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Annales de Chirurgie de La Main :... 1982The literature suggests that the frequency of Dupuytren's disease is ten times greater in diabetes than in the general population. We have studied 42 diabetic patients... (Review)
Review
The literature suggests that the frequency of Dupuytren's disease is ten times greater in diabetes than in the general population. We have studied 42 diabetic patients with a contracture of the palmar fascia. Dupuytren's contracture can be considered a complication of diabetes and of the local neurovascular changes since both are often associated. The contracture is usually not severe in diabetes, is nodular in form, and usually crushes the palmar surface of the long and ring fingers. It is usually well tolerated by the patients and surgery is rarely indicated, particularly in view of the advanced age of many patients. In caring for patients with Dupuytren's disease, surgeons should also rule out the presence of diabetes with appropriate test.
Topics: Adult; Age Distribution; Aged; Aged, 80 and over; Diabetes Complications; Dupuytren Contracture; Female; Humans; Incidence; Male; Middle Aged; Sex Distribution
PubMed: 9382632
DOI: 10.1016/s0753-9053(82)80089-6 -
Orthopedics Jan 2012Dupuytren's disease is a benign contractile disorder of the hand. The condition commonly affects older men of Celtic descent. Although fibroproliferation and collagen... (Review)
Review
Dupuytren's disease is a benign contractile disorder of the hand. The condition commonly affects older men of Celtic descent. Although fibroproliferation and collagen alteration play a role in its etiology, defining a cause remains elusive. Nonoperative intervention for advanced disease has shown only short-term benefit. Therefore, open fasciectomy has become the mainstay of treatment. Associated morbidity and recurrence have prompted investigation into less invasive techniques, including needle aponeurotomy and enzymatic fasciotomy. Data from phase III studies using injectable collagenase are changing treatment algorithms. Postoperative rehabilitation includes nighttime splinting and immediate active range of motion exercises to facilitate return to function.
Topics: Collagenases; Combined Modality Therapy; Dupuytren Contracture; Fasciotomy; Humans; Orthopedic Procedures
PubMed: 22229922
DOI: 10.3928/01477447-20111122-23 -
The Journal of Hand Surgery Nov 2006This article reviews the basic science elements involved in the pathogenesis of Dupuytren's disease. Dupuytren's contracture is effected by a multitude of complex... (Review)
Review
This article reviews the basic science elements involved in the pathogenesis of Dupuytren's disease. Dupuytren's contracture is effected by a multitude of complex processes at the cellular level and the exact relative contribution of each is unknown. Various investigators have proposed different theories and documented individual findings regarding the pathophysiology of Dupuytren's contracture. The current report attempts to summarize many of these findings together in a schema of pathogenesis.
Topics: Algorithms; Dupuytren Contracture; Humans
PubMed: 17095386
DOI: 10.1016/j.jhsa.2006.08.012 -
The Journal of Hand Surgery, European... Feb 2015Dynamism of Dupuytren's contractures may occur if a contracture crosses over both the metacarpophalangeal (MCPJ) and proximal interphalangeal (PIPJ) joints of one...
Dynamism of Dupuytren's contractures may occur if a contracture crosses over both the metacarpophalangeal (MCPJ) and proximal interphalangeal (PIPJ) joints of one finger. In this situation the extension deficit at one joint can be influenced by the position of the other. This may affect clinical measurements and introduce errors and bias into research using angular deformity as an endpoint. This study reports the dynamism encountered when measuring passive joint extension deficits in pre-operative contractures. Eighty-five digits with a contracture affecting the PIPJ or MCPJ and PIPJ on 72 hands from 70 patients were studied. Seventy-six digits showed dynamism at either the MCPJ or PIPJ (89%). Seventy-four showed dynamism at the PIPJ (87%). The mean dynamism observed was 6° at the MCPJ and 14° at the PIPJ. Previous Dupuytren's surgery to the finger did not influence the amount of dynamism seen. Dynamism is common and may be a source of error or bias in trials of Dupuytren's disease treatment.
Topics: Aged; Arthrometry, Articular; Dupuytren Contracture; Female; Finger Joint; Humans; Male; Range of Motion, Articular
PubMed: 24664160
DOI: 10.1177/1753193414529074 -
Bulletin of the Hospital For Joint... 1990Dupuytren's disease is found only rarely among black and oriental populations. In a retrospective study, the authors report on 9 cases of Dupuytren's disease which they... (Review)
Review
Dupuytren's disease is found only rarely among black and oriental populations. In a retrospective study, the authors report on 9 cases of Dupuytren's disease which they treated, and review an additional 10--the only other cases in Thailand reported in the literature.
