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Proceedings of the Society For... Jun 1964
Topics: Chlorides; Diuresis; Humans; Kidney; Kidney Transplantation; Kidney Tubules; Natriuresis; Transplantation, Homologous
PubMed: 14193379
DOI: 10.3181/00379727-116-29284 -
The Journal of Physiology Jul 19671. The relation between water loading and electrolyte excretion in dogs fed on a meat diet proved impossible to evaluate owing to the large variability in electrolyte...
1. The relation between water loading and electrolyte excretion in dogs fed on a meat diet proved impossible to evaluate owing to the large variability in electrolyte excretion rates in control experiments.2. In animals fed a synthetic diet of constant and known composition the administration of a water load of 2.5% of body weight caused significant increases in the rate of excretion of sodium (P < 0.01) and potassium (P < 0.05). The chloride excretion rate also increased in the one animal tested.3. The significance of these results is discussed.
Topics: Animals; Diet; Diuresis; Dogs; Female; Natriuresis; Potassium; Water Intoxication; Water-Electrolyte Balance
PubMed: 6050608
DOI: 10.1113/jphysiol.1967.sp008240 -
Clinica Chimica Acta; International... Jul 1960
Topics: Diuresis; Heparin; Humans
PubMed: 14420094
DOI: 10.1016/0009-8981(60)90073-5 -
The Journal of Clinical Investigation Jan 1961
Topics: Diuresis; Steroids; Vasopressins
PubMed: 13762308
DOI: 10.1172/JCI104229 -
European Journal of Clinical... Dec 1988The possible interaction between arginine vasopressin (AVP) and atrial natriuretic factor (ANF) in the control of urinary sodium and water excretion was investigated in... (Clinical Trial)
Clinical Trial Randomized Controlled Trial
The possible interaction between arginine vasopressin (AVP) and atrial natriuretic factor (ANF) in the control of urinary sodium and water excretion was investigated in man. Nine healthy male volunteers undergoing stable maximal water diuresis were studied on four separate occasions. Atrial natriuretic factor 15 pmol kg-1 min-1 or placebo (P) was concomitantly administered against a background infusion of either AVP 0.003 pmol kg-1 min-1 or P; thus the combinations P + P, AVP + P, P + ANF and AVP + ANF were studied. Atrial natriuretic factor caused a significant increase in sodium excretion (UNaV) [+56%], urinary flow rate (V) [+17%] and free water clearance (CH2O) [+23%]; creatinine clearance (Ccr) did not change. Arginine vasopressin reduced V (-58%) and CH2O (-68%) but did not alter UNaV or Ccr. On the AVP + ANF study day, UNaV increased (+64%) as with P + ANF, but V (-44%) and CH2O (-52%) continued to decrease below baseline levels; analysis of variance showed this antidiuresis reflected the prevalent effect of AVP rather than any specific interaction. These results show that AVP is able to dissociate the natriuretic and diuretic effects of ANF.
Topics: Adult; Arginine Vasopressin; Atrial Natriuretic Factor; Diuresis; Drug Interactions; Humans; Male; Natriuresis
PubMed: 2975995
DOI: 10.1111/j.1365-2362.1988.tb01278.x -
The Journal of Clinical Investigation Aug 1957
Topics: Diuresis; Diuretics; Ethanol; Humans; Male
PubMed: 13463082
DOI: 10.1172/JCI103516 -
Archivio Italiano Di Chirurgia 1967
Topics: Acute Kidney Injury; Diuresis; Humans; Mannitol; Postoperative Complications; Surgical Procedures, Operative
PubMed: 5621871
DOI: No ID Found -
Therapeutische Umschau. Revue... May 1954
Topics: Cation Exchange Resins; Diuresis; Diuretics; Ion Exchange Resins
PubMed: 13187421
DOI: No ID Found -
Journal of the American Society of... Sep 1998The present study examined the effect of renal denervation on the impairment of the pressure-diuresis response produced by nitric oxide synthesis blockade. The... (Comparative Study)
Comparative Study
