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The Journal of Reproductive Medicine Mar 2005Three cases of anaphylactoid syndrome of pregnancy developed in association with the use of intracervical dinoprostone for cervical ripening.
BACKGROUND
Three cases of anaphylactoid syndrome of pregnancy developed in association with the use of intracervical dinoprostone for cervical ripening.
CASES
All cases occurred at our institution between October 1996 and February 2001. The patients developed respiratory symptoms shortly after placement of 0.25 mg of intracervical dinoprostone gel. Hemodynamic changes, manifested by tetanic uterine contractions and fetal heart rate decelerations, followed. Subsequently all 3 patients developed disseminated intravascular coagulation, characterized by severe hypofibrinogenemia.
CONCLUSION
There appears to be an association between intracervical dinoprostone for cervical ripening and anaphylactoid syndrome of pregnancy. Clinicians utilizing this route of dinoprostone administration should be familiar with this rare but potentially life-threatening complication.
Topics: Administration, Topical; Adult; Anaphylaxis; Cervical Ripening; Dinoprostone; Disseminated Intravascular Coagulation; Female; Heart Rate, Fetal; Humans; Middle Aged; Oxytocics; Pregnancy; Syndrome
PubMed: 15841940
DOI: No ID Found -
Neurogastroenterology and Motility Apr 2004In this short review, it will be described that neurotransmitter-induced secretion in the intestine may be influenced by the tissue level of prostaglandin E2 (PGE2). In... (Review)
Review
In this short review, it will be described that neurotransmitter-induced secretion in the intestine may be influenced by the tissue level of prostaglandin E2 (PGE2). In the normal condition, vasoactive intestinal polypeptide (VIP) and acetylcholine (ACh) are the predominant neurotransmitters of secretomotor neurones. VIP and ACh activate distinct second messenger systems in epithelial cells, i.e. adenosine 3', 5'-cyclic monophosphate (cAMP) and calcium ion (Ca2+), respectively. An increase in intracellular cAMP induces a small amount of chloride (Cl-) secretion in epithelial cells, while simultaneous increases in intracellular Ca2+ and cAMP greatly enhances the cAMP-induced Cl- secretion. When the concentration of prostaglandins reaches a high level in the intestinal tissue substance P, which is a neurotransmitter of sensory neurones, can also induce a massive Cl- secretion by cross-potentiation of cAMP and Ca2+ in epithelial cells. In conclusion, it is considered that the concentration of tissue PGE2 may indicate tissue alert level, and when this level elevates, PGE2 enhances ACh and SP-induced Cl- secretion, thus mediating massive fluid secretion for host defence.
Topics: Animals; Dinoprostone; Enteric Nervous System; Humans; Intestinal Mucosa; Intestinal Secretions; Neurotransmitter Agents; Second Messenger Systems
PubMed: 15066012
DOI: 10.1111/j.1743-3150.2004.00482.x -
Medical Science Monitor : International... Aug 2012The aim of this study was to compare the possible clinical parameters for prediction of successful labor induction in Chinese nulliparous women.
BACKGROUND
The aim of this study was to compare the possible clinical parameters for prediction of successful labor induction in Chinese nulliparous women.
MATERIAL/METHODS
A retrospective, observational trial of labor induction was performed, using a single dose of 10 mg controlled-release dinoprostone for preinduction cervical ripening in 127 nulliparous women (gestational age 38-42 weeks, singleton cephalic presentation). The characteristics of the women with successful labor induction (defined as vaginal delivery achieved on the day of admission; n=80) and failed labor induction (n=47) were compared.
RESULTS
The main differences observed between the groups were gravidity (P<0.05), induction-active labor interval (5.16±2.98 vs. 8.40±3.41; P<0.05) and birth weight (3421.11±368.14 vs. 3566.36±345.16; P<0.05). Logistic regression demonstrated that gravidity (P<0.05) and induction-active labor interval (P<0.05), but not Bishop score, were significant and independent contributing factors for successful labor induction. In the receiver operating characteristic curves for the prediction of successful labor induction, the best cut-off value for gravidity was 3 (95% confidence interval [CI] 0.64-0.83, P=0.000), and the best cut-off value for the induction-active labor interval was 7.96 (95%CI 0.66-0.85, P=0.000).
