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The Journal of Biological Chemistry Oct 1988
Review
Topics: Animals; Brain; Dinoprostone; Prostaglandin D2; Sleep; Wakefulness
PubMed: 3049580
DOI: No ID Found -
Journal of Molecular Medicine (Berlin,... Jan 2002Upon immune challenge the brain launches a wide range of responses, such as fever, anorexia, and hyperalgesia that serve to maintain homeostasis. While these responses... (Review)
Review
Upon immune challenge the brain launches a wide range of responses, such as fever, anorexia, and hyperalgesia that serve to maintain homeostasis. While these responses are adaptive during acute infections, they may be destructive during chronic inflammatory conditions. Research performed during the last decade has given us insight into how the brain monitors the presence of a peripheral inflammation and the mechanisms underlying the brain-mediated acute-phase reactions. Here we give a brief review on this subject, with focus on the role of prostaglandin E2 produced in cells associated with the blood-brain barrier in immune-to-brain signaling. The recent advances in this field have not only elucidated the mechanisms behind the anti-pyretic and anti-hyperalgesic effects of cyclooxygenase inhibitors, but have also identified novel and more-selective potential drug targets.
Topics: Animals; Biological Transport; Blood-Brain Barrier; Dinoprostone; Humans; Inflammation; Neuroimmunomodulation
PubMed: 11862319
DOI: 10.1007/s00109-001-0289-z -
The Journal of Maternal-fetal &... May 2019This study aimed to qualify relevant factors for vaginal delivery among women who underwent labor induction with vaginal dinoprostone (PGE2) insert in a Chinese tertiary...
OBJECTIVE
This study aimed to qualify relevant factors for vaginal delivery among women who underwent labor induction with vaginal dinoprostone (PGE2) insert in a Chinese tertiary maternity hospital.
MATERIAL AND METHODS
A retrospective study was conducted in Hubei Maternal and Child Health Hospital. A total of 1656 pregnancies that underwent labor induction with vaginal dinoprostone insert between January and August 2016 were finally included in this study. Data were analyzed using univariate and multivariable regression modeling.
RESULTS
Of 1656 women with PGE2-induced labor at term, 396 (23.91%) gave birth by cesarean section, 1260 (76.09%) had a vaginal delivery among which 921 (55.61%) delivered vaginally within 24 h. Multivariable regression analysis showed that maternal age (p < .001, OR = 0.89, 95%CI 0.85-0.93), parity (multiparous versus nulliparous, p < .001, OR = 8.74, 95%CI 4.36-17.50), baseline fetal heart rate (p = .009, OR = 0.98, 95%CI 0.96-0.99), and birth weight (p < .001, OR = 0.37, 95%CI 0.28-0.51) were significantly correlated with vaginal delivery. Moreover, body mass index (p < .001, OR = 1.11, 95%CI 1.05-1.19), parity (multiparous versus nulliparous, p < .001, OR = 6.57, 95%CI 2.37-18.23), baseline fetal heart rate (p = .004, OR = 0.96, 95%CI 0.94-0.99), and birth weight (p < .001, OR = 0.34, 95%CI 0.21-0.54) were independent predictors of vaginal delivery within 24-h.
CONCLUSIONS
Our findings suggested a vaginal delivery rate of 76.09% when dinoprostone vaginal insert was used for labor induction, which was markedly higher than the overall annual vaginal delivery rate of 65.1% in China during 2014. Maternal age, parity, baseline fetal heart rate, and birth weight were significant factors for vaginal delivery. This study enables us to better understand the efficiency of dinoprostone and the potential predictors of vaginal delivery in dinoprostone-induced labor, which may be helpful to guide the clinical use of dinoprostone and therefore provide better service clinically.
Topics: Administration, Intravaginal; Adult; Cervical Ripening; China; Delivery, Obstetric; Dinoprostone; Female; Gestational Age; Heart Rate, Fetal; Humans; Labor, Induced; Maternal Age; Oxytocics; Parity; Pregnancy; Retrospective Studies
PubMed: 29268652
DOI: 10.1080/14767058.2017.1416351 -
Ophthalmic Research 2023Dry eye disease (DED) is a multifactor-induced disease accompanied by increased osmolarity of the tear film and inflammation of the ocular surface. Traditional...
INTRODUCTION
Dry eye disease (DED) is a multifactor-induced disease accompanied by increased osmolarity of the tear film and inflammation of the ocular surface. Traditional anti-inflammation agent corticosteroids applied in DED treatment could result in high intraocular pressure, especially in long-term treatment. Therefore, we explored a nano drug that aimed to block the formation pathway of DED which had anti-inflammatory, sustained release, and good biocompatibility characteristics in this study.
