-
BMJ (Clinical Research Ed.) Nov 1994
Topics: Child; Glossectomy; Humans; Macroglossia; Mental Disorders
PubMed: 7819836
DOI: 10.1136/bmj.309.6966.1386 -
International Journal of Oral and... Apr 2018Massive swelling of the tongue can occur after posterior fossa and craniofacial surgery. Several hypotheses have been proposed to explain the occurrence of such severe... (Review)
Review
Massive swelling of the tongue can occur after posterior fossa and craniofacial surgery. Several hypotheses have been proposed to explain the occurrence of such severe postoperative macroglossia, but this phenomenon is still poorly understood. Severe postoperative macroglossia can be a life-threatening condition due to upper airway obstruction. Three cases of severe postoperative macroglossia that occurred after cervical spine, craniofacial, and posterior fossa surgical procedures are reported here. These cases required specialized maxillofacial management and a prolonged stay in the intensive care unit. Causal factors involved in this condition are reported, in order to highlight appropriate prevention and treatment options adapted to the management of paediatric patients. An overview of the current literature on severe postoperative macroglossia in paediatric populations is also provided.
Topics: Adolescent; Cervical Vertebrae; Child; Cranial Fossa, Posterior; Craniofacial Abnormalities; Female; Humans; Infant; Macroglossia; Male; Postoperative Complications
PubMed: 29301676
DOI: 10.1016/j.ijom.2017.12.003 -
Critical Care Medicine Aug 1999
Review
Topics: Bites, Human; Critical Care; Humans; Macroglossia; Mouth Protectors; Patient Selection; Tongue
PubMed: 10470802
DOI: 10.1097/00003246-199908000-00070 -
European Journal of Neurology Jul 2022Pompe disease is a rare neuromuscular disorder caused by a deficiency of a lysosomal enzyme, acid α-glucosidase. Macroglossia is a classic clinical sign of several...
BACKGROUND
Pompe disease is a rare neuromuscular disorder caused by a deficiency of a lysosomal enzyme, acid α-glucosidase. Macroglossia is a classic clinical sign of several inherited myopathies and has also been reported to occur progressively in late-onset Pompe disease (LOPD).
METHODS
We describe patients with LOPD and macroglossia included in the French national Pompe disease registry. Clinical, functional, and radiological data were collected during periodic follow-up and analyzed retrospectively. These cases were compared with 15 previously reported cases.
RESULTS
Five patients, three females and two males, aged 71-88 years, were included in this study. All but one of the patients suffered from symptoms related to macroglossia before the diagnosis of Pompe disease. Three had localized tongue atrophy and one had significant localized tongue hypertrophy which led to glossectomy 10 years before diagnosis. Two patients had severe dysphagia, one of whom underwent gastrostomy for enteral nutritional support. One patient experienced the persistence of numerous sleep apneas despite nocturnal bilevel positive airway pressure (BiPAP) ventilation. All our patients had dysarthria, and two required speech therapy. Four patients had a tongue hypersignal on magnetic resonance imaging (MRI) T1 sequences.
CONCLUSIONS
Detection of macroglossia should be part of the clinical diagnosis and follow-up of patients with LOPD, with a careful evaluation of its main consequences. Macroglossia can have severe functional impacts on speech, swallowing, and sleep. Whole-body MRI with facial sections may facilitate the early diagnosis of Pompe disease with the "bright tongue sign".
Topics: Aged; Aged, 80 and over; Female; Glycogen Storage Disease Type II; Humans; Macroglossia; Male; Retrospective Studies; alpha-Glucosidases
PubMed: 35302691
DOI: 10.1111/ene.15330 -
Head and Neck Pathology Sep 2019Cervicofacial actinomycosis is a common form of Actinomyces infection. However, the latter seldom occurs in the tongue. We present a case of a 66 year-old man with... (Review)
Review
Cervicofacial actinomycosis is a common form of Actinomyces infection. However, the latter seldom occurs in the tongue. We present a case of a 66 year-old man with macroglossia caused by actinomycosis of the tongue. Radiographic features were compatible with a chronic inflammatory disease. Biopsies revealed granulomas containing giant cells and Gram positive bacterial clusters consistent with actinomycosis. The patient was treated with a 22 week course of antibiotics. Imaging showed a notable improvement in the extent of the lesions 1 year later. The patient was asymptomatic and in good condition during his second year follow-up. Diagnosis of actinomycosis of the tongue can prove to be challenging because of the non-specific nature of its symptoms, clinical signs, and radiographic features. Isolation of Actinomyces sp. is an added diagnostic hurdle, because of its fastidious nature.
