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Archives of Surgery (Chicago, Ill. :... Feb 1968
Topics: Adult; Humans; Intestinal Perforation; Jejunal Diseases; Male; Ulcer; Zollinger-Ellison Syndrome
PubMed: 5212461
DOI: 10.1001/archsurg.1968.01330200112023 -
Acta Medica Academiae Scientiarum... 1981Separation and measurement of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenine-adenosine, lipid phosphates (lipid P),...
Separation and measurement of adenosine triphosphate (ATP), adenosine diphosphate (ADP), adenosine monophosphate (AMP), adenine-adenosine, lipid phosphates (lipid P), ribonucleic acid (RNA), deoxyribonucleic acid (DNA), further of Mg2+-dependent, total (Mg2+-dependent plus Na+-K+-dependent) and Na+-K+-dependent ATPases was carried out in control (non-ulcerated) and ulcerated (mucosa up to 2.0 cm around the ulcer) jejunal mucosa of 11 patients with chronic jejunal ulcer, who had undergone a Billroth II gastric resection for duodenal ulcer. The levels of ATP, ADP, AMP, sum of ATP + ADP + AMP, lipid-P, RNA (related to 1.0 mg DNA) and the activity of Mg2+-dependent, total (Mg2+-dependent plus Na+-K+-dependent) and Na+-K+-dependent ATPase (related to 1.0 mg membrane protein) were significantly higher in the lacerated jejunal mucosa than in the control one. The results indicate that (1) no circulatory damage can be found in the ulcerated jejunal mucosa; (2) a cellular hyperactivity (increased ATP breakdown and increased ATP resynthesis, increased RNA and lipid synthesis) occurs in the ulcerated jejunal mucosa; (3) the biochemical structure of cells differs significantly in the control and the ulcerated jejunal mucosa.
Topics: Adenosine Diphosphate; Adenosine Monophosphate; Adenosine Triphosphatases; Adenosine Triphosphate; DNA; Humans; Intestinal Mucosa; Jejunal Diseases; Phosphates; RNA; Ulcer
PubMed: 6172948
DOI: No ID Found -
Clinical Gastroenterology and... Jan 2020
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Boron Compounds; Bortezomib; Cryoglobulinemia; Cryoglobulins; Crystallization; Cyclophosphamide; Dexamethasone; Double-Balloon Enteroscopy; Duodenal Ulcer; Glycine; Humans; Jejunal Diseases; Male; Ulcer; Vasculitis
PubMed: 30240893
DOI: 10.1016/j.cgh.2018.09.018 -
Fetal Diagnosis and Therapy 2019To examine the incidence of umbilical cord ulcer (UCU) that causes intrauterine fetal death (IUFD) in fetal duodenal or jejunoileal atresia and the association between...
OBJECTIVE
To examine the incidence of umbilical cord ulcer (UCU) that causes intrauterine fetal death (IUFD) in fetal duodenal or jejunoileal atresia and the association between UCU and bile acid concentrations in amniotic fluid.
METHODS
Perinatal outcomes were evaluated in cases of fetal intestinal atresia between 2003 and 2017. A pathological examination of the umbilical cord was performed, and bile acid concentrations in the amniotic fluid were measured.
RESULTS
Among the 46 cases included in this study, there were 27 with duodenal atresia and 19 with jejunoileal atresia. There were 4 cases (8.7%) of IUFD and 1 (2.2%) neonatal death with multiple structural anomalies. UCUs were found in 37.5% (15/40) of cases, and severe UCUs with exposed vessels were significantly more common in IUFD (3/4) than in livebirth (0/42) cases (p < 0.01). The incidences of chromosomal abnormality and structural anomalies were not markedly different between livebirth (9/30 and 11/42, respectively) and IUFD (1/3 and 1/4, respectively) cases. Bile acid concentrations in amniotic fluid were significantly higher in cases of UCUs than in those without (p < 0.01).
CONCLUSION
UCUs were not rare in fetal intestinal atresia and were associated with high bile acid concentrations in amniotic fluid. UCUs with exposed vessels were associated with IUFD in intestinal atresia.