METHODS
We prepared a novel nanomedicine (Tet-ATS@PLGA) by the thin film dispersion-hydration ultrasonic method and detected its nanostructure, particle size, and zeta potential. Flow cytometry was used to detect the cell survival rate of each group after 24 h of drug treatment on inflammed Statens Seruminstitut Rabbit Corneal (SIRC) cells. Observed and recorded corneal epithelial staining, tear film rupture time, and Schirmer test to detect tear secretion on the ocular surface of rabbits. The corneal epithelial thickness, morphology, and number of bulbar conjunctival goblet cells were recorded by H&E staining. Finally, we detected the expression of VEGF, IL-1β, PGE2, and TNF-α by cellular immunofluorescence staining and enzyme-linked immunosorbent assay (ELISA).
RESULTS
The encapsulation efficiency and drug loading of Tet-ATS@PLGA were 79.85% and 32.47%, respectively. At eye surface temperature, Tet can easily release from Tet-ATS@PLGA while that it was difficult to release at storage temperature and room temperature. After 2 weeks medication, Tet-ATS@PLGA can effectively improve the tear film rupture time and tear secretion time in a DED model (p <0.05). Compared with the normal group (62.34 ± 4.86 mm), the thickness of corneal epithelium in ATS (29.47 ± 3.21 mm), Tet-ATS (46.23 ± 2.87 mm), and Tet-ATS@PLGA (55.76 ± 3.95 mm) gradually increased. Furthermore, the flow cytometry indicated that Tet-ATS@PLGA can effectively promote the apoptosis of inflammatory SIRC cells, and the cellular immunofluorescence and ELISA experiments showed that the expression intensity of inflammatory factors such as VEGF, IL-1β, PGE2, and TNF-α decreased in this process. Interestingly, Tet also had the effect of reducing intraocular pressure.
CONCLUSION
Tet-ATS@PLGA can effectively promote the apoptosis of inflammatory corneal epithelial cells, thus inhibiting the expression of inflammatory factors to block the formation of DED and improve the secretion of tear on the ocular surface.
Topics: Animals; Rabbits; Polyglycolic Acid; Tumor Necrosis Factor-alpha; Dinoprostone; Vascular Endothelial Growth Factor A; Dry Eye Syndromes; Tears; Cornea; Anti-Inflammatory Agents; Nanoparticles
PubMed: 37690450
DOI: 10.1159/000533345 -
Clinical Obstetrics and Gynecology Jun 1995A limited number of studies have provided preliminary data on the efficacy and safety of PGE2 used as an outpatient cervical ripening agent. Multiple inpatient studies... (Review)
Review
A limited number of studies have provided preliminary data on the efficacy and safety of PGE2 used as an outpatient cervical ripening agent. Multiple inpatient studies have confirmed the effect of PGE2 in favorably changing the cervical score, reducing the incidence of failed inductions and instrumental deliveries, shortening the induction-to-delivery interval, and reducing oxytocin use with few maternal side effects and no known adverse effects on neonatal outcome. These studies, however, are difficult to compare because of differences in study design, PGE2 formulation, patient selection (including differences in cervical scoring criteria), indications for labor induction, placement of the PGE2 agent, and outcome variables, and they certainly cannot be extrapolated to outpatient use. Intracervically applied Prepidil is the only form of PGE2 approved by the Food and Drug Administration available for cervical ripening. The commercial production of an intravaginal form of PGE2, which would require less effort and expertise in administration and greater patient comfort, may warrant exploration. In an environment of increasing pressures for cost containment, the convenience and cost-effectiveness of outpatient cervical ripening provides a stimulus for further controlled studies in this area to delineate an effective and safe dose and vehicle for widespread application.
Topics: Ambulatory Care; Animals; Cervix Uteri; Dinoprostone; Female; Heart Rate, Fetal; Humans; Labor, Induced; Pregnancy; Randomized Controlled Trials as Topic; Safety; Suppositories
PubMed: 7554598
DOI: 10.1097/00003081-199506000-00013 -
The Journal of Reproductive Medicine Aug 1999To compare the safety, efficacy and cost of two methods of administering commercially available dinoprostone for preinduction cervical ripening at term. (Clinical Trial)
Clinical Trial Randomized Controlled Trial
OBJECTIVE
To compare the safety, efficacy and cost of two methods of administering commercially available dinoprostone for preinduction cervical ripening at term.
STUDY DESIGN
Sixty-nine women admitted for labor induction were randomized to receive one of two commercially available agents for cervical ripening. Half the patients received a gel containing 0.5 mg of dinoprostone placed intracervically every four hours. The other half received a polymer insert containing 10 mg of dinoprostone intravaginally. After 12 hours of cervical ripening, oxytocin was given and amniotomy performed to induce labor.
RESULTS
Among 69 women randomized, 35 received the gel and 34 the polymer. No significant differences were noted between the two groups in starting characteristics or indication for induction. Both groups were similar with respect to change in Bishop score, start-to-delivery interval, amount of oxytocin required, mode of delivery and success of induction. A slightly higher rate of hyperstimulation was noted in the polymer group, although this did not lead to fetal or maternal morbidity. The average costs per patient for the two agents were similar.
CONCLUSION
The two dinoprostone agents are similar with respect to efficacy. The polymer group had slightly more complications but without adverse fetal or maternal outcomes. A larger, multicenter trial would be required to determine actual differences in the efficacy, safety and cost of these two agents.