CONCLUSIONS
Less gravidity and shorter induction-active labor interval predict successful labor induction with reasonable accuracy.
Topics: Administration, Intravaginal; Adult; Asian People; China; Dinoprostone; Female; Humans; Labor, Induced; Logistic Models; Parity; Pregnancy; Prognosis; ROC Curve; Treatment Outcome
PubMed: 22847202
DOI: 10.12659/msm.883273 -
Journal of Pharmacobio-dynamics May 19925,6-trans-Prostaglandin E2 (trans-PG E2) was found to accelerate the fibrinolysis in a cell-free system. trans-PG E2 decreased the lysis time by 15% in the fibrin clot...
5,6-trans-Prostaglandin E2 (trans-PG E2) was found to accelerate the fibrinolysis in a cell-free system. trans-PG E2 decreased the lysis time by 15% in the fibrin clot lysis time method and increased the lysis area by 22% in the fibrin plate method. On the contrary, 5,6-cis-prostaglandin E2 did not have such effects. trans-PG E2 did not exert the effect in the absence of either tissue-plasminogen activator or plasminogen. These results suggest that trans-PG E2 enhances the generation of plasmin from plasminogen by tissue-plasminogen activator.
Topics: Cell-Free System; Dinoprostone; Fibrinolysis; In Vitro Techniques; Stereoisomerism
PubMed: 1527702
DOI: 10.1248/bpb1978.15.261 -
Zhonghua Fu Chan Ke Za Zhi Jul 2010To investigate safety and efficacy of dinoprostone suppositories (0.8 mm) used in cervical ripening and labor induction in women with term premature rupture of the... (Clinical Trial)
Clinical Trial
[Clinical study on dinoprostone suppositories 0.8 mm used in cervical ripening and labor induction of women with term pregnancy of premature rupture of the membranes: a multicenter study].
OBJECTIVE
To investigate safety and efficacy of dinoprostone suppositories (0.8 mm) used in cervical ripening and labor induction in women with term premature rupture of the membranes.
METHODS
One hundred women of term monocyesis with premature rupture of the membranes, head presentation, bishop score less than 6 (test group) and 180 women with intact fetal membranes (control group) were enrolled into this multicenter, prospective clinical study. The vaginal delivery system was inserted into the posterior fornix, and the patients were recumbent for 2 hours after insertion. The interval time from using dinoprostone suppositories to uterine contraction, to labor and delivery were recorded. The following index were also recorded and compared, including the mean inserted time of dinoprostone suppositories, fetal heart beat, meconium stained amniotic fluid, hyperstimulation of uterus and the other complications, mode of delivery, stage of labor, postpartum hemorrhage, status of neonates.
RESULTS
Three cases in test group and 23 cases in control group weren't in labor within 24 hours. The rate of labor within 24 hours in test group was significant higher than that in control group (97.0% vs. 87.2%, P < 0.01). It was observed that 73 cases undergoing vaginal deliveries (75.3%, 73/97) and 24 cases undergoing cesarean section deliveries (24.7%, 24/97)in test group and 107 cases undergoing vaginal delivery (68.2%, 107/157) and 50 cases undergoing cesarean section delivery (31.8%, 50/157) in control group, when compared the rate of vaginal or cesarean section deliveries between two group, it didn't reach statistical difference (P > 0.05). It had no significant difference in the interval time from using dinoprostone suppositories to labor starting and the mean inserted time and the total labor time between two groups (P > 0.05). The incidence of uterine tachysystole was 11.3% (11/97) in test group and 19.1% (30/157) in control group (P > 0.05), which did not reach statistical difference (P > 0.05). There wasn't neonatal asphyxia in both groups.
CONCLUSION
It was safe and efficient to use dinoprostone suppositories for cervical ripening and induction of term pregnancy with premature rupture of the membranes, however, monitoring should be intensified.
