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Journal of Gastroenterology and... Aug 2005Idiopathic ulcer of the small bowel is a poorly recognized entity. Herein is reported a case of idiopathic ulcer of the jejunum containing numerous lymphoplasmacytoid...
Idiopathic ulcer of the small bowel is a poorly recognized entity. Herein is reported a case of idiopathic ulcer of the jejunum containing numerous lymphoplasmacytoid infiltrates and mimicking mucosa-associated lymphoid tissue (MALT) lymphoma. An 82-year-old Japanese woman presented with nausea and vomiting. Following diagnosis of submucosal tumor, partial jejunal resection was performed. Macroscopically the resected specimen contained multiple small shallow ulcers. Histologically the lesion was composed of numerous plasma cells mixed with lymphocytes and histiocytes. Immunohistological study revealed that the plasma cells contained polytypic intracytoplasmic immunoglobulins. The patient remained free of disease after 36 months. Marginal zone B-cell lymphoma of MALT-type arising from small intestine occasionally shows prominent plasma cell differentiation. The present case demonstrates that idiopathic ulcer of the small bowel should be added to the differential diagnosis of MALT-type lymphoma of the small bowel.
Topics: Aged; Aged, 80 and over; Cell Differentiation; Diagnosis, Differential; Female; Humans; Immunohistochemistry; Japan; Jejunal Diseases; Jejunal Neoplasms; Lymphoma, B-Cell, Marginal Zone; Plasma Cells; Tomography, X-Ray Computed; Ulcer
PubMed: 16048586
DOI: 10.1111/j.1440-1746.2005.03246.x -
Journal of the South Carolina Medical... Mar 1969
Topics: Humans; Jejunum; Male; Middle Aged; Ulcer
PubMed: 5254101
DOI: No ID Found -
Journal of Gastrointestinal Surgery :... 2000Our hypothesis was that a jejunal pouch used as a rectal substitute after proctocolectomy would slow enteric transit, delay defecation, and decrease stool frequency... (Comparative Study)
Comparative Study
Our hypothesis was that a jejunal pouch used as a rectal substitute after proctocolectomy would slow enteric transit, delay defecation, and decrease stool frequency compared to an ileal pouch so used. Twelve dogs underwent proctocolectomy; six had a jejunal pouch-distal rectal anastomosis and six had an ileal pouch-distal rectal anastomosis. After recovery, postprandial mouth-to-anus transit was slower in jejunal pouch dogs (253 +/- 18 minutes [mean +/- SEM]) than in ileal pouch dogs (112 +/- 7.9 minutes; P <0.05). Moreover, jejunal pouch dogs passed only 4.1 +/- 0.3 stools during the 12 hours after eating, whereas ileal pouch dogs passed 6.3 +/- 0. 9 stools (P <0.05). The mean frequency of proximal ileal pacesetter potentials after feeding was less in jejunal pouch dogs (12 +/- 0.4 cycles/min) than in ileal pouch dogs (16 +/- 0.3 counts/min; P = 0. 01), and jejunal pouches had more action potentials (jejunal = 82% +/- 4.3% of pacesetter potentials had action potentials, ileal = 61% +/- 3.0%; P <0.05). In contrast, gastric emptying and pouch motility, emptying, mucosal integrity, and bacteriologic and histologic properties were similar in the two groups of dogs. We concluded that the jejunal pouch operation slowed enteric transit, delayed defecation, and decreased postprandial stooling compared to the ileal pouch operation.
Topics: Animals; Colitis, Ulcerative; Dogs; Electromyography; Feces; Female; Gastric Emptying; Ileum; Intestinal Mucosa; Jejunum; Proctocolectomy, Restorative
PubMed: 10675245
DOI: 10.1016/s1091-255x(00)80058-x -
Gastroenterology May 1996A patient with cryptogenic multifocal ulcerous stenosing enteritis characterized by repeated bouts of intestinal obstruction, ulcerative stenosis of the small bowel... (Review)
Review
A patient with cryptogenic multifocal ulcerous stenosing enteritis characterized by repeated bouts of intestinal obstruction, ulcerative stenosis of the small bowel relapsing after surgical resection, and steroid sensitivity is described. Fourteen strictures of the jejunum were found at laparotomy. Despite resection, abdominal pain persisted. Steroid therapy was effective but led to dependence. In our patient, cryptogenic multifocal ulcerous stenosing enteritis was associated with fever, asthma, Raynaud's phenomenon, sicca syndrome, heterozygous type I C2 deficiency (28-base pair gene deletion), stenosis, and aneurysms in selective mesenteric angiography. It is hypothesized that cryptogenic multifocal ulcerous stenosing enteritis might be related to a particular form of polyarteritis nodosa with mainly intestinal expression or to a yet unclassified independent vasculitis.
