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Blood Transfusion = Trasfusione Del... Jul 2014
Review
Topics: Administration, Intravenous; Anaphylaxis; Anti-Allergic Agents; Diphenhydramine; Drug Hypersensitivity; Humans; Iron
PubMed: 25074787
DOI: 10.2450/2014.0094-14 -
JAMA Mar 1971
Topics: Dermatitis; Diagnosis, Differential; Diphenhydramine
PubMed: 5107633
DOI: No ID Found -
Journal of the National Comprehensive... Dec 2018
Topics: Administration, Intravenous; Antineoplastic Agents; Diphenhydramine; Drug Industry; Drugs, Generic; Humans; Medical Oncology; Neoplasms; Patents as Topic
PubMed: 30545986
DOI: 10.6004/jnccn.2018.0090 -
Japanese Journal of Pharmacology Jun 1972
The influence of monoamine oxidase inhibitors and some other antidepressants on the anti-parkinsonian activity of sub-effective doses of diphenylhydramine in rats and mice.
Topics: Animals; Antidepressive Agents; Catatonia; Diphenhydramine; Humans; Mice; Monoamine Oxidase Inhibitors; Nortriptyline; Parasympatholytics; Parkinson Disease; Parkinson Disease, Secondary; Perphenazine; Phenelzine; Rats; Tremorine
PubMed: 4539394
DOI: 10.1254/jjp.22.301 -
Medical Times May 1958
Topics: Diphenhydramine; Humans; Meniere Disease
PubMed: 13540610
DOI: No ID Found -
Pharmacotherapy 1994A 45-year-old woman was administered oral and intravenous diphenhydramine 25 mg for the treatment of an allergic reaction. Within 2 minutes she rapidly developed...
A 45-year-old woman was administered oral and intravenous diphenhydramine 25 mg for the treatment of an allergic reaction. Within 2 minutes she rapidly developed trismus, dysarthria, tremors of the upper extremities, left-sided weakness, and diminished consciousness. She was treated with intravenous diazepam and benztropine with good response. After approximately 12 hours the patient's condition was completely resolved except for minor subjective weakness of her left extremities. Her hospital stay was uneventful, and she was discharged after 4 days after refusing rechallenge with the drug. Several cases of acute dystonic reactions secondary to antihistamines have been reported in the literature, four of which involved diphenhydramine. Such reactions may occur after short- or long-term therapy. Most patients experienced rapidly developing trismus, facial dystonia, dysarthria, and occasionally, decreases in consciousness, motor incoordination, and weakness. Because of the widespread availability of diphenhydramine and other antihistamines to the general public, awareness of this effect is of great importance.
Topics: Acute Disease; Administration, Oral; Diphenhydramine; Dystonia; Female; Humans; Middle Aged
PubMed: 7937288
DOI: No ID Found -
Wisconsin Medical Journal Aug 1991This paper will review an acute onset of mental confusion associated with hallucinations secondary to vigorous administration of topical Caladryl lotion and Benadryl...
This paper will review an acute onset of mental confusion associated with hallucinations secondary to vigorous administration of topical Caladryl lotion and Benadryl spray in an 8-year-old boy with chickenpox. The article discusses the toxicity of both oral and topical diphenhydramine use, along with the differentiation of varicella encephalitis from diphenhydramine toxicity. Delirium can be described as an acute clouding of consciousness associated with visual and tactile hallucinations, disorientation, and misperceptions. In a child who is already suffering from an infectious illness, encephalitis must be high on the list of the physician's differential diagnosis. The physician, however, must never overlook ingestions, even from topical, over-the-counter medications. The case described illustrates this point. Although this appears to be the fourth case report on this subject, the diagnosis was partially obscured by the fact that the local pharmacist could not find any documented cases despite a computer search of diphenhydramine toxicity at the time of admission and the report of only one or two cases by the Parke-Davis pharmacist.
Topics: Administration, Topical; Chickenpox; Child; Delirium; Diphenhydramine; Humans; Male; Pruritus
PubMed: 1926887
DOI: No ID Found -
Clinical Toxicology (Philadelphia, Pa.) Jan 2011
Topics: Diphenhydramine; Dose-Response Relationship, Drug; Humans; Triage
PubMed: 21288155
DOI: 10.3109/15563650.2010.550583 -
Journal of the American Medical... Jan 2021Despite a lack of evidence of benefit, the compounded product ABH gel (lorazepam, diphenhydramine, and haloperidol) continues to be prescribed for individuals in hospice...
Despite a lack of evidence of benefit, the compounded product ABH gel (lorazepam, diphenhydramine, and haloperidol) continues to be prescribed for individuals in hospice and palliative care settings for the treatment of nausea and vomiting and terminal delirium. More effective and reliable pharmacological and nonpharmacological strategies exist for the treatment of these conditions in the palliative care and hospice settings. We discuss the pharmacokinetic and clinical evidence for the individual components of ABH gel, as well as the compounded product, and attempt to understand the mechanism of effect that some purport to see, as well as why the compound continues to enjoy such a cult following. Truly, the continued use of ABH gel makes for a pricey placebo and delays the treatment of end-of-life symptoms with modalities that work.
Topics: Antipsychotic Agents; Diphenhydramine; Haloperidol; Hospices; Humans; Lorazepam; Palliative Care
PubMed: 33246839
DOI: 10.1016/j.jamda.2020.10.005 -
MD (Chicago, Ill.) Apr 1947
Topics: Amino Acids; Anesthetics, General; Diphenhydramine; Drug Combinations; Ethers; Humans; Sorbitol
PubMed: 20294856
DOI: No ID Found