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Journal of Oral and Maxillofacial... May 2015Macroglossia is a rare condition, but can severely affect the oral and maxillofacial region. Angioedema is a condition resulting from multiple mechanisms, all of which... (Review)
Review
Macroglossia is a rare condition, but can severely affect the oral and maxillofacial region. Angioedema is a condition resulting from multiple mechanisms, all of which can result in macroglossia. This report describes an unusual case of acquired macroglossia in an adult resulting from chronic edema secondary to angioedema in the setting of stroke. The patient had a morbidly enlarged tongue and presented with clinical signs and symptoms consistent with massive macroglossia. She required surgical intervention for acute management of her symptoms and definitive treatment of her macroglossia.
Topics: Angioedema; Female; Humans; Macroglossia; Middle Aged; Stroke; Tomography, X-Ray Computed
PubMed: 25883001
DOI: 10.1016/j.joms.2014.12.029 -
Ear, Nose, & Throat Journal Jun 2005Amyloidosis is characterized by an abnormal extracellular deposition of amyloid in different tissues and organs, where it usually causes some type of dysfunction. Its... (Review)
Review
Amyloidosis is characterized by an abnormal extracellular deposition of amyloid in different tissues and organs, where it usually causes some type of dysfunction. Its cause is unknown. The two main forms of amyloidosis are systemic and localized; the latter is rare. No satisfactory treatment for systemic amyloidosis has been discovered, and mean survival is poor, ranging from 5 to 15 months depending on the presence or absence of multiple myeloma. We report a case of primary systemic amyloidosis in a 71-year-old man. The diagnosis of amyloidosis was established by tongue biopsy, and its systemic nature was identified by analysis of aspirated abdominal fat. At the 1-year follow-up, the patient's clinical condition had not changed, and he was thereafter lost to follow-up.
Topics: Aged; Amyloidosis; Deglutition Disorders; Diagnosis, Differential; Humans; Macroglossia; Male; Submandibular Gland Neoplasms; Tomography, X-Ray Computed
PubMed: 16075859
DOI: No ID Found -
Canadian Journal of Anaesthesia =... Mar 2022
Topics: Child; Craniotomy; Humans; Infratentorial Neoplasms; Macroglossia; Patient Positioning; Postoperative Complications; Prone Position
PubMed: 34854023
DOI: 10.1007/s12630-021-02153-5 -
International Journal of Orthodontics...The tongue is a vital human organ that needs to be checked before beginning a dental treatment, especially one in orthodontics or sleep apnea. The size of the tongue is...
The tongue is a vital human organ that needs to be checked before beginning a dental treatment, especially one in orthodontics or sleep apnea. The size of the tongue is an issue because there is not yet a clear definition of what a normal-sized tongue is. This leads to further problems in defining macroglossia. The current article aims to define macroglossia and bringforth more information about the two different types: pseudo macroglossia and true macroglossia. It further discusses treatment solutions available, such as partial glossectomies, coblation technique, and radiofrequency waves treatment.
Topics: Glossectomy; Humans; Macroglossia; Tongue
PubMed: 29799703
DOI: No ID Found -
Lancet (London, England) Apr 1947
Topics: Amyloid; Amyloidosis; Humans; Macroglossia; Tongue Diseases
PubMed: 20340277
DOI: 10.1016/s0140-6736(47)91655-3 -
Lancet (London, England) Mar 1947
Topics: Amyloid; Amyloidosis; Humans; Macroglossia; Tongue Diseases
PubMed: 20288320
DOI: 10.1016/s0140-6736(47)90176-1 -
BMJ Case Reports Jul 2022We encountered a man in his 60s presenting with worsening macroglossia. The patient underwent extensive otolaryngology evaluation and was diagnosed with primary (AL)...
We encountered a man in his 60s presenting with worsening macroglossia. The patient underwent extensive otolaryngology evaluation and was diagnosed with primary (AL) amyloidosis on tongue biopsy with Congo red stain. The patient then underwent a bone marrow biopsy and was also found to have concurrent multiple myeloma. He started induction therapy with daratumumab and CyBorD (cyclophosphamide, bortezomib, dexamethasone). Cardiac MRI revealed extensive cardiac amyloidosis and the patient was deemed high risk for autologous stem cell transplant (auto-HCT). Unfortunately, the patient underwent hospitalisation for heart failure exacerbation requiring extensive medical management and passed away as a result of this pathology. AL amyloidosis is a rare disease to begin with and macroglossia as the only presenting sign is notable. This case emphasises the importance of considering AL amyloidosis in patients presenting with similar complaints as macroglossia can be attributed to other less serious aetiologies.
