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Current Opinion in Rheumatology Sep 2000A satisfactory classification of arthritis in childhood has still to be defined, and a system that can facilitate communication among physicians has been proposed by an... (Review)
Review
A satisfactory classification of arthritis in childhood has still to be defined, and a system that can facilitate communication among physicians has been proposed by an international committee. The immunopathogenesis of the diseases that are encompassed by the term juvenile rheumatoid arthritis is complex, and many studies have investigated the role of genetic and cytokine balance abnormalities. HLA associations have been confirmed in multiple series, and there is evidence that non-major histocompatibility complex genes might also contribute to disease pathogenesis. Recent studies have added knowledge to the diverse clinical features of the disease, including joint distribution at presentation, association with Turner syndrome, presence of arthritis mutilans, and alterations in mandibulofacial development. Medical treatment remains a challenge. For cases recalcitrant to conventional therapy autologous hemopoietic stem-cell transplantation has been attempted; the risks of this procedure must however be carefully balanced in individual patients.
Topics: Antigens, Differentiation; Antirheumatic Agents; Arthritis, Juvenile; Hematopoietic Stem Cell Transplantation; Immunosuppressive Agents; Methotrexate; Treatment Outcome
PubMed: 10990178
DOI: 10.1097/00002281-200009000-00011 -
Oral and Maxillofacial Surgery Clinics... Feb 2015The temporomandibular joint (TMJ) is one of the many joints involved in the inflammatory arthritides. As imaging of joints has developed, so have the data regarding... (Review)
Review
The temporomandibular joint (TMJ) is one of the many joints involved in the inflammatory arthritides. As imaging of joints has developed, so have the data regarding extent and prevalence of TMJ involvement in these diseases. TMJ disease is especially prevalent in juvenile arthritis. The adult and pediatric inflammatory arthritides share common pathophysiology but are still markedly different. The preponderance of TMJ arthritis research exists in juvenile arthritis. This article discusses classification, treatment, and TMJ involvement in juvenile idiopathic arthritis.
Topics: Adolescent; Adrenal Cortex Hormones; Anti-Inflammatory Agents; Antirheumatic Agents; Arthritis, Juvenile; Biological Products; Child; Diagnostic Imaging; Humans; Oral Surgical Procedures; Prevalence; Temporomandibular Joint Disorders
PubMed: 25483440
DOI: 10.1016/j.coms.2014.09.001 -
Arthritis and Rheumatism 1970
Review
Topics: Adolescent; Age Factors; Arthritis, Juvenile; Aspirin; Child; Child, Preschool; Humans; Radiography
PubMed: 4921517
DOI: No ID Found -
Arthritis and Rheumatism Feb 1966
Review
Topics: Antibodies; Arthritis, Juvenile; Arthritis, Rheumatoid; Diagnosis, Differential; Humans; Rheumatic Fever; Streptolysins; Time Factors
PubMed: 4952903
DOI: 10.1002/art.1780090112 -
Pediatrics in Review Oct 1997
Review
Topics: Antirheumatic Agents; Arthritis, Juvenile; Child; Diagnosis, Differential; Humans; Incidence; Prognosis
PubMed: 9311247
DOI: 10.1542/pir.18-10-337 -
Current Problems in Pediatrics Jul 1994
Review
Topics: Arthritis, Juvenile; Child; Diagnosis, Differential; Humans
PubMed: 7956319
DOI: 10.1016/0045-9380(94)90029-9 -
Indian Journal of Pediatrics 1996The assessment of overall health status of a child with juvenile rheumatoid arthritis (JRA) is complex and multi-dimensional. The general physical examination is... (Review)
Review
The assessment of overall health status of a child with juvenile rheumatoid arthritis (JRA) is complex and multi-dimensional. The general physical examination is complemented by a rheumatological evaluation that includes determination of articular indices of inflammation and duration of inactivity stiffness. Laboratory assessment plays a critical role in monitoring side effects of pharmacologic management, but is limited in its ability to portray accurately the degree of active inflammation. Newly measureable indicators of inflammatory activity, such as serum cytokine and soluble cytokine receptors will likely become part of routine laboratory assessment in the future. Radiographs remain a useful tool for assessing disease progression, but may be replaced in the future by magnetic resonance imaging. In recent years, rheumatologists have realized that measurement of overall physical and psycho-social functional ability, quality of life, and pain are major descriptors to consider during routine follow-up. They are also critical in the assessment of long-term clinical effectiveness. The importance of nutritional assessment has also been realized. This section seeks to describe some of the methodologic approaches currently used to assess the variables mentioned above, and includes a brief discussion of the evolving instrumentation which attempts to measure variables of a more cognitive or subjective aspect.
Topics: Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Female; Humans; Male; Nutritional Status; Pain Measurement; Physical Examination; Prognosis; Range of Motion, Articular
PubMed: 10830003
DOI: 10.1007/BF02751520 -
International Ophthalmology Clinics 2008
Review
Topics: Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Humans; Infant; Uveitis
PubMed: 18645397
DOI: 10.1097/IIO.0b013e31817d998f -
International Ophthalmology Clinics Jan 2022
Topics: Antirheumatic Agents; Arthritis, Juvenile; Humans; Uveitis
PubMed: 34965232
DOI: 10.1097/IIO.0000000000000391 -
Presse Medicale (Paris, France : 1983) Jan 2014Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This... (Review)
Review
Juvenile idiopathic arthritis is a broad term that describes a clinically heterogeneous group of arthritides of unknown cause, which begin before 16 years of age. This term encompasses several disease categories, each of which has distinct clinical signs and, in some cases, genetic background. The cause of disease is still poorly understood but seems to be related to both genetic and environmental factors. Prognosis has greatly improved as a result of substantial progresses in disease management. The most important new development has been the introduction of drugs such as anticytokine agents, which constitute a valuable treatment option for patients who are resistant to conventional antirheumatic agents. Further insights into the disease pathogenesis and treatment will be provided by the continuous advances in the understanding of the mechanisms connected to the immune response and inflammatory process, and by the development of more efficient new drugs.
Topics: Antirheumatic Agents; Arthritis, Juvenile; Diagnosis, Differential; Humans; Prognosis
PubMed: 23886930
DOI: 10.1016/j.lpm.2013.01.073