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American Journal of Obstetrics and... Jan 1962
Topics: Analgesia; Anesthesia; Anesthesia and Analgesia; Anesthesia, Obstetrical; Dimenhydrinate; Female; Humans; Labor, Obstetric; Pain Management; Pregnancy
PubMed: 13909999
DOI: 10.1016/0002-9378(62)90283-1 -
Zentralblatt Fur Gynakologie 1979Report is given about a case of Ptyalismus gravidarum. The data found in literature about the theories of etiology and the possibilities of therapy are discussed. The...
Report is given about a case of Ptyalismus gravidarum. The data found in literature about the theories of etiology and the possibilities of therapy are discussed. The use of psycho-therapy is advised.
Topics: Adult; Dimenhydrinate; Drug Therapy, Combination; Female; Humans; Pregnancy; Pregnancy Complications; Pyridoxine; Sialorrhea
PubMed: 442873
DOI: No ID Found -
Aviation, Space, and Environmental... Nov 1995Previous research in our laboratory has shown that symptoms of motion sickness are accompanied by the loss of normal 3 cpm activity and the development of... (Clinical Trial)
Clinical Trial
BACKGROUND
Previous research in our laboratory has shown that symptoms of motion sickness are accompanied by the loss of normal 3 cpm activity and the development of tachyarrhythmia in the electrogastrogram (EGG).
HYPOTHESIS
We hypothesized that dimenhydrinate would prevent the development of gastric tachyarrhythmia and reduce symptoms of motion sickness.
METHODS
Twenty health volunteers were tested in a counter-balanced, within-subject, double-blind design. Subjects were exposed to a rotating optokinetic drum to induce vection after receiving either dimenhydrinate (100 mg) or a placebo on two separate occasions. EGG's were recorded immediately before ingestion of capsules, 1 h after ingestion, and during rotation. Motion sickness symptom reports (SSMS) were obtained prior to and during rotation.
RESULTS
The average SSMS score was 5.9 points higher after placebo administration than after dimenhydrinate administration (t[19] = 4.87, P < 0.001). Significantly more subjects requested early termination of the rotating drum due to severe symptoms after placebo administration than after dimenhydrinate administration (McNemar's chi 2[1] = 6.00, p < 0.05). Drowsiness reports were significantly higher after dimenhydrinate administration than after placebo administration (t[19] = 2.65, p < 0.05). Analysis of EGG's showed a significant decrease in normal 3 cpm and tachyarrhythmic activity after dimenhydrinate, but no change after placebo (SR[19] = 53, p < 0.02 and SR[19] = 68, p < 0.01 respectively). During drum rotation gastric tachyarrhythmias increased significantly in the placebo condition (SR[18] = -0.61.5, p < 0.01), but not in the dimenhydrinate condition. EGG's were not significantly different between conditions.
CONCLUSIONS
We conclude that dimenhydrinate reduced motion sickness symptoms at least in part by depressing central nervous system activity and possibly by suppressing abnormal gastric myoelectric activity.
Topics: Adolescent; Adult; Dimenhydrinate; Double-Blind Method; Electrocardiography; Female; Histamine H1 Antagonists; Humans; Male; Motion Sickness; Stomach
PubMed: 8588792
DOI: No ID Found -
Anasthesiologie, Intensivmedizin,... May 2001Droperidol and dimenhydrinate are inexpensive antiemetic drugs. Droperidol, especially, has been studied extensively in the past, but there are no studies that used the... (Clinical Trial)
Clinical Trial Comparative Study Randomized Controlled Trial
BACKGROUND
Droperidol and dimenhydrinate are inexpensive antiemetic drugs. Droperidol, especially, has been studied extensively in the past, but there are no studies that used the combination of both drugs for prevention of postoperative nausea and vomiting (PONV). Thus, the aim of this randomised controlled and double-blinded study was to evaluate the antiemetic efficacy and the side effects of such a combination therapy.
METHODS
240 inpatients undergoing ENT surgery under general anaesthesia were randomised to receive one of four antiemetic regimes: placebo, dimenhydrinate (1 mg x kg-1), droperidol (15 micrograms x kg-1), or the combination of both drugs (droperidol 15 micrograms x kg-1 + dimenhydrinate 1 mg x kg-1) was administered after induction of anaesthesia and repeated 6 hours after the first administration. For general anaesthesia a standardised technique including benzodiazepine premedication, propofol, desflurane in N2O/O2, vecuronium, and a continuous infusion of remifentanil was used. Postoperative analgesia and antiemetic rescue medication were standardised. Episodes of vomiting, retching, nausea, and the need for additional antiemetics were recorded for 24 hours. The main goal of the study was to increase the number of patients who were completely free from PONV (chi 2-test with Fisher-Yates' correction). Furthermore, the severity of PONV was analysed using a standardised scoring algorithm.
