-
The Journal of Pharmacy and Pharmacology Oct 1980The preparation and release characteristics of microcapsules of isoniazid have been studied. The differing techniques of microencapsulation are assessed and the...
The preparation and release characteristics of microcapsules of isoniazid have been studied. The differing techniques of microencapsulation are assessed and the dissolution of drug from suspended and tableted microcapsules prepared using the chosen technique has been monitored for in vitro release.
Topics: Capsules; Delayed-Action Preparations; Isoniazid; Solubility; Tablets
PubMed: 6107339
DOI: 10.1111/j.2042-7158.1980.tb13037.x -
International Journal of Pharmaceutics Oct 2010Oral pulsatile/delayed delivery systems are designed to elicit programmable lag phases preceding a prompt and quantitative, repeated or prolonged release of drugs.... (Review)
Review
Oral pulsatile/delayed delivery systems are designed to elicit programmable lag phases preceding a prompt and quantitative, repeated or prolonged release of drugs. Accordingly, they draw increasing interest because of the inherent suitability for accomplishing chronotherapeutic goals, which have recently been highlighted in connection with a number of widespread chronic diseases with typical night or early-morning recurrence of symptoms (e.g. bronchial asthma, cardiovascular disease, rheumatoid arthritis, early-morning awakening). In addition, time-based colonic release can be attained when pulsatile delivery systems are properly adapted to overcome unpredictable gastric emptying and provide delay phases that would approximately match the small intestinal transit time. Oral pulsatile delivery is pursued by means of a variety of release platforms, namely reservoir, capsular and osmotic devices. The aim of the present review is to outline the rationale and main formulation strategies behind delayed-release dosage forms intended for the pharmacological treatment of chronopathologies.
Topics: Administration, Oral; Animals; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dosage Forms; Drug Chronotherapy; Drug Delivery Systems; Humans; Pharmaceutical Preparations; Tablets, Enteric-Coated
PubMed: 20655998
DOI: 10.1016/j.ijpharm.2010.07.026 -
American Journal of Health-system... Nov 2014
Topics: Dosage Forms; Drug Approval
PubMed: 25320126
DOI: 10.1093/ajhp/71.21.1823 -
Annales de Dermatologie Et de... Mar 2007
Topics: Administration, Cutaneous; Dermatologic Agents; Dosage Forms; Emulsions; Excipients; Gels; Humans; Ointments; Pharmaceutical Solutions; Powders
PubMed: 17563710
DOI: No ID Found -
Scientific Reports Feb 2024A straightforward and efficient spectrum technique was created using Ortho-chloranil as the electron acceptor (-acceptor) in a charge transfer (CT) complex formation...
A straightforward and efficient spectrum technique was created using Ortho-chloranil as the electron acceptor (-acceptor) in a charge transfer (CT) complex formation reaction to determine the concentration of famotidine (FMD) in solutions. Compared to the double-distilled blank solution, the reaction result detected a definite violet colour at a maximum absorption wavelength of 546 nm, For concentrations range 2-28 µg/ml, the technique demonstrated excellent compliance with Beer-Law and Lambert's, as evidenced by its molar absorptivity of 2159.648 L mol cm. Lower detection limits of 0.3024 µg/ml and 1.471 µg/ml, respectively, were discovered. The complexes of famotidine and Ortho-chloranil were found to have a 2:1 stoichiometry. Additionally, the suggested approach effectively estimated famotidine concentrations in pharmaceutical formulations, particularly in tablet form.
Topics: Famotidine; Chloranil; Spectrophotometry; Tablets; Dosage Forms
PubMed: 38351288
DOI: 10.1038/s41598-024-54402-4 -
Power of the Dissolution Test in Distinguishing a Change in Dosage Form Critical Quality Attributes.AAPS PharmSciTech Nov 2018For a dissolution method to be considered relevant to in vivo performance, the dissolution data profiles should show discrimination or meaningful change when there is a... (Review)
Review
For a dissolution method to be considered relevant to in vivo performance, the dissolution data profiles should show discrimination or meaningful change when there is a change in critical material attributes (CMAs) and critical product properties (CPPs). The dissolution test has been shown repeatedly to have the power to distinguish between significant changes in active pharmaceutical ingredient (API), formulation, and process that relate to the release mechanism of the in vivo performance. Examples will be discussed in the literature where the effects of formulation, drug substance, and manufacturing variables have been measured by dissolution testing. There will be a suggested plan on how to develop and challenge a discriminating method that may be utilized for regulatory purposes. A brief review of other challenges and considerations regarding discriminatory dissolution testing is presented.
Topics: Dosage Forms; Drug Liberation; Laboratory Critical Values; Quality Control; Solubility
PubMed: 30350251
DOI: 10.1208/s12249-018-1197-7 -
Pharmaceutical Research Mar 1991The variability in the gastrointestinal transit of a multiple-unit and single-unit dosage form was investigated following a light breakfast in six, healthy, male...
The variability in the gastrointestinal transit of a multiple-unit and single-unit dosage form was investigated following a light breakfast in six, healthy, male volunteers after repeated weekly administration. The dosage forms were labeled with gamma-emitting radionuclides and the transit of the formulations was monitored on 4 separate study days using the technique of dual-isotope gamma scintigraphy. Gastric emptying times and small intestinal transit times were calculated and compared statistically within and between subjects using the standard deviation and coefficient of variance. The variability in gastric emptying of single- and multiple-unit systems was large; the intrasubject variation being less than the intersubject. There was less variation in small intestinal transit times for the single- and multiple-unit formulations than in gastric emptying, intrasubject variation again being less than intersubject variation.
Topics: Adult; Chemistry, Pharmaceutical; Dosage Forms; Drug Implants; Gastrointestinal Transit; Genetic Variation; Humans; Indium Radioisotopes; Male; Pharmacokinetics; Scintillation Counting; Tablets
PubMed: 2052525
DOI: 10.1023/a:1015849700421 -
Journal of Pharmaceutical Sciences Oct 1970
Review
Topics: Aerosols; Capsules; Chemistry, Pharmaceutical; Delayed-Action Preparations; Dosage Forms; Hydrogen-Ion Concentration; Methods; Powders; Suspensions; Technology, Pharmaceutical
PubMed: 4919443
DOI: 10.1002/jps.2600591002 -
The Nurse Practitioner May 1986
Topics: Administration, Oral; Administration, Topical; Biological Availability; Delayed-Action Preparations; Dosage Forms; Humans; Pharmaceutical Preparations
PubMed: 3703398
DOI: No ID Found -
The Medical Letter on Drugs and... Aug 2012
Review
Topics: Animals; Chemistry, Pharmaceutical; Cost Savings; Dosage Forms; Humans; Pharmaceutical Preparations; Tablets
PubMed: 22869291
DOI: No ID Found