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The American Journal of Dermatopathology Aug 2000
Topics: Biomarkers, Tumor; Histocytochemistry; Humans; Male; Middle Aged; Myoepithelioma; Neoplasm Proteins; Skin Neoplasms
PubMed: 10949461
DOI: 10.1097/00000372-200008000-00009 -
Pathology Oct 2019
Review
Topics: Adult; Cytogenetics; Female; Humans; Immunohistochemistry; Immunophenotyping; Myoepithelioma; Vulva; Vulvar Neoplasms
PubMed: 31470996
DOI: 10.1016/j.pathol.2019.06.004 -
Yonsei Medical Journal Dec 2009A malignant myoepithelioma is one of the rarest salivary gland neoplasms which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign...
A malignant myoepithelioma is one of the rarest salivary gland neoplasms which may either arise de novo or develop within a preexisting pleomorphic adenoma or benign myoepithelioma. The parotid gland is the most common primary site and the palate the most common intra-oral site of occurrence. Herein is present a case of a malignant myoepithelioma arising in the hard palate of a 79-year-old woman. The lesion had been examined by biopsy at another hospital, and diagnosed as a poorly differentiated squamous cell carcinoma. The patient underwent a wide local tumor resection. Examination of the resection specimen showed the characteristic histopathological and immunohistochemical features of a malignant myoepithelioma. Five months after the operation, the patient was well without evidence of recurrence or metastasis.
Topics: Aged; Female; Humans; Immunohistochemistry; Myoepithelioma; Palatal Neoplasms; Palate
PubMed: 20046429
DOI: 10.3349/ymj.2009.50.6.848 -
Clinical & Translational Oncology :... Nov 2015Salivary gland myoepithelial carcinoma (MC) or malignant myoepithelioma is a rare entity. MC usually presents as a slow-growing painless mass arising in the parotid... (Review)
Review
Salivary gland myoepithelial carcinoma (MC) or malignant myoepithelioma is a rare entity. MC usually presents as a slow-growing painless mass arising in the parotid gland, but may involve other salivary glands. This tumour may be particularly locally aggressive, but its clinical and biological features are not yet fully understood. MC may arise from pre-existing benign lesions, such as pleomorphic adenomas or benign myoepitheliomas, or may arise de novo. It usually affects patients over 50 years old, with no gender preference. Because it is often asymptomatic, the presentation and diagnosis can be delayed by months, even years. The current WHO classification considers MC to be an intermediate- to high-grade malignancy. Other published data suggest it is likely to be a high-grade neoplasm, consistent with its aggressive behaviour. Its epidemiology, histopathological features, immunohistochemical profile, clinical behaviour and optimal management are not well understood. Following review of the current literature we aim to address these.
Topics: Carcinoma; Humans; Myoepithelioma; Salivary Gland Neoplasms
PubMed: 26133522
DOI: 10.1007/s12094-015-1329-4 -
Chest Jul 2011Myoepitheliomas have been described most commonly in salivary glands and have been reported elsewhere but are rare in the lung, with only six previously reported cases....
Myoepitheliomas have been described most commonly in salivary glands and have been reported elsewhere but are rare in the lung, with only six previously reported cases. To our knowledge, this represents the first endotracheal myoepithelioma. These tumors have characteristic features that distinguish them from other tumors, and the diagnosis is a pathologic one, based on the morphology and supported by immunohistochemistry. Myoepitheliomas should be considered in the diagnosis of any pulmonary nodule.
Topics: Actins; Aged; Biopsy; Bronchi; Bronchoscopy; Diagnosis, Differential; Humans; Immunohistochemistry; Lung Neoplasms; Male; Myoepithelioma; Tomography, X-Ray Computed
PubMed: 21729896
DOI: 10.1378/chest.10-2976 -
Pathology International Aug 2005Malignant myoepithelioma of soft tissue is extremely rare. Presented herein is a case arising in a 17-year-old man. The tumor was initially noticed as a painless deep...
