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Bollettino Della Societa Italiana Di... Dec 1956
Topics: Desoxycorticosterone; Diuresis; Diuretics
PubMed: 13446131
DOI: No ID Found -
Journal of the American Society of... Feb 2008
Topics: Animals; Diuresis; Humans; Kidney; Kidney Concentrating Ability; Oxytocin
PubMed: 18216307
DOI: 10.1681/ASN.2007121319 -
Journal of Applied Physiology... Sep 1992We tested the hypothesis that 1-desamino-8-D-arginine vasopressin (DDAVP), a V2-receptor agonist, could inhibit the diuresis induced by water immersion in humans. Water... (Clinical Trial)
Clinical Trial
We tested the hypothesis that 1-desamino-8-D-arginine vasopressin (DDAVP), a V2-receptor agonist, could inhibit the diuresis induced by water immersion in humans. Water and electrolyte excretion, plasma atrial natriuretic factor concentration, and plasma aldosterone concentration were measured initially and after 3 h of water immersion in 13 healthy sodium-replete men given either placebo or 20 micrograms of intranasal DDAVP. Guanosine 3',5'-cyclic monophosphate and urea excretion and urine osmolality were also determined. DDAVP inhibited the diuresis induced by water immersion in men: 758 +/- 168 (SE) ml/3 h in the placebo group vs. 159 +/- 28 ml/3 h in the DDAVP group (P less than 0.05). After 3 h of water immersion, plasma atrial natriuretic factor concentrations were increased from 11 +/- 2 to 20 +/- 4 pg/ml in the placebo group and from 14 +/- 2 to 33 +/- 4 pg/ml in the DDAVP group (P less than 0.05). Plasma aldosterone concentrations were decreased from 98 +/- 18 to 45 +/- 6 pg/ml in the placebo group (P less than 0.05) and from 54 +/- 17 to 25 +/- 5 pg/ml in the DDAVP group (P less than 0.05). Despite these changes in aldosterone and atrial natriuretic factor concentrations, which should increase sodium excretion, DDAVP decreased the natriuresis induced by water immersion in humans: 56 +/- 8 meq Na+/3 h in the placebo group vs. 36 +/- 6 meq Na+/3 h in the DDAVP group (P less than 0.05). DDAVP may be used to prevent the diuresis associated with central redistribution of blood volumes that occur during water immersion.(ABSTRACT TRUNCATED AT 250 WORDS)
Topics: Adult; Aldosterone; Atrial Natriuretic Factor; Blood Volume; Deamino Arginine Vasopressin; Diuresis; Humans; Immersion; Male; Middle Aged; Natriuresis
PubMed: 1400058
DOI: 10.1152/jappl.1992.73.3.932 -
American Journal of Respiratory and... Dec 2012
Topics: Biomarkers; Diuresis; Diuretics; Humans; Natriuretic Peptide, Brain; Randomized Controlled Trials as Topic; Ventilator Weaning
PubMed: 23250495
DOI: 10.1164/rccm.201210-1770ED -
The Journal of Clinical Investigation Nov 1959
Topics: Blood Pressure; Diuresis; Humans; Hypertension; Natriuresis; Respiration; Sodium
PubMed: 14403938
DOI: 10.1172/JCI103976 -
Naunyn-Schmiedebergs Archiv Fur... 1960
Topics: Animals; Diuresis; Rats
PubMed: 14442487
DOI: No ID Found -
British Journal of Pharmacology Apr 2001Lysosphingolipids such as sphingosine-1-phosphate (SPP) and sphingosylphosphorylcholine (SPPC) can act on specific G-protein-coupled receptors. Since SPP and SPPC cause...
Lysosphingolipids such as sphingosine-1-phosphate (SPP) and sphingosylphosphorylcholine (SPPC) can act on specific G-protein-coupled receptors. Since SPP and SPPC cause renal vasoconstriction, we have investigated their effects on urine and electrolyte excretion in anaesthetized rats. Infusion of SPP (1 - 30 microg kg(-1) min(-1)) for up to 120 min dose-dependently but transiently (peak after 15 min, disappearance after 60 min) reduced renal blood flow without altering endogenous creatinine clearance. Nevertheless, infusion of SPP increased diuresis, natriuresis and calciuresis and, to a lesser extent, kaliuresis. These tubular lysosphingolipid effects developed more slowly (maximum after 60 - 90 min) and also abated more slowly upon lysosphingolipid washout than the renovascular effects. Infusion of SPPC, sphingosine and glucopsychosine (3 - 30 microg kg(-1) min(-1) each) caused little if any alterations in renal blood flow but also increased diuresis, natriuresis and calciuresis and, to a lesser extent, kaliuresis. Pretreatment with pertussis toxin (10 microg kg(-1) 3 days before the acute experiment) abolished the renovascular and tubular effects of 30 microg kg(-1) min(-1) SPP. These findings suggest that lysosphingolipids are a hitherto unrecognized class of endogenous modulators of renal function. SPP affects renovascular tone and tubular function via receptors coupled to G(i)-type G-proteins. SPPC, sphingosine and glucopsychosine mimic only the tubular effects of SPP, and hence may act on distinct sites.
Topics: Anesthesia; Animals; Blood Pressure; Diuresis; Kidney Tubules; Male; Natriuresis; Pertussis Toxin; Psychosine; Rats; Rats, Wistar; Receptors, Cell Surface; Receptors, G-Protein-Coupled; Receptors, Lysophospholipid; Renal Circulation; Sphingolipids; Virulence Factors, Bordetella
PubMed: 11309265
DOI: 10.1038/sj.bjp.0703969 -
The Journal of Laboratory and Clinical... Aug 1961
Topics: Diuresis; Humans; Kidney Diseases; Kidney Failure, Chronic; Renal Insufficiency, Chronic
PubMed: 13756614
DOI: No ID Found -
The Journal of Urology Aug 1956
Topics: Diuresis; Humans; Male; Posture
PubMed: 13346836
DOI: 10.1016/S0022-5347(17)66685-0 -
Archives of Surgery (Chicago, Ill. :... Feb 1964
Topics: Blood Chemical Analysis; Diuresis; Humans; Hyponatremia; Mannitol; Natriuresis; Sodium; Surgical Procedures, Operative; Toxicology; Urine
PubMed: 14082806
DOI: 10.1001/archsurg.1964.01310200035009