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American Journal of Veterinary Research Mar 1967
Topics: Animals; Dog Diseases; Dogs; Dysgerminoma; Female
PubMed: 6067990
DOI: No ID Found -
Connecticut Medicine Apr 1989Thirteen cases of patients with dysgerminoma of the ovary, accrued from the Connecticut Tumor Registry from 1974-84, were reviewed. Seven of the 13 patients were stage I...
Thirteen cases of patients with dysgerminoma of the ovary, accrued from the Connecticut Tumor Registry from 1974-84, were reviewed. Seven of the 13 patients were stage I at the time of initial surgery. Two of these patients had a diagnosis of dysgerminoma arising within a gonadoblastoma. Five of the seven patients were treated with some form of adnexal surgery; one patient received adjuvant combination chemotherapy consisting of vincristine, dactinomycin, and cyclophosphamide (VAC) and another received radiation therapy. Two of the seven patients were treated with total abdominal hysterectomy and bilateral salpingo-oophorectomy (TAH/BSO) plus radiation therapy. One patient, whose tumor recurred after initial therapy with unilateral oophorectomy, was successfully treated with radiation therapy. Six patients had advanced disease at the time of initial surgery. One patient with stage II disease and three patients with stage III disease were treated with TAH/BSO plus radiation therapy. One patient with stage III disease was treated with unilateral adnexectomy plus combination chemotherapy consisting of vinblastine, bleomycin, dactinomycin, cyclophosphamide, and cisplatin (VAB-VI). One patient with stage IV disease was treated with decompressive laminectomy with tumor resection, removal of left pelvic mass, radiation therapy and adjuvant combination chemotherapy (VAC). In our series, no patient died from dysgerminoma (one patient died of an apparently unrelated cause). The role of radiation therapy in the treatment of advanced and recurrent dysgerminoma has been demonstrated. However, the use of combination chemotherapy has been playing an increasingly important role in patients treated with conservative surgery in which preservation of fertility is a concern.
Topics: Adolescent; Adult; Connecticut; Dysgerminoma; Humans; Registries
PubMed: 2743762
DOI: No ID Found -
Cancer Apr 1971
Topics: Adult; Castration; Dysgerminoma; Female; Humans; Neoplasm Recurrence, Local; Ovarian Neoplasms; Postoperative Complications; Time Factors; United States
PubMed: 5574081
DOI: 10.1002/1097-0142(197104)27:4<939::aid-cncr2820270428>3.0.co;2-q -
Pediatric Blood & Cancer Oct 2006Hypercalcemia is a rare complication of pediatric malignant germ cell tumors. The problem may be missed because of unawareness among pediatric oncologists. We describe a...
Hypercalcemia is a rare complication of pediatric malignant germ cell tumors. The problem may be missed because of unawareness among pediatric oncologists. We describe a 16-year-old girl with an ovarian dysgerminoma associated with severe hypercalcemia, a metabolic abnormality infrequently reported with this disease. We review some of the potential causes of malignancy-associated hypercalcemia and current treatment strategies. It is our recommendation that calcium levels should be monitored in all children with solid ovarian masses. Hypercalcemia seen in these situations may not improve until the tumor is removed.
Topics: Adolescent; Dysgerminoma; Female; Humans; Hypercalcemia; Neoplasm Staging; Time Factors; Treatment Outcome
PubMed: 16007592
DOI: 10.1002/pbc.20476 -
Ugeskrift For Laeger Jul 1992A patient with stage 2C pure dysgerminoma which produced free beta-HCG subunit is described. The importance of excluding elements of other germ cell tumors is stressed....
A patient with stage 2C pure dysgerminoma which produced free beta-HCG subunit is described. The importance of excluding elements of other germ cell tumors is stressed. HCG-positive dysgerminomas should be treated like other pure dysgerminomas, and beta-HCG will in this case be a useful monitor of the effect of treatment.
Topics: Adult; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Dysgerminoma; Female; Humans; Ovarian Neoplasms; Peptide Fragments
PubMed: 1380743
DOI: No ID Found -
Human Pathology Jun 1984A young woman with a preoperative diagnosis of molar pregnancy was found to have a pure dysgerminoma in the right ovary. Immunohistochemical study of formalin-fixed...
A young woman with a preoperative diagnosis of molar pregnancy was found to have a pure dysgerminoma in the right ovary. Immunohistochemical study of formalin-fixed tissue revealed human chorionic gonadotropin-secreting small stromal cells. This is in contradistinction to previous reports of functioning dysgerminomas, in which the secretory activity was associated with the presence of syncytiotrophoblasts and chorionic tissue. Reports of ultrastructural and biochemical analyses of pure dysgerminomas confirming this observation are discussed.
