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The Surgical Clinics of North America Oct 1978
Topics: Adult; Female; Gastrectomy; General Surgery; History, 20th Century; Humans; Jejunum; Stomach Ulcer; Ulcer; Vagotomy; Zollinger-Ellison Syndrome
PubMed: 364697
DOI: 10.1016/s0039-6109(16)41634-8 -
American Journal of Physiology.... Oct 2012Mixed-lineage kinase 3 (MLK3) activates multiple MAPK pathways and can initiate apoptosis, proliferation, migration, or differentiation in different cell types. However,...
Mixed-lineage kinase 3 (MLK3) activates multiple MAPK pathways and can initiate apoptosis, proliferation, migration, or differentiation in different cell types. However, whether MLK3 signaling regulates intestinal epithelial cell sheet migration in vivo is not known. We sought to investigate whether MLK3 signaling is important in intestinal mucosal healing and epithelial cell motility in vivo and in vitro. In vivo, we compared the healing of jejunal mucosal ulcers induced in MLK3 knockout (KO) mice with healing in wild-type (WT) mice. Ulcer healing was 20.8% less at day 3 (P < 0.05) and 18.9% less at day 5 (P < 0.05) in MLK3 KO than WT mice. Within the intestinal mucosa of MLK3 KO mice, ERK and JNK signaling were reduced, phosphatase and tensin homolog deleted on chromosome 10 (PTEN) level was increased, and p38 signaling was unchanged. Parallel in vitro studies using an MLK inhibitor assessed the role of MLK signaling in human Caco-2 intestinal epithelial migration across collagen substrates. The MLK inhibitor reduced closure of circular wounds in Caco-2 monolayers. MLK inhibition reduced ERK and JNK, but not p38, signaling in Caco-2 cells. Although PTEN is increased after MLK inhibition, it does not influence MLK-mediated cell migration. These findings indicate that disruption of MLK3 signaling impairs ulcer healing by suppressing ERK and JNK signaling in vitro and in mouse intestinal mucosa in vivo. These results reveal a novel role for MLK3 signaling in the regulation of intestinal epithelial migration in vivo and suggest that MLK3 may be an important target for the regulation of intestinal mucosal healing.
Topics: Animals; Cell Proliferation; Epithelial Cells; Intestinal Diseases; Intestinal Mucosa; Jejunum; MAP Kinase Kinase Kinases; MAP Kinase Signaling System; Mice; Mice, Knockout; Phosphorylation; Ulcer; Wound Healing; Mitogen-Activated Protein Kinase Kinase Kinase 11
PubMed: 22917630
DOI: 10.1152/ajpgi.00158.2012 -
Northwest Medicine Dec 1956
Topics: Gastrointestinal Diseases; Humans; Jejunum; Peritonitis; Ulcer
PubMed: 13378742
DOI: No ID Found -
Hepato-gastroenterology 2007The present study evaluates the findings of long-term follow-up endoscopy in patients who underwent proximal gastrectomy with jejunal interposition for gastric cancer.
BACKGROUND/AIMS
The present study evaluates the findings of long-term follow-up endoscopy in patients who underwent proximal gastrectomy with jejunal interposition for gastric cancer.
METHODOLOGY
A total of 55 patients (45 males, 10 females; 32 to 79 years; mean, 55.9 years), who underwent proximal gastrectomy with jejunal interposition, were enrolled in the present study. We reviewed the findings of follow-up endoscopy of all patients with particular reference to the development of esophagitis, jejunitis, jejunal ulcer and secondary tumors.
RESULTS
We found reflux esophagitis in 6 patients (10.9%) between 12 and 35 months with an average of 22 months after surgery. Jejunitis was discovered in 5 patients (9.0%) between 6 and 96 months with an average of 29 months after surgery. Jejunal ulcer was revealed in 6 patients (10.9%) between 6 and 75 months with an average of 37 months after surgery. Tumors of the remnant stomach, early gastric cancer and gastric adenoma, were identified in 2 patients (3.6%) at 24 months and 69 months, respectively.
CONCLUSIONS
Jejunal interposition combined with proximal gastrectomy does not always prevent complications related to regurgitation of gastric content, and may not be a suitable treatment in view of postoperative endoscopic surveillance. Further studies are required to identify an appropriate surgical approach to proximal gastrectomy for gastric cancer.
Topics: Adult; Aged; Endoscopy, Gastrointestinal; Enteritis; Esophagitis, Peptic; Female; Follow-Up Studies; Gastrectomy; Humans; Jejunal Diseases; Jejunum; Male; Middle Aged; Peptic Ulcer; Postoperative Complications; Stomach Neoplasms
PubMed: 17419280
DOI: No ID Found -
Hepato-gastroenterology 2000Marginal ulcer after proximal gastrectomy has never been previously reported, despite that this procedure preserves the fundic gland area of the stomach, which secretes...
