-
Annals of Translational Medicine Jan 2022Gastric cancer (GC) is a globally important disease. It is the 5th most common malignancy and the 4th most common cause of death from cancer in the world. Patients with...
Prediction of distant metastasis and survival prediction of gastric cancer patients with metastasis to the liver, lung, bone, and brain: research based on the SEER database.
BACKGROUND
Gastric cancer (GC) is a globally important disease. It is the 5th most common malignancy and the 4th most common cause of death from cancer in the world. Patients with GC are often at an advanced stage when they are first diagnosed, and their overall prognosis is poor due to locally advanced and distant metastasis. This study sought to establish a predictive model of GC distant metastasis and survival that can be used to guide individualized treatment.
METHODS
Patients diagnosed with GC from the Surveillance, Epidemiology, and End Results database were enrolled in the study. Univariate and multivariate logistic regression analyses were used to identify risk and prognostic factors for GC patients with distant metastasis. The factors were then used to construct nomograms to predict the probability of distant metastasis and the survival time of GC patients. Receiver operating characteristic (ROC) curve and decision curve analyses were used to verify the prediction ability of the nomograms.
RESULTS
We established a comprehensive nomogram to predict the survival time of GC patients and 4 nomograms to predict distant metastasis. Nomograms could help oncologists to formulate treatment strategies and provide hospice care under an overall management model.
CONCLUSIONS
Establishing a prediction model for distant metastasis and the survival of GC patients is of great clinical significance. The prediction of distant metastasis could help clinicians to make individualized assessments of patients and formulate individualized examination measures. Survival prediction models could help oncologists to formulate good treatment strategies and provide hospice care.
PubMed: 35242861
DOI: 10.21037/atm-21-6295 -
Explore (New York, N.Y.) 2019Distant intention research refers to experiments in which a distant interaction between two persons is assessed that precludes conventional communication. In these...
BACKGROUND
Distant intention research refers to experiments in which a distant interaction between two persons is assessed that precludes conventional communication. In these experiments the intention of one person is varied systematically while the effect of this variation is assessed in the remote other person.
AIMS
Our study aimed at improving effect sizes by participant selection based on a screening test and by including experienced meditators.
METHOD
66 participants with meditation experience participated in a forced-choice psi-test as a screening test. Participants with similar performance were invited as pairs for a distant intention experiment. The task of the helpee was to focus attention on a candle and to indicate lapses in attention by pressing a button. In a within-subject design the task of the remote helper was either to assist the helpee in this effort or to engage in a distraction task. Electrodermal activity (EDA) and button presses from the helpee served as dependent variables.
RESULTS AND CONCLUSION
Participants' performance in the psi-screening test did not exceed chance expectations. In the distant intention experiment with 30 sessions no distant intention effect could be found in the prespecified analyses. The results in the psi-screening test were not correlated with performance in the main experiment. However, we found a large negative correlation between self-reported exceptional experiences of the helper and two EDA variables, namely skin conductance level and number of non-specific skin conductance responses. This correlation, if replicated, can hardly be explained without the assumption of a distant interaction.
Topics: Adult; Female; Galvanic Skin Response; Humans; Intention; Male; Meditation; Middle Aged; Parapsychology; Self Report
PubMed: 30709783
DOI: 10.1016/j.explore.2018.12.002 -
In Vivo (Athens, Greece) 2022Distant metastasis has a strong influence on prognosis in patients with soft tissue sarcoma (STS). While various risk factors have been reported for distant metastases,...
BACKGROUND/AIM
Distant metastasis has a strong influence on prognosis in patients with soft tissue sarcoma (STS). While various risk factors have been reported for distant metastases, risk factors for distant metastases early after treatment of primary tumor have not been investigated. This study aimed to evaluate the factors of early distant metastasis after primary tumor resection in patients with STS.
PATIENTS AND METHODS
We retrospectively identified patients with STS involving the extremities or trunk without any metastasis at the first visit. Data on clinical information and detailed assessment were collected. We evaluated clinical information as a risk factor for distant or lung metastases. Additionally, we evaluated risk factors for metastases in patients with distant metastases as early as 6 months after the initial resection of the primary tumor.
