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Medecine Sciences : M/S Mar 2024
Topics: Humans; Diploidy; Depression
PubMed: 38520106
DOI: 10.1051/medsci/2024010 -
Experimental Cell Research Dec 1961
Topics: Diploidy; Tissue Culture Techniques
PubMed: 13905658
DOI: 10.1016/0014-4827(61)90192-6 -
Nature May 1991Although the evolutionary advantages of sexual reproduction have been extensively discussed, much less attention has been paid to haploid and diploid phases of the...
Although the evolutionary advantages of sexual reproduction have been extensively discussed, much less attention has been paid to haploid and diploid phases of the sexual life cycle. The relative lengths of these phases differ greatly in various taxa, including as extremes those with one or the other phase reduced to a single cell. Here we consider the efficiency of elimination of deleterious mutations as an evolutionary force and compare the mutation loads under haploid and diploid selection, Ln and L2n. With truncation-like selection, partial dominance, and heterozygous effect of a mutation less than about 1/4 its hemizygous effect, L2n less than Ln; otherwise L2n greater than Ln. The difference becomes important when the genomic deleterious mutation rate exceeds about 1 per genome. This suggests that the mutation rate, degree of dominance and mode of selection can be important in life-cycle evolution.
Topics: Biological Evolution; Diploidy; Genes, Dominant; Haploidy; Mutation; Selection, Genetic
PubMed: 2034273
DOI: 10.1038/351314a0 -
Genetics Jul 1992With two copies of every gene, a diploid organism is able to mask recessive deleterious mutations. In this paper we present the analysis of a two-locus model designed to...
With two copies of every gene, a diploid organism is able to mask recessive deleterious mutations. In this paper we present the analysis of a two-locus model designed to determine when the masking of deleterious alleles favors the evolution of a dominant diploid phase in organisms that alternate between haploid and diploid phases ("alternation of generations"). It is hypothesized that diploidy will be favored whenever masking occurs ("the masking hypothesis"). Using analytical methods, we confirm that this masking hypothesis is essentially correct under free recombination: as long as the heterozygous expression of deleterious alleles is sufficiently masked by the wild-type allele, diploidy is favored over haploidy. When the rate of recombination is lower, however, diploidy is much less likely to be favored over haploidy. In fact, according to our model, the evolution of diploidy is impossible without significant levels of recombination even when masking is fairly strong.
Topics: Biological Evolution; Diploidy; Genetic Linkage; Genotype; Mathematics; Meiosis; Models, Genetic; Recombination, Genetic
PubMed: 1628815
DOI: 10.1093/genetics/131.3.745 -
Nature Ecology & Evolution Oct 2023
Topics: Male; Selection, Genetic; Animals; Haploidy; Diploidy
PubMed: 37558805
DOI: 10.1038/s41559-023-02183-w -
Science (New York, N.Y.) Jun 2019
Topics: Clone Cells; Diploidy; Mutation; Sequence Analysis, RNA
PubMed: 31171683
DOI: 10.1126/science.aax5525 -
Cytologia Mar 1975
Topics: Animals; Cell Line; Diploidy; Female; Male; Ploidies; Rabbits
PubMed: 1157518
DOI: 10.1508/cytologia.40.119 -
Mutation Research Sep 1973
Topics: DNA Repair; Diploidy; Mutation; Oxygen; Radiation Effects; Saccharomyces
PubMed: 4755530
DOI: 10.1016/0027-5107(73)90230-3 -
Journal of Gerontology Oct 1952
Topics: Cells; Cellular Senescence; Diploidy; Humans
PubMed: 13000129
DOI: 10.1093/geronj/7.4.589 -
Science (New York, N.Y.) Jul 1948
Topics: Cell Physiological Phenomena; Diploidy; Humans; Phosphorylases
PubMed: 17838208
DOI: 10.1126/science.108.2795.87