Marginal ulcer after proximal gastrectomy has never been previously reported, despite that this procedure preserves the fundic gland area of the stomach, which secretes gastric acid. In this report, we describe a patient who developed a marginal ulcer on the oral side of the gastrojejunal anastomosis after proximal gastrectomy by jejunal interposition. This case serves as a reminder that gastric acid secretion of the remnant stomach must be carefully monitored after proximal gastrectomy in gastric cancer surgery.
Topics: Anastomosis, Surgical; Gastrectomy; Gastric Acid; Humans; Jejunal Diseases; Jejunum; Male; Middle Aged; Postoperative Complications; Ulcer
PubMed: 11149005
DOI: No ID Found -
The Nova Scotia Medical Bulletin May 1948
Topics: Humans; Jejunal Diseases; Peptic Ulcer; Stomach Ulcer; Ulcer
PubMed: 18874023
DOI: No ID Found -
Arquivos Brasileiros de Cirurgia... 2015The jejunal pouch interposition between the gastric body and the duodenum after the gastrectomy, although not frequent in the surgical practice today, has been...
BACKGROUND
The jejunal pouch interposition between the gastric body and the duodenum after the gastrectomy, although not frequent in the surgical practice today, has been successfully employed for the prevention and treatment of the postgastrectomy syndromes. In the latter, it is included the dumping syndrome, which affects 13-58% of the patients who undergo gastrectomy.
AIM
Retrospective assessment of the results of this procedure for the prevention of the dumping syndrome.
METHODS
Fourty patients were selected and treatetd surgically for peptic ulcer, between 1965 and 1970. Of these, 29 underwent vagotomy, antrectomy, gastrojejunalduodenostomy at the lesser curvature level, and the 11 remaining were submitted to vagotomy, antrectomy, gastrojejunal-duodenostomy at the greater curvature level. The gastro-jejuno-duodenal transit was assessed in the immediate or late postoperative with the contrasted study of the esophagus, stomach and duodenum. The clinical evolution was assessed according to the Visick grade.
RESULTS
Of the 40 patients, 28 were followed with the contrast evaluation in the late postoperative. Among those who were followed until the first month (n=22), 20 (90%) had slow gastro-jejuno-duodenal transit and in two (10%) the transit was normal. Among those who were followed after the first month (n=16), three (19%) and 13 (81%) had slow and normal gastric emptying, respectively. None had the contrasted exam compatible with the dumping syndrome. Among the 40 patients, 22 underwent postoperative clinical evaluation. Of these, 19 (86,5%) had excellent and good results (Visick 1 and 2, respectively).
CONCLUSIONS
The jejunal pouch interposition showed to be a very effective surgical procedure for the prevention of the dumping syndrome in gastrectomized patients.
Topics: Adult; Anastomosis, Surgical; Dumping Syndrome; Duodenum; Female; Gastrectomy; Gastrointestinal Transit; Humans; Jejunum; Male; Retrospective Studies; Stomach
PubMed: 26734789
DOI: 10.1590/S0102-6720201500040003 -
Hospital (Rio de Janeiro, Brazil) Apr 1961
Topics: Humans; Intestinal Diseases; Jejunum; Medical Records; Peptic Ulcer; Postoperative Period; Ulcer
PubMed: 13733488
DOI: No ID Found -
Surgery For Obesity and Related... 2009
Topics: Device Removal; Follow-Up Studies; Gastroplasty; Humans; Jejunal Diseases; Jejunum; Laparoscopy; Laparotomy; Male; Middle Aged; Obesity, Morbid; Postoperative Complications; Reoperation; Ulcer
PubMed: 19250878
DOI: 10.1016/j.soard.2008.07.015 -
Journal of Pediatric Surgery Jun 2012Biliary tract duplication cysts with heterotopic gastric mucosa are rare congenital anomalies, with our case representing only the fourth reported case in the... (Review)
Review
Biliary tract duplication cysts with heterotopic gastric mucosa are rare congenital anomalies, with our case representing only the fourth reported case in the literature. An 8-year-old girl with several months of abdominal pain was found to have a complex cystic mass communicating with the biliary system via the common hepatic duct. Intraoperatively, inflammation caused by the cystic mass was found to have resulted in a Mirizzi-like syndrome, with a nearly complete obstruction at the confluence of the left and right hepatic ducts. Histopathologic examination of the biliary mass revealed it to be a duplication cyst lined by heterotopic gastric mucosa with secondary ulceration and fibrosis. Biliary duplication cysts are a rare but important process that should be considered in a child with a mass in the portal triad and biliary obstruction.
Topics: Abdominal Pain; Anastomosis, Roux-en-Y; Bile Duct Diseases; Child; Cholangiography; Cholangiopancreatography, Endoscopic Retrograde; Choledochal Cyst; Cholestasis; Choristoma; Dilatation, Pathologic; Female; Gastric Mucosa; Hepatic Duct, Common; Humans; Hyperbilirubinemia; Jejunum; Liver; Radiography, Interventional; Ulcer
PubMed: 22703824
DOI: 10.1016/j.jpedsurg.2012.01.066