RESULTS
A total of 337 patients were included in the study. Multivariate analysis revealed that the size of the primary tumor (p=0.0011 and p=0.0167), consultation in a short period after onset (p=0.0325 and p=0.0402), histological high grade (p=0.0006 and p=0.0002), and inadequate surgical margin (p=0.0151 and p=0.0055) were significant predictors for poor prognosis for all distant and lung metastases, respectively. However, the only risk factor for early metastases within 6 months was young age (p=0.0148).
CONCLUSION
The only risk factor for early distant metastasis after primary tumor resection in patients with STS was young age, even though large tumor diameter and histological high grade were risk factors for distant metastasis.
Topics: Humans; Lung Neoplasms; Retrospective Studies; Risk Factors; Sarcoma; Soft Tissue Neoplasms
PubMed: 36099122
DOI: 10.21873/invivo.12954 -
Zootaxa Jun 2021The cicada genus Haphsa Distant, 1905 was reviewed based on the description of one new species (Haphsa acutipetala sp. n.) from China and phylogenetic analysis of Haphsa... (Review)
Review
A review of the cicada genus Haphsa Distant, 1905 with the description of one new species from China (Hemiptera: Cicadidae) and a phylogenetic analysis of Haphsa and its allies.
The cicada genus Haphsa Distant, 1905 was reviewed based on the description of one new species (Haphsa acutipetala sp. n.) from China and phylogenetic analysis of Haphsa and its allies. The phylogeny of six species of Haphsa and partial related species of Changa Lee, 2016, Sinosemia Matsumura, 1927 and Sinotympana Lee, 2009 was constructed based on COI sequences to understand better the phylogeny of Haphsa and related taxa. Sinosemia Matsumura, 1927 syn. n., Changa Lee, 2016 syn. n. and Sinotympana Lee, 2009 syn. n. are recognized to be new synonyms of Haphsa. Sinosemia shirakii Matsumura, 1927, Changa jsguillotsi (Boulard, 2005), Changa sita (Distant, 1881), Sinotympana incomparabilis Lee, 2009 and Sinotympana caobangensis Pham Sanborn, 2019 are transferred to Haphsa to become Haphsa shirakii (Matsumura, 1927) comb. n., Haphsa jsguillotsi (Boulard, 2005) comb. rev., Haphsa sita (Distant, 1881) comb. n., Haphsa incomparabilis (Lee, 2009) comb. n. and Haphsa caobangensis (Pham Sanborn, 2019) comb. n., respectively. A key to species of Haphsa is provided.
Topics: Animals; China; Hemiptera; Phylogeny
PubMed: 34186832
DOI: 10.11646/zootaxa.4991.3.5 -
The Journal of Investigative Dermatology Apr 2024The evolution of primary melanoma to lymph node and distant metastasis is incompletely understood. We examined the genomic diversity in melanoma progression in matched...
The evolution of primary melanoma to lymph node and distant metastasis is incompletely understood. We examined the genomic diversity in melanoma progression in matched primary melanomas and lymph node and distant metastases from 17 patients. FISH analysis revealed cancer cell fractions with monotonic copy number alterations, including PHIP gain and PTEN loss, in the metastatic cascade. By contrast, the cancer cell fraction with copy number alterations for BPTF and MITF was reduced in lymph node metastases but increased in distant metastases. Separately, the cancer cell fraction with NCOA3 copy number alteration was comparable between primary tumors and lymph node metastases yet increased in distant metastases. These results suggest enrichment of the phosphoinositide 3-kinase and MITF pathways in the transition through the metastatic cascade. By contrast, next-generation sequencing analysis did not identify a consistent pattern of changes in variant allele frequency while revealing several intriguing findings, including decreased variant allele frequency in distant metastases and distinct drivers in lymph node versus distant metastases. These results provide evidence that distant melanoma metastasis does not always emanate from lymph node metastasis. These results enhance our understanding of clonal patterns of melanoma metastasis, with possible implications for targeted therapy and metastasis competency.
PubMed: 38582370
DOI: 10.1016/j.jid.2024.03.029 -
Journal of Integrative Plant Biology Jun 2023Physical contact between genes distant on chromosomes is a potentially important way for genes to coordinate their expressions. To investigate the potential importance...
