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BMC Public Health Apr 2023Dissemination is a critical element of the knowledge translation pathway, and a necessary step to ensure research evidence is adopted and implemented by key end users in... (Review)
Review
BACKGROUND
Dissemination is a critical element of the knowledge translation pathway, and a necessary step to ensure research evidence is adopted and implemented by key end users in order to improve health outcomes. However, evidence-based guidance to inform dissemination activities in research is limited. This scoping review aimed to identify and describe the scientific literature examining strategies to disseminate public health evidence related to the prevention of non-communicable diseases.
METHODS
Medline, PsycInfo and EBSCO Search Ultimate were searched in May 2021 for studies published between January 2000 and the search date that reported on the dissemination of evidence to end users of public health evidence, within the context of the prevention of non-communicable diseases. Studies were synthesised according to the four components of Brownson and colleagues' Model for Dissemination of Research (source, message, channel and audience), as well as by study design.
RESULTS
Of the 107 included studies, only 14% (n = 15) directly tested dissemination strategies using experimental designs. The remainder primarily reported on dissemination preferences of different populations, or outcomes such as awareness, knowledge and intentions to adopt following evidence dissemination. Evidence related to diet, physical activity and/or obesity prevention was the most disseminated topic. Researchers were the source of disseminated evidence in over half the studies, and study findings/knowledge summaries were more frequently disseminated as the message compared to guidelines or an evidence-based program/intervention. A broad range of dissemination channels were utilised, although peer-reviewed publications/conferences and presentations/workshops predominated. Practitioners were the most commonly reported target audience.
CONCLUSIONS
There is a significant gap in the peer reviewed literature, with few experimental studies published that analyse and evaluate the effect of different sources, messages and target audiences on the determinants of uptake of public health evidence for prevention. Such studies are important as they can help inform and improve the effectiveness of current and future dissemination practices in public health contexts.
Topics: Public Health Systems Research; Noncommunicable Diseases; Humans; Public Health; Health Communication; Information Dissemination
PubMed: 37095484
DOI: 10.1186/s12889-023-15622-x -
Trauma, Violence & Abuse Oct 2008Trauma-focused cognitive behavioral therapy (TF-CBT) is an evidence-based practice (EBP) for children. TF-CBT is being disseminated and implemented through a variety of... (Review)
Review
Trauma-focused cognitive behavioral therapy (TF-CBT) is an evidence-based practice (EBP) for children. TF-CBT is being disseminated and implemented through a variety of strategies, including distance learning/ Internet training, live training + ongoing phone consultation, a learning collaborative model, and mixed models. Each dissemination and implementation model is described, examples are provided of how it has been used to spread the TF-CBT model among community clinicians treating traumatized children, and data regarding its use are presented. Quality and quantity of data from these dissemination/ implementation models varies, but overall they supports the effectiveness of both the TF-CBT model in treating traumatized children and a variety of dissemination and implementation models. More research is needed to learn about optimal strategies for disseminating and implementing EST for traumatized children, and to explore novel methodologies (e.g., including training in EST for traumatized children in graduate programs).
Topics: Cognitive Behavioral Therapy; Community Mental Health Services; Forecasting; Humans; Sociology; Stress Disorders, Post-Traumatic
PubMed: 18936280
DOI: 10.1177/1524838008324336 -
Gerontology & Geriatrics Education 2013The number of individuals with dementia is expected to increase dramatically over the next 20 years. Given the complicated clinical, sociobehavioral, and caregiving... (Review)
Review
The number of individuals with dementia is expected to increase dramatically over the next 20 years. Given the complicated clinical, sociobehavioral, and caregiving skills that are needed to comprehensively assess and manage individuals with dementia, the gold standard of care requires involvement of interprofessional teams. This systematic review examined 4,023 abstracts, finding 18 articles from 16 studies where an interprofessional dissemination program was performed. Most studies found some improvement in clinician knowledge or confidence, or patient outcomes, though methods and patient and clinician populations were disparate. Although a significant evidence base for assessing and managing individuals with dementia has been developed, few studies have examined how to disseminate this research, and even fewer in an interprofessional manner. These findings suggest that greater emphasis needs to be placed on disseminating existing evidence-based care and ensuring that programs are interprofessional in nature so that excellent, patient-centered care is provided.