Topics: Adult; Complement C2; Constriction, Pathologic; Enteritis; Female; Humans; Jejunal Diseases; Syndrome; Ulcer; Vasculitis
PubMed: 8613071
DOI: 10.1053/gast.1996.v110.pm8613071 -
British Medical Journal Apr 1978
Topics: Biopsy; Humans; Jejunum; Recurrence; Stomatitis, Aphthous
PubMed: 638660
DOI: 10.1136/bmj.1.6120.1145-b -
Gastrointestinal Endoscopy Aug 2020
Topics: Capsule Endoscopy; Celiac Disease; Enteritis; Humans; Ulcer
PubMed: 32113889
DOI: 10.1016/j.gie.2020.02.032 -
Lyon Medical Apr 1968
Topics: Aged; Caustics; Female; Gastroenterostomy; Humans; Jejunum; Nitrates; Ulcer
PubMed: 5672669
DOI: No ID Found -
Gut Sep 1970A patient is described with a severe malabsorption syndrome which failed to respond to a gluten-free diet. Although subtotal villous atrophy was present in the jejunal...
A patient is described with a severe malabsorption syndrome which failed to respond to a gluten-free diet. Although subtotal villous atrophy was present in the jejunal mucosa, histological features of subepithelial fibrosis and apparently normal enterocytes were not suggestive of coeliac disease. The findings of decreased mucosal thickness, of a normal mitotic rate in the crypt cell population, and of the decreased rate of loss of epithelial cells further suggested that the disease process producing the ;flat' mucosa was not that of coeliac disease. The condition was complicated by ileal ulceration and active tuberculosis.
Topics: Atrophy; Autopsy; Celiac Disease; Diagnosis, Differential; Diet Therapy; Female; Glutens; Humans; Ileum; Intestinal Diseases; Intestinal Mucosa; Intestine, Small; Iron; Jejunum; Malabsorption Syndromes; Middle Aged; Mitosis; Tuberculosis, Pulmonary; Ulcer
PubMed: 5473605
DOI: 10.1136/gut.11.9.743 -
Laboratory Investigation; a Journal of... Oct 2008Altered transforming growth factor-beta (TGFbeta) expression may contribute to inflammatory bowel disease and modulate epithelial cell restitution. Interference with...
Altered transforming growth factor-beta (TGFbeta) expression may contribute to inflammatory bowel disease and modulate epithelial cell restitution. Interference with TGFbeta-mediated signaling inhibits excisional skin wound healing, but accelerates healing of incisional cutaneous wounds and wounds in some other tissues. Therefore, we sought to clarify the potential role of Smad3-dependent TGFbeta signaling in intestinal mucosal healing in Smad3 null mice. Jejunal serosal application of filter disks saturated with 75% acetic acid yielded a circumscribed reproducible ischemic mucosal ulcer 1 day later. We compared ulcer area at 3 and 5 days to day 1 in Smad3 knockout mice and syngeneic wild-type mice, and evaluated mucosal immunoreactivity at the ulcer edge for TGFbeta, phosphorylated (activated) focal adhesion kinase (pFAK), phosphorylated extracellular signal-related kinase (pERK), proliferating cell nuclear antigen and apoptosis by TUNEL. Ulcer healing in Smad3 null mice was 17% less at day 3 (n=14, P=0.022) and 15% less at day 5 (n=14, P=0.004) than in wild-type littermates. In wild-type mice, pFAK, pERK and TGFbeta immunoreactivity were elevated in epithelium immediately adjacent to the ulcer compared with more distant mucosa. However, this pattern of immunoreactivity for pFAK, pERK and TGFbeta was not observed in Smad3 null mice. Smad3 null mice exhibited increased epithelial proliferation and no differences in apoptotic cell death compared with wild types, suggesting that ulcer healing may reflect differences in restitutive cell migration. Thus, Smad3-dependent disruption of the TGFbeta signaling pathway impairs the healing of murine intestinal mucosal ulcers and alters patterns of activated FAK and ERK immunoreactivity important for cell migration at the ulcer edge. These studies suggest a significant role for Smad3-dependent TGFbeta signaling in intestinal mucosal healing.
Topics: Animals; Disease Models, Animal; Female; Inflammatory Bowel Diseases; Intestinal Mucosa; Jejunum; Male; Mice; Mice, Knockout; Signal Transduction; Smad3 Protein; Transforming Growth Factor beta; Wound Healing
PubMed: 18711354
DOI: 10.1038/labinvest.2008.77 -
Placenta Nov 2010Umbilical cord ulceration is a serious complication of fetal intestinal atresia. To elucidate the relationship between fetal intestinal atresia and umbilical cord...
Umbilical cord ulceration is a serious complication of fetal intestinal atresia. To elucidate the relationship between fetal intestinal atresia and umbilical cord ulceration grade, we pathologically examined umbilical cords in 15 duodenal and 5 jejunal atresia cases and 28 control cases. Microscopic examination of the umbilical cords of patients with intestinal atresia revealed high-grade ulceration and a significant increase in macrophage numbers (P = 0.0087). Transudation of red blood cells was not associated with any specific clinical diagnosis, but was seen in all high-grade ulceration cases. It is suggested that clinical symptoms become apparent following gradual pathological changes.
Topics: Antigens, CD; Antigens, Differentiation, Myelomonocytic; Cell Count; Connective Tissue; Duodenal Obstruction; Erythrocytes; Exudates and Transudates; Humans; Immunohistochemistry; Infant, Newborn; Intestinal Atresia; Jejunum; Macrophages; Severity of Illness Index; Ulcer; Umbilical Cord
PubMed: 20810164
DOI: 10.1016/j.placenta.2010.08.005