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Presse Medicale (Paris, France : 1983) Feb 2018
Topics: Epidural Neoplasms; Humans; Male; Middle Aged; Multiple Myeloma; Thoracic Vertebrae
PubMed: 29373280
DOI: 10.1016/j.lpm.2017.11.009 -
Facial Plastic Surgery : FPS 1999The internal nasal valve incompetence (INVI) can be divided into (1) static: when the articulation between the dorsal edge of the upper lateral cartilages and the dorsal...
The internal nasal valve incompetence (INVI) can be divided into (1) static: when the articulation between the dorsal edge of the upper lateral cartilages and the dorsal edge of the septum forms an angle less than 10 to 15 degrees and (2) dynamic: when the upper lateral cartilages collapse attracted by the negative pressure during inspiration. To correct both the static and dynamic components in severe cases of INVI, the authors propose a surgical technique consisting of upper lateral cartilages suspension over dorsal grafts; the dorsal margins of the two upper lateral cartilages are pulled dorsally and sutured together over the dorsal edge of the septum and over the dorsal-spreader grafts. The post-operative results of 12 patients affected by INVI with severe nasal obstruction were evaluated. Such a technique, which utilizes both the widening and the suspension effects, is particularly useful in the most severe cases of dynamic INVI.
Topics: Adult; Cartilage; Female; Humans; Male; Middle Aged; Nasal Obstruction; Nasal Septum; Rhinoplasty
PubMed: 11816075
DOI: 10.1055/s-2008-1064332 -
Handchirurgie, Mikrochirurgie,... 1982A dorsal scapho-lunate dislocation resulted from a forced hyperflexion of the right wrist. X-rays demonstrated a dorsally displaced lunate bone and a palmar displacement...
A dorsal scapho-lunate dislocation resulted from a forced hyperflexion of the right wrist. X-rays demonstrated a dorsally displaced lunate bone and a palmar displacement of the distal carpus with respect to the radius. The dorsal dislocation of the lunate and the palmar perilunate dislocation were combined. Treatment consisted of closed reduction, a gauntlet cast and physical therapy. A follow-up radiological examination six years later revealed a palmar form of carpal instability. No subjective complaints were made on the part of the patient.
Topics: Adult; Carpal Bones; Humans; Joint Dislocations; Lunate Bone; Male; Postoperative Complications; Radiography
PubMed: 7182294
DOI: No ID Found -
Journal of Wrist Surgery Feb 2018Patients with scapholunate instability usually have pain in the dorsal wrist. This pain may occur due to the impingement between the scaphoid and the dorsal rim of...
Patients with scapholunate instability usually have pain in the dorsal wrist. This pain may occur due to the impingement between the scaphoid and the dorsal rim of the radius when the scaphoid is detached from the lunate. This pain appears as the scaphoid is displaced over the dorsal rim of the radius. The arthroscopic scaphoid 3D (dorsal, dynamic, displacement) test is described here to check this pathologic dorsal displacement of the scaphoid. The test should be performed both in the radiocarpal and midcarpal joints. Traction is released and the arthroscope is set under the lunate when tested in the radiocarpal joint and on the lunate when tested in the midcarpal joint. The scaphoid is manually pushed dorsally at the scaphoid tubercle. If there was no scapholunate instability, all the proximal row bones are minimally displaced: a negative test. If there was scapholunate instability, the scaphoid is displaced dorsally while the lunate remains static: evaluated as positive. This test can add information to the arthroscopic classifications of the scapholunate instability, which explore both the proximal to distal displacement of the scaphoid (the step-off) and the ulnar to radial displacement (the gap), as this test explores the volar to dorsal displacement.
PubMed: 29383283
DOI: 10.1055/s-0037-1601578 -
TheScientificWorldJournal Dec 2003We review key morphogenetic events that occur during Caenorhabditis elegans (www.wormbase.org/) embryogenesis. Morphogenesis transforms tissues from one shape into... (Review)
Review
We review key morphogenetic events that occur during Caenorhabditis elegans (www.wormbase.org/) embryogenesis. Morphogenesis transforms tissues from one shape into another through cell migrations and shape changes, often utilizing highly conserved actin-based contractile systems. Three major morphogenetic events occur during C. elegans embryogenesis: (1) dorsal intercalation, during which two rows of dorsal epidermal cells intercalate to form a single row; (2) ventral enclosure, where the dorsally located sheet of epidermal cells stretches to the ventral midline, encasing the embryo within a single epithelial sheet; and (3) elongation, during which actin-mediated contractions within the epithelial sheet lengthens the embryo. Here, we describe the known molecular players involved in each of these processes.
