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Urology Apr 1983Fourteen patients with anaplastic seminoma were analyzed retrospectively. At the time of presentation anaplastic seminoma has similar prognosis stage for stage as the...
Fourteen patients with anaplastic seminoma were analyzed retrospectively. At the time of presentation anaplastic seminoma has similar prognosis stage for stage as the classic seminoma. However, the distinctive histologic findings and the high rates of local invasion and of elevations of serum beta-subunit human chorionic gonadotropin serve to distinguish anaplastic seminoma from the classic seminoma. These features, suggesting a possibly greater metastatic potential for anaplastic seminoma, warrant its continued identification as a distinct pathologic subtype.
Topics: Adult; Aged; Dysgerminoma; Humans; Male; Middle Aged; Testicular Neoplasms
PubMed: 6836826
DOI: 10.1016/0090-4295(83)90156-5 -
Acta Neurochirurgica 1979
Topics: Adolescent; Adult; Brain Neoplasms; Child; Cytodiagnosis; Dysgerminoma; Female; Humans; Hypothalamus; Male; Tomography, X-Ray Computed
PubMed: 517187
DOI: 10.1007/BF01813552 -
The Journal of Urology Aug 1974
Topics: Aged; Autopsy; Castration; Diagnosis, Differential; Dysgerminoma; Humans; Male; Middle Aged; Testicular Neoplasms
PubMed: 4843334
DOI: 10.1016/s0022-5347(17)59689-5 -
Cancer Oct 1981Primary mediastinal seminoma is a rare germ cell neoplasm histologically identical to testicular seminoma. Thirteen patients have been treated with definitive...
Primary mediastinal seminoma is a rare germ cell neoplasm histologically identical to testicular seminoma. Thirteen patients have been treated with definitive megavoltage radiotherapy at the Stanford University Medical Center, Division of Radiation Therapy, between 1961 and 1976. Doses ranged from 2500 rads over five weeks to 6000 rads over seven weeks. Actuarial survival at ten years is 69% with relapse-free survival of 54%. No patient receiving greater than 4700 rads to the primary lesion had local or systemic relapse. Patterns of relapse and recommendations for diagnostic evaluation are discussed. Primary megavoltage irradiation to the mediastinum and neck with a dose of 4500 to 5000 rads over five to six weeks is appropriate treatment.
Topics: Adolescent; Adult; Bone Neoplasms; Dysgerminoma; Humans; Lymphography; Male; Mediastinal Neoplasms; Middle Aged; Neoplasm Recurrence, Local; Radiotherapy Dosage; Radiotherapy, High-Energy
PubMed: 6793227
DOI: 10.1002/1097-0142(19811015)48:8<1877::aid-cncr2820480827>3.0.co;2-b -
Gynecologic Oncology May 2005We present the first case of an ovarian dysgerminoma complicated by pseudo-Meigs' syndrome. Furthermore, this is the fourth reported case of ovarian dysgerminoma with...
BACKGROUND
We present the first case of an ovarian dysgerminoma complicated by pseudo-Meigs' syndrome. Furthermore, this is the fourth reported case of ovarian dysgerminoma with functioning ovarian stroma resulting elevated androgen levels preoperatively.
CASE
A 25-year-old white female was referred to our department for abdominal swelling and a rapidly enlarging abdominal mass. Chest X-ray showed massive right pleural effusion. Abdominopelvic CT scan showed a left adnexal solid mass and ascites. Preoperative abnormally elevated hormone levels were as follows: free testosterone 7.7 pg/mL, androstenodione 13.6 ng/mL, and cortisol 29.4 microg/dL. Left salpingo-oophorectomy and wedge resection of the right ovary were performed. Final histopathological investigation of the left ovary was dysgerminoma associated with stromal luteinization.
CONCLUSION
Dysgerminoma should be considered in the differential diagnosis in a young patient with a pelvic mass, ascites, and pleural effusion and preoperative counseling should be directed accordingly. In addition, dysgerminomas may be accompanied by ovarian stromal luteinization and steroid hormone production, which occasionally result in chemical or clinical hyperandrogenism.
Topics: Adult; Diagnosis, Differential; Dysgerminoma; Female; Humans; Meigs Syndrome; Ovarian Neoplasms
PubMed: 15863182
DOI: 10.1016/j.ygyno.2005.01.029 -
Modern Pathology : An Official Journal... Apr 2006Dysgerminoma is the most common malignant ovarian germ cell tumor and shares histological and immunophenotypical features with its testicular counterpart, seminoma....