Topics: Adult; Amniotic Fluid; Bile Acids and Salts; Duodenal Obstruction; Female; Fetal Death; Humans; Ileum; Incidence; Intestinal Atresia; Jejunum; Pregnancy; Prognosis; Retrospective Studies; Risk Factors; Tokyo; Ulcer; Umbilical Cord; Up-Regulation; Young Adult
PubMed: 30870842
DOI: 10.1159/000496840 -
Archives of Surgery (Chicago, Ill. :... Oct 1986A new technique of permanent gastrostomy interposes a vascularized jejunal conduit with an intussuscepted valve between the stomach and abdominal wall, creating a...
A new technique of permanent gastrostomy interposes a vascularized jejunal conduit with an intussuscepted valve between the stomach and abdominal wall, creating a "continent jejunal gastrostomy". In a series of dogs undergoing gastrostomy, the continent jejunal gastrostomy functioned well, with no leakage, and was superior to gastric tube gastrostomy in this regard. Furthermore, there was no evidence of marginal ulceration. A patient who underwent continent jejunal gastrostomy has an excellent one-month result.
Topics: Animals; Dogs; Enteral Nutrition; Esophageal Stenosis; Gastrectomy; Gastrostomy; Humans; Jejunum; Laryngeal Neoplasms; Male; Middle Aged; Postoperative Complications
PubMed: 3094479
DOI: 10.1001/archsurg.1986.01400100027004 -
Annals of Surgery Nov 1977The effect of intrajejunal infusion of a fat solution on pentagastrin-stimulated (0.5 microgram/kg-hr) gastric acid secretion was studied in five duodenal ulcer patients... (Comparative Study)
Comparative Study
The effect of intrajejunal infusion of a fat solution on pentagastrin-stimulated (0.5 microgram/kg-hr) gastric acid secretion was studied in five duodenal ulcer patients before and three to five months after truncal vagotomy. Preoperatively mean acid output was reduced from 41 +/- 5.2 meq H+/hr to 15.4 +/- 1.3 meq H+/hr (p less than 0.005), and postoperatively from 17.4 +/- 2.6 meq H+/hr to 12.7 +/- 2.4 meq H+/HR (P less than 0.01), demonstrating that fat induced jejunal inhibition of gastric acid secretion partly or wholly is humorally mediated. Furthermore the study shows that fat induced jejunal inhibition of acid secretion in duodenal ulcer patients seem to be of the same magnitude as previously found in healthy subjects.
Topics: Adult; Duodenal Ulcer; Female; Gastric Juice; Humans; Jejunum; Lipids; Male; Middle Aged; Pentagastrin; Vagotomy
PubMed: 921350
DOI: 10.1097/00000658-197711000-00005 -
World Journal of Gastroenterology Oct 2009Several reports have described an apparently uncommon clinicopathological disorder that is characterized by multifocal stenosing small-intestinal ulceration. Compared to... (Review)
Review
Several reports have described an apparently uncommon clinicopathological disorder that is characterized by multifocal stenosing small-intestinal ulceration. Compared to Crohn's disease, the ulcers are not transmural and typically remain shallow, and involve only the mucosa and submucosa. The disorder seems to be localized in the jejunum and proximal ileum only, and not the distal ileum or colon. Only nonspecific inflammatory changes are present without giant cells or other typical features of granulomatous inflammation. Most patients present clinically with recurrent obstructive events that usually respond to steroids, surgical resection, or both. With the development of newer imaging modalities to visualize the small-intestinal mucosa, such as double-balloon enteroscopy, improved understanding of the long-term natural history of this apparently distinctive disorder should emerge.
