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Gastroenterology Jun 1988Morphologic and physiologic experiments in rodents have demonstrated differences between jejunal and ileal fat absorption. Compared with the rat jejunum, absorbed lipid... (Comparative Study)
Comparative Study
Morphologic and physiologic experiments in rodents have demonstrated differences between jejunal and ileal fat absorption. Compared with the rat jejunum, absorbed lipid particles within rat ileal absorptive cells are larger and exit at a slower rate. To evaluate the relevance of these observations to humans, we studied jejunal and ileal ultrastructure in 3 volunteers, each of whom had an intact small intestine and an ileostomy postcolectomy for ulcerative colitis. Proximal jejunal biopsy specimens were obtained via a hydraulic tube after an overnight fast and again after a 20-min intrajejunal lipid infusion. On a separate day, terminal ileal biopsy specimens were taken via the stoma with a small steerable suction biopsy tube after an overnight fast and again after a 20-min intraileal infusion of the same lipid mixture. One volunteer underwent biopsy after a 60-min ileal infusion of a digested meal of higher lipid content. Electron microscopy of fasting human jejunal absorptive cells revealed obvious smooth endoplasmic reticulum in the extreme apical region beneath the terminal web; very low density lipoprotein particles were observed within smooth endoplasmic reticulum and Golgi cisternae. In contrast, fasting human ileal absorptive cells contained less apical smooth endoplasmic reticulum and fewer or no very low density lipoprotein particles. After the 20-min infusion of lower-lipid content, human jejunal and ileal absorptive cells were indistinguishable because they contained fat particles of the same size and number within smooth endoplasmic reticulum, Golgi cisternae, and extracellular spaces. After the 60-min ileal infusion of higher-lipid content, human ileal absorptive cells appeared to be the same as those of the human jejunum after similar lipid infusions. Our observations of the ultrastructural similarity in human jejunal and ileal absorptive cells after lipid infusions contrasts with those in rodents and may reflect species-specific differences in mechanisms of fat absorption.
Topics: Adult; Fasting; Female; Humans; Ileum; Intestinal Absorption; Intestinal Mucosa; Jejunum; Lipids; Male; Microscopy, Electron
PubMed: 3360260
DOI: 10.1016/0016-5085(88)90676-2 -
British Medical Journal Sep 1972
Topics: Adult; Bone Diseases; Celiac Disease; Colon, Sigmoid; Diet Therapy; Female; Glutens; Herpesviridae Infections; Histiocytes; Humans; Ileum; Intestinal Absorption; Jejunum; Liver; Liver Diseases; Lymphocytes; Necrosis; Neutrophils; Ulcer
PubMed: 4341971
DOI: No ID Found -
Australasian Radiology Nov 1998
Topics: Adult; Diagnosis, Differential; Duodenal Obstruction; Female; Humans; Jejunal Diseases; Syndrome; Ulcer
PubMed: 9833389
DOI: No ID Found -
Digestion 1979Jejunal mucosal function and structure was examined in 31 patients with ulcerative colitis and 29 patients with Crohn's disease with ileal, ileocolonic or colonic...
Jejunal mucosal function and structure was examined in 31 patients with ulcerative colitis and 29 patients with Crohn's disease with ileal, ileocolonic or colonic involvement; A significant reduction of the specific activity of disaccharidases (lactase, sucrase and trehalase) in jejunal mucosal homogenate occurred in patients with inflammatory bowel disease. Similarly, alkaline phosphatase was reduced in ulcerative colitis. Several dipeptidases such as glycyl-leucine, leucyl-glycine, glycyl-glycine and valyl-proline hydrolase activities were lower in patients with inflammatory bowel disease than in controls. Histological changes in jejunal mucosal biopsies occurred in 71% of patients with ulcerative colitis and 61% with Crohn's disease. These changes ranged from mild abnormalities of villus architecture to marked reduction of villus height. Most patients with a reduction in mucosal enzymes had concommitant morphological changes in jejunal mucosal biopsy. The results of this study indicate that functional and structural abnormalities of the jejunal mucosa frequently occur in patients with inflammatory bowel disease without radiologic evidence of proximal small bowel involvement.
