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Memorias Do Instituto Oswaldo Cruz Sep 2014Reported in Haiti as early as 1923, Mansonella ozzardi is still a neglected disease ignored by the health authorities of the country. This review is an update on the... (Review)
Review
Reported in Haiti as early as 1923, Mansonella ozzardi is still a neglected disease ignored by the health authorities of the country. This review is an update on the geographic distribution of the coastal foci of mansonelliasis in Haiti, the epidemiological profile and prevalence rates of microfilariae in people living in endemic areas, the clinical impact of the parasite on health and the efficiency of the transmission of the parasite among three Culicoides biting-midge species identified as vectors in Haiti. Additionally, interest in establishing a treatment programme to combat this parasite using a single dose of ivermectin is emphasised.
Topics: Animals; Antiparasitic Agents; Ceratopogonidae; Female; Haiti; Humans; Insect Vectors; Ivermectin; Male; Mansonelliasis; Microfilariae; Neglected Diseases; Parasite Load; Prevalence
PubMed: 25317697
DOI: 10.1590/0074-0276140107 -
Trends in Parasitology Jan 2021
Topics: Americas; Animals; Antiparasitic Agents; Host-Parasite Interactions; Humans; Mansonella; Mansonelliasis; Simuliidae
PubMed: 33168424
DOI: 10.1016/j.pt.2020.03.005 -
Arquivos Brasileiros de Oftalmologia 2008To evaluate eye manifestations in mansonelliasis patients from Coari, AM, rural area on the middle Amazonas River.
PURPOSE
To evaluate eye manifestations in mansonelliasis patients from Coari, AM, rural area on the middle Amazonas River.
METHODS
Cross-sectional study consisted of evaluation of 543 subjects from Coari rural area on Solimões River right margin. All subjects were submitted to blood test for microfilaria and the subjects who had a positive test also were submitted to skin biopsies and ophthalmologic examination. Histopathology and PCR research for microfilaria were done on eye biopsies of suspect lesions.
RESULTS
Mansonella ozzardi was found in peripheral blood of 103 (18.9%) subjects. Ninety-five mansonelliasis patients were examined. Punctate keratitis was observed in 12 of them, nummular keratitis in one subject and sclerosing keratitis in another one. Skin biopsies were negative in all subjects. Conjunctival and limbal biopsies were done in five mansonelliasis patients and corneal biopsy in another three patients. Conjunctival and limbal biopsies of two patients and corneal biopsy of one patient showed no microfilaria or alterations due to its presence on histopathology. PCR showed no evidence of microfilaria in the other biopsies.
CONCLUSION
Association between Mansonella ozzardi infection and corneal lesions with no evident etiology was observed in this study, but the lack of conclusive findings on histopathology and PCR make us doubt the corneal involvement in mansonelliasis. Large studies of high mansonelliasis prevalence populations and extensive employment of microfilaria identification tests in ocular tissue are needed to evaluate the microfilaria corneal pathogenicity.
Topics: Animals; Biopsy; Brazil; Cataract; Cross-Sectional Studies; Eye Infections, Parasitic; Female; Humans; Keratitis; Male; Mansonella; Mansonelliasis; Microfilariae; Polymerase Chain Reaction; Rural Population; Trachoma; Visual Acuity
PubMed: 18516413
DOI: 10.1590/s0004-27492008000200007 -
African Journal of Infectious Diseases 2010
PubMed: 23878696
DOI: 10.4314/ajid.v4i1.55085 -
Blood Mar 2018
Topics: Adolescent; Animals; Humans; Lymphadenopathy; Male; Mansonella; Mansonelliasis
PubMed: 29599146
DOI: 10.1182/blood-2018-01-825364 -
Journal of Clinical Microbiology Dec 2017
Topics: Animals; Blood; Eosinophilia; Humans; Immunoglobulin E; Male; Mansonella; Mansonelliasis; Microfilariae; Young Adult
PubMed: 29180506
DOI: 10.1128/JCM.03268-15 -
Hospital (Rio de Janeiro, Brazil) Mar 1961
Topics: Animals; Filariasis; Humans; Mansonelliasis
PubMed: 13730792
DOI: No ID Found -
The New England Journal of Medicine Oct 2009
Topics: Animals; Anti-Bacterial Agents; Doxycycline; Drug Therapy, Combination; Elephantiasis, Filarial; Filaricides; Humans; Mansonella; Mansonelliasis; Rickettsiaceae Infections; Symbiosis; Wolbachia; Wuchereria bancrofti
PubMed: 19812409
DOI: 10.1056/NEJMe0905193 -
Acta Tropica Sep 2011Mansonella perstans is a vector-borne human filarial nematode, transmitted by tiny blood-sucking flies (biting midges). It is widespread in many parts of Sub-Saharan... (Review)
Review
Mansonella perstans is a vector-borne human filarial nematode, transmitted by tiny blood-sucking flies (biting midges). It is widespread in many parts of Sub-Saharan Africa and also occurs in parts of Central and South America. Despite the commonness of this parasite very few studies have been carried out on its epidemiology and on the morbidity resulting from it, and only few thorough drug trials have been conducted to look for effective and suitable drugs and drug regimens for treatment and control. Here, we review currently available knowledge on M. perstans infections in Africa, including documented aspects of biology, vectors, transmission, diagnosis, epidemiology, morbidity and treatment. It is concluded that there is an urgent need for more research on this widespread but greatly neglected infection in order to properly assess its public health significance and as a background for identifying and recommending optimal means and strategies for treatment and control.
Topics: Africa; Animals; Ceratopogonidae; Clinical Trials as Topic; Filariasis; Filaricides; Humans; Insect Vectors; Mansonella; Mansonelliasis; Microfilariae
PubMed: 20152790
DOI: 10.1016/j.actatropica.2010.01.014 -
Bulletin de La Societe de Pathologie... 2018Haiti, like most limited-resources countries in the world, faces numerous neglected infectious diseases. They represent a real public health issue with lethal...
Haiti, like most limited-resources countries in the world, faces numerous neglected infectious diseases. They represent a real public health issue with lethal consequences especially in children. We are reviewing here the available literature on four neglected infectious diseases, mansonelliasis, tungiasis, leprosy and anthrax. Filariasis, due to , has been totally neglected since its discovery in 1920 in Haiti; it persists in coastal homes with a high prevalence in adults when an effective treatment is available. The skin lesions caused by have existed since the pre-Columbian period in Haiti. They persist in the most retreated and hard-to-reach areas where the population lives in precarious conditions and in extreme poverty. New available research data show the importance of the problem with very high prevalence rates in some rural communities far away from any healthcare center. Cases of leprosy are recently reemerging as no monitoring program has been in place since 2004. Finally, anthrax is still endemic; small epidemics resurfacing periodically in families in rural areas. Screening of people for these diseases and managing the cases are necessary to improve health and reduce morbidity and mortality in Haiti.
Topics: Adolescent; Adult; Aged; Animals; Anthrax; Child; Child, Preschool; Female; Filariasis; Haiti; Humans; Infant; Infant, Newborn; Leprosy; Male; Mansonelliasis; Middle Aged; Neglected Diseases; Prevalence; Tungiasis; Young Adult
PubMed: 30763500
DOI: 10.3166/bspe-2018-0005