Topics: Actinomycosis, Cervicofacial; Aged; Humans; Macroglossia; Male
PubMed: 30244331
DOI: 10.1007/s12105-018-0966-7 -
Oral Surgery, Oral Medicine, Oral... Jan 2019We describe here a new surgical technique, which allows for efficient tongue reduction with satisfactory appearance and avoids the complications of tip excision. (Review)
Review
OBJECTIVE
We describe here a new surgical technique, which allows for efficient tongue reduction with satisfactory appearance and avoids the complications of tip excision.
STUDY DESIGN
This is a retrospective case review that includes 6 patients who had macroglossia and underwent tongue reduction using our new central V-shaped excision technique. Three patients were operated on at an early age because of significant macroglossia with permanent tongue protrusion, cosmetic disorder, and speech delay. The other 3 patients underwent surgery performed in their teenage years because medical treatment had been unsuccessful. We assessed tongue shape, mobility, taste, and sensitivity.
RESULTS
The postoperative follow-up period ranged from 2 months to 16 years (average 7 years). On subjective evaluation, all patients were satisfied with the appearance of the tongue and reported no sensitive or sensory difficulties. The patients reported normal food progression in the oral cavity. Objective evaluation showed that the tongue had normal mobility, taste, and sensitivity. Postoperatively, there was no residual tongue protrusion, cosmetic disorder, or speech delay. None of the patients needed revision surgery.
CONCLUSIONS
This central V-shaped excision offers good surgical results, with efficient tongue reduction and none of the complications of other tongue reduction techniques, such as tip amputation or anterior wedge resection.
Topics: Glossectomy; Humans; Macroglossia; Retrospective Studies; Tongue
PubMed: 30241724
DOI: 10.1016/j.oooo.2018.06.013 -
Oral Surgery, Oral Medicine, and Oral... Jun 1948
Topics: Humans; Macroglossia; Tooth Extraction
PubMed: 18863885
DOI: 10.1016/0030-4220(48)90244-8 -
Journal of Infection and Public Health Jan 2022SARS-CoV-2 infection can lead to a variety of clinical manifestations. The occurrence of tongue swelling has recently reported in severe cases of COVID-19, and...
SARS-CoV-2 infection can lead to a variety of clinical manifestations. The occurrence of tongue swelling has recently reported in severe cases of COVID-19, and angioedema has suggested as the causative mechanism. Several factors, such as genetic predisposing factor and angiotensin-converting enzyme inhibitors (ACEI) therapies, have proposed to induce angioedema, especially as concerns patients requiring ICU treatments. Nevertheless, the question is still debated and other causes not yet recognized should be considered. Here we present a case of macroglossia occurred in a patient deceased for COVID-19 disease, who had no family history of angioedema and did not receive ACEI as antihypertensive drug. Histological and immune-histochemical analysis revealed tongue muscle atrophy with infiltrating macrophages suggesting repair mechanisms, as seen in nerve injury recovery. These new pathological findings may open new fields of study on the pathogenesis of SARS-CoV-2.
Topics: Angioedema; Angiotensin-Converting Enzyme Inhibitors; COVID-19; Humans; Macroglossia
PubMed: 34764043
DOI: 10.1016/j.jiph.2021.10.026 -
International Journal of Pediatric... Jan 2021Acute macroglossia and laryngeal edema are rare adverse side effects that can cause life-threatening airway obstruction. We report a case of acute macroglossia that...
Acute macroglossia and laryngeal edema are rare adverse side effects that can cause life-threatening airway obstruction. We report a case of acute macroglossia that began after initiation of ethosuximide in a 15-year-old female with severe medically refractory epilepsy. Macroglossia worsened over the next two weeks of ethosuximide administration, preventing extubation. Macroglossia and laryngeal edema improved upon ethosuximide wean, and completely resolved after discontinuation. The patient was extubated successfully, with precautionary nasal trumpet placement and dexamethasone administration prior to extubation. In medically complex patients on multiple pharmacologic agents, anti-epileptic drugs should be suspected as a possible cause of acute macroglossia.
Topics: Adolescent; Airway Extubation; Airway Obstruction; Edema; Ethosuximide; Female; Humans; Macroglossia
PubMed: 33218689
DOI: 10.1016/j.ijporl.2020.110498 -
Oral Diseases Nov 2022
Topics: Glossectomy; Humans; Macroglossia; Tongue
PubMed: 36214532
DOI: 10.1111/odi.14163