-
Modern Pathology : An Official Journal... Nov 2005The proto-oncogene c-kit encodes a tyrosine kinase receptor, c-kit (CD117), which has been implicated in the development of a number of human malignancies. While the...
The proto-oncogene c-kit encodes a tyrosine kinase receptor, c-kit (CD117), which has been implicated in the development of a number of human malignancies. While the preferential expression of this protein has been well documented in testicular seminomas, there is little data concerning its expression in dysgerminomas of the ovary. We examined the expression of c-kit in 30 cases of ovarian dysgerminomas using immunohistohemical staining with a polyclonal anti-CD117 antibody. Staining was graded in a semiquantitative manner as follows: negative (no staining), 1+(1-10% staining), 2+(10-29% staining), 3+(30-50% staining), or 4+ (>50% staining). Of the 30 cases examined, 26 (87%) demonstrated immunoreactivity for CD117. In total, 10 (33%) demonstrated 4+ staining; 9 (30%) demonstrated 3+staining; 3 (10%) demonstrated 2+staining; 4 (13%) demonstrated 1+staining; and 4 (13%) demonstrated no staining. In conclusion, CD117 immunoreactivity was detected in 87% of ovarian dysgerminomas, a finding that correlates with previously reported frequencies of CD117 expression in seminomas (78-100%). Thus, antibodies to c-kit may be a useful diagnostic marker for ovarian dysgerminoma. Although the prognosis of patients with dysgerminoma is generally good, this receptor could potentially serve as a target for site-specific immunotherapy as an alternative and/or complement to conventional treatment options.
Topics: Adolescent; Adult; Biomarkers, Tumor; Child; Dysgerminoma; Female; Humans; Immunohistochemistry; Middle Aged; Ovarian Neoplasms; Proto-Oncogene Mas; Proto-Oncogene Proteins c-kit
PubMed: 16056250
DOI: 10.1038/modpathol.3800463 -
Revue Medicale de Liege Sep 2008Dysgerminoma is an ovarian germ cell tumor occurring more frequently among young women. The efficacy of chemotherapy allows conservative surgery sparing fertility. A...
Dysgerminoma is an ovarian germ cell tumor occurring more frequently among young women. The efficacy of chemotherapy allows conservative surgery sparing fertility. A stadification surgery will avoid chemotherapy for patients with stage Ia. The others stages will receive a cisplatine-based regime. A ct-scan is performed twice a year and, in case of recurrence, a first or a second chemotherapy should be prescribed.
Topics: Adolescent; Adult; Dysgerminoma; Female; Humans; Ovarian Neoplasms
PubMed: 19051506
DOI: No ID Found -
Computerized Medical Imaging and... 1989Magnetic Resonance (MR) imaging has proved to be an excellent modality for the evaluation of CNS tumors and detection of metastatic seeding through CNS pathways. We...
Magnetic Resonance (MR) imaging has proved to be an excellent modality for the evaluation of CNS tumors and detection of metastatic seeding through CNS pathways. We present a case of cerebral dysgerminoma in which the use of gadopentetate dimeglumine (Gd-DTPA) enhancement added important information in lesion detection and delineation for treatment planning. Our results, and a review of recent literature, suggest that Gd-DTPA-enhanced MR imaging may be useful for initial and follow-up evaluation of CNS dysgerminomas.
Topics: Adolescent; Cerebral Ventricle Neoplasms; Contrast Media; Drug Combinations; Dysgerminoma; Gadolinium DTPA; Humans; Image Enhancement; Magnetic Resonance Imaging; Male; Meglumine; Organometallic Compounds; Patient Care Planning; Pentetic Acid; Sorbitol
PubMed: 2598155
DOI: 10.1016/0895-6111(89)90287-5 -
Gynecologic and Obstetric Investigation 1994The expression of p53 in 7 dysgerminomas of the ovary was investigated immunohistochemically with the monoclonal antibodies DAKO-p53/Do-7 and Dianova-p53/Do-1. All the...
The expression of p53 in 7 dysgerminomas of the ovary was investigated immunohistochemically with the monoclonal antibodies DAKO-p53/Do-7 and Dianova-p53/Do-1. All the tumors exhibited overexpression of p53 protein. Immunoreactive tumor cell nuclei amounted to more than 50% in 2 tumors, 10-50% in 2 tumors, and less than 10% in 3 tumors. No relationship was found between tumor stage and the degree of p53 expression. Overexpression of p53 thus appears to be very common in dysgerminoma, as it is in epithelial ovarian cancer.
Topics: Adolescent; Adult; Dysgerminoma; Female; Humans; Immunohistochemistry; Ovarian Neoplasms; Tumor Suppressor Protein p53
PubMed: 8150371
DOI: 10.1159/000292543 -
Neoplasma 1984The authors present the clinical, pathologic and therapeutic report on 5 cases of ovarian dysgerminoma in patients between 15 and 30 years of age, classified as Stage...
