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Anti-cancer Agents in Medicinal... 2022The objective of this study was to analyze the antitumor effect of BisBAL NP in a mouse melanoma model.
AIM
The objective of this study was to analyze the antitumor effect of BisBAL NP in a mouse melanoma model.
MATERIALS AND METHODS
The antitumor activity of BisBAL NP on murine B16-F10 melanoma cells was determined both in vitro (PrestoBlue cell viability assay and Live/Dead fluorescence) and in vivo, in a mouse model, with the following 15-day treatments: BisBAL NP, negative control (PBS), and cell-death control (docetaxel; DTX). Mouse survival and weight, as well as the tumor volume, were recorded daily during the in vivo study.
RESULTS
BisBAL NP were homogeneous in size (mean diameter, 14.7 nm) and bismuth content. In vitro, 0.1 mg/mL BisBAL NP inhibited B16-F10 cell growth stronger (88%) than 0.1 mg/mL DTX (82%) (*p<0.0001). In vivo, tumors in mice treated with BisBAL NP (50 mg/kg/day) or DTX (10 mg/kg/day) were 76% and 85% smaller than the tumors of negative control mice (*p<0.0001). The average weight of mice was 18.1 g and no statistically significant difference was detected among groups during the study. Alopecia was only observed in all DTX-treated mice. The survival rate was 100% for the control and BisBAL NP groups, but one DTX- treated mouse died at the end of the treatment period. The histopathological analysis revealed that exposure to BisBAL NP was cytotoxic for tumor tissue only, without affecting the liver or kidney.
CONCLUSION
BisBAL NP decreased the tumor growing in a mouse melanoma model without secondary effects, constituting an innovative low-cost alternative to treat melanoma.
Topics: Animals; Antineoplastic Agents; Bismuth; Cell Line, Tumor; Dimercaprol; Humans; Melanoma, Experimental; Mice; Nanoparticles; Organometallic Compounds
PubMed: 35168526
DOI: 10.2174/1871520622666220215124434 -
A.M.A. Archives of Neurology and... Jan 1953
Topics: Dimercaprol; Electroencephalography; Hepatolenticular Degeneration
PubMed: 12996137
DOI: 10.1001/archneurpsyc.1953.02320250090010 -
Duodecim; Laaketieteellinen... 1948
Topics: Dermatitis; Dimercaprol; Gold; Humans; Organogold Compounds; Poisoning
PubMed: 18888563
DOI: No ID Found -
Prensa Medica Argentina Apr 1959
Topics: Dimercaprol; Prednisolone; Thallium
PubMed: 14442443
DOI: No ID Found -
A Gyogyszeresz Jul 1955
Topics: Dimercaprol
PubMed: 24543726
DOI: No ID Found -
Journal de Medecine de Bordeaux Et Du... Jul 1954
Topics: Dimercaprol
PubMed: 13192423
DOI: No ID Found -
The Journal of Pediatrics Oct 1977Severe poisoning resulting from single ingestions of rodenticides, herbicides, or insecticides containing arsenic have been frequently recognized. We record three cases...
Severe poisoning resulting from single ingestions of rodenticides, herbicides, or insecticides containing arsenic have been frequently recognized. We record three cases of solubilized arsenic trioxide poisoning in Navajo Indian children and one case of sodium arsenate ingestion in an infant. One fatality occurred during dimercaprol therapy prior to initiation of therapy with D-penicillamine. Three survivors were treated with 2.3-dimercaprol intramuscularly and with oral D-penicillamine. The use of D-penicillamine in arsenic poisoning has not been generally appreciated. Excretion data from the three children are presented which document the effectiveness of D-penicillamine, administered orally in four daily doses of 25 mg/kg/dose, in the therapy of arsenic intoxication. Excretion data for the trace metals, zinc and copper, during D-penicillamine chelation therapy are also reported.
Topics: Acute Disease; Arsenic Poisoning; Child, Preschool; Dimercaprol; Humans; Infant; Male; Penicillamine
PubMed: 908992
DOI: 10.1016/s0022-3476(77)80528-3 -
Critical Care Medicine Mar 1990Four cases of acute oral antimony intoxication are reported. Three patients survived without sequelae. One patient, a 93-yr-old male, died from multiple organ failure....
Four cases of acute oral antimony intoxication are reported. Three patients survived without sequelae. One patient, a 93-yr-old male, died from multiple organ failure. Toxicological analysis of blood, urine, and tissues revealed a severe intoxication.
Topics: Adult; Aged; Aged, 80 and over; Antimony; Blood Chemical Analysis; Blood Gas Analysis; Combined Modality Therapy; Dimercaprol; Female; Humans; Male; Middle Aged; Multiple Organ Failure
PubMed: 2302961
DOI: 10.1097/00003246-199003000-00017 -
The Journal of Pharmacology and... Dec 1959
Topics: Dimercaprol; Diuretics; Humans; Kidney; Organomercury Compounds; Renal Elimination
PubMed: 13843572
DOI: No ID Found -
Lancet (London, England) Mar 1955
Topics: Burns; Diabetes Mellitus; Dimercaprol; Humans; Hyperglycemia; Hypoglycemic Agents; Insulin
PubMed: 13234426
DOI: 10.1016/s0140-6736(55)90270-1