Physical contact between genes distant on chromosomes is a potentially important way for genes to coordinate their expressions. To investigate the potential importance of distant contacts, we performed high-throughput chromatin conformation capture (Hi-C) experiments on leaf nuclei isolated from Brassica rapa and Brassica oleracea. We then combined our results with published Hi-C data from Arabidopsis thaliana. We found that distant genes come into physical contact and do so preferentially between the proximal promoter of one gene and the downstream region of another gene. Genes with higher numbers of conserved noncoding sequences (CNSs) nearby were more likely to have contact with distant genes. With more CNSs came higher numbers of transcription factor binding sites and more histone modifications associated with the activity. In addition, for the genes we studied, distant contacting genes with CNSs were more likely to be transcriptionally coordinated. These observations suggest that CNSs may enrich active histone modifications and recruit transcription factors, correlating with distant contacts to ensure coordinated expression. This study advances our knowledge of gene contacts and provides insights into the relationship between CNSs and distant gene contacts in plants.
Topics: Arabidopsis; Brassica; Conserved Sequence; Transcription Factors; Promoter Regions, Genetic; Genome, Plant
PubMed: 36762577
DOI: 10.1111/jipb.13465 -
Journal of Cranio-maxillo-facial... Apr 2021Although mostly associated with good survival outcomes, some patients with HPV-positive oropharyngeal squamous cell carcinoma develop distant metastasis and face dire...
Although mostly associated with good survival outcomes, some patients with HPV-positive oropharyngeal squamous cell carcinoma develop distant metastasis and face dire prognosis. The aim of this study was to analyze distant metastatic patients in regards to survival, clinical staging, therapy approach and p16/HPV status. This retrospective single-centre study assessed patients with HPV-associated oropharyngeal cancer with distant metastasis treated in a tertiary referral center from 2005 to 2019. Overall- (OS) and survival after diagnosis of distant metastasis (OMS), clinical staging and different therapy approaches were assessed. Moreover, the overall mortality was assessed, as well as the association of different therapy approaches and p16/HPV status with the survival outcome. Out of 211 patients with HPV-associated oropharyngeal cancer that were treated in the study period, 15 developed distant metastases (7.1%). Median OS and OMS of the total group were 11 months (range 0.1-32 months) and 3 months (range 0.1-21 months), respectively. The overall mortality rate was 53.3% (n = 8). Significantly better outcome was present in patients treated with primary chemoradiotherapy (median OS 17 months vs. not reached, p = .03, median OMS 8 months vs not reached, p = .05). The OMS was significantly better in patients treated with chemotherapy initially after diagnosis (mean OMS 21 months vs 4 months; P = .001). Surgical resection after initial diagnosis was associated with a significantly shorter OMS (median OMS 3 vs. 21 months, p = .005). Interestingly, postoperative adjuvant therapy was delayed in all of these cases due to surgical site complications. Systemic treatment after initial diagnosis may be beneficial in clinical outcome of HPV associated distant metastases. Furthermore, surgical site complications should be treated with immediate care in order to avoid delay of adjuvant therapy. Further studies are warranted for validation of our results.
Topics: Carcinoma, Squamous Cell; Head and Neck Neoplasms; Humans; Oropharyngeal Neoplasms; Papillomaviridae; Papillomavirus Infections; Prognosis; Retrospective Studies; Squamous Cell Carcinoma of Head and Neck
PubMed: 33612410
DOI: 10.1016/j.jcms.2021.01.012 -
International Journal of Gynecological... 2003Distant metastases are unusual at presentation and during the course of ovarian carcinoma. The aim of the present study was to determine the incidence and prognostic...
