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British Medical Journal Jan 1969
Topics: Arthritis; Dipetalonema; Humans; Nematode Infections
PubMed: 5812535
DOI: No ID Found -
Indian Journal of Ophthalmology 2012Parasitic infestations of the eye have been reported since centuries, affecting various parts of the eye. Some are subtle, coexisting with vision, while many others...
Parasitic infestations of the eye have been reported since centuries, affecting various parts of the eye. Some are subtle, coexisting with vision, while many others damage and destroy, in part or totally, the gift of sight. This report describes a patient with live subconjunctival dipetalonema infestation of the right eye, with 22 parasites removed live in one sitting from one eye.
Topics: Aged; Animals; Conjunctiva; Conjunctival Diseases; Diagnosis, Differential; Dipetalonema; Dipetalonema Infections; Eye Infections, Parasitic; Humans; Male
PubMed: 22569390
DOI: 10.4103/0301-4738.95881 -
Veterinary Parasitology Sep 1989The acid phosphatase activity and some morphological characteristics of Dipetalonema dracunculoides microfilariae are described. Their morphological features are closely...
The acid phosphatase activity and some morphological characteristics of Dipetalonema dracunculoides microfilariae are described. Their morphological features are closely related to those of the pathogenic Dirofilaria immitis when Knott's technique is used for the microfilarial diagnosis. The acid phosphatase activity pattern found in Dip. dracunculoides microfilariae is clearly different from those previously described for D. immitis, D. repens and Dip. reconditum.
Topics: Acid Phosphatase; Animals; Dipetalonema; Histocytochemistry; Microfilariae
PubMed: 2800304
DOI: 10.1016/0304-4017(89)90066-6 -
The Southeast Asian Journal of Tropical... Sep 1973
Review
Topics: Animals; Birds; Carnivora; Cats; Culicidae; Deer; Dipetalonema; Diptera; Dirofilariasis; Disease Models, Animal; Disease Vectors; Dogs; Ecology; Filariasis; Filarioidea; Humans; Loa; Mansonella; Nematode Infections; Onchocerca; Onchocerciasis; Primates; Rodentia; Siphonaptera; Wuchereria
PubMed: 4149036
DOI: No ID Found -
Parasitology Dec 1987The class-specific antibody responses of 3 strains of mice (C57/Bl10, BALB/C and CBA/N) known to vary in their ability to control the microfilaraemia which follows the...
The class-specific antibody responses of 3 strains of mice (C57/Bl10, BALB/C and CBA/N) known to vary in their ability to control the microfilaraemia which follows the subcutaneous transplantation of adult female Dipetalonema viteae has been investigated. The 3 mouse strains showed significant variation (a) in total levels of immunoglobulins and (b) in ability to recognize individual radio-isotope-labelled antigens as measured by coprecipitation. Within each mouse strain it was noted that antigens could vary with respect to the nature of the isotype of the antibody response which they elicited. Furthermore, by comparing results obtained from class-specific coprecipitation with surface ELISA it was found that a similar variation between responses to individual epitopes was also likely. No differences were observed in the humoral response of the 3 mouse strains which could explain the known resistance of the C57/Bl10 strain; reasons for this are discussed.
Topics: Animals; Antibodies, Helminth; Antibody Affinity; Antibody Specificity; Antigen-Antibody Reactions; Antigens, Helminth; Dipetalonema; Electrophoresis, Polyacrylamide Gel; Enzyme-Linked Immunosorbent Assay; Epitopes; Immunoglobulins; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Inbred CBA; Microfilariae
PubMed: 2447552
DOI: 10.1017/s003118200005798x -
The American Journal of Tropical... Sep 1967
Topics: Dipetalonema; Female; Filariasis; Guyana; Humans; Indians, South American; Male; Mansonella
PubMed: 6069567
DOI: 10.4269/ajtmh.1967.16.628 -
Current Protein & Peptide Science Feb 2003ES-62 is a major secreted glycoprotein of the rodent filarial nematode Acanthocheilonema viteae and homologue of molecules found in filarial nematodes which parasitise... (Review)
Review
