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Journal of Medical Internet Research May 2020Social media use continues to gain momentum in academic neurosurgery. To increase journal impact and broaden engagement, many scholarly publications have turned to...
BACKGROUND
Social media use continues to gain momentum in academic neurosurgery. To increase journal impact and broaden engagement, many scholarly publications have turned to social media to disseminate research. The Journal of Neurosurgery Publishing Group (JNSPG) established a dedicated, specialized social media team (SMT) in November 2016 to provide targeted improvement in digital outreach.
OBJECTIVE
The goal of this study was to examine the impact of the JNSPG SMT as measured by increased engagement.
METHODS
We analyzed various metrics, including impressions, engagements, retweets, likes, profile clicks, and URL clicks, from consecutive social media posts from the JNSPG's Twitter and Facebook platforms between February 1, 2015 and February 28, 2019. Standard descriptive statistics were utilized.
RESULTS
Between February 2015 and October 2016, when a specialized SMT was created, 170 tweets (8.1 tweets/month) were posted compared to 3220 tweets (115.0 tweets/month) between November 2016 and February 2019. All metrics significantly increased, including the impressions per tweet (mean 1646.3, SD 934.9 vs mean 4605.6, SD 65,546.5; P=.01), engagements per tweet (mean 35.2, SD 40.6 vs mean 198.2, SD 1037.2; P<.001), retweets (mean 2.5, SD 2.8 vs mean 10.5, SD 15.3; P<.001), likes (mean 2.5, SD 4.0 vs mean 18.0, SD 37.9; P<.001), profile clicks (mean 1.5, SD 2.0 vs mean 5.2, SD 43.3; P<.001), and URL clicks (mean 13.1, SD 14.9 vs mean 38.3, SD 67.9; P<.001). Tweets that were posted on the weekend compared to weekdays had significantly more retweets (mean 9.2, SD 9.8 vs mean 13.4, SD 25.6; P<.001), likes (mean 15.3, SD 17.9 vs mean 23.7, SD 70.4; P=.001), and URL clicks (mean 33.4, SD 40.5 vs mean 49.5, SD 117.3; P<.001). Between November 2015 and October 2016, 49 Facebook posts (2.3 posts/month) were sent compared to 2282 posts (81.5 posts/month) sent between November 2016 and February 2019. All Facebook metrics significantly increased, including impressions (mean 5475.9, SD 5483.0 vs mean 8506.1, SD 13,113.9; P<.001), engagements (mean 119.3, SD 194.8 vs mean 283.8, SD 733.8; P<.001), and reach (mean 2266.6, SD 2388.3 vs mean 5344.1, SD 8399.2; P<.001). Weekend Facebook posts had significantly more impressions per post (mean 7967.9, SD 9901.0 vs mean 9737.8, SD 19,013.4; P=.03) and a higher total reach (mean 4975.8, SD 6309.8 vs mean 6108.2, SD 12,219.7; P=.03) than weekday posts.
CONCLUSIONS
Social media has been established as a crucial tool for the propagation of neurosurgical research and education. Implementation of the JNSPG specialized SMT had a demonstrable impact on increasing the online visibility of social media content.
Topics: Humans; Internet; Neurosurgery; Publications; Social Media
PubMed: 32163371
DOI: 10.2196/17741 -
Journal of Blood Medicine 2023Cerebral Venous Sinus Thrombosis (CVST) is a cerebrovascular disease with an estimated annual incidence of 3-4 cases per 1 million population with an 8% mortality rate...
BACKGROUND
Cerebral Venous Sinus Thrombosis (CVST) is a cerebrovascular disease with an estimated annual incidence of 3-4 cases per 1 million population with an 8% mortality rate caused by hypercoagulable conditions and hyper aggregation and also Platelet Selectin (P-Selectin) as one of coagulation biomarker for both of them. This study aimed to describe the levels of P-selectin in CVST patients at RSHS Bandung.
OBJECTIVE
This study aimed to describe the levels of P-selectin in CVST patients at RSHS Bandung.
METHODS
This is a descriptive observational study on patients ≥18 years old diagnosed with CVST at the Neurology outpatient polyclinic of RSUP Dr. Hasan Sadikin Bandung for March-May 2022. All samples that meet the inclusion criteria will be included as research subjects.
