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American Journal of Physiology.... Nov 2015This year represents the fifth annual Data Diuresis session of the Water and Electrolyte Homeostasis (WEH) section of the American Physiological Society (APS) at the... (Review)
Review
This year represents the fifth annual Data Diuresis session of the Water and Electrolyte Homeostasis (WEH) section of the American Physiological Society (APS) at the 2015 Experimental Biology meeting. As opposed to taking a single organ approach to the study of physiology, the WEH section employs an integrative approach to encompass how the different organ systems interact to regulate numerous physiological and pathophysiological processes. The goal of this minireview is to highlight the broad spectrum of research themes that were presented over the first five years of Data Diuresis. Presentation topics include (but are not limited to) oxidative stress, inflammation, obesity, pregnancy, and hypertension spanning the brain, heart and vasculature, and kidney. WEH researchers continue to impact and help drive the direction of physiological research across multiple disciplines, leaving us excited to see what the next five years of Data Diuresis will bring.
Topics: Animals; Diuresis; Evidence-Based Medicine; Humans; Models, Biological; Water-Electrolyte Balance
PubMed: 25855306
DOI: 10.1152/ajpregu.00107.2015 -
Acta Endocrinologica 1951
Topics: Diuresis; Diuretics; Ethanol
PubMed: 14894109
DOI: 10.1530/acta.0.0070110 -
Nursing Times Jun 1967
Topics: Diuresis; Diuretics; Humans; Organomercury Compounds
PubMed: 6026411
DOI: No ID Found -
Journal of Neurosurgery. Pediatrics Jun 2016
Topics: Acetazolamide; Diuresis; Humans; Neural Tube Defects
PubMed: 26824598
DOI: 10.3171/2015.9.PEDS15484 -
Southern Medical Journal Feb 2010
Topics: Diuresis; Humans; Hypertension, Pulmonary; Piperazines; Purines; Sildenafil Citrate; Sulfones; Vasodilator Agents; Ventricular Dysfunction, Right
PubMed: 20065906
DOI: 10.1097/SMJ.0b013e3181c98dd2 -
Neurourology and Urodynamics 1995Micturition can be characterized experimentally by monitoring both the frequency and volume of micturition. Previous studies demonstrated that the functional capacity of...
Micturition can be characterized experimentally by monitoring both the frequency and volume of micturition. Previous studies demonstrated that the functional capacity of the rat and rabbit bladder, as determined by cystometry, is approximately equal to the maximal single micturition volume as recorded over a 24 hour period. Studies in many laboratories have demonstrated that chronic increases in diuresis induce increases in micturition frequency and capacity, and an increase in bladder mass. The current study compares the temporal relationship among these parameters in three models of diuresis: streptozotocin-induced diabetes in rats, sucrose-induced diuresis in rats, and furosemide-induced diuresis in rabbits. In both sucrose diuresis in rats and furosemide diuresis in rabbits there were immediate increases in both the frequency and volume of micturition. The magnitude of the increases in micturition frequency and micturition volume paralleled the increase in the total volume of urine excreted. Bladder mass increased progressively over the time course of the study. Streptozotocin-induced diabetes resulted in a more gradual (but parallel) increase in micturition frequency and volume, and again a more gradual increase in bladder mass. These studies demonstrate that functional bladder capacity is increased immediately upon the initiation of diuresis with sucrose or furosemide, as is the frequency of micturition. This indicates that functional bladder capacity is probably under neuronal regulation and the change in capacity is not a function of the increased bladder mass which occurs at a later time period.(ABSTRACT TRUNCATED AT 250 WORDS)
Topics: Animals; Diabetes Mellitus, Experimental; Diuresis; Furosemide; Male; Rabbits; Rats; Rats, Sprague-Dawley; Sucrose; Urination
PubMed: 7780442
DOI: 10.1002/nau.1930140209 -
British Journal of Urology Dec 1995To analyse how differences in diuresis affect the normal pattern of micturition of healthy children.
OBJECTIVE
To analyse how differences in diuresis affect the normal pattern of micturition of healthy children.
SUBJECTS AND METHODS
Two hundred and six healthy continent schoolchildren, aged 7-15 years, completed a frequency/volume chart for 24 h by recording the time and volume of each micturition. Several diuresis variables were calculated from these charts and compared with sex, age, oral fluid intake, functional bladder capacity, voiding intervals and volumes.
RESULTS
The weight-corrected mean diuresis per 24 h varied 10-fold between individuals, independently of recorded fluid intake. In the majority, the diuresis decreased during the night, but the opposite diurnal pattern occurred in 12% of the children. The individual night-time diuresis was positively correlated with functional bladder capacity and the daytime diuresis was positively correlated with voiding frequency.
CONCLUSIONS
The weight-corrected diuresis varies many-fold among healthy continent children. A substantial proportion has a reversed diurnal pattern with a larger diuresis during the night. The individual bladder size is adapted to accommodate their typical nightly urine production.
Topics: Adolescent; Child; Circadian Rhythm; Diuresis; Drinking; Female; Humans; Male; Urinary Bladder; Urination
PubMed: 8535727
DOI: 10.1111/j.1464-410x.1995.tb00775.x -
American Journal of Physiology. Renal... Jun 2015Caffeine is one of the most widely consumed behavioral substances. We have previously shown that caffeine- and theophylline-induced inhibition of renal reabsorption...
Caffeine is one of the most widely consumed behavioral substances. We have previously shown that caffeine- and theophylline-induced inhibition of renal reabsorption causes diuresis and natriuresis, an effect that requires functional adenosine A1 receptors. In this study, we tested the hypothesis that blocking the Gi protein-coupled adenosine A1 receptor via the nonselective adenosine receptor antagonist caffeine changes Na(+)/H(+) exchanger isoform 3 (NHE3) localization and phosphorylation, resulting in diuresis and natriuresis. We generated tubulus-specific NHE3 knockout mice (Pax8-Cre), where NHE3 abundance in the S1, S2, and S3 segments of the proximal tubule was completely absent or severely reduced (>85%) in the thick ascending limb. Consumption of fluid and food, as well as glomerular filtration rate, were comparable in control or tubulus-specific NHE3 knockout mice under basal conditions, while urinary pH was significantly more alkaline without evidence for metabolic acidosis. Caffeine self-administration increased total fluid and food intake comparably between genotypes, without significant differences in consumption of caffeinated solution. Acute caffeine application via oral gavage elicited a diuresis and natriuresis that was comparable between control and tubulus-specific NHE3 knockout mice. The diuretic and natriuretic response was independent of changes in total NHE3 expression, phosphorylation of serine-552 and serine-605, or apical plasma membrane NHE3 localization. Although caffeine had no clear effect on localization of the basolateral Na(+)/bicarbonate cotransporter NBCe1, pretreatment with DIDS inhibited caffeine-induced diuresis and natriuresis. In summary, NHE3 is not required for caffeine-induced diuresis and natriuresis.
Topics: Animals; Caffeine; Diuresis; Diuretics; Female; Glomerular Filtration Rate; Kidney Tubules; Male; Mice; Natriuresis; Sodium; Sodium-Hydrogen Exchanger 3; Sodium-Hydrogen Exchangers
PubMed: 25925253
DOI: 10.1152/ajprenal.00129.2015 -
Lille Medical : Journal de La Faculte... Feb 1960
Topics: Diuresis; Diuretics
PubMed: 13813226
DOI: No ID Found -
Annales de Chirurgie Mar 1961
Topics: Diuresis
PubMed: 13731096
DOI: No ID Found