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Nature Communications Jan 2024A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is...
A subgroup of patients infected with SARS-CoV-2 remain symptomatic over three months after infection. A distinctive symptom of patients with long COVID is post-exertional malaise, which is associated with a worsening of fatigue- and pain-related symptoms after acute mental or physical exercise, but its underlying pathophysiology is unclear. With this longitudinal case-control study (NCT05225688), we provide new insights into the pathophysiology of post-exertional malaise in patients with long COVID. We show that skeletal muscle structure is associated with a lower exercise capacity in patients, and local and systemic metabolic disturbances, severe exercise-induced myopathy and tissue infiltration of amyloid-containing deposits in skeletal muscles of patients with long COVID worsen after induction of post-exertional malaise. This study highlights novel pathways that help to understand the pathophysiology of post-exertional malaise in patients suffering from long COVID and other post-infectious diseases.
Topics: Humans; Post-Acute COVID-19 Syndrome; SARS-CoV-2; Case-Control Studies; COVID-19; Fatigue; Musculoskeletal Abnormalities; Muscle, Skeletal; Pain; Plaque, Amyloid
PubMed: 38177128
DOI: 10.1038/s41467-023-44432-3 -
Western Journal of Nursing Research May 2019
Topics: Career Mobility; Faculty, Nursing; Humans
PubMed: 30658559
DOI: 10.1177/0193945918825445 -
JAMA Jun 2022
Topics: Humans; Jaundice
PubMed: 35696255
DOI: 10.1001/jama.2022.8384 -
Journal of Medical Entomology Sep 2022This review describes an innovative and efficient modification of a type of Malaise trap meme overlooked in a recent review of such insect traps. It further identifies... (Review)
Review
This review describes an innovative and efficient modification of a type of Malaise trap meme overlooked in a recent review of such insect traps. It further identifies the large variety of dipteran parasites of vertebrates caught in the traps when CO2 was added as an attractant that otherwise rarely were caught in unbaited traps. Baited trap catches of parasitic flies mimicked those caught attacking cervid hosts. This review particularly focuses on comprehensive studies of: 1) several hematophagous species of largely unknown snipe flies (Diptera: Rhagionidae: Symphoromyia [Artiodactyla: Cervidae]) found host specific for Columbian black-tailed deer (Odocoileus hemionus columbianus Richardson), and 2) the biology of oestrid fly (Diptera: Oestridae) parasites of black-tailed deer and caribou/reindeer [Rangifer tarandus (L.) (Artiodactyla: Cervidae)], after it was discovered that the non-hematophagous females are guided to their vertebrate hosts by tracking a source of CO2, as done by many hematophagous flies.
Topics: Animals; Carbon Dioxide; Deer; Diptera; Female; Insecta; Reindeer
PubMed: 35863983
DOI: 10.1093/jme/tjac088 -
Nutrients Oct 2021As medical doctors, we routinely check patient blood chemistry and CBC data to diagnose disease. However, these data and methods of analysis are very rarely used to find... (Review)
Review
As medical doctors, we routinely check patient blood chemistry and CBC data to diagnose disease. However, these data and methods of analysis are very rarely used to find pre-disease conditions or treat undiagnosed malaise. Masatoshi Kaneko Ph.D. found that many pre-disease conditions and types of malaise could be detected using his unique method of blood data analysis, and could also be treated using personalized nutritional therapy as an alternative to using drugs. The authors of this article introduce personalized nutritional therapy based on blood data analysis (Kaneko's method), and present and discuss some clinical cases. In total, 253 pre-disease or undiagnosed patients were treated using this nutritional therapy approach, and most of them recovered from their chronic symptoms and pre-disease conditions. This novel nutritional therapy has the potential to help many presymptomatic and undiagnosed patients suffering from malaise.