Topics: Adolescent; Adult; Cervical Ripening; Chemistry, Pharmaceutical; Dinoprostone; Drug Costs; Female; Gels; Health Care Costs; Humans; Labor, Induced; Oxytocics; Polymers; Pregnancy; Pregnancy Outcome; Prospective Studies
PubMed: 10483544
DOI: No ID Found -
The International Journal of... Feb 2010Prostaglandin E(2) (PGE(2)) is the most abundant eicosanoid and a very potent lipid mediator. PGE(2) is produced predominantly from arachidonic acid by its tightly... (Review)
Review
Prostaglandin E(2) (PGE(2)) is the most abundant eicosanoid and a very potent lipid mediator. PGE(2) is produced predominantly from arachidonic acid by its tightly regulated cyclooxygenases (COX) and prostaglandin E synthases (PGES). Secreted PGE(2) acts in an autocrine or paracrine manner through its four cognate G protein coupled receptors EP1 to EP4. Under physiological conditions, PGE(2) is key in many biological functions, such as regulation of immune responses, blood pressure, gastrointestinal integrity, and fertility. Deregulated PGE(2) synthesis or degradation is associated with severe pathological conditions like chronic inflammation, Alzheimer's disease, or tumorigenesis. Therefore, pharmacological inhibition of COX enzymes and PGE(2) receptor antagonism is of great therapeutic interest.
Topics: Animals; Dinoprostone; Drug Discovery; Gene Expression Regulation; Humans; Receptors, Prostaglandin E; Substrate Specificity
PubMed: 19788928
DOI: 10.1016/j.biocel.2009.09.015 -
Irish Journal of Medical Science Jun 2024Dinoprostone vaginal insert is the most common pharmacological method for induction of labor (IOL); however, studies on assessing the time to vaginal delivery (DT)... (Observational Study)
Observational Study
BACKGROUND
Dinoprostone vaginal insert is the most common pharmacological method for induction of labor (IOL); however, studies on assessing the time to vaginal delivery (DT) following dinoprostone administration are limited.
AIMS
We sought to identify the primary factors influencing DT in women from central China, at or beyond term, who underwent IOL with dinoprostone vaginal inserts.
METHODS
In this retrospective observational study, we analyzed the data of 1562 women at 37 weeks 0 days to 41 weeks 6 days of gestation who underwent dinoprostone-induced labor between January 1, 2019, and December 31, 2021. The outcomes of interest were vaginal or cesarean delivery and factors influencing DT, including maternal complications and neonatal characteristics.
RESULTS
Among the enrolled women, 71% (1109/1562) delivered vaginally, with median DT of 740.50 min (interquartile range 443.25 to 1264.50 min). Of the remaining 29% (453/1562), who delivered by cesarean section, 11.9% (54/453) were multiparous. Multiple linear regression analysis showed that multiparity, advanced maternal age, fetal macrosomia, premature rupture of membranes (PROM), and daytime insertion of dinoprostone were the factors that significantly influenced DT. Time to vaginal delivery increased with advanced maternal age and fetal macrosomia and decreased with multiparity, PROM, and daytime insertion of dinoprostone. A mathematical model was developed to integrate these factors for predicting DT: Y = 804.478 - 125.284 × multiparity + 765.637 × advanced maternal age + 411.511 × fetal macrosomia-593.358 × daytime insertion of dinoprostone - 125.284 × PROM.
CONCLUSIONS
Our findings may help obstetricians estimate the DT before placing a dinoprostone insert, which may improve patient management in busy maternity wards and minimize potential risks.
Topics: Humans; Female; Labor, Induced; Retrospective Studies; Dinoprostone; Pregnancy; Adult; Administration, Intravaginal; Oxytocics; Time Factors; Delivery, Obstetric; Cesarean Section
PubMed: 37947994
DOI: 10.1007/s11845-023-03568-3 -
Proceedings of the National Academy of... Jul 2003
Review
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase 2; Cyclooxygenase 2 Inhibitors; Cyclooxygenase Inhibitors; Dinoprostone; Drug Design; Enzyme Inhibitors; Humans; Inflammation Mediators; Intramolecular Oxidoreductases; Isoenzymes; Membrane Proteins; Mice; Prostaglandin-E Synthases; Prostaglandin-Endoperoxide Synthases
PubMed: 12861081
DOI: 10.1073/pnas.1733589100 -
Revue Francaise de Gynecologie Et... Mar 1993The authors report a case of uterine rupture following intra-cervical application of dinoprostone (two doses at an interval of 6 hours). No oxytocic had been... (Review)
Review
The authors report a case of uterine rupture following intra-cervical application of dinoprostone (two doses at an interval of 6 hours). No oxytocic had been administered and recording of the contractions had revealed no hyperkinesia or hypertonia one hour before rupture occurred.
Topics: Administration, Intravaginal; Adult; Cesarean Section; Dinoprostone; Female; Humans; Labor, Induced; Parity; Pregnancy; Pregnancy Trimester, Third; Uterine Rupture
PubMed: 8493447
DOI: No ID Found