-
Spectrochimica Acta. Part A, Molecular... Nov 2020Doxorubicin hydrochloride (DOX) is an effective anthracycline anticancer drug. However, the exceeded taken up could induce several side-effects such as cardiotoxicity,...
Doxorubicin hydrochloride (DOX) is an effective anthracycline anticancer drug. However, the exceeded taken up could induce several side-effects such as cardiotoxicity, alopecia. Therefore, the level of DOX needs to be closely monitored to avoid the occurrence of its side-effects. Herein, we report a novel core CuInSe - shell ZnS quantum dots (CuInSe@ZnS, QDs) and Ag nanoparticles (NPs) fluorescence sensor based on the surface plasmon resonance effect (SPR) of Ag NPs. The CuInSe@ZnS QDs were prepared by water phase reflux method with the 3-mercaptopropionic acid (MPA) as stabilizer and ligand. The fluorescence intensity of CuInSe@ZnS QDs/Ag NPs significantly reduced by DOX, which is mainly based on the electrostatic interaction between the DOX and fluorescence sensors. The inhibition of photoluminescence (ln F/F) was linearly relationship to the concentration of DOX in the range of 2-100 μM with the detection limit as low as 0.05 μM. The as-prepared sensor has a high selectivity and sensitivity to DOX. Furthermore, the new sensor has been successfully applied to the determination of DOX in human serum samples with satisfactory results. Our work provides a clue for developing a novel CuInSe@ZnS QDs/Ag NPs based fluorescence sensor for DOX detection.
Topics: Doxorubicin; Humans; Metal Nanoparticles; Quantum Dots; Silver; Sulfides; Zinc Compounds
PubMed: 32679484
DOI: 10.1016/j.saa.2020.118673 -
The Journal of Pediatrics Jul 1980To characterize the long-term effects of doxorubicin hydrochloride (Adriamycin) on left ventricular function, a total of 588 echocardiograms were obtained prospectively...
To characterize the long-term effects of doxorubicin hydrochloride (Adriamycin) on left ventricular function, a total of 588 echocardiograms were obtained prospectively in 46 children who were treated for malignancy. We found shortening fraction of the left ventricle to be more useful than systolic time intervals for detecting cardiotoxic effects. Abnormal cardiac function occurred in 43% of patients but only 4% developed congestive heart failure which was irreversible. There appeared to be strong individual variation in response to the effects of doxorubicin on the heart unrelated to treatment regimen, age of onset of treatment, or total cumulative dose. If the SF remained normal it was possible to give a dose greater than 550 mg/m2. If cardiac dysfunction occurred following cessation of doxorubicin, it did so within five months in 95% of patients. Discontinuing doxorubicin therapy in patients with SF LEss than 20% who did not have clinical signs of congestive heart failure resulted in improved shortening fraction and administration of digoxin did not further improve the SF. Sequential echographic evaluation of cardiac function at frequent intervals has proven to be useful during and following treatment with doxorubicin.
Topics: Adolescent; Adult; Child; Child, Preschool; Doxorubicin; Echocardiography; Female; Heart; Humans; Infant; Male; Neoplasms
PubMed: 7381647
DOI: 10.1016/s0022-3476(80)80128-4 -
Materials Science & Engineering. C,... May 2019Since FeO nanoparticles synthesized by plant extracts possess good bio-compatibility and superparamagnetic properties, the possibility of these could be used as a...
Since FeO nanoparticles synthesized by plant extracts possess good bio-compatibility and superparamagnetic properties, the possibility of these could be used as a carrier in drug delivery. In this work, doxorubicin hydrochloride (DOX), an anti-cancer drug, loaded on glutaric anhydride-functionalized magnetic nanoparticles (FeO@SiO-Glu) was investigated at varying pH values for effective drug delivery. Various factors affecting the adsorption of DOX onto the FeO@SiO-Glu were examined, where the adsorption efficiency of DOX reached 92% at a concentration of 20 mg/L employing 10 mg of FeO@SiO-Glu at 303 K in pH 7.4. However, the adsorption efficiency of DOX was decreased to 18% at acidic pH value down to 3.0, implicating that the drug releasing process was controlled by pH. Adsorption kinetics was fitting to pseudo-second-order and the isothermal adsorption conformed to Freundlich isotherm. The morphology and surface composition of the synthesized FeO@SiO-Glu were characterized by SEM, TEM, and N adsorption/desorption isotherms, revealing that the specific surface area being 62.6 m/g and the size ranging from ~30 to 50 nm. The zeta potential results indicated that FeO@SiO-Glu were negatively charged in various pH from 3 to 8.5. Characterizations by FTIR and UV-Vis techniques suggested that the DOX was absorbed and it can be delivered by FeO@SiO-Glu.