Topics: Aging; Data Analysis; Hematologic Tests; Humans; Nutrition Therapy; Quality of Life; Surveys and Questionnaires
PubMed: 34684641
DOI: 10.3390/nu13103641 -
L'Encephale Apr 2016The main hypothesis of this paper is the presence of malaise in psychiatry. The malaise has two sides: on one hand, the end of psychiatry hegemony that dominated the... (Review)
Review
The main hypothesis of this paper is the presence of malaise in psychiatry. The malaise has two sides: on one hand, the end of psychiatry hegemony that dominated the theoretical field of psychiatry until the 1990s. The loss of influence of psychoanalysis is due to its inability to be submitted to any kind of assessment. On the other hand, the supremacy of neurosciences. The idea is not to underestimate the importance of neurosciences but rather to affirm that they occupy the whole theoretical field of psychiatry. This is an unusual situation that is specific to our time. Indeed, this monism has succeeded to an epistemological dualism that has existed throughout the history of psychiatry. In this article, we'll try to draw a history of dualism in psychiatry. Firstly, with Pinel, we find a tension between a metaphysical philosophical pole and a physiological one. Pinel's philosophy has something to do with Condillac's ideology as Pinel applies the analytical method to mental diseases. Under Cabanis's influence, the author of the famous Rapports du physique et du moral de l'homme, this ideology is under pressure with physiologism. As a materialist, he gives an essential part to the brain that distributes pieces of information throughout the body because he thinks that mind influences body. Secondly, dualism lies between the doctrine of localizations defended by Gall and the theory of degeneration elaborated by Magnan. Gall, in Anatomie et physiologie du système nerveux en général, seeks to know how bumps or hollows that are found on the skull are shaped. Gall is for the theory of delocalizations. He is the counterpart of Magnan who wrote a work about Les Dégénérés, that takes its part in the physiological trend with the famous theory of degeneration. For him, degeneration means the imperfect state of a subject whose cerebral functions are in a noticeably imperfect state. Thirdly, with Henry Ey, dualism starts to be less important. Indeed, he tends a monist synthesis with its organodynamic model described in Des idées de Jackson à un modèle organodynamique en psychiatrie. Indeed, he is inspired by the English neurologist Jackson to assert that there are levels of conscience structuring where negative symptomatology appears through its dissolution. Current monism with neuroscience domination sets fundamental epistemological issues. Perhaps neurosciences were setting an impossible task to achieve while following Changeux's intuition. In L'homme neuronal, this latter was developing the idea that to each psychic function, one could associate a neuron. This is a way to go back to Gall who doesn't seem to us to be heuristic. Indeed, let's first introduce the fact that there is no specific cortical area just as the most recent works have shown. Therefore, saying that a cerebral area is correlated to a symptom or a function is no more than relying on parallelism theory. Thus, Bergson, from whom we took the analysis, showed the futility of such a concept and the apporias to which it leads. The research of precise cerebral areas implied in mental diseases, as important as it is, leaves open the question of meaning. The meaning of the disease raises many economic, cultural, psychological and social factors. Thus, we can formulate the hypothesis that psychiatry should be between two complementary poles. First, the pole of neurosciences whose researches are fundamental for research in disease etiology and the development of a new medicine. Second, there is a pole which is more polymorphous and that would deal with the question of meaning. We think that each of these poles should have their own investigation field and their specific methods. We defend the idea that creating subjects such as neuropsychoanalysis is an illusion.
Topics: History, 18th Century; History, 19th Century; History, 20th Century; History, 21st Century; Humans; Neurosciences; Psychiatry; Psychoanalysis; Psychoanalytic Theory
PubMed: 26796559
DOI: 10.1016/j.encep.2015.12.011 -
Public Health Jul 1999
Topics: Absenteeism; Humans; Job Satisfaction; Morale; Stress, Psychological; United Kingdom
PubMed: 10483074
DOI: 10.1016/s0033-3506(99)00144-4 -
Nature Biotechnology Nov 2022
PubMed: 36347986
DOI: 10.1038/s41587-022-01541-6 -
Expert Review of Clinical Immunology May 2024Fatigue and malaise are commonly associated with a wide range of medical conditions, including rheumatoid arthritis (RA). Evidence suggests that fatigue and malaise can... (Review)
Review
INTRODUCTION
Fatigue and malaise are commonly associated with a wide range of medical conditions, including rheumatoid arthritis (RA). Evidence suggests that fatigue and malaise can be overwhelming for patients, yet these symptoms remain inadequately-managed, largely due to an incomplete elucidation of the underlying causes.
AREAS COVERED
In this assessment of the published literature relating to the pathogenesis of fatigue or malaise in chronic conditions, four key mechanistic themes were identified. Each theme (inflammation, hypothalamic-pituitary-adrenal axis, dysautonomia, and monoamines) is discussed, as well as the complex network of interconnections between themes which suggests a key role for inflammatory cytokines in the development and persistence of fatigue.
EXPERT OPINION
Fatigue is multifaceted, poorly defined, and imperfectly comprehended. Moreover, the cause and severity of fatigue may change over time, as a consequence of the natural disease course or pharmacologic treatment. This detailed synthesis of available evidence permits us to identify avenues for current treatment optimization and future research, to improve the management of fatigue and malaise in RA. Within the development pipeline, several new anti-inflammatory therapies are currently under investigation, and we anticipate that the next five years will herald much-needed progress to reduce the debilitating nature of fatigue in patients with RA.
Topics: Humans; Hypothalamo-Hypophyseal System; Pituitary-Adrenal System; Arthritis, Rheumatoid; Inflammation; Fatigue
PubMed: 38224064
DOI: 10.1080/1744666X.2024.2306220 -
Journal of Health Psychology Feb 2019Post-exertional malaise is a cardinal symptom of myalgic encephalomyelitis and chronic fatigue syndrome. There are two differing focuses when defining post-exertional...
Post-exertional malaise is a cardinal symptom of myalgic encephalomyelitis and chronic fatigue syndrome. There are two differing focuses when defining post-exertional malaise: a generalized, full-body fatigue and a muscle-specific fatigue. This study aimed to discern whether post-exertional malaise is a unified construct or whether it is composed of two smaller constructs, muscle fatigue and generalized fatigue. An exploratory factor analysis was conducted on several symptoms that assess post-exertional malaise. The results suggest that post-exertional malaise is composed of two empirically different experiences, one for generalized fatigue and one for muscle-specific fatigue.
Topics: Adult; Diagnosis, Differential; Exercise Test; Factor Analysis, Statistical; Fatigue Syndrome, Chronic; Female; Humans; Male; Middle Aged; Muscle Fatigue; Psychometrics; Surveys and Questionnaires
PubMed: 27557649
DOI: 10.1177/1359105316664139