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In Vivo (Athens, Greece) 2023A recommendation of radiotherapy for patients with malignant gliomas may trigger emotional distress. Frequency and risk factors of this complication were investigated.
BACKGROUND/AIM
A recommendation of radiotherapy for patients with malignant gliomas may trigger emotional distress. Frequency and risk factors of this complication were investigated.
PATIENTS AND METHODS
Prevalence of six emotional problems and 11 potential risk factors were evaluated in 103 patients irradiated for grade II-IV gliomas. p-Values <0.0045 were considered significant.
RESULTS
Seventy-six patients (74%) had ≥1 emotional problem. Prevalence of specific emotional problems ranged between 23% and 63%. Associations were found between ≥5 physical problems and worry (p=0.0010), fear (p=0.0001), sadness (p=0.0023), depression (p=0.0006), and loss of interest (p=0.0006), and Karnofsky performance score ≤80 and depression (p=0.0002). Trends were found for physical problems and nervousness (p=0.040), age ≥60 years and depression (p=0.043) or loss of interest (p=0.045), grade IV glioma and sadness (p=0.042), and ≥2 involved sites and loss of interest (p=0.022).
CONCLUSION
Three-fourths of glioma patients had pre-radiotherapy emotional distress. Psychological support should be offered very soon, particularly for high-risk patients.
Topics: Humans; Middle Aged; Brain Neoplasms; Glioma; Radiotherapy Dosage; Risk Factors; Psychological Distress
PubMed: 37103101
DOI: 10.21873/invivo.13196 -
British Journal of Neurosurgery 1991Multicentre gliomas are a well recognized entity but the occurrence of such tumours both above and below the tentorium remains uncommon. We report the case of an...
Multicentre gliomas are a well recognized entity but the occurrence of such tumours both above and below the tentorium remains uncommon. We report the case of an 11-year-old boy who underwent stereotactic biopsy of a brain stem ring enhancing tumour with histology of an anaplastic astrocytoma (Grade 3). Nine months following his radiotherapy a large left frontal mass was biopsied and found to be a malignant glioma (Grade 4). Advances in neuroradiological imaging will readily show multiple cerebral lesions and multicentre glioma should be considered in the differential diagnosis of such lesions and biopsy is indicated.
Topics: Astrocytoma; Brain Neoplasms; Brain Stem; Child; Frontal Lobe; Glioma; Humans; Male; Neoplasms, Multiple Primary; Tomography, X-Ray Computed
PubMed: 1772610
DOI: 10.3109/02688699109002887 -
Targeting brain cancer: advances in the molecular pathology of malignant glioma and medulloblastoma.Nature Reviews. Cancer May 2010Malignant brain tumours continue to be the cause of a disproportionate level of morbidity and mortality across a wide range of individuals. The most common variants in... (Review)
Review
Malignant brain tumours continue to be the cause of a disproportionate level of morbidity and mortality across a wide range of individuals. The most common variants in the adult and paediatric populations - malignant glioma and medulloblastoma, respectively - have been the subject of increasingly intensive research over the past two decades that has led to considerable advances in the understanding of their basic biology and pathogenesis. This Review summarizes these developments in the context of the evolving notion of molecular pathology and discusses the implications that this work has on the design of new treatment regimens.
