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The American Journal of Dermatopathology Jan 2020
Review
Topics: Acupuncture Therapy; Biopsy, Needle; Diagnosis, Differential; Humans; Immunohistochemistry; Low Back Pain; Male; Middle Aged; Nevus, Blue; Ochronosis; Pigmentation Disorders; Rare Diseases
PubMed: 31880637
DOI: 10.1097/DAD.0000000000001267 -
BMJ (Clinical Research Ed.) Dec 2023
PubMed: 38061779
DOI: 10.1136/bmj-2023-077135 -
Actas Dermo-sifiliograficas Jan 2021
Topics: Humans; Melanosis; Nevus, Pigmented; Scalp; Skin Abnormalities; Skin Neoplasms
PubMed: 33049275
DOI: 10.1016/j.ad.2019.04.021 -
Head and Neck Pathology Jun 2023Congenital melanotic macule of the tongue (CMMT) has been described as a distinct entity, despite its unknown etiology. However, the diagnosis and management of affected... (Review)
Review
BACKGROUND
Congenital melanotic macule of the tongue (CMMT) has been described as a distinct entity, despite its unknown etiology. However, the diagnosis and management of affected newborns may challenge clinicians and pediatric dentists.
METHODS
We document here the clinicopathological findings of two additional cases of CMMT. A literature review of CMMT reports identified across PubMed, Web of Science, Embase, and Scopus was also conducted.
RESULTS
The patients, 2- and 4 month-old Venezuelan boys, respectively, presented at birth with a single or multiple dark-brown-pigmented macule exclusively on the dorsum of the tongue. Histopathological features revealed increased melanin pigmentation in the basal epithelial layer with overlying hyperkeratosis and pigment-laden subepithelial macrophages with normal morphological appearance. Nine studies comprising 17 cases of CMMT have been described hitherto. Most cases were from the USA and France (n = 6 each). Twelve (70.6%) patients were males, eight (50%) were white, and median age was 2.7 months. CMMT presented as brownish to black, solitary or multiple pigmentations located in the right or left region of the dorsum of the tongue, ranging in size from 3.0 to 30.0 mm.
CONCLUSION
An important feature for the diagnosis of CMMT is the information about the manifestation at birth and consequent proportional growth. This report intends to draw the attention of pediatricians and dentists to this apparently underdiagnosed condition for decision-making and management of affected newborns.
Topics: Male; Child; Humans; Infant, Newborn; Infant; Female; Melanosis; Pigmentation Disorders; Tongue Diseases; Tongue; Pigmentation
PubMed: 36723851
DOI: 10.1007/s12105-023-01530-4 -
Cutis Feb 2022
Topics: Arm; Humans; Melanosis; Skin Abnormalities; Upper Extremity
PubMed: 35659809
DOI: 10.12788/cutis.0447 -
Dermatology Practical & Conceptual Oct 2021
PubMed: 35024231
DOI: 10.5826/dpc.1104a122 -
Actas Dermo-sifiliograficas May 2020
Topics: Eyelids; Humans; Port-Wine Stain; Skin Abnormalities
PubMed: 31122648
DOI: 10.1016/j.ad.2018.05.018 -
JAAD Case Reports Feb 2019
PubMed: 30733985
DOI: 10.1016/j.jdcr.2018.11.020 -
International Journal of Molecular... May 2023McCune-Albright syndrome (MAS) is a rare sporadic condition defined by the classic triad of fibrous dysplasia of bone, café au lait skin macules, and hyperfunctioning... (Review)
Review
McCune-Albright syndrome (MAS) is a rare sporadic condition defined by the classic triad of fibrous dysplasia of bone, café au lait skin macules, and hyperfunctioning endocrinopathies. The molecular basis of MAS has been ascribed to the post-zygotic somatic gain-of-function mutations in the gene, which encodes the alpha subunit of G proteins, leading to constitutive activation of several G Protein-Coupled Receptors (GPCRs). The co-occurrence of two of the above-mentioned cardinal clinical manifestations sets the diagnosis at the clinical level. In this case report, we describe a 27-month-old girl who presented with gonadotropin-independent precocious puberty secondary to an estrogen-secreting ovarian cyst, a café au lait skin macule and growth hormone, and prolactin excess, and we provide an updated review of the scientific literature on the clinical features, diagnostic work-up, and therapeutic management of MAS.
Topics: Female; Humans; Child, Preschool; Fibrous Dysplasia, Polyostotic; Puberty, Precocious; Endocrine System Diseases; Human Growth Hormone; Cafe-au-Lait Spots
PubMed: 37239810
DOI: 10.3390/ijms24108464 -
The American Journal of Dermatopathology Jan 2020
Topics: Acupuncture Therapy; Biopsy, Needle; Chronic Pain; Diagnosis, Differential; Follow-Up Studies; Humans; Immunohistochemistry; Low Back Pain; Male; Middle Aged; Nevus, Blue; Ochronosis; Pigmentation Disorders; Rare Diseases
PubMed: 30308544
DOI: 10.1097/DAD.0000000000001268