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Dermatology Online Journal Feb 2017Tinea versicolor (TV) is typically an asymptomatic fungal infection of the stratum corneum owing to Malassezia overgrowth. It presents as hypo or hyperpigmented macules...
Tinea versicolor (TV) is typically an asymptomatic fungal infection of the stratum corneum owing to Malassezia overgrowth. It presents as hypo or hyperpigmented macules with fine scale that coalesce into patches on the trunk, neck, and/or arms. Presented in this report is a 34-year-old man with an interesting case of folliculocentric tinea versicolor manifesting as perifollicular hypopigmented macules on the lower back.
Topics: Adult; Hair Follicle; Humans; Hypopigmentation; Male; Tinea Versicolor
PubMed: 28329492
DOI: No ID Found -
Oral Surgery, Oral Medicine, and Oral... Sep 1979A series of 105 cases of melanotic macule of the oral mucosa is analyzed, both clinically and histologically. In most patients the melanotic macule was a solitary...
A series of 105 cases of melanotic macule of the oral mucosa is analyzed, both clinically and histologically. In most patients the melanotic macule was a solitary lesion, and the most common location was the vermilion border, followed by the gingiva. Histologically, the melanotic macule is characterized by increased pigmentation in either the basal-cell layer, the lamina propria (mainly within melanophages), or in both locations. It is suggested that the term melanotic macule be reserved for lesions in which there is a definite clinicopathologic correlation between a clinically pigmented macule and the aforementioned histologic features and that the term focal melanosis be used only as a histologic designation when these features appear in clinically nonpigmented pathologic conditions.
Topics: Adolescent; Adult; Aged; Child; Child, Preschool; Diagnosis, Differential; Female; Humans; Lentigo; Male; Melanins; Melanosis; Middle Aged; Mouth Diseases; Mouth Mucosa; Pigmentation Disorders; Terminology as Topic
PubMed: 289929
DOI: 10.1016/0030-4220(79)90011-2 -
Actas Dermo-sifiliograficas Jun 2024
PubMed: 38857844
DOI: 10.1016/j.ad.2024.02.034 -
Molecular Genetics & Genomic Medicine Oct 2020Neurofibromatosis type 1 (NF1) is a tumor-predisposition disorder that arises due to pathogenic variants in tumor suppressor NF1. NF1 has variable expressivity that may...
BACKGROUND
Neurofibromatosis type 1 (NF1) is a tumor-predisposition disorder that arises due to pathogenic variants in tumor suppressor NF1. NF1 has variable expressivity that may be due, at least in part, from heritable elements such as modifier genes; however, few genetic modifiers have been identified to date.
METHODS
In this study, we performed a genome-wide association analysis of the number of café-au-lait macules (CALM) that are considered a tumor-like trait as a clinical phenotype modifying NF1.
RESULTS
A borderline genome-wide significant association was identified in the discovery cohort (CALM1, N = 112) between CALM number and rs12190451 (and rs3799603, r = 1.0; p = 7.4 × 10 ) in the intronic region of RPS6KA2. Although, this association was not replicated in the second cohort (CALM2, N = 59) and a meta-analysis did not show significantly associated variants in this region, a significant corroboration score (0.72) was obtained for the RPS6KA2 signal in the discovery cohort (CALM1) using Complementary Pairs Stability Selection for Genome-Wide Association Studies (ComPaSS-GWAS) analysis, suggesting that the lack of replication may be due to heterogeneity of the cohorts rather than type I error.
CONCLUSION
rs12190451 is located in a melanocyte-specific enhancer and may influence RPS6KA2 expression in melanocytes-warranting further functional studies.
Topics: Adult; Cafe-au-Lait Spots; Female; Humans; Male; Middle Aged; Neurofibromatosis 1; Polymorphism, Single Nucleotide; Ribosomal Protein S6 Kinases, 90-kDa
PubMed: 32869517
DOI: 10.1002/mgg3.1400 -
Actas Dermo-sifiliograficas Jun 2007
Topics: Adult; Dental Amalgam; Gingival Diseases; Humans; Hyperpigmentation; Male
PubMed: 17555684
DOI: 10.1016/s0001-7310(07)70085-6 -
Acta Dermato-venereologica 2008
Topics: Dermis; Dermoscopy; Female; Humans; Lip Diseases; Melanosis; Middle Aged
PubMed: 18779902
DOI: 10.2340/00015555-0493 -
Indian Dermatology Online Journal 2015
PubMed: 26009730
DOI: 10.4103/2229-5178.156439 -
International Journal of STD & AIDS Nov 2004There are two opposing schools of thought regarding the management of pigmented penile macules. Allan and Spitz, as well as Pack and Davis, are of the opinion that... (Review)
Review
There are two opposing schools of thought regarding the management of pigmented penile macules. Allan and Spitz, as well as Pack and Davis, are of the opinion that almost all pigmented naevi present on the palms, soles and genitalia are junctional naevi and have a higher incidence of malignant change and, therefore, should be removed. On the other hand, because most cases of penile and urethral melanomas arise de novo with only a few arising from previous long-standing naevi and as precursor lesions are not identified in most cases, Scott et al. and Stegmaire et al. consider prophylactic excision unnecessary. A more practical approach has been taken up by Barnhill et al. and their view is that management should be individualized with multiple biopsies to establish the diagnosis. The purpose of this paper is to review the literature regarding the natural history, risk of melanoma development on the penis and the management of cases presenting with pigmented penile macules.
Topics: Humans; Male; Melanoma; Nevus, Pigmented; Penile Neoplasms; Skin Neoplasms
PubMed: 15537454
DOI: 10.1258/0956462042395276 -
Practical Neurology Mar 2024Two patients presented with side-locked frontal head pain, involving the supraorbital nerve territory, with an associated hypopigmented macule. The clinical progress and...
Two patients presented with side-locked frontal head pain, involving the supraorbital nerve territory, with an associated hypopigmented macule. The clinical progress and nerve biopsy in one indicated leprosy. In endemic regions, supraorbital neuralgia may be caused by leprosy sometimes without other neurocutaneous markers.
Topics: Humans; Neuralgia; Headache; Leprosy
PubMed: 37949660
DOI: 10.1136/pn-2023-003844 -
Cureus Feb 2023In this case report, we outline a case of a 36-year-old woman who presented to the dermatology clinic with a history of a hypopigmented macule on her lip. After...
In this case report, we outline a case of a 36-year-old woman who presented to the dermatology clinic with a history of a hypopigmented macule on her lip. After conducting hepatitis C antibody testing and a shave biopsy, the patient was diagnosed with lichen sclerosus. Because of the increased risk for squamous cell carcinoma, she underwent an anogenital exam, where no lesions were found.
PubMed: 36968933
DOI: 10.7759/cureus.35234