-
American Pharmacy Feb 1986
Topics: Adult; Child; Diphenhydramine; Female; Humans; Pregnancy
PubMed: 3962845
DOI: 10.1016/s0095-9561(16)38634-0 -
Anesthesiology Sep 1998Diphenhydramine is used as an antipruritic and antiemetic in patients receiving opioids. Whether it might exacerbate opioid-induced ventilatory depression has not been...
BACKGROUND
Diphenhydramine is used as an antipruritic and antiemetic in patients receiving opioids. Whether it might exacerbate opioid-induced ventilatory depression has not been determined.
METHODS
The ventilatory response to carbon dioxide during hyperoxia and the ventilatory response to hypoxia during hypercapnia (end-tidal pressure of carbon dioxide [PETCO2] is approximately equal to 54 mmHg) were determined in eight healthy volunteers. Ventilatory responses to carbon dioxide and hypoxia were calculated at baseline and during an alfentanil infusion (estimated blood levels approximately equal to 10 ng/ml) before and after diphenhydramine 0.7 mg/kg.
RESULTS
The slope of the ventilatory response to carbon dioxide decreased from 1.08+/-0.38 to 0.79+/-0.36 l x min(-1) x mmHg(-1) (x +/- SD, P < 0.05) during alfentanil infusion; after diphenhydramine, the slope increased to 1.17+/-0.28 l x min(-1) x mmHg(-1) (P < 0.05). The minute ventilation (VE) at PETCO2 approximately equal to 46 mmHg (VE46) decreased from 12.1+/-3.7 to 9.7+/-3.6 l/min (P < 0.05) and the VE at 54 mmHg (VE54) decreased from 21.3+/-4.8 to 16.6+/-4.7 l/min during alfentanil (P < 0.05). After diphenhydramine, (VE46 did not change significantly, remaining lower than baseline at 9.9+/-2.9 l/min (P < 0.05), whereas VE54 increased significantly to 20.5+/-3.0 l/min. During hypoxia, VE at SpO2 = 90% (VE90) decreased from 30.5+/-9.7 to 23.1+/-6.9 l/min during alfentanil (P < 0.05). After diphenhydramine, the increase in VE90 to 27.2+/-9.2 l/min was not significant (P = 0.06).
CONCLUSIONS
Diphenhydramine counteracts the alfentanil-induced decrease in the slope of the ventilatory response to carbon dioxide. However, at PETCO2 = 46 mmHg, it does not significantly alter the alfentanil-induced shift in the carbon dioxide response curve. In addition, diphenhydramine does not exacerbate the opioid-induced depression of the hypoxic ventilatory response during moderate hypercarbia.
Topics: Adult; Alfentanil; Analgesics, Opioid; Antiemetics; Antipruritics; Diphenhydramine; Female; Humans; Male; Respiration
PubMed: 9743400
DOI: 10.1097/00000542-199809000-00013 -
Lancet (London, England) Jun 1979
Clinical Trial
Topics: Clinical Trials as Topic; Diphenhydramine; Drug Evaluation; Humans; Male; Motion Sickness; Vision, Ocular
PubMed: 87735
DOI: No ID Found -
Archives of Dermatology Aug 1974
Topics: Aged; Australia; Diphenhydramine; Drug Eruptions; Edema; Erythema; Female; Humans; Insect Bites and Stings; Photosensitivity Disorders; Skin Tests; Spectrophotometry; Ultraviolet Rays
PubMed: 4277438
DOI: No ID Found -
Journal of Psychosocial Nursing and... Apr 1990
Topics: Anxiety Disorders; Diphenhydramine; Humans; Hydroxyzine
PubMed: 2332844
DOI: 10.3928/0279-3695-19900401-04 -
Prescrire International Nov 2015
Topics: Dimenhydrinate; Diphenhydramine; France; Histamine H1 Antagonists; Humans; Substance-Related Disorders
PubMed: 26688907
DOI: No ID Found -
Clinical Toxicology (Philadelphia, Pa.) Nov 2022
Topics: Humans; Diphenhydramine; Histamine H1 Antagonists; Drug Overdose
PubMed: 36106980
DOI: 10.1080/15563650.2022.2121717 -
The Journal of Allergy and Clinical... Dec 2022Diphenhydramine is one of the most widely available, longest-used antihistamine medications but has many side effects including sedation and risk of toxicity in overdose...
Diphenhydramine is one of the most widely available, longest-used antihistamine medications but has many side effects including sedation and risk of toxicity in overdose including cardiac toxicity. It is frequently inappropriately used when newer, more favorable antihistamine medications are available. Second-generation antihistamines are also widely available and affordable, with many of the same desired effects as diphenhydramine and fewer, if any, of the undesirable side effects. Because of the negative side effects and wide availability of alternative antihistamine medications, it is definitively time to move on from diphenhydramine.
Topics: Humans; Diphenhydramine; Histamine H1 Antagonists, Non-Sedating; Histamine H1 Antagonists; Histamine Antagonists; Drug-Related Side Effects and Adverse Reactions
PubMed: 35999169
DOI: 10.1016/j.jaip.2022.07.018 -
Archives of Physiology and Biochemistry Dec 1998Tyr-MIF-1 is a representative of the MIF's family of endogenous peptides. It has been isolated from bovine hypothalamus and human parietal cortex that suggests its...
Tyr-MIF-1 is a representative of the MIF's family of endogenous peptides. It has been isolated from bovine hypothalamus and human parietal cortex that suggests its involvement in nociception. Tyr-MIF-1 can bind to the mu-receptors as well as to its specific non-opiate receptors in the brain. Data in the literature rise the idea that histamine (HA), a well known nociceptive agent, and Tyr-MIF-1 might have a common pathway in their effects on nociception. We tested that possibility by investigation of the combined action of diphenhydramine (DPH, an H (1) -antagonist) and Tyr-MIF-1 on nociception. The changes in the nociceptive effects were examined in the male Wistar rats by the Randall-Sellito paw-pressure (PP) and the tail-flick (TF) tests. Tyr-MIF-1 in a dose of 1 mg/kg exerted strong naloxone-reversible analgesic effects. DPH (100 microg/kg, i.p.) had an antinociceptive action, too. The co-administration of Tyr-MIF-1 and DPH enhanced the antinociceptive effect, as compared to DPH (PP) and to TYR-MIF-1 alone (TF). These effects were reversed when methylene blue (MB, 500 microg/rat) was applied 1h before the combination. However, naloxone (1 mg/kg, i.p.) only slightly affected the antinociceptive effect of DPH and TYR-MIF-1, compared to that of MB. The results obtained confirmed the hypothesis that cyclic nucleotides are involved in the realization of nociceptive effects of both HA and Tyr-MIF-1.
Topics: Analgesics; Animals; Diphenhydramine; Drug Combinations; Hindlimb; Histamine H1 Antagonists; Hot Temperature; Injections, Intraperitoneal; MSH Release-Inhibiting Hormone; Male; Naloxone; Narcotic Antagonists; Rats; Rats, Wistar; Tail
PubMed: 10441059
DOI: 10.1076/apab.106.5.378.4363 -
Vestnik Dermatologii I Venerologii 1982
Topics: Administration, Topical; Diphenhydramine; Eczema; Humans; Male; Middle Aged
PubMed: 7072360
DOI: No ID Found