personnel; Motion Sickness; Neuropsychological Tests; Psychomotor Performance; Scopolamine
PubMed: 11565623
DOI: 10.1177/026988110101500311 -
Aesthetic Plastic Surgery Feb 2018
Topics: Antiemetics; Dexamethasone; Dimenhydrinate; Double-Blind Method; Drug Therapy, Combination; Humans; Nausea; Ondansetron; Vomiting
PubMed: 29026948
DOI: 10.1007/s00266-017-0972-2 -
Canadian Medical Association Journal Mar 1961
Topics: Dimenhydrinate; Female; Humans; Obstetrics; Oxytocics; Pregnancy
PubMed: 13783459
DOI: No ID Found -
Drug Delivery and Translational Research Oct 2019The objective of the study was the development and in vitro characterization of a self-emulsifying drug delivery system (SEDDS) for the nasal application of...
The objective of the study was the development and in vitro characterization of a self-emulsifying drug delivery system (SEDDS) for the nasal application of dimenhydrinate. Final composition of SEDDS was established based on drug solubility and stability studies. Dimenhydrinate was loaded into the SEDDS pre-concentrates to 7.5% (m/v). The droplet size of the final SEDDS formulations was in a range between 60 and 220 nm. Permeability, as well as tissue toxicity, of the formulations was investigated using bovine nasal mucosa. Enhancement in permeation up to 2.8-fold compared to pure dimenhydrinate was confirmed. Furthermore, toxicity studies did not reveal any serious tissue damages related to the SEDDS. Additionally, irritation potential of SEDDS was evaluated in ciliary beat frequency measurements. Incorporation of dimenhydrinate into SEDDS might therefore be considered as a promising approach within the field of nasal delivery of antiemetics by utilizing permeation enhancement strategy.
Topics: Administration, Intranasal; Animals; Antiemetics; Cattle; Cilia; Dimenhydrinate; Drug Delivery Systems; Drug Liberation; Emulsions; In Vitro Techniques; Nasal Mucosa; Permeability; Solubility
PubMed: 30877627
DOI: 10.1007/s13346-019-00634-1 -
BMJ Case Reports Mar 2024Dimenhydrinate is an over-the-counter antihistaminergic medication with anticholinergic properties used to treat nausea or motion sickness worldwide. There is a...
Dimenhydrinate is an over-the-counter antihistaminergic medication with anticholinergic properties used to treat nausea or motion sickness worldwide. There is a well-established correlation between the use of anticholinergic medications and dementia, however, it is unclear if a causal role exists. We report a case of minor neurocognitive disorder in a woman in her 40s with several years of high-dose daily dimenhydrinate abuse who subsequently developed significant delusional beliefs. Her clinical presentation was confounded by numerous other factors that could have impacted her cognition, such as a longstanding presumed learning disability, ankylosing spondylitis with adalimumab treatment, extensive cannabis use or potential development of a primary psychotic disorder. Her workup was within normal limits, and she has not responded to first-line antipsychotic medications to date. This case report adds to the growing evidence supporting concerns about potentially irreversible cognitive deficits in chronic misuse of anticholinergic agents, an association previously observed only in the elderly population.
Topics: Adult; Female; Humans; Middle Aged; Cholinergic Antagonists; Cognitive Dysfunction; Dimenhydrinate; Psychotic Disorders
PubMed: 38453220
DOI: 10.1136/bcr-2023-258493 -
Aesthetic Plastic Surgery Feb 2017Postoperative Nausea and Vomiting is one of the most common problems after implementation of general anesthesia. The incidence can reach 80% in high-risk patients,... (Comparative Study)
Comparative Study Randomized Controlled Trial
INTRODUCTION
Postoperative Nausea and Vomiting is one of the most common problems after implementation of general anesthesia. The incidence can reach 80% in high-risk patients, depending on the type of surgery. In our study, we aimed to compare dexamethasone-dimenhydrinate and dexamethasone-ondansetron combinations in prevention of nausea and vomiting in postoperative patients.
METHOD
Sixty 18-65-year-olds ASAI-II females who underwent rhinoplasty were included in the study. Patients were randomly included in two groups: Dexamethasone-dimenhydrinate group (group DD) and dexamethasone-ondansetron group (group DO). All patients received dexamethasone 8 mg iv after endotracheal intubation. Anesthesia continuation was established with sevoflurane, air-oxygen mixture and remifentanil infusion. At the 30th minute of the operation, group DO received ondansetron 4 mg iv and group DD received dimenhydrinate 1 mg/kg iv. For postoperative analgesia tramadol (1.5 mg/kg) iv, tenoksikam (20 mg) and afterward for postoperative patient-controlled tramadol was used. In the postoperative recovery room, nausea and vomiting were evaluated at the 30th, 60th, 120th minutes and at the end of 24 h. Total amount of tramadol was recorded. All results were statistically evaluated.