Dysgerminoma is the most common malignant ovarian germ cell tumor and shares histological and immunophenotypical features with its testicular counterpart, seminoma. Chromosome 12p abnormalities are genetic hallmarks of testicular seminomas. Little is known about these genetic changes in dysgerminoma. We performed dual color fluorescence in situ hybridization (FISH) analyses with a centromeric alpha-satellite probe for chromosome 12 and a subtelomeric probe for 12p on paraffin-embedded tissue sections from 21 dysgerminomas and two gonadoblastomas. Chromosome 12p abnormalities were detected in 81% of dysgerminomas. In all, 57% of cases had only isochromosome 12p and 5% had only 12p overrepresentation. In all, 19% had both isochrome 12p and 12p overrepresentation. Gonadoblastomas were negative for isochromosome 12p or 12p overrepresentation. Chromosome 12p abnormalities are common in dysgerminoma of the ovary. FISH analyses for chromosome 12p abnormalities may be a useful diagnostic adjunct for confirming the diagnosis of dysgerminoma and for distinguishing it from nongerm cell malignancies that enter into the differential diagnosis.
Topics: Adolescent; Adult; Child; Chromosome Aberrations; Chromosomes, Human, Pair 12; Dysgerminoma; Female; Humans; In Situ Hybridization, Fluorescence; Middle Aged; Ovarian Neoplasms
PubMed: 16554737
DOI: 10.1038/modpathol.3800576 -
Casopis Lekaru Ceskych 2004To review the treatment strategy, follow up and outcome for all patients with pure ovarian dysgerminoma treated in childhood and adolescence.
BACKGROUND
To review the treatment strategy, follow up and outcome for all patients with pure ovarian dysgerminoma treated in childhood and adolescence.
METHODS AND RESULTS
Twenty-one patients younger than 18 years were treated between 1979-2002 in Faculty Hospital Motol for newly diagnosed pure ovarian dysgerminoma. Patients were included into the cohort on the basis of revision of archival biopsy specimens deposited in Institute of Pathology and in Molecular Medicine tumor registry. The staging was reviewed retrospectively on the basis of surgical and pathological findings and on results of imaging investigations and outlined according to the TNM and International Federation of Gynecology and Obstetrics (FIGO) classification. The median age at the time of diagnosis was 12.5 years (range 6 years, 5 months--17 years, 11 months). There were ten FIGO stage IA tumors, one stage IB, two of stage IIC, one stage IIIB and seven IIIC tumors. All patients, except two girls with bilateral dysgerminoma, underwent unilateral adnexectomy or ovarectomy. Ten girls were treated postoperatively with chemotherapy, eight with chemotherapy and radiotherapy (eleven with cisplatine based chemotherapy). Three girls with dysgerminoma confined to the ovary (stage IA) have not received adjuvant chemotherapy. With a median follow up 7.1 years all girls remained continuously disease free. The 5-year overall and event free survival is 100%. Majority of patients does not have severe treatment sequelae, three pregnancies have occurred so far.
CONCLUSIONS
Most patients with dysgerminoma, including those with metastases can expect cure when treated with conservative surgery and cisplatine based chemotherapy. Reduction of treatment toxicity and preservation of reproductive function is a main task. The girls with dysgerminoma confined to the ovary (stage IA) can be treated with fertility sparing surgery, other should be treated with cisplatine based chemotherapy.
Topics: Adolescent; Child; Dysgerminoma; Female; Humans; Ovarian Neoplasms
PubMed: 15218724
DOI: No ID Found -
Military Medicine Jan 1988
Topics: Adult; Combined Modality Therapy; Diagnosis, Differential; Dysgerminoma; Humans; Male; Mediastinal Neoplasms; Military Personnel; United States
PubMed: 3126421
DOI: No ID Found -
Chest May 1971
Topics: Adult; Biopsy; Combined Modality Therapy; Dysgerminoma; Humans; Lymph Nodes; Male; Mediastinal Neoplasms; Mediastinum
PubMed: 4952562
DOI: 10.1378/chest.59.5.575 -
Australian Veterinary Journal Mar 2009A mare was referred for further evaluation of a mass found in the left caudal abdomen during a routine postpartum reproductive palpation. The mare was clinically normal...
A mare was referred for further evaluation of a mass found in the left caudal abdomen during a routine postpartum reproductive palpation. The mare was clinically normal with no history of health problems. Ultrasonographic examination of the mass confirmed its presence, but the origin of the mass could not be accurately determined. Routine haematology and serum biochemistry results were within normal limits. The mare was initially treated conservatively with antibiotics, but the mass continued to increase in size, so it was surgically excised. The mass involved the left ovary. The mare showed transient abdominal pain after surgery, but developed no other complications and was in foal 7 months later. On histology, the mass was diagnosed as a dysgerminoma, a rare ovarian tumour of germ cell origin.
Topics: Animals; Dysgerminoma; Female; Horse Diseases; Horses; Ovarian Neoplasms; Treatment Outcome
PubMed: 19245624
DOI: 10.1111/j.1751-0813.2009.00392.x