Distant metastases are unusual at presentation and during the course of ovarian carcinoma. The aim of the present study was to determine the incidence and prognostic factors of distant metastases consistent with stage IV disease in ovarian cancer patients. A retrospective chart review was conducted on 162 patients with epithelial ovarian carcinoma treated at our Unit between 1991 and 2000. Pertinent clinical information, pathologic data, treatment, and prognostic factors for survival following documentation of distant metastatic disease were collected. The significance of the association between metastatic status and various clinical variables was assessed using the standard chi-square test. Survival time was calculated from the time of diagnosis of ovarian cancer and from the time of diagnosis of the distant metastases. A logistic regression procedure was used to estimate the odds of metastatic status given the presence of certain clinical variables. A total of 67 metastatic sites were diagnosed in 50 patients. Thirteen patients (8%) had distant metastatic disease at the time of diagnosis, 37 patients (22%) had distant metastases at the time of recurrent of progressive disease. Site of metastases were: liver, 21; pleura, 11; lung, 8; central nervous system and skin, 7 each; extra-abdominal lymph nodes and spleen, 5 each; bone, 2; and breast, 1. Significant risk factors for the development of distant metastases were stage, grade, and lymph node involvement. Median interval time between diagnosis of ovarian cancer and documentation of metastatic disease was 44 months (range 3-105), and at the time of diagnosis of distant disease, 36 of 50 patients (72%) had other sites of disease (intra-abdominal or extra-abdominal). Median survival from diagnosis of distant disease was 12 months (range 1-58). In univariate analysis performance status (P = 0.03), the presence of other sites of disease (P = 0.04) and interval time between diagnosis of ovarian cancer and documentation of distant metases (P = 0.03) were the only factors significantly associated with survival. Long interval time remained significant for prognosis in multivariate analysis also (P = 0.04). Distant metastasis consistent with stage IV disease is a late complication that occurs in about one third of ovarian cancer patients. Prognosis after documentation of distant metastases is poor. We conclude the most important prognostic factor associated with survival is the interval time between diagnosis of ovarian cancer and documentation of distant metastases.
Topics: Carcinoma; Central Nervous System Neoplasms; Female; Humans; Incidence; Italy; Liver Neoplasms; Logistic Models; Lung Neoplasms; Medical Records; Neoplasm Metastasis; Neoplasm Staging; Ovarian Neoplasms; Prognosis; Retrospective Studies; Risk Factors; Skin Neoplasms; Survival Analysis
PubMed: 12657111
DOI: 10.1046/j.1525-1438.2003.13054.x -
Oncology Letters May 2017At present, the risk factors for distant recurrence among patients with early ipsilateral breast tumor recurrence (IBTR) require further investigation. Early IBTR is...
At present, the risk factors for distant recurrence among patients with early ipsilateral breast tumor recurrence (IBTR) require further investigation. Early IBTR is defined as occurring within 3 years following the initial surgery. In the current study, 40 patients with early IBTR were examined to determine the risk factors for distant recurrence. A node-positive status at the time of primary surgery and the administration of adjuvant chemotherapy following the primary surgery were significantly correlated with poorer distant disease-free survival (P=0.001 and P=0.002, respectively). Multivariate analyses revealed that the nodal status at the time of primary surgery was an independent predictive factor for distant recurrence (P=0.050). Therefore, the results of the current study revealed that the nodal status at the time of primary surgery was an independent predictive factor for distant recurrence among patients with early IBTR.
PubMed: 28521393
DOI: 10.3892/ol.2017.5797 -
Computers in Biology and Medicine Feb 2024Breast cancer is the most prevalent malignancy in women. Advanced breast cancer can develop distant metastases, posing a severe threat to the life of patients. Because...
BACKGROUND
Breast cancer is the most prevalent malignancy in women. Advanced breast cancer can develop distant metastases, posing a severe threat to the life of patients. Because the clinical warning signs of distant metastasis are manifested in the late stage of the disease, there is a need for better methods of predicting metastasis.
METHODS
First, we screened breast cancer distant metastasis target genes by performing difference analysis and weighted gene co-expression network analysis (WGCNA) on the selected datasets, and performed analyses such as GO enrichment analysis on these target genes. Secondly, we screened breast cancer distant metastasis target genes by LASSO regression analysis and performed correlation analysis and other analyses on these biomarkers. Finally, we constructed several breast cancer distant metastasis prediction models based on Logistic Regression (LR) model, Random Forest (RF) model, Support Vector Machine (SVM) model, Gradient Boosting Decision Tree (GBDT) model and eXtreme Gradient Boosting (XGBoost) model, and selected the optimal model from them.
RESULTS
Several 21-gene breast cancer distant metastasis prediction models were constructed, with the best performance of the model constructed based on the random forest model. This model accurately predicted the emergence of distant metastases from breast cancer, with an accuracy of 93.6 %, an F1-score of 88.9 % and an AUC value of 91.3 % on the validation set.
CONCLUSION
Our findings have the potential to be translated into a point-of-care prognostic analysis to reduce breast cancer mortality.
Topics: Humans; Female; Breast Neoplasms; Breast; Gene Expression Profiling; Logistic Models; Machine Learning
PubMed: 38211382
DOI: 10.1016/j.compbiomed.2024.107943