Topics: Aged; Clinical Trials as Topic; Dementia; Disease Management; Evidence-Based Practice; Geriatric Assessment; Health Transition; Humans; Information Dissemination; Needs Assessment; Outcome Assessment, Health Care; Patient Care Team; Patient-Centered Care; Prevalence
PubMed: 23879387
DOI: 10.1080/02701960.2013.801342 -
Frontiers in Cell and Developmental... 2021Pre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived... (Review)
Review
Pre-metastatic niches provide favorable conditions for tumor cells to disseminate, home to and grow in otherwise unfamiliar and distal microenvironments. Tumor-derived extracellular vesicles are now recognized as carriers of key messengers secreted by primary tumors, signals that induce the formation of pre-metastatic niches. Recent evidence suggests that tumor cells can disseminate from the very earliest stages of primary tumor development. However, once they reach distal sites, tumor cells can persist in a dormant state for long periods of time until their growth is reactivated and they produce metastatic lesions. In this new scenario, the question arises as to whether extracellular vesicles could influence the formation of these metastatic niches with dormant tumor cells? (here defined as "sleepy niches"). If so, what are the molecular mechanisms involved? In this perspective-review article, we discuss the possible influence of extracellular vesicles in early metastatic dissemination and whether they might play a role in tumor cell dormancy. In addition, we comment whether extracellular vesicle-mediated signals may be involved in tumor cell awakening, considering the possibility that extracellular vesicles might serve as biomarkers to detect early metastasis and/or minimal residual disease (MRD) monitoring.
PubMed: 33738282
DOI: 10.3389/fcell.2021.625221 -
Brain Injury 2013To disseminate the proceedings of a 1-day multidisciplinary stakeholder workshop aimed at examining the inter-relationship between traumatic brain injury (TBI) and... (Review)
Review
PURPOSE
To disseminate the proceedings of a 1-day multidisciplinary stakeholder workshop aimed at examining the inter-relationship between traumatic brain injury (TBI) and homelessness.
METHODS
Thirty-seven stakeholders participated in the workshop, including frontline workers with individuals who are homeless, physicians, nurses and other healthcare workers, researchers, policy-makers, students and individuals with lived experience of homelessness. Didactic presentations, large group discussions and break-out sessions were used to disseminate knowledge, identify service and research gaps, develop a research agenda and facilitate networking.
RESULTS
The participants identified barriers to service provision for individuals who are homeless and have sustained TBI with a focus on age- and gender-related issues, co-morbid TBI and mental illness and jurisdictional differences. Challenges and strategies related to engaging stakeholders in research with this population, as well as disseminating knowledge were discussed and research questions were identified.
CONCLUSION
There is very little empirical literature on the topic of TBI and homelessness. The workshop identified key issues for consideration, including gaps in knowledge related to this topic.
Topics: Advisory Committees; Brain Injuries; Comorbidity; Evidence-Based Medicine; Female; Health Planning; Health Policy; Ill-Housed Persons; Humans; Information Dissemination; Interprofessional Relations; Male; Mental Disorders; Patient Care Team; Quality of Health Care; Quality of Life; Research; Social Stigma
PubMed: 24131277
DOI: 10.3109/02699052.2013.823666 -
Acta Informatica Medica : AIM : Journal... Dec 2019Dissemination benefits come from the outputs integration and implementation by the key audience, who will also determine the relevance and usability of the disseminated...
INTRODUCTION
Dissemination benefits come from the outputs integration and implementation by the key audience, who will also determine the relevance and usability of the disseminated content.
AIM
One of the CrowdHEALTH project's objectives is the transition from patient health records towards the Holistic Health Records (HHRs) and Social HHR. The CrowdHEALTH project aims at integrating high volumes of health-related data collected from various sources to support policy-making decisions.
METHODS
The European Federation for Medical Informatics (EFMI) supports the development of an effective Communication and Collaboration Plan identifying the messages, the tools and channels in disseminating the project and its outcomes to the target audience based on the McGuire approach.
RESULTS
The process for defining the dissemination strategy is a cyclic one as shown in the following figure involving review of each step periodically The next step was to define the four dimension dissemination approach based on McGuire attributes of persuasive communication. The objectives, target groups, key messages, the tools and channels where defined at this stage.
CONCLUSION
The CrowdHEALTH project and its outcomes were disseminated with a variety of tools and channels such as scientific journals, conferences, exhibitions and social media communication.
PubMed: 32210503
DOI: 10.5455/aim.2019.27.348-354 -
Current Urology Reports Oct 2019There has been a remarkable change in how people connect, access, and share professional and medical information over social media. This perspective article describes... (Review)
Review
PURPOSE OF REVIEW
There has been a remarkable change in how people connect, access, and share professional and medical information over social media. This perspective article describes opportunities, potential pitfalls, and guidelines for social media use by pediatric urology providers.
RECENT FINDINGS
Pediatric urologists have effectively used social media to connect and share expertise, augment scientific conference participation, promote themselves and their research, disseminate guidelines and best practices, participate in virtual journal clubs, and engage with patients and their families. Information shared over social media is not protected by copyright law, not confidential, not regulated, permanent, and subjected to public domain and scrutiny. Despite these potential pitfalls, social media is a useful tool if best practices are observed and online communication adheres to professional guidelines and organizational policy. Social media use in healthcare is here to stay and pediatric urologists have online visibility whether or not they choose to actively participate. Despite new legal, ethical, and professional considerations that social media introduces, a well-executed social media presence provides pediatric urologists a wealth of new opportunities for networking, research, and disseminating high-quality medical information online.
