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The Journal of the Royal Society For... Mar 2002Hemihypertrophy refers to asymmetry of the body to a greater degree than can be attributed to normal variation. Most causes can be diagnosed from history and physical... (Review)
Review
Hemihypertrophy refers to asymmetry of the body to a greater degree than can be attributed to normal variation. Most causes can be diagnosed from history and physical examination. Hemihypertrophy is cosmetically unsightly and the psychological impact can be quite prolonged. This article reviews the causes and differential diagnosis of hemihypertrophy and offers an approach to the management of this condition. Children with isolated hemihypertrophy are at increased risk for neoplasms. Periodic abdominal ultrasound examination and physical examination during infancy and childhood are recommended for early tumour detection.
Topics: Congenital Abnormalities; Humans; Hypertrophy; Neoplasms
PubMed: 11989139
DOI: 10.1177/146642400212200111 -
Pediatrics Sep 1965
Review
Topics: Adolescent; Congenital Abnormalities; Humans; Hypertrophy
PubMed: 5318604
DOI: No ID Found -
Proceedings of the Royal Society of... 1908
PubMed: 19972767
DOI: No ID Found -
Saudi Medical Journal Apr 2014Idiopathic hemihypertrophy is a congenital overgrowth disorder associated with an augmented risk for embryonal tumors. We present 4 cases of hemihypertrophy in Yemeni...
Idiopathic hemihypertrophy is a congenital overgrowth disorder associated with an augmented risk for embryonal tumors. We present 4 cases of hemihypertrophy in Yemeni children living in Sana`a city. They presented to the outpatient clinics in a private hospital in Sana`a city, Yemen, over a period of 3 years from January 2009 to December 2011. The first 2 cases had no complaints apart from asymmetrical size of one side of their bodies (left side hemihypertrophy). The third case presented with left side hemihypertrophy and an abdominal mass, which upon referral to a cancer center was confirmed to be Wilms` tumor. The fourth case had overgrowth of the right leg and foot with polydactyly, and a right sided abdominal mass. He was diagnosed to have an ureteropelvic junction stricture with hydronephrosis and absent left kidney.
Topics: Child, Preschool; Constriction, Pathologic; Female; Humans; Hydronephrosis; Hypertrophy; Infant; Kidney; Kidney Neoplasms; Kidney Pelvis; Lower Extremity; Male; Polydactyly; Upper Extremity; Ureter; Wilms Tumor; Yemen
PubMed: 24749139
DOI: No ID Found -
Clinical Orthopaedics and Related... Jun 1982Analysis of 30 patients with skeletal asymmetry indicates that hemihypertrophy and hemihypotrophy are separate and distinct clinical syndromes. Hemihypotrophy is often...
Analysis of 30 patients with skeletal asymmetry indicates that hemihypertrophy and hemihypotrophy are separate and distinct clinical syndromes. Hemihypotrophy is often associated with scoliosis, mental retardation, and chromosomal mosaicism and occasionally associated with the Silver syndrome. It is not associated with childhood neoplasia. Limb-length inequality is usually mild. Hemihypertrophy is more common than hemihypotrophy and is sometimes associated with primitive neoplasms of the liver, adrenals and kidneys, as well as with benign organ growth aberrations. It is not normally associated with fixed scoliosis nor with mental retardation. Limb-length discrepancy usually requires surgical management. Family counseling and periodic assessment for neoplasia are indicated during childhood.
Topics: Abnormalities, Multiple; Child; Child, Preschool; Female; Growth Disorders; Humans; Hypertrophy; Infant; Infant, Newborn; Leg Length Inequality; Male; Neoplasms; Syndrome
PubMed: 7083673
DOI: No ID Found -
Ryoikibetsu Shokogun Shirizu 2001
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Proceedings of the Royal Society of... Jul 1949
Topics: Fetal Diseases; Hemangioma; Humans; Hypertrophy; Neoplasms
PubMed: 18228987
DOI: No ID Found -
International Journal of Adolescent... Jan 2019The reported incidence of isolated hemihyperplasia (IH) has a very wide range (from 1:13,000 to 1:86,000 live births) and further clarification is needed. We...
AIM
The reported incidence of isolated hemihyperplasia (IH) has a very wide range (from 1:13,000 to 1:86,000 live births) and further clarification is needed. We hypothesized that a survey of the birth prevalence of IH among newborn infants may underestimate the incidence of IH by overlooking late-onset cases.
METHODS
The prospective international multicenter study utilized the two-steps selection tool for an anonymous survey of volunteers of 15-18 years old. The initial step was "three measurements-three questions" screening, or "face-palms-calves survey". The subsequent step was an in-depth assessment of selected cases to exclude localized, lesional and syndrome-related cases as well as body asymmetry within normative range and to select suspected cases of IH. This step included measurements of various anatomical regions and a subsequent questionnaire. The participants that were selected in a risk group were advised to refer to medical institutions for clinical, genetic and instrumental investigation.
RESULTS
Out of 6000 of selected participants (male, M 3452, female, F 2548), 229 (3.82%) were selected for detailed investigation and 57 (0.95%) were assigned to the risk group. Only 36 of them were actually referred to medical institutions and in two cases the diagnosis of IH was confirmed.
CONCLUSION
Our survey indicated the prevalence of IH at the age of adolescence as approximately 1:3000. While IH is a hereditary genetic disorder, it may not be detected in newborns and infants and the true prevalence of the disease can be estimated if older age children are screened.
PubMed: 30645194
DOI: 10.1515/ijamh-2018-0066 -
Clinical Genetics Sep 2021The congenital imprinting disorder, Beckwith-Wiedemann syndrome (BWS) is associated with variable clinical features including hemihypertrophy/lateralised overgrowth (LO)... (Review)
Review
The congenital imprinting disorder, Beckwith-Wiedemann syndrome (BWS) is associated with variable clinical features including hemihypertrophy/lateralised overgrowth (LO) and embryonal tumour predisposition. BWS-associated (epi)genetic alterations occur in a subset of patients with isolated LO (ILO), leading to the concept of BWS spectrum disorder (BWSp). We investigated the relationship between clinical features and molecular diagnostic results in a cohort with LO using the BWSp international consensus group (BWSICG) clinical scoring system. Clinical/molecular findings in 94 previously-unreported patients with LO referred for BWSp molecular studies were reviewed retrospectively. The BWSICG score was assigned and diagnostic rate calculated. BWSp-associated (epi)genetic alteration was identified in 15/94 (16%). The molecular diagnostic rate by MS-MLPA (blood DNA) for BWS-related molecular findings in patients with LO was positively correlated with the BWSICG score. 3/48 with ILO had a molecular alteration. No individuals with ILO had developed an embryonal tumour at last follow up. Among a cohort of individuals with LO referred for BWSp molecular testing, the BWSICG score correlated with diagnostic yield. The embryonal tumour risk in children with ILO and negative molecular testing appeared very low, however longer- and more complete follow up is required to better define tumour risks in this group.
Topics: Adolescent; Adult; Beckwith-Wiedemann Syndrome; Child; Child, Preschool; Cohort Studies; Female; Genetic Testing; Humans; Hypertrophy; Infant; Infant, Newborn; Male; Microsatellite Repeats; Molecular Diagnostic Techniques; Neoplasms, Germ Cell and Embryonal; Retrospective Studies; Young Adult
PubMed: 33993487
DOI: 10.1111/cge.13997 -
Global Pediatric Health 2016
PubMed: 35211649
DOI: 10.1177/2333794X16655255