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Northwest Medicine Oct 1947
Topics: Diphenhydramine; Humans
PubMed: 20265333
DOI: No ID Found -
Journal of the American Pharmaceutical... Oct 1996
Topics: Diphenhydramine; Humans; Metabolic Clearance Rate
PubMed: 8908928
DOI: No ID Found -
Kidney International Apr 2021Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors. Unfortunately, it causes kidney toxicity as a critical side effect, limiting its use,...
Cisplatin is widely used as an anti-tumor drug for the treatment of solid tumors. Unfortunately, it causes kidney toxicity as a critical side effect, limiting its use, given that no preventive drug against cisplatin-induced kidney toxicity is currently available. Here, based on a repositioning analysis of the Food and Drug Administration Adverse Events Reporting System, we found that a previously developed drug, diphenhydramine, may provide a novel treatment for cisplatin-induced kidney toxicity. To confirm this, the actual efficacy of diphenhydramine was evaluated in in vitro and in vivo experiments. Diphenhydramine inhibited cisplatin-induced cell death in kidney proximal tubular cells. Mice administered cisplatin developed kidney injury with significant dysfunction (mean plasma creatinine: 0.43 vs 0.15 mg/dl) and showed augmented oxidative stress, increased apoptosis, elevated inflammatory cytokines, and MAPKs activation. However, most of these symptoms were suppressed by treatment with diphenhydramine. Furthermore, the concentration of cisplatin in the kidney was significantly attenuated in diphenhydramine-treated mice (mean platinum content: 70.0 vs 53.4 μg/g dry kidney weight). Importantly, diphenhydramine did not influence or interfere with the anti-tumor effect of cisplatin in any of the in vitro or in vivo experiments. In a selected cohort of 98 1:1 matched patients from a retrospective database of 1467 patients showed that patients with malignant cancer who had used diphenhydramine before cisplatin treatment exhibited significantly less acute kidney injury compared to ones who did not (6.1 % vs 22.4 %, respectively). Thus, diphenhydramine demonstrated efficacy as a novel preventive medicine against cisplatin-induced kidney toxicity.
Topics: Acute Kidney Injury; Animals; Antineoplastic Agents; Apoptosis; Cisplatin; Diphenhydramine; Humans; Kidney; Mice; Oxidative Stress; Retrospective Studies
PubMed: 33307103
DOI: 10.1016/j.kint.2020.10.041 -
Journal of Pediatric Hematology/oncology Oct 2013Mannitol is used for increased intracranial pressure and prevention of nephrotoxicity. We present a case report of a patient who experienced an anaphylactic response to...
Mannitol is used for increased intracranial pressure and prevention of nephrotoxicity. We present a case report of a patient who experienced an anaphylactic response to mannitol and review the literature.
Topics: Anaphylaxis; Diphenhydramine; Drug Hypersensitivity; Fatal Outcome; Histamine H1 Antagonists; Humans; Infant; Male; Mannitol
PubMed: 24060838
DOI: 10.1097/MPH.0b013e31828d5b3e -
Journal of Pharmacokinetics and... Jun 1975
Topics: Adult; Biological Availability; Diphenhydramine; Half-Life; Humans; Kinetics; Male; Models, Biological; Protein Binding
PubMed: 1159620
DOI: 10.1007/BF01067905 -
Clinical Pharmacology and Therapeutics Aug 1980The kinetics and psychomotor effects of diphenhydramine were investigated in Orientals and Caucasians. Each of 5 Oriental and 5 Caucasian young adults received on 1 of 3... (Clinical Trial)
Clinical Trial
The kinetics and psychomotor effects of diphenhydramine were investigated in Orientals and Caucasians. Each of 5 Oriental and 5 Caucasian young adults received on 1 of 3 occasions diphenhydramine 50 mg/70 kg body weight either intravenously or orally, or placebo. Plasma levels of diphenhydramine were measured hourly for 8 hr at each session. Tests of subjective sedation and psychomotor performance were performed at hourly intervals. The results showed that after both intravenous and oral diphenhydramine, at all times Orientals had plasma levels approximately half those of Caucasians. With the assumption of linear kinetics and a 1-compartment open model, analysis of the data showed that the volume of distribution (VD) and plasma clearance (Cl) but not plasma half-life (t 1/2) were higher in Orientals than Caucasians: [VD = 480 +/- 24 (SEM) and 292 +/- 36 1/70 kg; Cl = 79 +/- 7 and 51 +/- 7 1/70 kg/hr; t 1/2 = 4.1 +/- 0.4 and 4.3 +/- 0.4 hr]. Unbound diphenhydramine in fresh plasma was higher in Orientals than Caucasians [24.0 +/- 1.9% (SEM) and 14.8 +/- 1.5%] and probably explains the increased VD in Orientals. Orientals had significantly less sedation and deterioration in psychomotor performance.
Topics: Adult; Asian People; Diet; Diphenhydramine; Female; Humans; Hypnotics and Sedatives; Kinetics; Male; Metabolic Clearance Rate; Protein Binding; White People
PubMed: 7398190
DOI: 10.1038/clpt.1980.155 -
Vestnik Otorinolaringologii 1991
Topics: Allium; Child, Preschool; Diphenhydramine; Drug Combinations; Garlic; Helianthus; Humans; Infant; Plant Extracts; Plant Oils; Plants, Medicinal; Sinusitis
PubMed: 2048259
DOI: No ID Found -
British Medical Journal Jul 1973
Topics: Diphenhydramine; Drug Prescriptions; Methaqualone; United Kingdom
PubMed: 4720780
DOI: No ID Found -
Journal of the American Medical... Jul 1958
Topics: Diphenhydramine; Orphenadrine
PubMed: 13563160
DOI: No ID Found -
The Journal of Emergency Medicine 1990We report the case of a 2 1/2-year-old child who manifested acute anticholinergic toxicity after the applications of a topical calamine-antihistamine lotion. This...
We report the case of a 2 1/2-year-old child who manifested acute anticholinergic toxicity after the applications of a topical calamine-antihistamine lotion. This mechanism of diphenhydramine toxicity is uncommon, with only a few other case reports noted in the literature. This case is also intriguing in that this child had an underlying varicella illness with fever that tended to obscure the picture. This report describes the characteristic history and physical examination pertinent to anticholinergic toxicity, varicella complication considerations, and case management.
Topics: Administration, Cutaneous; Chickenpox; Child, Preschool; Diphenhydramine; Hallucinations; Humans; Male
PubMed: 2351800
DOI: 10.1016/0736-4679(90)90389-d