The present study examined the effect of renal denervation on the impairment of the pressure-diuresis response produced by nitric oxide synthesis blockade. The experiments were performed in Inactin-anesthetized Munich-Wistar rats. The animals with innervated kidneys had lower baseline values of renal blood flow, GFR, sodium excretion (UNaV), and urine flow (V) than rats with denervated kidneys. Also, renal denervation shifted pressure-diuresis and natriuresis toward lower pressures. A low dose of N(omega)-nitro-L-arginine methyl esther (NAME, 3.7 nmol/kg per min) reduced UNaV and the fractional excretion of sodium (FENa) and blunted pressure-natriuresis only in rats with innervated kidneys, whereas it had no effects in rats with denervated kidneys. A medium dose of NAME (37 nmol/kg per min) lowered FENa only in rats with innervated kidneys. The administration of NAME (37 nmol/kg per min) blunted pressure-diuresis and natriuresis in kidneys with or without the renal nerves, but the effect was more pronounced in rats with innervated kidneys. A high dose of NAME (3.7 micromol + 185 nmol/kg per min) increased UNaV and FENa only in rats with innervated kidneys, whereas it reduced GFR, V, UnaV, and FENa in rats with denervated kidneys. However, pressure-natriuresis and diuresis were blunted by this high dose of NAME independently of the presence or absence of renal nerves. These results demonstrate that renal nerves potentiate the renal effects of low doses of NAME on renal function and pressure-diuresis and natriuresis. However, high doses of NAME abolish pressure-diuresis independently of renal nerves, and the natriuretic effect of NAME in innervated kidneys may be attributed to reflex inhibition of sympathetic tone due to the rise in arterial pressure.
Topics: Analysis of Variance; Animals; Denervation; Disease Models, Animal; Diuresis; Dose-Response Relationship, Drug; Enzyme Inhibitors; Female; Kidney; Kidney Function Tests; Male; NG-Nitroarginine Methyl Ester; Natriuresis; Nitric Oxide; Rats; Rats, Wistar; Reference Values; Regional Blood Flow
PubMed: 9727366
DOI: 10.1681/ASN.V991588 -
Clinical and Experimental Pharmacology... Apr 2014Administration of exogenous L-arginine (L-Arg) attenuates angiotensin-II (AngII)-mediated hypertension and kidney disease in rats. The present study assessed renal...
Administration of exogenous L-arginine (L-Arg) attenuates angiotensin-II (AngII)-mediated hypertension and kidney disease in rats. The present study assessed renal hemodynamics and pressure diuresis-natriuresis in anaesthetized rats infused with vehicle, AngII (20 ng/kg per min i.v.) or AngII + L-Arg (300 μg/kg per min i.v.). Experiments in isolated aortic rings were carried out to assess L-Arg effects on the vasculature. Increasing renal perfusion pressure (RPP) from ~100 to 140 mmHg resulted in a nine- to tenfold increase in urine flow and sodium excretion rate in control animals. In comparison, AngII infusion significantly reduced renal blood flow (RBF) and glomerular filtration rate (GFR) by 40-42%, and blunted the pressure-dependent increase in urine flow and sodium excretion rate by 54-58% at elevated RPP. Supplementation of L-Arg reversed the vasoconstrictor effects of AngII and restored pressure-dependent diuresis to levels not significantly different from control rats. Dose-dependent contraction to AngII (10(-10) mol/L to 10(-7) mol/L) was observed with a maximal force equal to 27 ± 3% of the response to 10(-5) mol/L phenylephrine. Contraction to 10(-7) mol/L AngII was blunted by 75 ± 3% with 10(-4) mol/L L-Arg. The influence of L-Arg to blunt AngII-mediated contraction was eliminated by endothelial denudation or incubation with nitric oxide synthase inhibitors. Furthermore, the addition of 10(-3) mol/L cationic or neutral amino acids, which compete with L-Arg for cellular uptake, blocked the effect of L-Arg. Anionic amino acids did not influence the effects of L-Arg on AngII-mediated contraction. These studies show that L-Arg blunts AngII-mediated vascular contraction by an endothelial- and nitric oxide synthase-dependent mechanism involving cellular uptake of L-Arg.
Topics: Angiotensin II; Animals; Arginine; Diuresis; Glomerular Filtration Rate; Hemodynamics; Kidney; Natriuresis; Rats; Renal Circulation
PubMed: 24472006
DOI: 10.1111/1440-1681.12212