Topics: Administration, Intravaginal; Adult; Cervical Ripening; Cesarean Section; Delivery, Obstetric; Dinoprostone; Female; Fetal Membranes, Premature Rupture; Humans; Labor, Induced; Oxytocics; Pregnancy; Pregnancy Outcome; Pregnancy Trimester, Third; Prospective Studies; Suppositories; Time Factors; Uterine Contraction
PubMed: 21029599
DOI: No ID Found -
MCN. the American Journal of Maternal... 1993
Review
Topics: Administration, Intravaginal; Cervix Uteri; Dinoprostone; Female; Fetus; Humans; Labor, Induced; Pessaries; Pregnancy
PubMed: 8271913
DOI: 10.1097/00005721-199309001-00004 -
Zeitschrift Fur Geburtshilfe Und... Oct 2008It was the objective of this study to compare the efficacy and safety of oral misoprostol with those of vaginal dinoprostone for the induction of labour at term. (Comparative Study)
Comparative Study Randomized Controlled Trial
BACKGROUND
It was the objective of this study to compare the efficacy and safety of oral misoprostol with those of vaginal dinoprostone for the induction of labour at term.
PATIENTS AND METHODS
Between 2003 and 2006 224 pregnant women were included in our prospective randomised clinical trial. All of them were admitted for induction of labor at term. Half of the patients received oral misoprostol, initially at a test dose of 25 microg, followed by 50 microg and 100 microg every 4 hours. The control group received 3 mg vaginal dinoprostone every 6 hours. Primary endpoints were time interval until delivery and mode of delivery as well as maternal and neonatal outcome, secondary endpoints were side effects and costs.
RESULTS
In the dinoprostone group, the median time interval until delivery was 17.6 hours compared to 24.1 hours in the misoprostol group. Without the test dose, the difference was no longer significant. After dinoprostone induction, more patients had a vaginal delivery within 24 hours (n=60, 53.6%, vs. n=46, 41.1%). The frequencies of spontaneous deliveries and emergency Caesarean sections did not differ between the groups. The rate of vacuum extractions was higher in the misoprostol group (23 vs. 11, i. e. 20.5 vs. 9.8%, p<0.05). With regard to side effects there was no significant difference. No case of hyperstimulation was documented.
CONCLUSION
Oral misoprostol is effective and safe for induction of labour at term. In addition, it is much cheaper and independent of storage conditions. At the doses and with the administration intervals used in this study, dinoprostone was slightly more effective than misoprostol.
Topics: Administration, Intravaginal; Administration, Oral; Adult; Apgar Score; Cardiotocography; Dinoprostone; Dose-Response Relationship, Drug; Drug Administration Schedule; Female; Germany; Humans; Labor, Induced; Misoprostol; Oxytocics; Pregnancy; Prospective Studies
PubMed: 18956276
DOI: 10.1055/s-2008-1077027 -
American Family Physician Jun 1999
Topics: Dinoprostone; Emergencies; Emergency Treatment; Female; Humans; Obstetrics; Oxytocics; Postpartum Hemorrhage; Pregnancy; Societies, Medical; United States
PubMed: 10392586
DOI: No ID Found -
Cell Cycle (Georgetown, Tex.) Dec 2007We have recently demonstrated through a chemical screen in the zebrafish embryo that prostaglandin E2 (PGE2) is an evolutionarily conserved regulator of hematopoietic... (Review)
Review
We have recently demonstrated through a chemical screen in the zebrafish embryo that prostaglandin E2 (PGE2) is an evolutionarily conserved regulator of hematopoietic stem cell (HSC) number. These results have further been confirmed by in vitro and in vivo studies in the murine model. Bioactive PGE2 derivatives have potential clinical application to accelerate recovery of the hematopoietic system following chemotherapy or irradiation. Ex vivo expansion of HSCs prior to stem cell transplantation may improve reconstitution of hematopoiesis and immune function. This article aims to summarize current knowledge of PGE2-mediated regulation of blood cell homeostasis as well as to discuss the proposed use of PGE2 to expand hematopoietic stem cells for transplantation in the clinical setting.
Topics: Animals; Bone Marrow; Dinoprostone; Hematopoiesis; Hematopoietic Stem Cell Transplantation; Hematopoietic Stem Cells; Humans; Mice; Signal Transduction; Zebrafish
PubMed: 18075310
DOI: 10.4161/cc.6.24.5129 -
American Journal of Physiology. Renal... Sep 2012
Topics: Animals; Dinoprostone; Female
PubMed: 22739535
DOI: 10.1152/ajprenal.00331.2012