Topics: Animals; Caenorhabditis elegans; Morphogenesis
PubMed: 14755119
DOI: 10.1100/tsw.2003.123 -
Brain Research Apr 1986The possible involvement of efferent pathways from the suprachiasmatic nucleus (SCN) in the photoperiodic regulation of reproduction was studied by measuring the testis...
The possible involvement of efferent pathways from the suprachiasmatic nucleus (SCN) in the photoperiodic regulation of reproduction was studied by measuring the testis size of hamsters bearing a horizontal knife cut either ventral or dorsal to the hypothalamic paraventricular nucleus (PVN) that were transferred from photostimulatory long days (light:dark (L:D) 14:10 h) to non-stimulatory short days (L:D 6:18 h). Knife cuts placed either ventral or dorsal to the PVN blocked testicular regression induced by exposure to short days. These results indicate that efferent fibers running dorsally from the SCN to the PVN are involved in relaying photoperiodic information from the SCN to the PVN. Furthermore, recently-defined efferents that leave the PVN dorsally and terminate in the spinal cord appear to be responsible for relaying seasonal information about day-length to the pineal-reproductive axis of hamsters.
Topics: Animals; Brain Mapping; Cricetinae; Light; Male; Mesocricetus; Neural Pathways; Paraventricular Hypothalamic Nucleus; Periodicity; Pineal Gland; Seasons; Suprachiasmatic Nucleus; Testis
PubMed: 3708315
DOI: 10.1016/0006-8993(86)91109-1 -
Hand Surgery & Rehabilitation Dec 2023In volar distal radius fixation, conventional and additional fluoroscopic views could not be sufficient to assess dorsal screw penetration. Ultrasound (US) has been...
OBJECTIVES
In volar distal radius fixation, conventional and additional fluoroscopic views could not be sufficient to assess dorsal screw penetration. Ultrasound (US) has been suggested as a technique to improve this assessment. The objective was to determine the agreement between these two explorations in a clinical study. Quantify time-consuming of intraoperative US was the secondary objective.
MATERIAL AND METHODS
A prospective descriptive study was performed. Thirty patients with a surgical distal radius fracture were treated with volar fixation by five consultant surgeons in a level I Trauma Centre. Final intraoperative fluoroscopic views: AP, lateral, 20º tilted lateral and Dorsal Tangential views (DTV) were performed assessing for dorsal screw protrusion. Then, ultrasound was performed to reassess dorsal cortex integrity. Those protruding screws were registered and changed.
RESULTS
A total of 153 screws were examined. Four protruding screws were observed with no multiple protruding screws in the same fixation. Intraoperative ultrasound detected a dorsal screw protrusion in one fixation, assessed as correct by radiological projections. Almost perfect agreement was found between DTV and US examination k = 0.83 (p < 0.001). The mean surgical time was 63 ± 20.3 min while the addition of the ultrasound, supposed an average of 4 ± 1 min more.
CONCLUSION
Ultrasound did not show a clinically significant improvement in the assessment dorsal screw penetration in distal radius fixation. A high agreement was observed between US and the described fluoroscopic views. The addition of intraoperative US was a non-significant time-consuming procedure.
Topics: Humans; Radius; Radius Fractures; Bone Plates; Fracture Fixation, Internal; Fluoroscopy
PubMed: 37499797
DOI: 10.1016/j.hansur.2023.07.010 -
BioRxiv : the Preprint Server For... Mar 2024The cloaca is a transient structure that forms in the terminal hindgut giving rise to the rectum dorsally and the urogenital sinus ventrally. Similarly, human hindgut...
