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American Journal of Hospital Pharmacy Feb 1983
Topics: Aluminum; Doxorubicin; Drug Incompatibility; Needles
PubMed: 6829575
DOI: No ID Found -
Pharmaceutical Development and... Dec 2020An approach for cancer treatment is modulation of tumor microenvironment. Based on the role of extracellular matrix in cell modulation, fabrication of textured materials...
An approach for cancer treatment is modulation of tumor microenvironment. Based on the role of extracellular matrix in cell modulation, fabrication of textured materials mimicking extracellular matrix could provide novel opportunities such as determining cancer cell behaviour. With this background, in this work, we have fabricated doxorubicin hydrochloride loaded nanotextured films which promote topographical attachment of cancer cells to film surface, and eliminate cells by release of the anti-cancer drug encapsulated within the films. These films are designed to be placed during surgical removal of the tumor with the intent to prevent ovarian cancer recurrence by capturing cancer cell residuals. With this aim, hemispherical protrusion shaped surface textures were acquired using colloidal lithography technique using 280 nm, 210 nm or 99 nm polystyrene particles. Once moulds were formed, nanotextured films were obtained by casting water-in-oil stable polycaprolactone emulsions encapsulating doxorubicin hydrochloride. Films were then characterized, and evaluated as drug delivery systems. According to results, we found that template morphologies were successfully transferred to films by atomic force microscopy studies. Hydrophilic surfaces were formed with contact angle values around 40°. drug release studies indicated that nanotextured films best fit into the Higuchi model, and ∼30% of the drug is released from the films within 60 days. Cell culture results indicated increases in the attachment and viability of human ovarian cancer cells to nanotextured surfaces, particularly to the film fabricated using 99 nm particles. Our results demonstrated that delivery of anti-cancer drugs by use of nanotextured materials could be efficient in cancer therapy, and may offer new possibilities for cancer treatment.
Topics: Antibiotics, Antineoplastic; Cell Line, Tumor; Cell Survival; Doxorubicin; Drug Delivery Systems; Drug Liberation; Female; Humans; Microscopy, Atomic Force; Nanostructures; Ovarian Neoplasms; Particle Size; Polyesters; Tumor Microenvironment
PubMed: 32930020
DOI: 10.1080/10837450.2020.1823992 -
The Western Journal of Medicine Sep 1983Despite its vast utility in clinical oncology, the use of doxorubicin hydrochloride (Adriamycin) is limited by a potentially fatal cardiomyopathy. The following critical... (Review)
Review
Despite its vast utility in clinical oncology, the use of doxorubicin hydrochloride (Adriamycin) is limited by a potentially fatal cardiomyopathy. The following critical review, which examines the natural course, histopathologic effects, risk factors and monitoring indicators of this toxicity, also analyzes recent research of proposed mechanisms, including free radical formation with depletion of detoxifying enzymes, inhibition of vital enzyme systems and alterations in relative calcium concentrations. Prevention of the adverse reaction has been attempted by using such agents as alpha-tocopherol, selenium sulfide, coenzyme Q(10), sulfhydryl donors, nucleosides and razoxane, and via liposomal carriage and alternative methods of administration.
Topics: Biopsy; Cardiomyopathies; Dose-Response Relationship, Drug; Doxorubicin; Endocardium; Heart Function Tests; Humans; Myocardium; Risk
PubMed: 6356608
DOI: No ID Found -
Molecules (Basel, Switzerland) Jun 2021Silica nanoparticles (SiO NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto...
Silica nanoparticles (SiO NPs) synthesized by the Stober method were used as drug delivery vehicles. Doxorubicin hydrochloride (DOX·HCl) is a chemo-drug absorbed onto the SiO NPs surfaces. The DOX·HCl loading onto and release from the SiO NPs was monitored via UV-VIS and fluorescence spectra. Alternatively, the zeta potential was also used to monitor and evaluate the DOX·HCl loading process. The results showed that nearly 98% of DOX·HCl was effectively loaded onto the SiO NPs' surfaces by electrostatic interaction. The pH-dependence of the process wherein DOX·HCl release out of DOX·HCl-SiO NPs was investigated as well. For comparison, both the free DOX·HCl molecules and DOX·HCl-SiO NPs were used as the labels for cultured cancer cells. Confocal laser scanning microscopy images showed that the DOX·HCl-SiO NPs were better delivered to cancer cells which are more acidic than healthy cells. We propose that engineered DOX·HCl-SiO systems are good candidates for drug delivery and clinical applications.
