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Clinical and Experimental Rheumatology 1999Epidemiological studies of chronic arthritis in childhood can provide clues to genetic determinants of disease manifestations and environmental triggers. Available data... (Review)
Review
Epidemiological studies of chronic arthritis in childhood can provide clues to genetic determinants of disease manifestations and environmental triggers. Available data are difficult to compare, however, because of the heterogeneity of the disease, differences in the classification criteria used for definition and inclusion, and differences in source populations and case ascertainment. Nevertheless, when the data are interpreted according to the methodologies used, geographical and ethnic differences can be found with regard to occurrence rates, age at onset, subgroup distribution and immunological markers. Seasonal variations have been detected in systemic disease. Variations in the incidence of childhood arthritis over time have also been observed, indicating environmental influences on disease frequency, while familial aggregations suggest the presence of genetic factors. These epidemiological data from a challenging puzzle which we hope will provide clues to future understanding of etiologies and cures, with the help of basic scientific research.
Topics: Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Cluster Analysis; Female; Global Health; Humans; Incidence; Infant; Male; Prevalence
PubMed: 10410275
DOI: No ID Found -
Arthritis Research 2002Studies have established the magnitude of the genetic basis of juvenile idiopathic arthritis (JIA). JIA is a complex genetic condition and the genes that influence... (Review)
Review
Studies have established the magnitude of the genetic basis of juvenile idiopathic arthritis (JIA). JIA is a complex genetic condition and the genes that influence susceptibility are actively being sought. A candidate gene approach is being used by several groups. MHC-, cytokine- and T-cell-related genes have all been positively associated with JIA. Here we review some of the latest genetic data, and discuss ways in which JIA genetic research might proceed.
Topics: Arthritis, Juvenile; Child; Child, Preschool; Gene Expression Profiling; Genetic Predisposition to Disease; Genotype; Global Health; Humans; International Cooperation; Molecular Epidemiology
PubMed: 12223104
DOI: 10.1186/ar591 -
Annali Italiani Di Medicina Interna :... 2005Juvenile idiopathic arthritis represents a heterogeneous group of autoimmune diseases. It arises before 16 years of age and lasts more than 6 months. We can distinguish... (Review)
Review
Juvenile idiopathic arthritis represents a heterogeneous group of autoimmune diseases. It arises before 16 years of age and lasts more than 6 months. We can distinguish many arthritis sub-types. A serious problem in juvenile idiopathic arthritis is skeletal growth retardation, osteopenia and greater risk of developing fractures. Juvenile idiopathic arthritis diagnosis is an exclusion diagnosis. Many conditions can simulate it. First-choice drugs in juvenile idiopathic arthritis treatment are nonsteroidal anti-inflammatory drugs, analgesic and antipyretic drugs. The second-choice drugs are "slow-acting" antirheumatic drugs, like methotrexate. The use of glucocorticoids is strongly influenced by their side effects, in particular the inhibition of statural growth and the premature appearance of osteoporosis. Recent findings on the central role of tumor necrosis factor-alpha, in particular damage pathogenesis in the course of juvenile idiopathic arthritis, have permitted the development of new therapeutic strategies (infliximab, etanercept), aimed at blocking this cytokine.
Topics: Adolescent; Arthritis, Juvenile; Child; Humans
PubMed: 16610252
DOI: No ID Found -
Pediatric Rheumatology Online Journal May 2022
Topics: Alleles; Arthritis, Juvenile; Celiac Disease; Haplotypes; Humans
PubMed: 35550597
DOI: 10.1186/s12969-022-00694-7 -
The Journal of Rheumatology Sep 1997
Review
Topics: Arthritis, Juvenile; Black People; Child; Humans; White People
PubMed: 9292786
DOI: No ID Found -
La Pediatria Medica E Chirurgica :... 1990Juvenile rheumatoid arthritis (JRA) is the most common rheumatic disease in children. It is one of the more frequent chronic illnesses of childhood and an important... (Review)
Review
Juvenile rheumatoid arthritis (JRA) is the most common rheumatic disease in children. It is one of the more frequent chronic illnesses of childhood and an important cause of disability. Authors review the literature about JRA.
Topics: Arthritis, Juvenile; Child; Diagnosis, Differential; Humans
PubMed: 2087419
DOI: No ID Found -
Revista Clinica Espanola May 2000
Review
Topics: Arthritis, Juvenile; Cytokines; Genetic Markers; Humans; Incidence; Prevalence
PubMed: 10901028
DOI: No ID Found -
International Ophthalmology Clinics 2001
Review
Topics: Adolescent; Arthritis, Juvenile; Child; Child, Preschool; Diagnosis, Differential; Humans; Infant; Uveitis, Anterior
PubMed: 11698750
DOI: 10.1097/00004397-200110000-00020 -
Ocular Immunology and Inflammation 2022To evaluate the long-term efficacy of methotrexate (MTX) monotherapy in patients with juvenile idiopathic arthritis-associated uveitis (JIA-U).
OBJECTIVE
To evaluate the long-term efficacy of methotrexate (MTX) monotherapy in patients with juvenile idiopathic arthritis-associated uveitis (JIA-U).
METHODS
We analyzed a cohort of patients with JIA-U treated with MTX monotherapy, divided into two groups depending on whether MTX was started before (on-MTX group) or after uveitis diagnosis (MTX-naïve group). The primary endpoint was the time between uveitis inactivity and first relapse.
RESULTS
84 patients entered the study. The median duration of remission on MTX monotherapy resulted 8.2 months. The on-MTX group showed a significant longer time interval between arthritis and uveitis onset and higher need for biologic agents (bDMARD). During follow-up, 40 patients (47.6%) needed bDMARD due to poor control of uveitis. Clinical remission off medication was achieved in 11.9% of patients, all belonging to the MTX-naïve group.
CONCLUSIONS
MTX monotherapy, although effective in early stages of JIA-U, showed poor disease control in the long term.
Topics: Humans; Arthritis, Juvenile; Methotrexate
PubMed: 34287104
DOI: 10.1080/09273948.2021.1951303 -
Pediatric Radiology Aug 2006Paediatric rheumatology is a relatively new specialty that has developed rapidly over the last 30 years. There have been major advances, which have included improvements... (Review)
Review
Paediatric rheumatology is a relatively new specialty that has developed rapidly over the last 30 years. There have been major advances, which have included improvements in the classification and management of juvenile idiopathic arthritis (JIA). The former has led to enhanced international collaboration with disease registries, multicentre research and the development of new therapeutic agents. This has resulted in improved disease control and remission induction in many. There is, however, still significant morbidity associated with JIA during childhood, adolescence and adulthood, and challenges for the future include early identification of those with a poorer prognosis, appropriate administration of safe therapies and optimizing outcomes as young people move through adolescence into adulthood.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antirheumatic Agents; Arthritis, Juvenile; Arthrography; Child; Female; Humans; Male
PubMed: 16688446
DOI: 10.1007/s00247-006-0165-7