Topics: Adsorption; Anhydrides; Doxorubicin; Drug Carriers; Glutarates; Humans; Magnetite Nanoparticles; Silicon Dioxide; Spectroscopy, Fourier Transform Infrared
PubMed: 30813069
DOI: 10.1016/j.msec.2018.12.145 -
Report on Carcinogens : Carcinogen... 2004
Topics: Animals; Antineoplastic Agents; Carcinogenicity Tests; Carcinogens; Doxorubicin; Female; Government Regulation; Guidelines as Topic; Humans; Models, Biological; Occupational Exposure; Rats; United States
PubMed: 21089796
DOI: No ID Found -
Drug Intelligence & Clinical Pharmacy Oct 1984An uncommon side effect of the anthracycline antibiotics is allergic reactions. We report three patients treated with doxorubicin hydrochloride who developed systemic...
An uncommon side effect of the anthracycline antibiotics is allergic reactions. We report three patients treated with doxorubicin hydrochloride who developed systemic hypersensitivity reactions to the drug. In all three cases, the onset of the reaction coincided with the initiation of the doxorubicin, and was confirmed by rechallenge with the drug. An urticarial rash with pruritus was the primary clinical manifestation seen in all cases. All reactions responded to treatment with diphenhydramine, or diphenhydramine and hydrocortisone. None of the reactions were life-threatening or required hospitalization of the patient. In two patients, use of the drug was discontinued because of the reaction. Pretreatment with diphenhydramine, prednisone, and cimetidine may have reduced the severity of the reaction in one patient.
Topics: Adult; Doxorubicin; Drug Eruptions; Drug Hypersensitivity; Humans; Male; Middle Aged; Pruritus; Urticaria
PubMed: 6237897
DOI: 10.1177/106002808401801007 -
Urology Jul 1976Twenty-five patients with advanced transitional cell carcinoma of the urinary tract were treated with doxorubicin hydrochloride (Adriamycin). Eight evaluable patients...
Twenty-five patients with advanced transitional cell carcinoma of the urinary tract were treated with doxorubicin hydrochloride (Adriamycin). Eight evaluable patients who received extensive external irradiation therapy and at least two doses of doxorubicin hydrochloride were studied to assess bone marrow toxicity and possible augmentation of radiation dermatitis. Myelosuppression was similar in both irradiated patients and those who received doxorubicin alone. None of the irradiated patients displayed skin augmentation reactions with doxorubicin. In the dose range used chemotherapy with doxorubicin did not appear to be particularly hazardous in irradiated patients.
Topics: Aged; Carcinoma, Transitional Cell; Doxorubicin; Humans; Kidney Neoplasms; Male; Middle Aged; Urinary Bladder Neoplasms
PubMed: 941355
DOI: 10.1016/0090-4295(76)90047-9 -
Analytical Sciences : the International... Jan 2020A highly sensitive and selective electrochemical sensor has been fabricated by the electrodepositing of nickel hexacyanoferrate (NiHCF) on a Ni-Al layered double...
A highly sensitive and selective electrochemical sensor has been fabricated by the electrodepositing of nickel hexacyanoferrate (NiHCF) on a Ni-Al layered double hydroxides (Ni-Al-LDH) modified Au electrode for the quantification of doxorubicin hydrochloride (DOX). The characterization of synthesized nanomaterials has been conducted by scanning electron microscopy, energy dispersive X-ray spectroscopy and electrochemical methods. The synergistic effect of NiHCF and Ni-Al-LDH not only excellently improves the performance of DOX electro-reduction, but also promotes electron transfer between DOX and the NiHCF/Ni-Al-LDH/Au sensor. The differential pulse voltammetric response of the NiHCF/Ni-Al-LDH/Au sensor shows a linear relationship with the concentration of DOX in the range of 1.0 × 10 - 6.2 × 10 mol L, a limit of detection of 1.9 × 10 mol L (S/N = 3) and a sensibility of 14.71 A mol L cm. The developed sensor exhibits good sensitivity, reproducibility, anti-interference and a long-term stability property. Furthermore, the NiHCF/Ni-Al-LDH/Au sensor has been successfully applied to determine DOX in biological samples and human blood serum samples.