ES-62 is a major secreted glycoprotein of the rodent filarial nematode Acanthocheilonema viteae and homologue of molecules found in filarial nematodes which parasitise humans. The molecule consists of a tetramer of apparently identical monomers of ~62 kDa which we have shown by sedimentation equilibrium analytical ultracentrifugation to strongly associate. ES-62 is one of several filarial nematode proteins to contain the unusual post-translational modification of phosphorylcholine (PC) addition. Specifically, we have found that PC is attached to one of three distinct N-type glycans we have characterised on the molecule. The amino acid sequence of ES-62 shows 37-39% identity with a family of 6 other proteins, some of which have been predicted to be amino- or carboxy-peptidases. We have also found that ES-62 is able to interact with a number of cells of the immune system, specifically B- and T-lymphocytes, macrophages and dendritic cells. Lymphocytes exposed to ES-62 in vitro or in vivo are less able to proliferate in response to ligation via the antigen receptor. Peritoneal macrophages pre-exposed to the molecule are less able to produce the cytokines IL-12, IL-6 and TNF-alpha following subsequent incubation with the classical stimulators IFNgamma and LPS. Dendritic cells allowed to mature in the presence of ES-62 acquire a phenotype, which allows them to induce anti-inflammatory "TH2-type" responses. With respect to immunomodulation, the PC moiety of the parasite molecule appears to be predominantly responsible for the effects on lymphocyte proliferation at least and we have also found that its removal converts the murine IgG antibody response to ES-62 from solely IgG1 to mixed IgG1/IgG2a. ES-62 appears to interact with cells of the immune system in a PC-dependent manner and, at least in part, via a molecule of ~82 kDa. Studies of the interaction in lymphocytes show that it is associated with activation of certain signal transduction molecules including a number of protein tyrosine kinases and mitogen activated protein kinases (MAPkinases). Although such activation is insufficient to induce proliferation, it serves to almost completely desensitise the cells to antigen-receptor ligation-induced activation of the phosphoinositide 3-kinase (PI-3-kinase) and Ras/MAPkinase pathways, events critical for lymphocyte proliferation. Such desensitisation reflects ES-62-primed recruitment of a number of negative regulators of these pathways, such as the phosphatases SHP-1 and Pac-1.
Topics: Amino Acid Sequence; Animals; Dipetalonema; Glycoproteins; Helminth Proteins; Molecular Sequence Data; Phosphorylcholine; Sequence Homology; Structure-Activity Relationship
PubMed: 12570785
DOI: 10.2174/1389203033380368 -
The Journal of Parasitology Jun 1980Dipetalonema (Cercopithifilaria) kenyensis subgen. et sp. n. is described from the subcutaneous connective tissues of Papio anubis, from Kenya, Africa. Of the six...
Dipetalonema (Cercopithifilaria) kenyensis subgen. et sp. n. is described from the subcutaneous connective tissues of Papio anubis, from Kenya, Africa. Of the six recognized subgenera of the genus Dipetalonema, Cercopithifilaria most closely resembles Loxodontofilaria and Chenofilaria in having an undividied esophagus. The appearance of the female tail and the number and arrangement of the caudal papillae in the male distinguish it from these two subgenera. The species kenyensis is distinct from all other species by its body size, its microfilaria, and the size and shape of the spicules. This is the first species of Dipetalonema to be described from an African primate.
Topics: Animals; Connective Tissue; Dipetalonema; Female; Haplorhini; Male; Microfilariae; Papio; Tail
PubMed: 6771380
DOI: No ID Found -
The Journal of Parasitology Jun 1983Dipetalonema (Alafilaria) hydrochoerus subgen. et sp. n. is described from specimens recovered from skeletal muscle fascia of the capybara, Hydrochoerus hydrochacris,...
Dipetalonema (Alafilaria) hydrochoerus subgen. et sp. n. is described from specimens recovered from skeletal muscle fascia of the capybara, Hydrochoerus hydrochacris, from several localities in Colombia, South America. The microfilaria, which is found in the skin of the host, is also described for the first time. The monotypic species of the subgenus Alafilaria can be distinguished from existing Dipetalonema subgenera and all filariae known to us, on the basis of numerous preanal caudal papillae in males, small size of petals on the caudal extremity of each sex, and low, bluntly-rounded lateral alae in the cuticle of adult worms of both sexes. Unusual and distinctive features of the microfilaria include conspicuous lateral cuticular alae and a caudal extremity devoid of nuclei.
Topics: Animals; Colombia; Dipetalonema; Female; Male; Rodentia; Terminology as Topic
PubMed: 6685177
DOI: No ID Found -
Tropical Diseases Bulletin Dec 1969
Review
Topics: Animals; Ascariasis; Dipetalonema; Dirofilariasis; Dracunculiasis; Enterobius; Filariasis; Haplorhini; Hookworm Infections; Humans; Loa; Mansonella; Metastrongyloidea; Nematode Infections; Onchocerciasis; Oxyuriasis; Rabbits; Rats; Strongyloidiasis; Trichinellosis; Trichostrongyloidiasis; Wuchereria
PubMed: 4243492
DOI: No ID Found