RESULTS
There were 55 research subjects with a median age of 48 (range 22-69 years), the majority were women (80%), the most complaints were headaches (92.7%), the majority onset was chronic (96.4%) with a length of treatment ≥12 months (61.8%). P-selectin levels were found to increase in the group of subjects with subacute onset (mean 5.20 ± 2.977), infectious etiology (mean 5.26 ± 3.561), duration of treatment <3 Months (mean 3.79 ± 3.065), history of hyper aggregation (mean 3.89±2.805), hypercoagulation (mean 3.50±2.719), increased D-dimer (mean 3.93±2.710), normal fibrinogen (mean 3.38±2.693), and in the group with multiple affected sinuses (mean 6.08±2.681).
CONCLUSION
P-selectin could be a diagnostic marker for hyper aggregation and hypercoagulable state in patients with CVST, but it still needs further research to prove it.
PubMed: 37284611
DOI: 10.2147/JBM.S405975 -
Journal of Inequalities and Applications 2018This note aims to generalize the reverse weighted arithmetic-geometric mean inequality of positive invertible operators due to Lawson and Lim. In addition, we make...
This note aims to generalize the reverse weighted arithmetic-geometric mean inequality of positive invertible operators due to Lawson and Lim. In addition, we make comparisons between the weighted Karcher mean and Lawson-Lim geometric mean for higher powers.
PubMed: 30839602
DOI: 10.1186/s13660-018-1817-5 -
Academic Psychiatry : the Journal of... Jun 2015The aim of this study was to determine if communication skills differ for medical students entering person or technique-oriented specialties.
OBJECTIVE
The aim of this study was to determine if communication skills differ for medical students entering person or technique-oriented specialties.
METHODS
Communication ratings by clerkship preceptors on an institutionally required end of clerkship medical student performance evaluation (SPE) form were compiled for 2011/2012 academic year (Class of 2013). M3 clerkships and the Class of 2013 match appointments were categorized as person or technique-oriented clerkships/specialties. Mean differences in SPE communication scores were determined by analyses of variance (ANOVA) and independent t tests. Score associations were determined by Pearson correlations. Inter-item reliability was reported with Cronbach alpha.
RESULTS
The Class of 2013 match appointments were as follows: person-oriented (N = 91) and technique-oriented (N = 91) residency specialties. There was no significant difference in mean communication scores for medical students who entered person-oriented (mean 7.8, SD 0.4) versus technique-oriented (mean 7.9, SD 0.4) specialties (p = 0.258) or for person-oriented clerkship (mean 7.8, SD 0.4) versus technique-oriented clerkship (mean 7.9, SD 0.6) ratings for medical students who matched into person-oriented specialties (p = 0.124). Medical students who matched into technique-oriented specialties (mean 8.1, SD 0.5) received significantly higher (p = 0.001) communication ratings as compared with those matching into person-oriented specialties (mean 7.8, SD 0.5) from technique-oriented clerkships.
CONCLUSIONS
Communication with patients and families is a complex constellation of specific abilities that appear to be influenced by the rater's specialty. Further study is needed to determine if technique-oriented specialties communication skill rating criteria differ from those used by raters from person-oriented specialties.
Topics: Adult; Career Choice; Clinical Clerkship; Communication; Employee Performance Appraisal; Female; Humans; Male; Professional-Patient Relations; Students, Medical; Young Adult
PubMed: 25037248
DOI: 10.1007/s40596-014-0165-0 -
The Journal of the Association of... Jun 2022Stroke is the third common cause of death in India after ischemic heart disease and chronic obstructive pulmonary disease. Clinical features and outcomes vary in...
INTRODUCTION
Stroke is the third common cause of death in India after ischemic heart disease and chronic obstructive pulmonary disease. Clinical features and outcomes vary in different types of strokes.
OBJECTIVES
To compare the National Institutes of Health Stroke Scale (NIHSS) score of anterior and posterior circulation stroke patients (confirmed by neuroimaging) on the day of admission, admitted in Department of General Medicine, R. G. Kar Medical College and Hospital (RGKMCH), Kolkata and to predict the prognosis and outcome of the two types of strokes based on the modified Rankin Scale (mRS) on day 5 of admission.
