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Acta Paediatrica May 1952
Topics: Dimercaprol; Mercury; Mercury Poisoning
PubMed: 12976117
DOI: 10.1111/j.1651-2227.1952.tb17033.x -
Journal of Chromatographic Science May 1973
Topics: Chromatography, Gas; Dimercaprol; Drug Contamination; Propane; Sulfhydryl Compounds
PubMed: 4710648
DOI: 10.1093/chromsci/11.5.269 -
British Medical Journal Sep 1953
Topics: Dimercaprol; Humans; Mercuric Chloride; Mercury; Mercury Poisoning
PubMed: 13082034
DOI: 10.1136/bmj.2.4835.545 -
American Professional Pharmacist Mar 1947
Topics: Dimercaprol; Sulfhydryl Compounds
PubMed: 20245452
DOI: No ID Found -
British Medical Journal Jun 1972
Topics: Blood Cell Count; Blood Platelets; Blood Transfusion; Dimercaprol; Female; Gold; Humans; Injections, Intramuscular; Leukocyte Count; Middle Aged; Prednisolone; Thrombocytopenia
PubMed: 5036882
DOI: 10.1136/bmj.2.5816.748 -
Clinical Rheumatology Dec 1987Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia. All three patients experienced remission of their disease at the...
Three patients receiving gold salt treatment for rheumatoid arthritis developed severe aplastic anemia. All three patients experienced remission of their disease at the time of the occurrence of marrow aplasia. Reviewing data on these patients and recent literature indicate that fatal marrow aplasia seems to occur more frequently in sero-negative women who respond well to therapy with gold salts. Frequent blood monitoring in search for any pronounced or sustained drop in red, white or platelet count, even within normal range could serve as a warning sign for myelotoxicity. Despite intensive supportive measures and specific therapeutic attempts, all three patients eventually died of septic shock.
Topics: Adult; Aged; Anemia, Aplastic; Arthritis, Rheumatoid; Dimercaprol; Female; Humans; Metalloproteins; Middle Aged; Organogold Compounds; Organometallic Compounds; Propanols; Shock, Septic; Sulfhydryl Compounds
PubMed: 3449312
DOI: 10.1007/BF02330601 -
Anaesthesia and Intensive Care Aug 1981
Topics: Adolescent; Dimercaprol; Female; Gastric Lavage; Humans; Mercury Poisoning
PubMed: 7283123
DOI: 10.1177/0310057X8100900310 -
The Journal of Antimicrobial... Nov 1999Microorganisms in biofilms, cells attached to a surface and embedded in secreted insoluble extracellular polymers, are recalcitrant to chemical biocides and antibiotics....
Microorganisms in biofilms, cells attached to a surface and embedded in secreted insoluble extracellular polymers, are recalcitrant to chemical biocides and antibiotics. When Pseudomonas aeruginosa ERC1 biofilms were treated continuously with 1 x MIC of bismuth dimercaprol (BisBAL), biofilm density determined by both total cell counts and viable cell counts increased during the first 30 h period then decreased thereafter. After 120 h of treatment there was an approximate 3-log reduction in viable cell areal density compared with the untreated control. Per-cell total polysaccharide production was significantly reduced in biofilms exposed to 12.5 microM BisBAL compared with the untreated control. In biofilm cultures, 1 x MIC of BisBAL did not initially kill attached cells but was enough to reduce polysaccharide production. As treatment proceeded, the normalized polysaccharide content was reduced and those cells attached became susceptible to 1 x MIC of BisBAL.
Topics: Anti-Bacterial Agents; Biofilms; Bismuth; Colony Count, Microbial; Culture Media; Dimercaprol; Drug Combinations; Microbial Sensitivity Tests; Organometallic Compounds; Polysaccharides, Bacterial; Pseudomonas aeruginosa
PubMed: 10552975
DOI: 10.1093/jac/44.5.601 -
Drug Intelligence & Clinical Pharmacy Dec 1988Deliberate parenteral self-injection of mercury is extremely rare, and is associated with a high degree of mortality and morbidity. Because mercury depresses cellular...
Deliberate parenteral self-injection of mercury is extremely rare, and is associated with a high degree of mortality and morbidity. Because mercury depresses cellular enzymatic mechanisms by combining with sulfhydryl groups, soluble mercuric salts are toxic to all cells. Embolization of mercury in the lungs has been reported with varying degrees of changes in pulmonary function. Mercury causes urticaria progressing to weeping dermatitis, leukopenia, anemia, diarrhea, salivation, liver damage, and renal damage progressing to acute renal failure with anuria. Dimercaprol is an effective antidote in acute heavy metal intoxication because its two sulfhydryl groups successfully compete with tissue enzyme sulfhydryl groups for the offending metal. Experience with dimercaprol therapy months after the original exposure to mercury is not available. We describe the hospital course of a patient after intravenous elemental injection and the results of dimercaprol therapy months after the original exposure.
Topics: Adult; Dimercaprol; Humans; Injections, Intravenous; Male; Mercury; Mercury Poisoning; Self Administration; Suicide
PubMed: 3243178
DOI: 10.1177/106002808802201208 -
Toxicology Mar 1995Four chelating agents that have been used most commonly for the treatment of humans intoxicated with lead, mercury, arsenic or other heavy metals and metalloids are... (Review)
Review
Four chelating agents that have been used most commonly for the treatment of humans intoxicated with lead, mercury, arsenic or other heavy metals and metalloids are reviewed as to their advantages, disadvantages, metabolism and specificity. Of these, CaNa2EDTA and dimercaprol (British anti-lewisite, BAL) are becoming outmoded and can be expected to be replaced by meso-2,3-dimercaptosuccinic acid (DMSA, succimer) for treatment of lead intoxication and by the sodium salt of 2,3-dimercapto-1-propanesulfonic acid (DMPS, Dimaval) for treating lead, mercury or arsenic intoxication. Meso-2,3-DMSA and DMPS are biotransformed differently in humans. More than 90% of the DMSA excreted in the urine is found in the form of a mixed disulfide in which each of the sulfur atoms of DMSA is in disulfide linkage with an L-cysteine molecule. After DMPS administration, however, acyclic and cyclic disulfides of DMPS are found in the urine. The Dimaval-mercury challenge test holds great promise as a diagnostic test for mercury exposure, especially for low level mercurialism. Urinary mercury after Dimaval challenge may be a better biomarker of low level mercurialism than unchallenged urinary mercury excretion.
Topics: Animals; Chelating Agents; Dimercaprol; Edetic Acid; Humans; Metals; Succimer; Unithiol
PubMed: 7716789
DOI: 10.1016/0300-483x(95)02965-b