Topics: Adolescent; Adult; Aged; Alkaline Phosphatase; Colitis, Ulcerative; Crohn Disease; Dipeptidases; Disaccharidases; Female; Humans; Intestinal Mucosa; Jejunum; Male; Middle Aged
PubMed: 478207
DOI: 10.1159/000198354 -
Revista Brasileira de Cirurgia May 1958
Topics: Disease; Esophageal Diseases; Esophagectomy; Esophagitis, Peptic; Esophagus; Gastrectomy; Humans; Jejunum; Ulcer
PubMed: 13579418
DOI: No ID Found -
The Review of Gastroenterology Dec 1951
Topics: Disease; Humans; Jejunal Diseases; Jejunum; Ulcer
PubMed: 14912500
DOI: No ID Found -
Endoscopy Mar 2021
Topics: Endoscopy; Gastrointestinal Hemorrhage; Hemostasis, Endoscopic; Humans; Jejunum; Ligation; Ulcer
PubMed: 32590857
DOI: 10.1055/a-1195-1795 -
The Journal of Obstetrics and... Oct 2003We encountered two cases of severe intrauterine hemorrhage associated with congenital intestinal atresia. In both cases, the first sign that necessitated immediate... (Review)
Review
We encountered two cases of severe intrauterine hemorrhage associated with congenital intestinal atresia. In both cases, the first sign that necessitated immediate clinical management was the abnormal fetal heart rate patterns, represented by prolonged bradycardias and late decelerations. This occurred immediately after the onset of labor. An emergency cesarean section was performed on both patients and, despite being born with severe anemia, the condition of the infants was excellent. We found that continuous fetal heart rate monitoring should be performed if polyhydramniosis suspected, when the fetus is diagnosed with congenital intestinal atresia and when changes in intrauterine pressure are clinically expected, such as at the onset of labor or after amniocentesis.
Topics: Adult; Cesarean Section; Digestive System Surgical Procedures; Duodenal Obstruction; Female; Fetal Diseases; Fetal Monitoring; Humans; Infant, Newborn; Intestinal Atresia; Jejunum; Pregnancy; Pregnancy Outcome; Treatment Outcome; Ulcer; Umbilical Cord; Uterine Hemorrhage
PubMed: 14641701
DOI: 10.1046/j.1341-8076.2003.00121.x -
Lancet (London, England)
Topics: Adult; Endoscopy, Gastrointestinal; Humans; IgA Vasculitis; Jejunal Diseases; Male; Middle Aged; Ulcer
PubMed: 11191571
DOI: 10.1016/S0140-6736(05)67269-8 -
World Journal of Gastroenterology Oct 2008Jejunal diverticulosis is a rare entity with variable clinical and anatomical presentations. Its reported incidence varies from 0.05% to 6%. Although there is no...
Jejunal diverticulosis is a rare entity with variable clinical and anatomical presentations. Its reported incidence varies from 0.05% to 6%. Although there is no consensus on the management of asymptomatic jejunal diverticular disease, some complications are potentially life threatening and require early surgical treatment. We report a case of an 88-year-old man investigated for acute abdominal pain with a high biological inflammatory syndrome. Inflammation of multiple giant jejunal diverticulum was discovered at abdominal computed tomography (CT). As a result of the clinical and biological signs of early peritonitis, an emergency surgical exploration was performed. The first jejunal loop showed clear signs of jejunal diverticulitis. Primary segmental jejunum resection with end-to-end anastomosis was performed. Histopathology report confirmed an ulcerative jejunal diverticulitis with imminent perforation and acute local peritonitis. The patient made an excellent rapid postoperative recovery. Jejunal diverticulum is rare but may cause serious complications. It should be considered a possible etiology of acute abdomen, especially in elderly patients with unusual symptomatology. Abdominal CT is the diagnostic tool of choice. The best treatment is emergency surgical management.
Topics: Abdomen, Acute; Aged, 80 and over; Anastomosis, Surgical; Diverticulitis; Diverticulum; Humans; Jejunal Diseases; Male; Peritonitis; Tomography, X-Ray Computed; Treatment Outcome; Ulcer
PubMed: 18985822
DOI: 10.3748/wjg.14.6265