RESULTS
Data of 227 patients could be analysed. The incidence of patients who suffered from PONV was 41.3% (95%-confidence interval: 29-55%) in the placebo-group. Dimenhydrinate alone reduced PONV to 34.5% (95%-CI: 22-48%). This marginal effect and the effect of droperidol (PONV: 26.4% (95%-CI: 15-40%)) could not be proven statistically, since the power of the study was too small. The combination of both drugs decreased PONV to 19.6% (95%-CI: 10-32%) and also reduced the severity of the symptoms to a clinically acceptable level.
CONCLUSION
Dimenhydrinate failed to reduce the incidence and severity of PONV. The efficiency of droperidol given alone was within the ranges previously known from metaanalytic data. The combination of both drugs showed a moderate synergistic effect.
Topics: Adult; Aged; Antiemetics; Dimenhydrinate; Double-Blind Method; Droperidol; Drug Therapy, Combination; Female; Humans; Male; Middle Aged; Postoperative Nausea and Vomiting
PubMed: 11413698
DOI: 10.1055/s-2001-14473 -
Canadian Medical Association Journal Jul 1964Dimenhydrinate was administered intravenously to patients in spontaneous labour in order to evaluate its effect on the length of labour, its analgesic property, its...
Dimenhydrinate was administered intravenously to patients in spontaneous labour in order to evaluate its effect on the length of labour, its analgesic property, its potentiation of the effects of standard analgesics and its overall safety. The results of this study provided no evidence that labour was shortened or that uterine activity was increased in those receiving intravenous dimenhydrinate, nor did this drug decrease the need for conventional analgesics. There were no maternal or fetal complications. It is concluded that intravenous administration of dimenhydrinate has no advantage over analgesics administered by other routes and has a limited use in current obstetrical practice.
Topics: Administration, Intravenous; Analgesics; Biomedical Research; Dimenhydrinate; Drug Therapy; Female; Fetus; Humans; Injections; Injections, Intravenous; Labor, Obstetric; Meperidine; Placebos; Pregnancy; Work
PubMed: 14180526
DOI: No ID Found -
The Annals of Otology, Rhinology, and... May 2020The aim of this study was to compare the effects of betahistine with dimenhydrinate on the resolution of residual dizziness (RD) of patients with benign paroxysmal...
The Impact of Betahistine versus Dimenhydrinate in the Resolution of Residual Dizziness in Patients with Benign Paroxysmal Positional Vertigo: A Randomized Clinical Trial.
OBJECTIVES
The aim of this study was to compare the effects of betahistine with dimenhydrinate on the resolution of residual dizziness (RD) of patients with benign paroxysmal positional vertigo (BPPV) after successful Epley maneuver.
METHODS
In this double-blind, randomized clinical trial, patients with posterior semicircular canal type of BPPV were included. After execution of the Epley maneuver, patients were assigned randomly to one group for 1 week: betahistine, dimenhydrinate or placebo. The primary outcomes were scores of the Dizziness Handicap Inventory (DHI) and the modified Berg balance scale (mBBS). All patients were asked to describe the characteristics of their subjective residual symptoms. Binary logistic regression analysis was performed to examine the predictors of improved RD. All analyses were conducted using SPSS 19.0.
RESULTS
In total, 117 patients (age range: 20-65 years) participated in this study. After the Epley maneuver, 88 participants had RD. After the intervention, 38 patients exhibited an improved RD. Less than 50% of participants in the three groups showed mild to moderate dizziness handicap. However, there was no significant difference between mBBS scores of groups before or after the intervention. Logistic regression was shown that patients with receiving betahistine were 3.18 times more likely to have no RD than the placebo group. Increasing age was associated with a decreased likelihood of improving RD ( = .05).
CONCLUSION
The analysis of data showed that the use of betahistine had more effect on improving RD symptoms. We recommended future studies using objective indicators of residual dizziness.
Topics: Adolescent; Adult; Aged; Benign Paroxysmal Positional Vertigo; Betahistine; Dimenhydrinate; Dizziness; Double-Blind Method; Female; Follow-Up Studies; Histamine H1 Antagonists; Humans; Male; Middle Aged; Retrospective Studies; Treatment Outcome; Vasodilator Agents; Young Adult
PubMed: 31810393
DOI: 10.1177/0003489419892285 -
Klinische Padiatrie 2009Dimenhydrinate overdosage in a 3(1/2) year-old-girl with dilative cardiomyopathy. Dimenhydrinate (Vomex(R)) is frequently used in the treatment of sickness and vomiting....
