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Nephrology, Dialysis, Transplantation :... Sep 1997
Review
Topics: Adult; Antihypertensive Agents; Arterioles; Female; Humans; Hypertension, Malignant; Kidney Glomerulus; Renal Dialysis; Retina
PubMed: 9306367
DOI: 10.1093/ndt/12.9.2019 -
Revista Clinica Espanola Apr 1997
Comparative Study Review
Topics: Adult; Child; Diagnosis, Differential; Humans; Hypertension, Malignant; Risk Factors
PubMed: 9254402
DOI: No ID Found -
Nihon Rinsho. Japanese Journal of... Mar 2004
Review
Topics: Aortic Dissection; Antihypertensive Agents; Aortic Aneurysm; Body Water; Brain Edema; Contraindications; Humans; Hypertension, Malignant; Intracranial Hemorrhage, Hypertensive; Myocardial Infarction; Renin; Sodium, Dietary; Ventricular Dysfunction, Left
PubMed: 15171413
DOI: No ID Found -
Nihon Rinsho. Japanese Journal of... Mar 2005
Review
Topics: Animals; Humans; Hypertension, Malignant; Mice; Renin-Angiotensin System
PubMed: 15813058
DOI: No ID Found -
BMJ Case Reports Dec 2023A woman in her 30s presented with complaints of sudden onset of defective vision in the right eye for 2 days, with history of headache for a month. On examination,...
A woman in her 30s presented with complaints of sudden onset of defective vision in the right eye for 2 days, with history of headache for a month. On examination, best corrected visual acuity was 20/40 in the right eye and 20/20 in the left eye. Anterior segment examination was normal. Fundus examination of both the eyes showed generalised arteriolar attenuation with diffuse, hyperaemic disc oedema and serous retinal detachment at macula in the right eye. Her blood pressure (BP) was 230/140 mm Hg. Other systemic evaluation was unremarkable. In the review visit, patient's BP reduced to 140/100 mm Hg, and visual acuity in the right eye improved to 20/20. Fundus in the right eye showed resolving disc oedema with macular star formation, and the left eye had developed soft exudates. This seemed to confirm the diagnosis of the disc oedema being caused by hypertension and a highly asymmetrical presentation of hypertensive retinopathy.
Topics: Female; Humans; Hypertension, Malignant; Retinal Detachment; Fundus Oculi; Macula Lutea; Edema
PubMed: 38061857
DOI: 10.1136/bcr-2023-255723 -
Journal of Human Hypertension May 2022
Topics: Atypical Hemolytic Uremic Syndrome; Humans; Hypertension, Malignant
PubMed: 35082378
DOI: 10.1038/s41371-021-00651-z -
Journal of Nephrology 2002The history of accelerated (malignant) hypertension is reviewed, and unsolved problems related to the disease are illustrated, including its relationship to malignant... (Review)
Review
The history of accelerated (malignant) hypertension is reviewed, and unsolved problems related to the disease are illustrated, including its relationship to malignant nephrosclerosis, as well as terminology, current frequency and treatment. Over the past 25 years, out of a series of 131 patients, 53 were classified as suffering from essential malignant hypertension, the only suitable model on which the effects of pharmacological treatment on the disease can correctly be evaluated. In 2000, there were 24 survivors in our series and the maximum follow-up was 290 months. Multiple daily B.P. self-measurements allowed us to establish that pharmacological treatment was only able to approximate, to a varying degree, the conventional threshold of 140/90. Yet, despite this incomplete control over blood pressure levels, renal function was maintained in those patients whose initial creatininemia levels had not been higher than 2 mg/L. The renal protection effect of treatment was preserved even in patients who relapsed intoaccelerated disease phase one or more times over the study period.
Topics: Adult; Age Distribution; Aged; Antihypertensive Agents; Blood Pressure Determination; Female; Follow-Up Studies; Humans; Hypertension, Malignant; Male; Middle Aged; Monitoring, Physiologic; Nephrosclerosis; Risk Assessment; Severity of Illness Index; Sex Distribution; Survival Analysis
PubMed: 12243376
DOI: No ID Found -
British Journal of Hospital Medicine... Mar 2015
Topics: Glomerulonephritis, IGA; Humans; Hypertension, Malignant; Hypertensive Retinopathy
PubMed: 25761814
DOI: 10.12968/hmed.2015.76.3.177 -
Kidney International Oct 2019Malignant hypertension is listed among the causes of secondary thrombotic microangiopathy, but pathogenic mutations in complement genes have been reported in patients...
Malignant hypertension is listed among the causes of secondary thrombotic microangiopathy, but pathogenic mutations in complement genes have been reported in patients with hypertension-induced thrombotic microangiopathy. Here we investigated the frequency and severity of hypertension in 55 patients with primary atypical hemolytic uremic syndrome (aHUS). A genetic analysis was performed in all patients, and funduscopic examination was performed in all the patients with Grades 2 and 3 hypertension. A cohort of 110 patients with malignant hypertension caused by diseases other than aHUS served as control. Thirty-six patients with aHUS presented Grade 2 or Grade 3 hypertension and funduscopic examination showed malignant hypertension in 19. Genetic abnormalities in complement were found in 19 patients (37% among patients with malignant hypertension). Plasmapheresis was performed in 46 patients and 26 received eculizumab. Renal and hematological responses were significantly lower after plasmapheresis (24%) than after eculizumab (81%). Renal survival was significantly higher in patients treated with eculizumab (85% at one, three and five years) compared to patients who did not receive this treatment (54%, 46% and 41%), respectively. Response to eculizumab was independent of hypertension severity and the presence of complement genetic abnormalities. Among patients with malignant hypertension caused by other diseases the prevalence of thrombotic microangiopathy was very low (5%). Thus, severe and malignant hypertension are common among patients with aHUS and eculizumab treatment leads to a higher renal survival when compared to plasmapheresis. However, thrombotic microangiopathy is uncommon among patients presenting with malignant hypertension caused by diseases other than aHUS.
Topics: Adult; Antibodies, Monoclonal, Humanized; Atypical Hemolytic Uremic Syndrome; Complement Inactivating Agents; Complement System Proteins; Female; Humans; Hypertension, Malignant; Incidence; Male; Middle Aged; Plasmapheresis; Retrospective Studies; Severity of Illness Index; Young Adult
PubMed: 31420192
DOI: 10.1016/j.kint.2019.05.014 -
Archives of Internal Medicine May 1974
Review
Topics: Anticoagulants; Antihypertensive Agents; Drug Therapy, Combination; Hospitalization; Humans; Hypertension, Malignant; Neurologic Manifestations; Renal Dialysis; Rest
PubMed: 4595400
DOI: 10.1001/archinte.133.5.791