Topics: Adult; Chorionic Gonadotropin; Dysgerminoma; Female; Humans; Ovarian Neoplasms
PubMed: 6724577
DOI: 10.1016/s0046-8177(84)80015-5 -
African Journal of Medicine and Medical... Jun 2013Ovarian cancer is the second most frequent gynaecological cancer in Nigeria ranking next after carcinoma of the cervix. It has the highest case-fatality rate worldwide...
INTRODUCTION
Ovarian cancer is the second most frequent gynaecological cancer in Nigeria ranking next after carcinoma of the cervix. It has the highest case-fatality rate worldwide because of insidious onset, lack of effective screening methods and late presentation. This case of a sixteen-year old girl with a three-week history of abdominal pain which was later accompanied by abdominal swelling is a classic example of how dysgerminomas present.
METHOD
The presumptive diagnosis of an ovarian tumour was made after physical examination and this was later confirmed by ultrasound scan. Urgent laparotomy was carried out based on a suspicion of torsion of the pedicle of the cyst.
RESULT
At laparotomy, torsion of the pedicle with an intact capsule and imminent gangrene were found. The histology report revealed a malignant germ cell neoplasm (Dysgerminoma) with focal areas of necrosis without infiltration of the attached omentum.
CONCLUSION
She had conservative surgery (left oophorectomy) done. She, however, defaulted from further follow-up.
Topics: Abdominal Pain; Adolescent; Dysgerminoma; Female; Humans; Ovarian Neoplasms; Ovariectomy
PubMed: 24377208
DOI: No ID Found -
The Journal of Small Animal Practice Oct 1970
Topics: Animals; Dysgerminoma
PubMed: 5533241
DOI: 10.1111/j.1748-5827.1970.tb07051.x -
Gynecologic Oncology Feb 1985Pure ovarian dysgerminomas with associated elevation of human chorionic gonadotropin (hCG) are rare, and their optimum management is unclear. We report here a...
Pure ovarian dysgerminomas with associated elevation of human chorionic gonadotropin (hCG) are rare, and their optimum management is unclear. We report here a 24-year-old woman with stage III dysgerminoma of the ovaries, with bulky intrapelvic disease, paraaortic adenopathy, and elevated pre- and postsurgical serum beta-hCG titers. Following administration of whole abdominal-pelvic and mediastinal irradiation therapy, the patient's adenopathy regressed, her serial beta-hCG titers returned to normal, and she has remained free of disease for the past 30 months. Histopathological studies revealed a pure dysgerminoma with scattered giant cells which were negative for hCG by immunoperoxidase staining. The literature is reviewed with reference to the significance of elevated hCG levels, the presence of giant cells in association with dysgerminoma of the ovary, and therapeutic implications. Serial determinations of beta-hCG titers may prove to be as valuable in the management of these patients as they are in patients with testicular tumors.
Topics: Adult; Chorionic Gonadotropin; Chorionic Gonadotropin, beta Subunit, Human; Dysgerminoma; Female; Humans; Ovarian Neoplasms; Peptide Fragments
PubMed: 2579008
DOI: 10.1016/0090-8258(85)90146-5 -
Gynecologic Oncology Feb 1989Neuron-specific enolase (NSE) was measured with an enzyme-immunoassay in sera from 54 patients with malignant (24 cases) and benign (30 cases) germ cell tumors of...
Neuron-specific enolase (NSE) was measured with an enzyme-immunoassay in sera from 54 patients with malignant (24 cases) and benign (30 cases) germ cell tumors of ovarian origin. Serum NSE contents were clearly raised above control value (greater than 10 ng/mg) in 4 of 8 patients with immature teratomas and 5 of 6 with dysgerminomas. NSE was also measured in nine cell lines of germ cell tumors. Among these cell lines, high NSE contents were detected in the cell extracts and culture supernatants from PA-1 and Tera-II lines. In immunohistochemical study, widespread positive staining for NSE was shown in dysgerminomas, whereas the immunostaining was confined to neural elements in both an immature teratoma and xenograft tumors derived from PA-1 and Tera-II lines in nude mice. These findings suggest that serum NSE measurements are of diagnostic value not only for immature teratomas but also for dysgerminomas.
Topics: Biomarkers, Tumor; Dysgerminoma; Female; Humans; Immunohistochemistry; Ovarian Neoplasms; Phosphopyruvate Hydratase; Teratoma; Tumor Cells, Cultured
PubMed: 2910781
DOI: 10.1016/s0090-8258(89)80032-0