Topics: Constriction, Pathologic; Diagnosis, Differential; Digestive System Surgical Procedures; Endoscopy, Gastrointestinal; Humans; Ileum; Inflammatory Bowel Diseases; Intestinal Mucosa; Intestinal Obstruction; Jejunum; Steroids; Treatment Outcome; Ulcer
PubMed: 19842217
DOI: 10.3748/wjg.15.4883 -
American Journal of Surgery Sep 1957
Topics: Gastroenterostomy; Humans; Intestinal Diseases; Jejunum; Peptic Ulcer; Ulcer; Vagotomy
PubMed: 13458629
DOI: 10.1016/0002-9610(57)90818-8 -
Scientific Reports Oct 2019GI mucosal healing requires epithelial sheet migration. The non-receptor tyrosine kinase focal adhesion kinase (FAK) stimulates epithelial motility. A virtual screen...
GI mucosal healing requires epithelial sheet migration. The non-receptor tyrosine kinase focal adhesion kinase (FAK) stimulates epithelial motility. A virtual screen identified the small drug-like FAK mimic ZINC40099027, which activates FAK. We assessed whether ZINC40099027 promotes FAK-Tyr-397 phosphorylation and wound healing in Caco-2 monolayers and two mouse intestinal injury models. Murine small bowel ulcers were generated by topical serosal acetic acid or subcutaneous indomethacin in C57BL/6J mice. One day later, we began treatment with ZINC40099027 or DMSO, staining the mucosa for phosphorylated FAK and Ki-67 and measuring mucosal ulcer area, serum creatinine, ALT, and body weight at day 4. ZINC40099027 (10-1000 nM) dose-dependently activated FAK phosphorylation, without activating Pyk2-Tyr-402 or Src-Tyr-419. ZINC40099027 did not stimulate proliferation, and stimulated wound closure independently of proliferation. The FAK inhibitor PF-573228 prevented ZINC40099027-stimulated wound closure. In both mouse ulcer models, ZINC40099027accelerated mucosal wound healing. FAK phosphorylation was increased in jejunal epithelium at the ulcer edge, and Ki-67 staining was unchanged in jejunal mucosa. ZINC40099027 serum concentration at sacrifice resembled the effective concentration in vitro. Weight, creatinine and ALT did not differ between groups. Small molecule FAK activators can specifically promote epithelial restitution and mucosal healing and may be useful to treat gut mucosal injury.
Topics: Animals; Caco-2 Cells; Cell Movement; Epithelial Cells; Focal Adhesion Protein-Tyrosine Kinases; Humans; Intestinal Mucosa; Jejunum; Mice; Mice, Inbred C57BL; Phosphorylation; Quinolones; Small Molecule Libraries; Sulfones; Ulcer; Wound Closure Techniques; Wound Healing
PubMed: 31604999
DOI: 10.1038/s41598-019-51183-z -
Clinical Journal of Gastroenterology Feb 2018Rapunzel syndrome is a rare form of gastric trichobezoar (hair ball) involving extension of a tail of the hair into the small bowel. A 13-year-old girl was admitted with...
Rapunzel syndrome is a rare form of gastric trichobezoar (hair ball) involving extension of a tail of the hair into the small bowel. A 13-year-old girl was admitted with a 4-day history of epigastric pain and nausea which worsened after meals. Abdominal ultrasound showed duodenal wall thickening and lymphadenopathy. Esophagogastroduodenoscopy identified a gastric trichobezoar with a tail extending into the duodenum. In addition, multiple longitudinal duodenal and jejunal ulcers were noted. The ulcers appeared to be a result of direct pressure by the tail itself against the intestinal mucosa. The trichobezoar was successfully retrieved endoscopically under general anesthesia. Her symptoms resolved completely after retrieval. Psychiatric follow-up was carried out to help reduce the risk of recurrence. Here, we describe a novel complication of Rapunzel syndrome, i.e., multiple longitudinal ulcers of the small intestine. This novel finding suggests that the mucosal damage caused by the trichobezoar of Rapunzel syndrome can occur in an earlier stage than previously thought. In addition, we also strongly recommend using general anesthesia with intubation when removing a gastric trichobezoar to ensure protection of the airway.
Topics: Abdominal Pain; Adolescent; Bezoars; Duodenal Diseases; Endoscopy, Digestive System; Female; Humans; Jejunal Diseases; Stomach; Syndrome; Ulcer
PubMed: 29067636
DOI: 10.1007/s12328-017-0790-8