Topics: Animals; Brain Neoplasms; Cerebellar Neoplasms; Glioma; Humans; Medulloblastoma; Pathology, Molecular
PubMed: 20414201
DOI: 10.1038/nrc2818 -
Wiener Medizinische Wochenschrift (1946) Jun 2006Due to the dismal prognosis of malignant glioma with currently available therapies there is an urgent need for new treatments based on a better molecular understanding... (Review)
Review
Due to the dismal prognosis of malignant glioma with currently available therapies there is an urgent need for new treatments based on a better molecular understanding of gliomagenesis. Several concepts of molecular therapies for malignant glioma are currently being studied in preclinical and clinical settings, including small molecules targeting specific receptor-mediated signaling pathways and gene therapy. Many growth factors, growth factor receptors--usually receptor tyrosine kinases--and receptor-associated signaling pathways are critically involved in gliomagenesis. Numerous selective inhibitors, which specifically block such molecules, are currently evaluated for clinical applicability. Several gene therapy approaches have shown antitumor efficacy in experimental studies, and the first clinical trials for the treatment of malignant glioma were conducted in the 1990s. In clinical trials, retroviral herpes-simplex-thymidinkinase- (HSV-Tk-) gene therapy has been the pioneering and most commonly used approach. However, efficient gene delivery into the tumor cells still remains the crucial obstacle for successful clinical gene therapy. During the past few years a number of new gene transfer vectors based on adeno-, adeno-associated-, herpes- and lentiviruses as well as new carrier cell systems, including neural and endothelial progenitor cells, have been developed. In addition, antisense technologies have advanced in recent years and entered clinical testing utilizing intratumoral administration by convection-enhanced delivery, exemplified by ongoing clinical trials of intratumoral administration of antisense TGF-beta. This paper summarizes some of these recent developments in molecular therapies for malignant glioma, focusing on targeted therapies using selective small molecules and gene therapy concepts.
Topics: Antineoplastic Agents; Antisense Elements (Genetics); Brain Neoplasms; Clinical Trials as Topic; Drug Delivery Systems; Gene Transfer Techniques; Genetic Therapy; Glioma; Humans; Treatment Outcome
PubMed: 16944367
DOI: 10.1007/s10354-006-0308-3 -
The Cochrane Database of Systematic... 2001Patients with isolated supratentorial brain tumours, presumed to be primary on imaging, have two surgical management options - biopsy or resection. Surgical opinions... (Review)
Review
BACKGROUND
Patients with isolated supratentorial brain tumours, presumed to be primary on imaging, have two surgical management options - biopsy or resection. Surgical opinions appear to be equally divided when considering the relative risks and benefits of these two procedures.
OBJECTIVES
To estimate the clinical effectiveness of radical surgical resection compared to simple biopsy in patients with malignant glioma.
SEARCH STRATEGY
Electronic database searches of COCHRANE CONTROLLED TRIALS REGISTER (including the Cochrane Cancer Network Specialised Register of Trials), MEDLINE, CANCERLIT, EMBASE, BIOSIS and SCIENCE CITATION INDEX. Hand searching the references of all identified studies; hand searching the Journal of Neuro-Oncology over the previous 10 years, including all conference abstracts; personal communication.
SELECTION CRITERIA
Randomised and clinical controlled trials were included if they compared biopsy to resection, or looked at effect of extent of resection on survival, time to progression or quality of life, for malignant glioma patients of all ages.
DATA COLLECTION AND ANALYSIS
Studies were to be identified, critically appraised and data extracted by the author (SEM). Ideally hazard ratios for overall survival were to be calculated along with the estimates of odds ratios from the percentage survival at one and two years. For dichotomous data, Peto odds ratios (OR) with 95% confidence intervals (CI) were hoped to have been estimated. Normal continuous data were to have been summated using the weighted mean difference (WMD).
MAIN RESULTS
The electronic database search yielded 2100 citations. Of these, two articles were identified for possible inclusion, however both were excluded. The hand search and personal communication were similarly unproductive. No studies were included in the review and no data was synthesised.
REVIEWER'S CONCLUSIONS
Given that no qualifying studies were identified and because this is an important issue, both in terms of patient risk and benefit and health economics, the authors feels it important to conduct a randomised controlled trial in this subject.