Topics: Adult; Aged; Dupuytren Contracture; Female; Humans; Male; Middle Aged; Retrospective Studies; Thailand
PubMed: 2163703
DOI: No ID Found -
Journal of Hand Surgery (Edinburgh,... Aug 1992The phenomenon of clinical regression of Dupuytren's contracture is described and discussed. It is already recognized and used in fasciotomy where it follows the release...
The phenomenon of clinical regression of Dupuytren's contracture is described and discussed. It is already recognized and used in fasciotomy where it follows the release of longitudinal tension. The quite extraordinary resolution produced by continuous passive skeletal traction in extension is presented. Regression beneath grafted skin is described and discussed with its clinical implications. The generally accepted view of Dupuytren's contracture being "irreversible" now presents a challenge for further clinical and pharmacological studies. The possibility of non-surgical control does exist.
Topics: Dupuytren Contracture; Fasciotomy; Humans; Remission, Spontaneous; Skin Transplantation; Traction
PubMed: 1402277
DOI: 10.1016/s0266-7681(05)80273-6 -
Polski Przeglad Chirurgiczny Oct 2022<b><br>Introduction:</b> Dupuytren's disease is a common fibrotic disorder of the palmar aponeurosis characterized by the formation of nodules and... (Review)
Review
<b><br>Introduction:</b> Dupuytren's disease is a common fibrotic disorder of the palmar aponeurosis characterized by the formation of nodules and cords, as well as development of progressive flexion deformities in the digits, leading to functional impairment. Surgical excision of the affected aponeurosis remains the most common treatment. Quite a few new information appeared about epidemiology, pathogenesis and particularly treatment of the disorder.</br> <b><br>Aim:</b> The aim of this study is an updated review of scientific data in this topic.</br> <b><br>Results:</b> Results of epidemiologic studies showed that Dupuytren's disease is not so uncommon in Asian and African population as it was earlier believed. An important role of genetic factors on development of the disease in a proportion of patients was demonstrated, however, it did not translate neither to the treatment nor to the prognosis. The most changes concerned the management of Dupuytren's disease. A positive effect of steroids injections into the nodules and cords for inhibition of the disease in early stages was shown. In the advanced stages, a standard technique of partial fasciectomy was partly replaced by mini-invasive methods such as needle fasciotomy and collagenase Clostirdium hystolyticum injections. Unexpected withdrawal of collagenase from the market in 2020 resulted in considerable limitation of the availability of this treatment.</br> <b><br>Conclusion:</b> It seems that updated knowledge on Dupuytren's disease may be interested and useful for surgeons involved in management of the disorder.</br>.
Topics: Humans; Dupuytren Contracture; Collagenases; Fasciotomy
PubMed: 38058165
DOI: 10.5604/01.3001.0016.0058 -
Hand Clinics Nov 1991This article presents the medical and legal aspects of Dupuytren's contracture. It also presents a rational basis for the assessment of the relationship, if any, between... (Review)
Review
This article presents the medical and legal aspects of Dupuytren's contracture. It also presents a rational basis for the assessment of the relationship, if any, between a patient's occupation and the development of Dupuytren's contracture.
Topics: Australia; Dupuytren Contracture; Humans; Occupational Diseases; Occupational Medicine; Recurrence; United States; Wounds and Injuries
PubMed: 1769984
DOI: No ID Found -
The Journal of the Kansas Medical... Mar 1972
Review
Topics: Acute Disease; Disease Susceptibility; Dupuytren Contracture; Humans; Prognosis; Recurrence
PubMed: 4551364
DOI: No ID Found -
The Journal of Hand Surgery, European... Sep 2017Radiotherapy has been advocated as an alternative treatment in early Dupuytren's disease. We have systematically reviewed the evidence on the use of radiotherapy in... (Review)
Review
UNLABELLED
Radiotherapy has been advocated as an alternative treatment in early Dupuytren's disease. We have systematically reviewed the evidence on the use of radiotherapy in Dupuytren's disease. Only six articles met a minimum set standard, five of which were retrospective cohort studies and one a randomized controlled study. A total of 770 Dupuytren's hands, nearly all with Tubiana stage 0-1 disease, were irradiated with an average 30 Gy. Disease regression ranged from 0%-56%, stability from 14%-98% and progression from 2%-86%. Salvage surgery was successful in all cases of disease progression post-radiotherapy. There were no reports of adverse wound healing problems associated with such surgery or radiotherapy-associated malignancy. On balance, radiotherapy should be considered an unproven treatment for early Dupuytren's disease due to a scarce evidence base and unknown long-term adverse effects. Well-designed randomized controlled studies are required to confirm the benefits of radiotherapy treatment.
LEVEL OF EVIDENCE
II.
Topics: Disease Progression; Dupuytren Contracture; Humans; Radiotherapy
PubMed: 28490266
DOI: 10.1177/1753193417695996