The cloaca is a transient structure that forms in the terminal hindgut giving rise to the rectum dorsally and the urogenital sinus ventrally. Similarly, human hindgut cultures derived from human pluripotent stem cells generate human colonic organoids (HCOs) which also contain co-developing urothelial tissue. In this study, our goal was to identify pathways involved in cloacal patterning and apply this to human hindgut cultures. RNA-seq data comparing dorsal versus ventral cloaca in e10.5 mice revealed that WNT signaling was elevated in the ventral versus dorsal cloaca. Inhibition of WNT signaling in hindgut cultures biased their differentiation towards a colorectal fate. WNT activation biased differentiation towards a urothelial fate, giving rise to human urothelial organoids (HUOs). HUOs contained cell types present in human urothelial tissue. Based on our results, we propose a mechanism whereby WNT signaling patterns the ventral cloaca, prior to cloacal septation, to give rise to the urogenital sinus.
PubMed: 38496665
DOI: 10.1101/2024.03.04.583343 -
Journal of Orthopaedic Trauma Mar 2005To compare the biomechanical stability of internal fixation of extra-articular, dorsally unstable distal radius fractures fixed by 1 of 2 methods, either a standard... (Comparative Study)
Comparative Study
OBJECTIVES
To compare the biomechanical stability of internal fixation of extra-articular, dorsally unstable distal radius fractures fixed by 1 of 2 methods, either a standard dorsal nonlocked T-plate or a volar locked fixed-angle plate.
DESIGN
Biomechanical cadaveric study.
SETTING
Biomechanical testing laboratory.
INTERVENTION
In 6 matched pairs of fresh-frozen cadaveric specimens, a simulated unstable extra-articular distal radius fracture was created. The fractures were stabilized with either a dorsal 3.5-mm stainless steel T-plate or a titanium locked volar fixed-angle plate. Specimens were axially loaded at 5 points (centrally, volarly, dorsally, radially, and ulnarly) and then cyclically loaded for 5000 cycles with an 80 N central load. Postcyclical loading, specimens were once again axially loaded at the 5 points.
MAIN OUTCOME MEASURES
Initial fixation stiffness and stiffness after midaxial cyclical loading was compared at the 5 points.
RESULTS
With the volar locked fixed-angle plate, fixation was significantly stiffer than with the dorsal nonlocked T-plate for ulnar and volar loading in single-cycle testing. After cyclic loading, the locked volar fixed-angle plate maintained more of its initial stiffness than the dorsal nonlocked T-plate. The dorsal 3.5-mm stainless steel T-plate's stiffness when dorsally loaded significantly decreased after cyclical loading.
CONCLUSIONS
The volar locked fixed-angle plate maintained a greater percentage of its initial stiffness after cyclic loading compared to the dorsal nonlocked plate. Also, the volar locked plate was stiffer than the dorsal nonlocked plate for all loading configurations tested except when subjected to a dorsally applied eccentric load.
Topics: Adult; Aged; Biomechanical Phenomena; Bone Plates; Equipment Design; Female; Humans; Male; Middle Aged; Radius Fractures
PubMed: 15758672
DOI: 10.1097/00005131-200503000-00006 -
Developmental and Comparative Immunology Dec 2013Dorsal as a crucial component of Toll signaling pathway, played important roles in induction and regulation of innate immune responses. In this study, we cloned a...
Dorsal as a crucial component of Toll signaling pathway, played important roles in induction and regulation of innate immune responses. In this study, we cloned a NF-κB-like transcription factor Dorsal from Eriocheir sinensis and designated it as EsDorsal. The full-length cDNA of EsDorsal was 2493 bp with a 2022-bp open reading frame (ORF) encoding a 673-amino acid protein. This protein contained a 171-residue conserved Rel homology domain (RHD) and a 102-residue Ig-like, plexins and transcription factors domain (IPT). By phylogenetic analysis, EsDorsal was clustered into one group together with other invertebrate Dorsals or NF-κBs, and then clustered with vertebrate NF-κBs. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis results showed that (a) EsDorsal had higher expression level in immune organs; (b) EsDorsal differentially induced after injection of lipopolysaccharides (LPS), peptidoglycan (PG) or zymosan (GLU). Importantly, EsDorsal was more responsive to LPS than GLU and PG. Collectively, EsDorsal was differentially inducibility in response to various PAMPs, suggesting its involvement in a specific innate immune regulation in E. sinensis.
Topics: Amino Acid Sequence; Animals; Brachyura; Cloning, Molecular; DNA, Complementary; Immunity, Innate; Molecular Sequence Data; NF-kappa B; Phylogeny; Sequence Alignment; Transcription Factors
PubMed: 23981326
DOI: 10.1016/j.dci.2013.08.013