Topics: Amyloidosis; Humans; Immunoglobulin Light-chain Amyloidosis; Macroglossia; Male; Multiple Myeloma
PubMed: 35817492
DOI: 10.1136/bcr-2022-249737 -
Skeletal Muscle Oct 2022Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes the plasma membrane of myofibers. The orofacial...
BACKGROUND
Duchenne muscular dystrophy (DMD) is an X-linked muscle disease caused by a complete lack of dystrophin, which stabilizes the plasma membrane of myofibers. The orofacial function is affected in an advanced stage of DMD and this often leads to an eating disorder such as dysphagia. Dysphagia is caused by multiple etiologies including decreased mastication and swallowing. Therefore, preventing the functional declines of mastication and swallowing in DMD is important to improve the patient's quality of life. In the present study, using a rat model of DMD we generated previously, we performed analyses on the masseter and tongue muscles, both are required for proper eating function.
METHODS
Age-related changes of the masseter and tongue muscle of DMD rats were analyzed morphometrically, histologically, and immunohistochemically. Also, transcription of cellular senescent markers, and utrophin (Utrn), a functional analog of dystrophin, was examined.
RESULTS
The masseter muscle of DMD rats showed progressive dystrophic changes as observed in their hindlimb muscle, accompanied by increased transcription of p16 and p19. On the other hand, the tongue of DMD rats showed macroglossia due to hypertrophy of myofibers with less dystrophic changes. Proliferative activity was preserved in the satellite cells from the tongue muscle but was perturbed severely in those from the masseter muscle. While Utrn transcription was increased in the masseter muscle of DMD rats compared to WT rats, probably due to a compensatory mechanism, its level in the tongue muscle was comparable between WT and DMD rats and was similar to that in the masseter muscle of DMD rats.
CONCLUSIONS
Muscular dystrophy is less advanced in the tongue muscle compared to the masseter muscle in the DMD rat.
Topics: Mice; Rats; Animals; Dystrophin; Muscular Dystrophy, Duchenne; Utrophin; Mice, Inbred mdx; Macroglossia; Deglutition Disorders; Quality of Life; Muscle, Skeletal; Tongue
PubMed: 36258243
DOI: 10.1186/s13395-022-00307-7 -
Journal of Ayub Medical College,... 2022Amyloidosis is characterised by the deposition of fibrillar insoluble proteinaceous material called amyloid in the extracellular spaces. It may present as localized form...
Amyloidosis is characterised by the deposition of fibrillar insoluble proteinaceous material called amyloid in the extracellular spaces. It may present as localized form which is rare and systemic form. Systemic amyloidosis involves many organs like kidney, heart and liver. Manifestations of both types may vary based on the age of onset, degree and extension of the deposition. Understandably, the diagnosis is challenging but the early identification of the condition and the type of amyloidosis can increase the efficiency of treatment. Positive Congo red staining is the gold standard for demonstration of amyloid in tissue sections. Here we are presenting a case of a 77-year-old female patient who presented with the complaint of difficulty in swallowing for 2 years due to bilateral symmetrical enlargement of the tongue which was subsequently diagnosed as systemic amyloidosis.
Topics: Aged; Amyloidosis; Female; Humans; Immunoglobulin Light-chain Amyloidosis; Macroglossia; Tongue
PubMed: 35466653
DOI: 10.55519/JAMC-01-9317 -
The Annals of Otology, Rhinology, and... Sep 1993A case of severe macroglossia resulting from trauma (tongue biting) during eclampsia and causing respiratory obstruction is described. Despite medical treatment with...
A case of severe macroglossia resulting from trauma (tongue biting) during eclampsia and causing respiratory obstruction is described. Despite medical treatment with steroids and antibiotics for a week, followed by tracheostomy, no significant improvement was observed. After an energetic but cautious maneuver of reducing and restraining the tongue in the oral cavity, the swelling reduced dramatically in 24 to 48 hours. Earlier manual replacement of the tongue into the oral cavity is advised in order to arrest the cycle of venous and lymphatic obstruction and congestion that leads to further edema and increased tongue swelling. The mechanism of traumatic macroglossia is discussed.
Topics: Adult; Eclampsia; Female; Hematoma; Humans; Macroglossia; Oral Hemorrhage; Pregnancy; Puerperal Disorders; Seizures; Tongue
PubMed: 8373099
DOI: 10.1177/000348949310200915