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Science Progress 2021Paraneoplastic syndromes are rarely seen in gynecological tumors especially in endometrial cancer. Early identification of paraneoplastic syndromes plays a significant... (Review)
Review
Paraneoplastic syndromes are rarely seen in gynecological tumors especially in endometrial cancer. Early identification of paraneoplastic syndromes plays a significant role in the treatment and prognosis of cancer. Here, we reported a rare case with endometrial cancer with a 2.7 cm × 2.2 cm × 3.4 cm lesion in the posterior cervix presenting leukemoid reaction and hypercalcemia as paraneoplastic syndromes simultaneously. During the progress of the endometrial cancer, her leukocyte level rose up to 60.7 × 10/L after anti-infection treatment. Meanwhile, the patient represented a series of severe clinical situation including hypercalcemia, hypokalemia, metabolic alkalosis. and respiratory failure. Finally, the patient died of respiratory circulatory failure 2 weeks later. In addition to symptomatic treatment, possible treatment targeted on the primary tumor as early as possible might help to improve the clinical prognosis.
Topics: Endometrial Neoplasms; Female; Humans; Hypercalcemia; Leukemoid Reaction; Leukocytes; Paraneoplastic Syndromes
PubMed: 33844610
DOI: 10.1177/00368504211004028 -
Indian Pediatrics Feb 2021
Topics: Humans; Leukemoid Reaction; Nasopharyngeal Carcinoma; Nasopharyngeal Neoplasms; Paraneoplastic Syndromes
PubMed: 33632959
DOI: No ID Found -
The Journal of Thoracic and... Apr 2018
Topics: Aged; Aortic Valve; Aortic Valve Stenosis; Diagnosis, Differential; Female; Heart Valve Prosthesis Implantation; Humans; Leukemoid Reaction; Leukocytes; Predictive Value of Tests; Treatment Outcome
PubMed: 29366572
DOI: 10.1016/j.jtcvs.2017.08.125 -
Journal of the College of Physicians... Sep 2022Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare and aggressive inflammatory myofibroblastic tumour (IMT) variant. This report identifies the first case...
Epithelioid inflammatory myofibroblastic sarcoma (EIMS) is a rare and aggressive inflammatory myofibroblastic tumour (IMT) variant. This report identifies the first case of EIMS with leukemoid reaction. This is also the first case in which pancreatic infiltration occurred from the disease onset. A 14-year male patient presented with an 18×18×10 cm mass at the retroperitoneal space and a white blood cell (WBC) count of 85×109/L. The mass and the invaded tissues were surgically removed with tumour-free margins. Histopathology and bone marrow aspiration confirmed the diagnosis of EIMS with leukemoid reaction. The tumour recurred with hepatic and pulmonary metastasis one month after the surgery. WBC count also increased progressively with the tumour recurrence. There is no consensus on the treatment of EIMS. Since ALK rearrangement presents in all the EIMS cases, surgical resection combined with crizotinib or other targeted drugs may improve the prognosis. Key Words: Sarcoma, Soft tissue neoplasms, Leukemoid reaction, Crizotinib.
Topics: Crizotinib; Humans; Leukemoid Reaction; Male; Neoplasm Recurrence, Local; Sarcoma; Soft Tissue Neoplasms
PubMed: 36089724
DOI: 10.29271/jcpsp.2022.09.1212 -
The Journal of Pediatrics Mar 1972
Review
Topics: Age Factors; Child, Preschool; Chromosome Aberrations; Collagen Diseases; Diagnosis, Differential; Eosinophils; Female; Humans; Infant; Karyotyping; Leukemia, Myeloid; Leukemoid Reaction; Prognosis; Sex Factors
PubMed: 4552149
DOI: 10.1016/s0022-3476(72)80499-2 -
Indian Pediatrics Nov 2015
Topics: Child; Child, Preschool; Female; History, 20th Century; History, 21st Century; Humans; Infant; Infant, Newborn; Leukemoid Reaction; Male
PubMed: 26615346
DOI: 10.1007/s13312-015-0755-2 -
Romanian Journal of Internal Medicine =... Sep 2019Several diagnoses have been associated with leukemoid reaction (LR). In patients with LR the diagnostic and prognostic value of detailed manual blood smear counts (such... (Review)
Review
INTRODUCTION
Several diagnoses have been associated with leukemoid reaction (LR). In patients with LR the diagnostic and prognostic value of detailed manual blood smear counts (such as the percentage of band cells or grading of neutrophil toxic changes) has not been studied previously.
METHODS
We prospectively recorded all hospitalized adult (> 18 years old) patients with LR (≥ 30000/ul) of neutrophilic predominance, excluding patients with pre-existing leukocytosis due to hematological malignancies. We examined the diagnoses and prognosis (in-hospital mortality and post-discharge mortality up to a year after the end of the study) of these patients as well as the value of manual peripheral smear review.
RESULTS
We recorded a total of 93 patients with LR from January 2017 to December 2017. Infection was the most common diagnosis (70%), followed by malignancy (7.5%) and bleeding (6.5%). In-hospital mortality (45%) and post-discharge mortality (35% of those discharged) were very high. Among blood smear findings, only neutrophil vacuolation was significantly more common in patients with infections (34%), although it was also observed in many patients without any infection (13%). Blood smear findings were not associated with prognosis.
CONCLUSION
Detailed manual smear review is a labor-intensive procedure and it has limited diagnostic and prognostic value in unselected hospitalized patients with neutrophilic LR.
Topics: Adult; Aged; Aged, 80 and over; Blood Cell Count; C-Reactive Protein; Female; Hemorrhage; Hospital Mortality; Hospitalization; Humans; Infections; Leukemoid Reaction; Male; Middle Aged; Neoplasms; Neutrophils; Prognosis; Prospective Studies
PubMed: 30862764
DOI: 10.2478/rjim-2019-0006 -
Indian Journal of Pediatrics Nov 2016
Topics: Humans; Leukemoid Reaction; Malaria, Falciparum
PubMed: 27352841
DOI: 10.1007/s12098-016-2192-1 -
The Journal of Pediatrics Sep 1972
Topics: Child; Eosinophilia; Humans; Leukemoid Reaction; Leukocyte Count; Male
PubMed: 5049840
DOI: 10.1016/s0022-3476(72)80209-9 -
Ryoikibetsu Shokogun Shirizu 1998