Dimenhydrinate overdosage in a 3(1/2) year-old-girl with dilative cardiomyopathy. Dimenhydrinate (Vomex(R)) is frequently used in the treatment of sickness and vomiting. The symptoms of overdosage present like an anticholinergic syndrome. We report on the clinical findings of an intoxication with dimenhydrinate in a 3(1/2) year-old-girl with functional dilative cardiomyopathy following a congenital left ventricular diverticle. Especially in small children, with the application of 40 mg suppositories once or twice per day the maximum dose of 3.75 mg/kgBW/d is achieved.
Topics: Antiemetics; Cardiomyopathy, Dilated; Child, Preschool; Dimenhydrinate; Drug Overdose; Female; Follow-Up Studies; Humans; Suppositories; Time Factors
PubMed: 18240110
DOI: 10.1055/s-2007-984371 -
Acta Oto-laryngologica. Supplementum 1988A review of the treatment of vestibular disorders with drugs is presented. In animal experiments, administration of certain drugs, e.g. alcohol, barbiturates and... (Review)
Review
A review of the treatment of vestibular disorders with drugs is presented. In animal experiments, administration of certain drugs, e.g. alcohol, barbiturates and chlorpromazine, retards the vestibular compensation, while others, e.g. caffeine, amphetamine and ACTH, accelerate the compensation. In compensated animals, some drugs produce overcompensation and some decompensation. A double-blind, randomized trial of the effect of scopolamine and dimenhydrinate in patients with vertigo of varying origin showed, as compared with placebo, that these drugs did not significantly alleviate the vestibular imbalance. The reason for the poor efficacy of the treatment may have been overcompensation of vestibular function loss and adverse effects caused by the drugs. Care should be taken that the drugs used do not retard the vestibular compensation caused by the central nervous system.
Topics: Animals; Dimenhydrinate; Humans; Meniere Disease; Motion Sickness; Scopolamine; Vertigo; Vestibule, Labyrinth
PubMed: 3064540
DOI: 10.3109/00016488809125063 -
Journal of Addiction Medicine 2019: Reporting of intoxication and withdrawal from aberrant use of over-the-counter medication has been sparse and inconsistent in literature. Attributed to their...
: Reporting of intoxication and withdrawal from aberrant use of over-the-counter medication has been sparse and inconsistent in literature. Attributed to their anticholinergic properties, medications such as dimenhydrinate (Gravol) taken in supratherapeutic doses have been associated with euphoria, anxiolysis, and hallucinations. We present a case of a woman in her forties, with a psychiatric history of bipolar disorder, and complex concurrent medical history including familial Mediterranean fever (FMF), and fibromyalgia, admitted for withdrawal management of her intravenous dimenhydrinate use. As a result of her FMF, there were numerous hospital admissions and treatment which required intravenous access. Hence, a physician-inserted intravenous access port was placed on her chest. The port was maintained monthly with the help of a community agency. In this port, she was injecting 100 to 200 mg of dimenhydrinate hourly for its euphoric and calming effects, consuming upwards of 2400 mg/d. Comprehensive laboratory work-up and urine drug screening were unremarkable. Vital signs were stable. Her mental status at time of admission was lethargic, unfocused, but calm. Her withdrawal symptoms included severe nausea, vomiting, sedation, headaches, dizziness, anxiety, and muscle stiffness. Her detoxification was managed with benztropine and lorazepam, and was well tolerated. The patient was discharged to a community inpatient rehabilitation center. Urine drug testing before discharge was negative. This case draws attention to the addictive potential of dimenhydrinate and offers a regime for its medical withdrawal management. Additionally, this case highlights that screening and management of over-the-counter medications warrants further clinical consideration and investigation.
Topics: Benztropine; Bipolar Disorder; Dimenhydrinate; Female; Humans; Infusions, Intravenous; Lorazepam; Middle Aged; Poisoning; Psychotropic Drugs
PubMed: 30844875
DOI: 10.1097/ADM.0000000000000511 -
Proceedings of the Society For... Mar 1953
Topics: Animals; Apomorphine; Cats; Dimenhydrinate; Diphenhydramine; Dogs; Vomiting
PubMed: 13047426
DOI: 10.3181/00379727-82-20141