OBSERVATIONS
Demographics and Apfel risk scores of both groups were similar. Surgical operation duration (p = 0.038) and total preoperative remifentanil consumption were higher in group DD (p = 0.006). In group DO, nausea at 30 and 60 min (p = 0.001, p = 0.007), retching at 30 and 60 min (p = 0.002, p = 0.006) were higher than group DD. The additional antiemetic need in group DO was significantly higher at 30 min (p = 0.001). Postoperative analgesic consumption was similar in both groups.
RESULT
Our study revealed that dexamethasone-dimenhydrinate combination was more effective than dexamethasone-ondansetron in prevention of nausea and vomiting after rhinoplasty operations.
LEVEL OF EVIDENCE IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 .
Topics: Adult; Aged; Anesthesia, General; Dexamethasone; Dimenhydrinate; Double-Blind Method; Drug Therapy, Combination; Elective Surgical Procedures; Female; Follow-Up Studies; Humans; Middle Aged; Ondansetron; Postoperative Nausea and Vomiting; Prospective Studies; Rhinoplasty; Risk Assessment; Treatment Outcome; Young Adult
PubMed: 28039501
DOI: 10.1007/s00266-016-0772-0 -
Canadian Medical Association Journal Dec 1969
Topics: Adolescent; Dimenhydrinate; Humans; Male; Psychoses, Substance-Induced; Substance-Related Disorders
PubMed: 5362300
DOI: No ID Found -
Advanced Pharmaceutical Bulletin Nov 2018To develop fast dissolving oral film to address vomiting and nausea in pediatric population. Oral films of Dimenhydrinate were prepared by solvent casting method by...
To develop fast dissolving oral film to address vomiting and nausea in pediatric population. Oral films of Dimenhydrinate were prepared by solvent casting method by using hydroxypropylmethyl cellulose E5 (HPMC E5), polyethylene glycol 400 (PEG 400) and croscarmellose sodium. Solubility of dimenhydrinate was enhanced by ethanol as a co-solvent. To make dimenhydrinate palatable sodium saccharin and peppermint oil were used. All films were evaluated for mechanical parameters, surface pH, morphology, disintegration time and percent dissolution. Films were smooth, acceptable and white in colour. For optimized batch, drug content (99.106%), disintegration time (25 sec), dissolution (99.10% in 210 sec), surface pH (6.81) were acceptable. Optimized batch, due to its potential to deliver through fast dissolving film, can be developed for clinical use.
PubMed: 30607345
DOI: 10.15171/apb.2018.081 -
CMAJ : Canadian Medical Association... Mar 1988
Topics: Adult; Dimenhydrinate; Drug Tolerance; Female; Humans; Substance Withdrawal Syndrome; Substance-Related Disorders
PubMed: 3342361
DOI: No ID Found -
Likars'ka Sprava 2003Among varieties of migraine characteristic of liquidators of effects of the Chernobyl catastrophy and ChNPP personnel migraine with a manifest vestibular component holds...
Among varieties of migraine characteristic of liquidators of effects of the Chernobyl catastrophy and ChNPP personnel migraine with a manifest vestibular component holds a prominent place. As many as 803 middle-aged patients, average age (39.6 +/- 11.8) years, were examined. Among these were the ChNPP personnel, liquidators, and migrators from Pripyat, who had received low doses of radiation to 0.5 rem. Used in the examination were questionnaire survey (HOACK), vestibular tests (Uemura, Fukuda, etc.), nistagmography, cardiography with Takagasi loading tests, multisensory evoked potentials. Virtually all examinees demonstrated disturbances in the vestibular function. Of these, 92.4 percent of subjects had headache complaints. In 35 percent of the examinees, pain was of a typical migranous character. Additional signs included asthenization, vegetative symptomatology, vestibulocardial syndrome, emotional derangements. The histamine blocking agents dimenhydrinate and betaserk proved to be the most effective treatment options in the above patient population.
Topics: Adult; Affective Symptoms; Betahistine; Dimenhydrinate; Environmental Exposure; Histamine H1 Antagonists; Humans; Migraine Disorders; Occupational Diseases; Radiation Injuries; Radioactive Hazard Release; Ukraine; Vestibular Diseases; Vestibular Function Tests
PubMed: 12712619
DOI: No ID Found