Topics: Aluminum; Doxorubicin; Electrochemical Techniques; Electrodes; Ferrocyanides; Gold; Hydroxides; Molecular Structure; Nickel; Particle Size; Surface Properties
PubMed: 31474662
DOI: 10.2116/analsci.19P271 -
Health Technology Assessment... 2002
Review
Topics: Aged; Antineoplastic Agents; Cost-Benefit Analysis; Doxorubicin; Female; Humans; Middle Aged; Outcome Assessment, Health Care; Ovarian Neoplasms; Quality of Life; Randomized Controlled Trials as Topic; State Medicine; Survival; United Kingdom
PubMed: 12433314
DOI: 10.3310/hta6230 -
ACS Applied Materials & Interfaces Dec 2021Nanomaterial selection is critical for photoelectrochemical (PEC) sensing. In this report, a novel cathodic photoelectrochemical (PEC) strategy was proposed for the...
Nanomaterial selection is critical for photoelectrochemical (PEC) sensing. In this report, a novel cathodic photoelectrochemical (PEC) strategy was proposed for the detection of doxorubicin hydrochloride (Dox) and gentamicin sulfate (CN). The photocathode was synthesized by noncovalently coupling cadmium sulfide (CdS) to the porphyrin-derived metal-organic framework (CdS@PCN-224). This type of assembly created a pleasant interface for the combination of doxorubicin hydrochloride and gentamicin sulfate, resulting in a good CdS@PCN-224 donor-acceptor system. When compared to a single optoelectronic material, its photocurrent is enhanced by unprecedented nine times. This research could pave the way for the realization of PCN-224's enormous potential in PEC sensing.
Topics: Anti-Bacterial Agents; Antibiotics, Antineoplastic; Biomimetic Materials; Biosensing Techniques; Cadmium Compounds; Doxorubicin; Electrochemical Techniques; Gentamicins; Materials Testing; Metal-Organic Frameworks; Molecular Structure; Particle Size; Photochemical Processes; Sulfides
PubMed: 34807581
DOI: 10.1021/acsami.1c19481 -
Journal of Fluorescence Jan 2021Drug delivery systems for the sustained and target delivery of doxorubicin to tumor cells are a topic of interest due to the efficacy of the doxorubicin in cancer...
Drug delivery systems for the sustained and target delivery of doxorubicin to tumor cells are a topic of interest due to the efficacy of the doxorubicin in cancer treatment. The use of polymers such as Pluronic is being studied widely for the formulation of doxorubicin hydrochloride. However, the basic understanding of the physicochemical properties of pluronic micelles in presence of doxorubicin hydrochloride is a very essential topic of study. Doxorubicin hydrochloride is fluorescent; this helped us to study its sensitivity towards the Pluronic microenvironment using the fluorescence technique. In this work, the interaction and place of location of doxorubicin hydrochloride in Pluronic F127 and P123 micelles has been studied extensively using steady-state fluorescence intensity, dynamic fluorescence lifetime, quenching studies, dynamic light scattering, and zeta potential measurements, at different Pluronic concentrations. Using a fluorescence quenching experiment, doxorubicin hydrochloride was found to reside near the hydrophilic PEO corona region of the Pluronic micelles. For both the Pluronic, in the concentration range of study, the micellar size was found to be below 30 nm; this may have a greater advantage for various applications.
Topics: Antineoplastic Agents; Doxorubicin; Fluorescence; Hydrophobic and Hydrophilic Interactions; Micelles; Poloxalene; Polyethylenes; Polypropylenes
PubMed: 33037527
DOI: 10.1007/s10895-020-02630-y