Topics: Biopsy; Brain Neoplasms; Craniotomy; Glioma; Humans; Randomized Controlled Trials as Topic; Risk; Stereotaxic Techniques
PubMed: 11687008
DOI: 10.1002/14651858.CD002034 -
The Journal of Neuroscience Nursing :... Feb 1991Cytoreduction through multimodality therapy is the primary goal in management of malignant gliomas. Clinical trials such as those offered by the Brain Tumor Cooperative... (Review)
Review
Cytoreduction through multimodality therapy is the primary goal in management of malignant gliomas. Clinical trials such as those offered by the Brain Tumor Cooperative Group help to define current standards of care and investigate new therapies. Available therapies are in the medical, surgical, radiation and chemotherapeutic realms.
Topics: Brachytherapy; Brain Neoplasms; Combined Modality Therapy; Glioma; Humans; Iodine Radioisotopes; Radiotherapy Dosage
PubMed: 1826711
DOI: 10.1097/01376517-199102000-00003 -
Southern Medical Journal Feb 1988
Topics: Adult; Brain Neoplasms; Cost-Benefit Analysis; Costs and Cost Analysis; Ethics, Medical; Glioma; Hospitalization; Humans; Insurance, Health, Reimbursement; Male; Nursing Homes; Patient Advocacy; Rehabilitation; United States
PubMed: 3124274
DOI: 10.1097/00007611-198802000-00023 -
Journal of Neuro-oncology Sep 2014The Joint Section on Tumors of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons is now in its 30th year. In many ways its... (Review)
Review
The Joint Section on Tumors of the American Association of Neurological Surgeons and the Congress of Neurological Surgeons is now in its 30th year. In many ways its growth and development has paralleled neurosurgery and medicine as a whole. This is most evident in our endeavor towards more patient-centered care and focus on quantity and quality of life. As the push towards evidence-based care continues, it is important to ensure that individualized care remains a guiding principle. Conscientious surgeons continue to refine techniques and develop technologies that push the boundaries of surgical efficacy while better defining the risks of surgery and the impacts of surgical complications. This article provides a review of the factors involved in minimizing risk and obtaining maximal outcomes for patients through insightful patient selection and evidence-based surgical decision-making. Herein, we present the philosophy and practice of the Hermelin Brain Tumor Center at the Henry Ford Health System as one type of approach to caring for the patient with a malignant glioma.
Topics: Brain Neoplasms; Decision Making; Glioma; Humans; Neurosurgical Procedures; Patient-Centered Care
PubMed: 24962199
DOI: 10.1007/s11060-014-1492-4 -
Neurologia Medico-chirurgica 2013To add a further contribution to the literature supporting the relationship between previous head trauma and the development of glioma. We present the first case of... (Review)
Review
To add a further contribution to the literature supporting the relationship between previous head trauma and the development of glioma. We present the first case of pregnancy-related post-traumatic malignant glioma in a 29-year-old female who was admitted because of left sided hemiplegia and epilepsy due to a malignant glial tumor. She had been operated for a right frontal hematoma caused by a motorbike accident 9 years before. Neuroimaging showed a large neoplasia in the right frontal region beneath the material used for cranialplasty, and postoperative pathological revealed a glioblastoma multiforme (GBM) in continuity with the scar resulting from the trauma. While epidemiologic studies may not be conclusive, a pathologic basis has been suggested which show that trauma act as a cocarcinogen in the presence of an initiating carcinogen. Our case fulfilled the widely established criteria for brain tumors of traumatic origin. We believe that in specific cases it is reasonable to acknowledge an etiological association between head trauma and glioma. And additional factors such as pregnancy may promote the manifestation of the clinical symptoms.
Topics: Adult; Brain Injuries; Brain Neoplasms; Female; Glioma; Humans; Pregnancy; Pregnancy Complications, Neoplastic
PubMed: 24067777
DOI: 10.2176/nmc.cr2013-0029 -
Proceedings. National Cancer Conference 1972
Review
Topics: Antineoplastic Agents; Blood-Brain Barrier; Brain Neoplasms; Carmustine; Evaluation Studies as Topic; Glioma; Humans; Plicamycin
PubMed: 4271815
DOI: No ID Found