-
The British Journal of Ophthalmology Jul 1955
Topics: Arsenicals; Dimercaprol; Humans; Neuritis; Optic Neuritis
PubMed: 13240036
DOI: 10.1136/bjo.39.7.422 -
Neurology Sep 2002In 1951 Denny-Brown and Porter described the successful treatment of Wilson's disease using the chelating agent British antilewisite. The presentation of their results...
In 1951 Denny-Brown and Porter described the successful treatment of Wilson's disease using the chelating agent British antilewisite. The presentation of their results both at meetings and in print changed the traditional view of neurology from a descriptive to an interventional discipline using treatments based on the underlying biochemical disorder. The authors review the importance of these reports and provide edited digital versions of the films Denny-Brown made of the five patients described in the initial reports.
Topics: Dimercaprol; Female; Hepatolenticular Degeneration; History, 20th Century; Humans; Male; Motion Pictures
PubMed: 12297577
DOI: 10.1212/wnl.59.6.914 -
Clinical Toxicology 1972
Topics: Arsenic Poisoning; Arsenicals; Chemistry; Dimercaprol; History, 20th Century; Humans; Lethal Dose 50; Poisoning; Sulfhydryl Compounds
PubMed: 4559017
DOI: 10.3109/15563657208991000 -
Deutsches Medizinisches Journal Aug 1953
Topics: Dimercaprol
PubMed: 13095165
DOI: No ID Found -
Folia Medica. Folia Medica (Naples,... Feb 1955
Topics: Antimony; Dimercaprol; Humans; Occupational Diseases; Poisoning
PubMed: 14380442
DOI: No ID Found -
Comptes Rendus Des Seances de La... 1971
Topics: Animals; Cestode Infections; Dimercaprol; Haplorhini; Lead Poisoning; Rats
PubMed: 4261950
DOI: No ID Found -
Journal of Biochemistry and Molecular... Jul 2003The present work describes a colorimetric microplate assay for lipase activity based on the reaction between 5,5'-dithiobis(2-nitro benzoic acid) (DTNB) and the...
The present work describes a colorimetric microplate assay for lipase activity based on the reaction between 5,5'-dithiobis(2-nitro benzoic acid) (DTNB) and the hydrolysis product of 2,3-dimercapto-1-propanol tributyrate (DMPTB). Reaction mixtures containing DTNB, DMPTB, and lipase were prepared in microplate wells, and the absorbance at 405nm was recorded after incubation at 37 degrees C for 30 min. A linear relationship was obtained in the range of 0.1-1 U of lipase activity by this method. The reaction conditions were also optimized for the range of 0.01-0.1 U or 1-10 U. When assaying crude tissue extracts, the reaction of DTNB with non-specific reducing agents created a major source of error. However, this error was corrected by the use of blank samples that did not contain DMPTB.
Topics: Animals; Candida; Colorimetry; Decapodiformes; Dimercaprol; Dithionitrobenzoic Acid; Lipase; Time Factors
PubMed: 12895302
DOI: 10.5483/bmbrep.2003.36.4.417 -
Proceedings of the Royal Society of... Jan 1959
Topics: Cysteine; Dimercaprol; Hepatolenticular Degeneration; Humans
PubMed: 13623852
DOI: No ID Found -
Acta Tropica Oct 1996Both melarsomine dichlorhydrate (mel Cy, Cymelarsan) and melarsen oxide can be dissolved in dimethylsulfoxide and converted into a gel by the addition of... (Comparative Study)
Comparative Study
Both melarsomine dichlorhydrate (mel Cy, Cymelarsan) and melarsen oxide can be dissolved in dimethylsulfoxide and converted into a gel by the addition of hydroxypropylcellulose. When Trypanosoma brucei brucei-infected mice are treated topically with these gels the circulating trypanosomes are rapidly cleared from the circulation but the infections relapse soon after the last application. However, when these two compounds are allowed to react with 2,3-dimercaptopropinol (British anti-lewisite, BAL) and form "melarsoprol" their efficacy, especially in the case of mel Cy, is restored to that of commercial melarsoprol (Arsobal) and trypanosomes in the central nervous system (CNS) can be eliminated. This would indicate that the dimercaptopropinol portion of the molecule does not act solely as an "antidote" to arsenic toxicity, but also plays an important role in the absorption of melarsoprol through the skin and/or blood-brain barrier into the CNS and/or into the trypanosome.
Topics: Administration, Topical; Animals; Arsenicals; Dimercaprol; Drug Combinations; Female; Gels; Melarsoprol; Mice; Trypanocidal Agents; Trypanosoma brucei brucei; Trypanosomiasis, African
PubMed: 8988309
DOI: 10.1016/s0001-706x(96)00036-8 -
Nature Jan 1975
Topics: Antidotes; Dimercaprol; In Vitro Techniques; Mercury; Mercury Poisoning; Solvents; Structure-Activity Relationship
PubMed: 1110756
DOI: 10.1038/253123a0