Malignant myoepithelioma of soft tissue is extremely rare. Presented herein is a case arising in a 17-year-old man. The tumor was initially noticed as a painless deep soft-tissue mass in the right forearm when the patient was aged 3 years. Thereafter, it grew without remarkable symptoms, such as pain or tenderness, until his visit to the hospital because of swelling of his forearm when he was 17 years old. An excisional biopsy specimen disclosed an invasive tumor exhibiting a lobular architecture. The tumor cells were arranged in a reticular and/or trabecular fashion with a myxoid background, and nuclear atypia was evident. Mitoses and tumor necrosis were also observed. Immunohistochemically, S-100 protein and epithelial markers were diffusely positive. Faint intercellular junctions and basal laminae were identified by electronmicroscopy. On the basis of these findings, the tumor was diagnosed as a malignant myoepithelioma of soft tissue. Six months later, multiple lung metastases were observed, and an open biopsy revealed a neoplasm displaying the same histological feature as the previously biopsied specimens. The patient died of his disease 18 months after the lung biopsy. Malignant myoepithelioma should be kept in mind in diagnosis of deep soft-tissue tumors with epithelioid features.
Topics: Adolescent; Fatal Outcome; Humans; Immunohistochemistry; Keratins; Male; Microscopy, Electron; Mucin-1; Myoepithelioma; S100 Proteins; Soft Tissue Neoplasms
PubMed: 15998380
DOI: 10.1111/j.1440-1827.2005.01861.x -
Pathology International Jun 1999A myoepithelioma occurred in the subcutaneous tissue of the right shoulder of a 28-year-old man. The well-demarcated nodular tumor (3. 0 x 2.8 cm) was located in the... (Review)
Review
A myoepithelioma occurred in the subcutaneous tissue of the right shoulder of a 28-year-old man. The well-demarcated nodular tumor (3. 0 x 2.8 cm) was located in the subcutaneous tissue with no adhesion to the deltoid muscle. The tumor was composed of a fascicular proliferation of spindle cells with variable amounts of stroma and showed areas of sheets of epithelioid cells. In most areas, the tumor cells had uniform nuclei, but pleomorphic epithelioid cells were focally present. Mitotic activity was three per 10 high-power fields. No ductular structure was found throughout the tumor. Immunohistochemical and ultrastructural studies confirmed the myoepithelial origin of the tumor cells. The occurrence of myoepithelioma in the subcutaneous tissue has been rarely reported. Even though the tumor showed no aggressive behavior on the 2-year follow-up, it is still too early to comment definitely on the behav- ior of myoepithelioma of the subcutaneous tissue. This case provides further information about soft tissue myoepithelioma.
Topics: Adult; Antibodies, Monoclonal; Biomarkers, Tumor; Diagnosis, Differential; Epithelioid Cells; Humans; Immunoenzyme Techniques; Leiomyosarcoma; Male; Myoepithelioma; Shoulder; Soft Tissue Neoplasms
PubMed: 10469403
DOI: 10.1046/j.1440-1827.1999.00912.x -
Anticancer Research Feb 2009Malignant myoepithelioma of the head and neck usually arises in the salivary glands. We experienced a rare case with malignant myoepithelioma in the maxillary sinus. A...
Malignant myoepithelioma of the head and neck usually arises in the salivary glands. We experienced a rare case with malignant myoepithelioma in the maxillary sinus. A 47-year-old woman with malignant myoepithelioma in the maxillary sinus underwent partial maxillectomy. However, local recurrence occurred 28 months after surgery and she was subsequently treated with radiation therapy with proton beams. The recurrent tumor showed complete response and the patient was alive with no evidence of disease 30 months after irradiation. No therapy-related severe toxicities were observed. A rare case with malignant myoepithelioma in the maxillary sinus was successfully treated with radiation therapy.
Topics: Female; Humans; Maxillary Sinus Neoplasms; Middle Aged; Myoepithelioma; Neoplasm Recurrence, Local
PubMed: 19331194
DOI: No ID Found -
International Journal of Dermatology May 2020
Topics: Adult; Biomarkers, Tumor; Cytoreduction Surgical Procedures; Foot; Humans; Immunohistochemistry; Male; Margins of Excision; Myoepithelioma; Skin; Skin Neoplasms; Treatment Outcome
PubMed: 31769018
DOI: 10.1111/ijd.14734 -
Asian Journal of Surgery Apr 2023
Topics: Humans; Female; Carcinoma, Intraductal, Noninfiltrating; Myoepithelioma; Breast; Breast Neoplasms
PubMed: 36328843
DOI: 10.1016/j.asjsur.2022.10.070