The authors present the clinical, pathologic and therapeutic report on 5 cases of ovarian dysgerminoma in patients between 15 and 30 years of age, classified as Stage Iai in 3 cases and Stage III in 2 cases. Treatment was surgical in 4 cases; in 1 case the surgery was followed by radiation and chemotherapy. All the patients survive free of disease from 4 to 11 years. One of these neoplasms showed a particular histologic pattern in some way similar to the "spermatocytic seminoma" of the testis. This should be the first time that such a type of ovarian dysgerminoma has been reported in the literature.
Topics: Adolescent; Adult; Combined Modality Therapy; Dysgerminoma; Female; Humans; Neoplasm Staging; Ovarian Neoplasms
PubMed: 6472517
DOI: No ID Found -
Obstetrics and Gynecology Oct 1966
Topics: Adolescent; Ascites; Dysgerminoma; Female; Humans; Ovarian Neoplasms; Pregnancy; Pregnancy Complications
PubMed: 5925036
DOI: No ID Found -
International Journal of Radiation... Jun 1987The experience of the Istituto Nazionale Tumori of Milan on dysgerminoma is presented. Between 1970 and December of 1982, 25 patients were treated with a unique protocol...
The experience of the Istituto Nazionale Tumori of Milan on dysgerminoma is presented. Between 1970 and December of 1982, 25 patients were treated with a unique protocol which considered surgery and radiotherapy with different schedules according to the extension of the disease. With this treatment protocol all 13 patients at Stage I were alive and free of disease with a median follow-up of 77 months. Of 12 patients at Stage III (10 retroperitoneal and 2 retroperitoneal and peritoneal) 4 relapsed. The 5-year relapse-free survival of Stage III patients was 61.4% and the overall survival 89.5%. Amenorrhea due to radiation dose absorbed by the contralateral shielded ovary was found in 7.7%. The excellent results in Stage I patients were balanced by the unsatisfactory results in Stage III patients. A more aggressive treatment and the knowledge of other prognostic factors seem necessary.
Topics: Adolescent; Adult; Child; Combined Modality Therapy; Dysgerminoma; Female; Humans; Ovarian Neoplasms; Prognosis
PubMed: 3583856
DOI: 10.1016/0360-3016(87)90099-x -
Obstetrics and Gynecology Oct 1981One hundred and fifty-eight dysgerminomas from the Emil Novak Ovarian Tumor Registry and the Gynecologic Pathology Laboratory of The Johns Hopkins Hospital were...
One hundred and fifty-eight dysgerminomas from the Emil Novak Ovarian Tumor Registry and the Gynecologic Pathology Laboratory of The Johns Hopkins Hospital were reviewed. Five-year follow-up was available for 82% and 10-year follow-up was available for 65%, with survival rates of 83% and 74% for pure tumors, respectively. Survival was related to stage of disease and presence of other germ cell elements. Patients treated by unilateral adnexectomy alone for stage IA pure dysgerminoma had a 95% 5-year survival. Survival of these patients was not affected by tumor size.
Topics: Adolescent; Adult; Child; Child, Preschool; Disorders of Sex Development; Dysgerminoma; Female; Fertility; Humans; Maryland; Middle Aged; Neoplasm Recurrence, Local; Neoplasm Staging; Ovarian Neoplasms; Registries
PubMed: 7279343
DOI: No ID Found -
Ginecologia Y Obstetricia de Mexico Jul 1979
Topics: Adolescent; Adult; Dysgerminoma; Female; Humans; Hysterectomy; Hysterosalpingography; Palpation; Pregnancy
PubMed: 527852
DOI: No ID Found -
Human Pathology Jan 1995An immunohistochemical study of 15 ovarian formalin-fixed, paraffin-embedded dysgerminomas showed positive staining of tumor cells for vimentin in all cases. Ten...
An immunohistochemical study of 15 ovarian formalin-fixed, paraffin-embedded dysgerminomas showed positive staining of tumor cells for vimentin in all cases. Ten dysgerminomas stained for cytokeratin 18. Desmin positivity of single tumor cells was detected in four dysgerminomas. Glial fibrillary acidic protein was present in two tumors. Prominent human beta chorionic gonadotropin staining was seen in one tumor. S-100 protein was found in two and carcinoembryonic antigen in one of the dysgerminomas. Placental alkaline phosphatase was present in 12 of the 15 tumors studied. The heterogeneity of the cytoskeletal profile and of other markers showed some similarities to our previously published results on testicular seminomas. Thus, in contrast to previous concepts, dysgerminoma, as is the case with its testicular counterpart the seminoma, appears to be capable of further differentiation, albeit at a primitive level. Our observations also may help to elucidate the relationship between dysgerminoma and other nondysgerminomatous ovarian germ cell tumors, and may be of help in the differential diagnosis with poorly differentiated carcinoma, ovarian lymphoma, or other germ cell tumors.
Topics: Biomarkers, Tumor; Cell Differentiation; Dysgerminoma; Female; Humans; Immunohistochemistry; Intermediate Filament Proteins; Ovarian Neoplasms
PubMed: 7821917
DOI: 10.1016/0046-8177(95)90115-9