Topics: Antineoplastic Agents; Doxorubicin; Drug Carriers; Humans; MCF-7 Cells; Microscopy, Confocal; Nanoparticles; Neoplasms; Silicon Dioxide
PubMed: 34209621
DOI: 10.3390/molecules26133968 -
International Journal of Biological... Jul 2023Hybrid nanoparticles made up of zein and various stabilizers were developed and characterized. In detail, a zein concentration of 2 mg/ml was blended with various...
Hybrid nanoparticles made up of zein and various stabilizers were developed and characterized. In detail, a zein concentration of 2 mg/ml was blended with various amounts of different phospholipids or PEG-derivatives in order to obtain formulations with suitable physico-chemical properties for drug delivery purposes. Doxorubicin hydrochloride (DOX) was used as a model of a hydrophilic compound and its entrapment efficiency, release profile and cytotoxic activity were investigated. Photon correlation spectroscopy showed that the best formulations were obtained using DMPG, DOTAP and DSPE-mPEG2000 as stabilizers of zein nanoparticles, which were characterized by an average diameter of ~100 nm, a narrow size distribution and a significant time- and temperature-dependent stability. The interaction between protein and stabilizers was confirmed through FT-IR analysis, while TEM analysis showed the presence of a shell-like structure around the zein core. The release profiles of the drug from the zein/DSPE-mPEG2000 nanosystems, evaluated at two pHs (5.5 and 7.4), showed a prolonged and constant leakage of the drug. The encapsulation of DOX within zein/DSPE-mPEG2000 nanosystems did not compromise its biological efficacy, demonstrating the potential application of these hybrid nanoparticles as drug carriers.
Topics: Doxorubicin; Zein; Spectroscopy, Fourier Transform Infrared; Drug Delivery Systems; Drug Carriers; Nanoparticles; Particle Size
PubMed: 37285879
DOI: 10.1016/j.ijbiomac.2023.125222 -
Bio-medical Materials and Engineering 2014Doxorubicin hydrochloride is widely used to treat various types of cancers. Its therapeutic and side effects are well documented. However, the developmental toxicity of...
Doxorubicin hydrochloride is widely used to treat various types of cancers. Its therapeutic and side effects are well documented. However, the developmental toxicity of doxorubicin has not been previously described. Lethal and sublethal effects on embryo-larval stages of zebrafish in a study of the developmental toxicity of doxorubicin were observed. Zebrafish embryos were exposed to different concentrations (0-100 mg/L) of doxorubicin between 4 and 120 h post fertilization, and zebrafish larvae were exposed to different concentrations (0-200 mg/L) of doxorubicin for 96 h. The markers about the development toxicity of doxorubicin in zebrafish were observed under a stereomicroscope. Higher doxorubicin concentrations mainly caused acute lethal effects, and lower doxorubicin concentrations mainly caused sublethal effects, such as multiple malformations in embryos and larvae. Moreover, with the increase of doxorubicin concentration, the malformation rate increased. The heart rate of embryos was accelerated at lower concentrations of doxorubicin (≤ 10 mg/L) and decelerated at higher concentrations (≥ 25 mg/L). The hatching rate and body length were inhibited at higher concentrations of doxorubicin (≥ 25 mg/L).In conclusion, doxorubicin has serious developmental toxicity and this raises a concern for developmental effects of doxorubicin in clinical practice.
Topics: Animals; Antibiotics, Antineoplastic; Body Size; Dose-Response Relationship, Drug; Doxorubicin; Embryo, Nonmammalian; Heart; Heart Rate; Hydrogen-Ion Concentration; Temperature; Time Factors; Zebrafish
PubMed: 24211979
DOI: 10.3233/BME-130885 -
Drug Delivery and Translational Research Dec 2022Limited targeted therapies are available for triple-negative breast cancer (TNBC). Thus, the current research focused on developing a targeted protein nanoparticle for...
