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The New England Journal of Medicine Jul 2021
Topics: Adult; Cheek; Exanthema; Female; Humans; Lupus Erythematosus, Systemic
PubMed: 34233099
DOI: 10.1056/NEJMicm2029589 -
European Journal of Internal Medicine Oct 2022
Topics: Autoimmune Diseases; Chronic Disease; Epstein-Barr Virus Infections; Exanthema; Humans; Pancytopenia
PubMed: 35798590
DOI: 10.1016/j.ejim.2022.06.021 -
Pediatrics International : Official... Jan 2022
Topics: Child; Humans; Exanthema; Autoimmune Diseases
PubMed: 36271769
DOI: 10.1111/ped.15309 -
JAMA Jan 2019
Topics: Antibodies, Antinuclear; Arthritis; Erythema Infectiosum; Exanthema; Female; Humans; Middle Aged; Parvovirus
PubMed: 30589916
DOI: 10.1001/jama.2018.19498 -
Archives of Disease in Childhood.... Feb 2022-A 14-month-old boy born to consanguineous parents presented to our Dermatology Department with a 6-month history of a malar eczematous rash that worsens with sun...
-A 14-month-old boy born to consanguineous parents presented to our Dermatology Department with a 6-month history of a malar eczematous rash that worsens with sun exposure. He had butterfly-shaped, hyperpigmented exfoliating plaques, preceded by blister formation (figure 1). He was also noticed to have enophthalmos, a pinched nose, microcephaly and a cachectic physique. His height and weight were below the first percentile for his age. In addition, the patient was noticed to have motor and psychosocial delay; he does not respond to simple spoken requests, cannot get into sitting position without help or stand/walk with help of furniture. The eye examination was completely normal including the absence of retinal and corneal changes. Complete blood count, liver function tests and a karyotype did not show any abnormal findings. Imaging studies were not done.edpract;107/1/28/F1F1F1Figure 1Clinical image. A hyperpigmented exfoliating plaque distributed over the malar area associated with enophthalmos and a pinched nose. WHAT'S YOUR DIAGNOSIS?: Bloom syndrome.Rothmund Thomson syndrome.Cockayne syndrome.Xeroderma pigmentosum.Trichothiodystrophy.
Topics: Body Height; Exanthema; Humans; Infant; Male; Xeroderma Pigmentosum
PubMed: 32447277
DOI: 10.1136/archdischild-2019-318334 -
Clinical Rheumatology Sep 2019Systemic lupus erythematosus (SLE) is a chronic, auto-immune, multi-organ disease that can affect both the skin and the lungs. Malar rash is a common skin manifestation...
BACKGROUND
Systemic lupus erythematosus (SLE) is a chronic, auto-immune, multi-organ disease that can affect both the skin and the lungs. Malar rash is a common skin manifestation of SLE and is linked to SLE disease activity, whereas lung involvement is a generally negative prognostic factor for these patients. However, a sensitive and non-invasive screening tool for potential lung involvement in SLE patients is still not available.
METHODS
This study aimed to investigate the relationship between malar rash and airway inflammation in adult SLE patients who were not known to have any lung involvement (clinical or radiologic). The study comprised of the measurement of the concentration of NO in exhaled breath or fraction of exhaled nitric oxide (FeNO) and levels were compared between those with and without malar rash. This tool is considered as a sensitive and non-invasive method that is routinely used in patients with asthma or other respiratory diseases to identify airway inflammation.
RESULTS
A total of 125 patients (100 females, 25 males) were enrolled during the study period from January 2011 to December 2014. Patients with malar rash (N = 35) had a significant decrease in serum levels of C4 (p < 0.05) compared to patients without malar rash (N = 90). The mean levels of FeNO in overall patients were 36.44 ± 8.87 ppb. A statistically significant difference in FeNO values between patients with malar rash (43.46 ± 6.72 ppb) and without (29.43 ± 3.64 ppb) was found (p < 0.001). FeNO values were inversely correlated only with serum C4 (p < 0.01). However, no correlation between FeNO values and SLE clinical disease activity scores was found.
CONCLUSIONS
The presence of a malar rash may predict sub-clinical airway inflammation in SLE patients. Further prospective studies are needed to confirm the usefulness of FeNO measurements in monitoring SLE-associated airway inflammation.
Topics: Adult; Breath Tests; Complement C4; Cross-Sectional Studies; Exanthema; Female; Humans; Inflammation; Lupus Erythematosus, Systemic; Male; Middle Aged; Pilot Projects; Prospective Studies
PubMed: 31020473
DOI: 10.1007/s10067-019-04536-y -
Rheumatology (Oxford, England) Jan 2024
Topics: Infant; Humans; Mucocutaneous Lymph Node Syndrome; Fever; Exanthema
PubMed: 37436704
DOI: 10.1093/rheumatology/kead338 -
Clinical Case Reports Apr 2023Considering the clinical polymorphism of the disease, longstanding skin lesions located on the face, resembling erysipelas in an endemic area should always be...
Considering the clinical polymorphism of the disease, longstanding skin lesions located on the face, resembling erysipelas in an endemic area should always be investigated for CL and thus, atypical presentations should be kept in mind.
PubMed: 37020670
DOI: 10.1002/ccr3.7163 -
BMJ Case Reports May 2017
Topics: Cheek; Child; Facial Dermatoses; Female; Homocystinuria; Humans; Intellectual Disability; Vision Disorders
PubMed: 28473367
DOI: 10.1136/bcr-2017-220296