Topics: Congresses as Topic; Delivery of Health Care; Guidelines as Topic; Humans; Information Dissemination; Interprofessional Relations; Marketing of Health Services; Online Social Networking; Pediatrics; Physician-Patient Relations; Professionalism; Social Media; Urology
PubMed: 31620926
DOI: 10.1007/s11934-019-0928-y -
Cancers Nov 2020Tissue biopsy is considered the gold standard when establishing a diagnosis of cancer. However, tissue biopsies of intraocular ophthalmic malignancies are hard to... (Review)
Review
Tissue biopsy is considered the gold standard when establishing a diagnosis of cancer. However, tissue biopsies of intraocular ophthalmic malignancies are hard to collect and are thought to be associated with a non-negligible risk of extraocular dissemination. Recently, the liquid biopsy (LB) has emerged as a viable, non-invasive, repeatable, and promising way of obtaining a diagnosis, prognosis, and theragnosis of patients with solid tumors. LB refers to blood, as well as any human liquid. The natural history of uveal melanoma (UM) and retinoblastoma (RB) are radically opposed. On the one hand, UM is known to disseminate through the bloodstream, and is, therefore, more accessible to systemic venous liquid biopsy. On the other hand, RB rarely disseminates hematogenous, and is, therefore, more accessible to local liquid biopsy by performing an anterior chamber puncture. In this review, we summarize the current knowledge concerning LB in UM, RB, conjunctival tumors, and choroidal metastases. We also develop the current limitations encountered, as well as the perspectives.
PubMed: 33172021
DOI: 10.3390/cancers12113284 -
Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer.Cancer Metastasis Reviews Dec 2012As yet, there is no cure for metastatic breast cancer. Historically, considerable research effort has been concentrated on understanding the processes of metastasis, how... (Review)
Review
As yet, there is no cure for metastatic breast cancer. Historically, considerable research effort has been concentrated on understanding the processes of metastasis, how a primary tumour locally invades and systemically disseminates using the phenotypic switching mechanism of epithelial to mesenchymal transition (EMT); however, much less is understood about how metastases are then formed. Breast cancer metastases often look (and may even function) as 'normal' breast tissue, a bizarre observation against the backdrop of the organ structure of the lung, liver, bone or brain. Mesenchymal to epithelial transition (MET), the opposite of EMT, has been proposed as a mechanism for establishment of the metastatic neoplasm, leading to questions such as: Can MET be clearly demonstrated in vivo? What factors cause this phenotypic switch within the cancer cell? Are these signals/factors derived from the metastatic site (soil) or expressed by the cancer cells themselves (seed)? How do the cancer cells then grow into a detectable secondary tumour and further disseminate? And finally--Can we design and develop therapies that may combat this dissemination switch? This review aims to address these important questions by evaluating long-standing paradigms and novel emerging concepts in the field of epithelial mesencyhmal plasticity.
Topics: Animals; Breast Neoplasms; Cadherins; Cell Proliferation; Epithelial-Mesenchymal Transition; Female; Humans; Neoplasm Invasiveness; Neoplasm Metastasis; Tumor Microenvironment
PubMed: 22729277
DOI: 10.1007/s10555-012-9377-5 -
Journal of Biochemistry Jun 2011Contrary to the long believed hypothesis, it is now evident that breast cancer cells can disseminate from the early phases of the oncogenesis; and that such early... (Review)
Review
Contrary to the long believed hypothesis, it is now evident that breast cancer cells can disseminate from the early phases of the oncogenesis; and that such early disseminated cells sometimes survive at the sites of dissemination and may outgrow after a long latency of years and decades. For cancer cells to leave their origin, they must at least transiently loosen their adhesion with adjacent epithelial cells and stroma, and become motile while avoiding anoikis. Such processes resemble epithelial-mesenchymal transdifferentiation (EMT), which normally takes place in situations such as embryogenesis and wound healing. Interestingly, the occurrence of an EMT-like process in breast cancer cells has been implicated in the generation of cancer stem-like cells, in which TGFβ1 signalling often plays core roles. Here, I discuss the current knowledge regarding cancerous EMT and its signalling pathways with the aim to consider the possible mechanisms of early dissemination, and also the generation of cancer stem-like cells in mammary tumour.
Topics: Animals; Breast Neoplasms; Cell Transdifferentiation; Epithelial-Mesenchymal Transition; Female; Humans; Signal Transduction; Transforming Growth Factor beta
PubMed: 21478191
DOI: 10.1093/jb/mvr044