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Journal of Hypertension Nov 2006
Topics: Black People; Emigration and Immigration; Europe; Humans; Hypertension, Malignant; Incidence; Risk Factors; Socioeconomic Factors
PubMed: 17053535
DOI: 10.1097/01.hjh.0000249691.88865.d9 -
Journal of the American Optometric... Feb 1976
Topics: Eye Manifestations; Humans; Hypertension, Malignant; Male; Middle Aged; Ophthalmoscopy
PubMed: 1027784
DOI: No ID Found -
The American Journal of the Medical... Nov 2016We describe 2 patients, a 52-year-old woman and a 57-year-old man, with rapidly progressive hypertension and marked elevation of brain natriuretic peptide who exhibited... (Review)
Review
We describe 2 patients, a 52-year-old woman and a 57-year-old man, with rapidly progressive hypertension and marked elevation of brain natriuretic peptide who exhibited polyuria, natriuresis, hypokalemia, posterior reversible encephalopathy syndrome and left ventricular dysfunction together with retinopathy and nephropathy, which were attenuated in a short time span of 1-2 months with normalization of blood pressure after the antihypertensive treatment. The possible role of brain natriuretic peptide in the pathophysiology of accelerated malignant hypertension was discussed and a review of the literature was completed.
Topics: Antihypertensive Agents; Female; Humans; Hypertension, Malignant; Male; Middle Aged; Natriuretic Peptide, Brain; Renin-Angiotensin System
PubMed: 27865304
DOI: 10.1016/j.amjms.2016.08.001 -
Journal of Internal Medicine Nov 1999Malignant hypertension (MHT) is a rare and life-threatening condition which is defined clinically as severe hypertension accompanied by bilateral retinal haemorrhages... (Review)
Review
Malignant hypertension (MHT) is a rare and life-threatening condition which is defined clinically as severe hypertension accompanied by bilateral retinal haemorrhages and/or hard exudates, with or without papilloedema. If untreated, the prognosis of MHT is poor. With MHT being a relatively rare condition, it would be unusual to see it on more than one occasion in the same patient. We describe in detail two cases from a disease register of 400 cases of MHT seen in one medical centre over 33 years.
Topics: Adult; Female; Humans; Hypertension, Malignant; Prognosis; Recurrence; Retinal Hemorrhage; Risk Factors
PubMed: 10583722
DOI: 10.1046/j.1365-2796.1999.00596.x -
Seminars in Nephrology Jun 1988
Review
Topics: Antihypertensive Agents; Humans; Hypertension, Malignant; Kidney
PubMed: 3293138
DOI: No ID Found -
Internal Medicine (Tokyo, Japan) Oct 1997
Topics: Adult; Blood Pressure; Endothelium, Vascular; Female; Humans; Hypertension, Malignant; Renin-Angiotensin System; Vascular Resistance
PubMed: 9372322
DOI: 10.2169/internalmedicine.36.669 -
British Medical Journal (Clinical... Apr 1987Eleven of 34 women aged 15-44 with malignant phase hypertension were taking oral contraceptives at presentation. All had had normal blood pressure before starting to...
Eleven of 34 women aged 15-44 with malignant phase hypertension were taking oral contraceptives at presentation. All had had normal blood pressure before starting to take the pill. In four the interval between the start of oral contraception and the diagnosis of malignant hypertension was less than four months, and in eight no other cause for the hypertension was found. Underlying renal disease and renal failure were less common among pill users than among non-users with malignant hypertension who were of similar age. No pill user became normotensive after withdrawal of the pill, but blood pressure was well controlled (diastolic less than 90 mm Hg) in three patients taking only one drug. By contrast, all 23 non-users needed two or more antihypertensive drugs to control blood pressure. Ten year survival was 90% among pill users and 50% among non-users. These results suggest that oral contraceptives may be a common cause of malignant hypertension in women of child-bearing age. If the pill is stopped and underlying renal disease excluded the long term prognosis for such patients is excellent.
Topics: Adult; Blood Pressure; Contraceptives, Oral, Hormonal; Female; Humans; Hypertension, Malignant; Smoking
PubMed: 3107691
DOI: 10.1136/bmj.294.6579.1057 -
Physiological Reports Mar 2016A previously healthy 7-year-old male presented with hypertensive emergency, hypokalemia, and elevated plasma renin activity and aldosterone levels. There was no evidence... (Review)
Review
A previously healthy 7-year-old male presented with hypertensive emergency, hypokalemia, and elevated plasma renin activity and aldosterone levels. There was no evidence of virilization or cushingoid features. MRI of the abdomen revealed a large (5 × 5 × 3 cm) peripherally enhancing, heterogeneous mass arising from the left adrenal gland. The patient was treated for a suspected pheochromocytoma. However, his blood pressure was not responsive to alpha-blockade. Blood pressure was controlled with a calcium channel blocker and an angiotensin-converting enzyme (ACE) inhibitor. A complete surgical resection of the mass was performed. Postoperatively, his blood pressure normalized and he did not require antihypertensives. On pathological examination, the tumor tissue stained negative for chromogranin and positive for renin. The final diagnosis was renin-secreting adrenal corticoadenoma, an extremely rare adrenal tumor not previously reported in a pediatric patient. Malignant hypertension due to a renin-secreting tumor may need to be distinguished from a pheochromocytoma if alpha-adrenergic blockade is ineffective.
Topics: Adrenal Cortex Neoplasms; Adrenocortical Adenoma; Child; Humans; Hypertension, Malignant; Male; Renin
PubMed: 26997629
DOI: 10.14814/phy2.12728 -
The American Journal of Case Reports Jun 2015Thrombotic thrombocytopenic purpura (TTP) is a rare hematologic disorder resulting in hemolysis of red blood cells, consumption of platelets, and occlusion of...
BACKGROUND
Thrombotic thrombocytopenic purpura (TTP) is a rare hematologic disorder resulting in hemolysis of red blood cells, consumption of platelets, and occlusion of microvasculature. Malignant hypertension is the clinical syndrome of severe elevations in blood pressure and funduscopic hypertensive retinopathy, including bilateral flame-shaped hemorrhage and papilledema.
CASE REPORT
We describe the case of a 63-year-old man who presented with features of TTP and malignant hypertension treated with plasma exchange and developing end-stage renal disease.
CONCLUSIONS
Given the diagnostic uncertainty at presentation, clinicians should quickly intervene to control hypertension and institute plasma exchange as needed.
Topics: Biopsy; Blood Pressure; Diagnosis, Differential; Humans; Hypertension, Malignant; Male; Middle Aged; Purpura, Thrombotic Thrombocytopenic
PubMed: 26083445
DOI: 10.12659/AJCR.892787 -
Hypertension (Dallas, Tex. : 1979) Oct 2008
Topics: Blood Coagulation; Endothelium, Vascular; Humans; Hypertension, Malignant; Microcirculation; Risk Factors; Thrombosis; Vasoconstriction
PubMed: 18695140
DOI: 10.1161/HYPERTENSIONAHA.108.118679