Limited targeted therapies are available for triple-negative breast cancer (TNBC). Thus, the current research focused on developing a targeted protein nanoparticle for TNBC. First, the doxorubicin hydrochloride (Dox)-loaded genipin-crosslinked whey protein nanoparticles (WD) were prepared and optimised by the QbD method using BBD. The hydrodynamic diameter of WD was found to be 364.38 ± 49.23 nm, zeta potential -27.59 ± 1.038 mV, entrapment 63.03 ± 3.625% and Dox loading was found to be 1.419 ± 0.422%. The drug recovery after 18 months of storage was 69%. Then, it was incubated with NAC to obtain modified WD (CyWD). WD followed first-order release kinetics, whereas CyWD followed the Higuchi model. Hemagglutination and hemolysis were not found qualitatively in WD and CyWD. Upon injecting the nanoformulations to 4T1-induced mice, the highest efficacy was found to be in CyWD followed by WD and Dox injection. Upon histopathological observance, it was found that the CyWD group gave the most significant damage to the 4T1 tumour tissue. Thus, NAC-modified protein nanoparticles carrying chemotherapeutic agents can be an excellent targeted therapeutic system against TNBC.
Topics: Humans; Mice; Animals; Doxorubicin; Triple Negative Breast Neoplasms; Whey Proteins; Acetylcysteine; Cell Line, Tumor; Nanoparticles
PubMed: 35499714
DOI: 10.1007/s13346-022-01169-8 -
Physical Chemistry Chemical Physics :... May 2022The experimental absorption measurements in the interval 350-600 nm (Vis), molecular dynamics simulations, quantum-mechanics calculations and an advanced molecular...
The experimental absorption measurements in the interval 350-600 nm (Vis), molecular dynamics simulations, quantum-mechanics calculations and an advanced molecular treatment of simulation data are here combined to provide a complete picture of the absorption behavior in the visible portion of the electromagnetic spectrum of the doxorubicin hydrochloride (DX) molecule in different environments. By such an approach, we have shown that it is possible to characterize the effect of the environment on the DX absorption behavior - including the vibronic contributions - as well as to interpret such differences in terms of molecular electronic excited states, which are found to be strongly influenced by the environment.
Topics: Doxorubicin; Molecular Dynamics Simulation; Quantum Theory
PubMed: 35536553
DOI: 10.1039/d1cp05182b -
Acta Chimica Slovenica Jun 2020In this study the adsorption properties of the doxorubicin anticancer drug on the designed and fabricated system is investigated. A novel nanocomposite based on green...
In this study the adsorption properties of the doxorubicin anticancer drug on the designed and fabricated system is investigated. A novel nanocomposite based on green magnetic - Graphene Oxide - Chitosan - Allium Sativum- Quercus was successfully fabricated. To evaluate of the doxorubicin adsorption the effectiveness parameters on the adsorption process containing the contact time, pH value, concentration, the adsorbent dosage, and temperature were investigated. The results indicated that the adsorption maximum of doxorubicin on the fabricated nanocomposite was at pH 6.3, concentration 3.6 mg/1.8 ml, the contact time 10 minutes and the adsorbent dosage 1.4 g/L. This designed system not only has increased the drug adsorption up to 100%, but it also could absorb the further concentrations of doxorubicin, indicating that the current challenge at using the higher concentrations of doxorubicin due to the used excellent components at the nanocomposite structure could be essentially minimized. Therefore the fabricated nanocomposite with having natural components and the superior properties improves the doxorubicin adsorption.
Topics: Adsorption; Antineoplastic Agents; Chitosan; Doxorubicin; Drug Carriers; Fabaceae; Garlic; Graphite; Hydrogen-Ion Concentration; Kinetics; Nanocomposites; Quercus; Temperature
PubMed: 33855548
DOI: No ID Found -
Archives of Internal Medicine Mar 1977Doxorubicin hydrochloride (Adriamycin) therapy was associated with renal failure in a 78-year-old man. The pathophysiologic findings in this patient were similar to... (Comparative Study)
Comparative Study
Doxorubicin hydrochloride (Adriamycin) therapy was associated with renal failure in a 78-year-old man. The pathophysiologic findings in this patient were similar to those seen following administration of structural analogues of doxorubicin. Daunorubicin hydrochloride, particularly, is known to cause renal failure in experimental animals. Renal function should be monitored in patients receiving doxorubicin.
Topics: Acute Kidney Injury; Aged; Bronchial Neoplasms; Carcinoma, Squamous Cell; Daunorubicin; Doxorubicin; Humans; Kidney Glomerulus; Male
PubMed: 843156
DOI: No ID Found