METHODOLOGY
After approval from Institutional Ethics Committee and taking written informed consent from participants an observational cross-sectional study was conducted in the Department of General Medicine of a tertiary care hospital over 1.5 years. Clinical features, outcome, and prognosis between anterior and posterior circulation stroke group are compared and results are analyzed.
RESULTS
In anterior circulation, the mean of age (mean ± SD) of patients was 59.2875 ± 6.7790 years; 25 (31.3%) patients were female and 55 (68.8%) patients were male; three (3.8%) patients were Christian, 39 (48.8%) patients were Hindu, and 38 (47.5%) patients were Muslim; the mean of BMI (mean ± SD) of patients was 24.7038 ± 2.3695 kg/m2 ; 71 (88.8%) patients were from rural area and nine (11.3%) patients were from urban area; 73 (91.3%) patients had hypertension, 51 (63.8%) patients had diabetes mellitus, 24 (30.0%) patients had hypothyroidism, and 56 (70.0%) patients had ischemic heart disease; the mean of NIHSS score on day 0 (mean ± SD) of patients was 13.9875 ± 4.0362, the mean of mRS score on day 5 (mean ± SD) of patients was 2.1125 ±.9936. In posterior circulation, the mean of age (mean ± SD) of patients was 59.2167 ± 6.7826 years; 20 (33.2%) patients were female and 40 (66.7%) patients were male; two (3.3) patients were Christian, 29 (48.3%) patients were Hindu, and 29 (48.3%) patients were Muslim; the mean of BMI (mean ± SD) of patients was 24.7017 ± 2.3265 kg/m2 ; 51 (85.0%) patients were from rural area and nine (15.0%) patients were from urban area; 54 (90.0%) patients had hypertension, 37 (61.7%) patients had diabetes mellitus, 18 (30.0%) patients had hypothyroidism, and 42 (70.0%) patients had ischemic heart disease; the mean of NIHSS score on day 0 (mean ± SD) of patients was 23.8833 ± 4.5737, the mean of mRS score on day 5 (mean ± SD) of patients was 4.6333 ± .8227.
CONCLUSION
Symptoms of PCI stroke patients are more severe than that of ACI stroke patients. The outcome and prognosis of PCI stroke patients are worse compared to the ACI stroke patients.
Topics: Aged; Cross-Sectional Studies; Diabetes Mellitus; Female; Humans; Hypertension; Hypothyroidism; Male; Middle Aged; Myocardial Ischemia; Percutaneous Coronary Intervention; Prognosis; Stroke; Tertiary Care Centers; Treatment Outcome
PubMed: 35702838
DOI: 10.5005/japi-11001-0022 -
Chest Apr 1993Right-heart catheterization was performed in ten patients who suffered heat stroke on their pilgrimage to Mecca, Saudi Arabia. The group included seven men and three...
Right-heart catheterization was performed in ten patients who suffered heat stroke on their pilgrimage to Mecca, Saudi Arabia. The group included seven men and three women who had mean rectal temperatures of 42.4 degrees C. Other findings included the following: heart rate (mean, 120 beats/min); cardiac output (mean, 8.2 ml/min/m2); arterial pressure (mean, 65 mm Hg); cardiac indices (mean, 4.4 ml/min/m2); right atrial pressure (mean, 6 mm Hg); pulmonary capillary wedge pressure (mean, 10 mm Hg); systemic vascular resistance (mean, 684 dyne.s.cm-5); pulmonary vascular resistance (mean, 86 dyne.s.cm-5); oxygen delivery (mean 837 ml/min/m2); oxygen consumption (mean 160 ml/min/m2); mixed venous oxygen tension (mean, 56 mm Hg); and shunt fraction (mean, 20 percent). Nine patients survived. One, who had a cardiopulmonary arrest before any treatment could be administered, died.
Topics: Adult; Aged; Cardiac Catheterization; Female; Heat Exhaustion; Hemodynamics; Humans; Male; Middle Aged; Oxygen; Oxygen Consumption; Respiration
PubMed: 8131467
DOI: 10.1378/chest.103.4.1210 -
JAMA Neurology Feb 2015Numerically, the most important genetic risk factor for the development of Parkinson disease (PD) is the presence of a glucocerebrosidase gene (GBA) mutation.
IMPORTANCE
Numerically, the most important genetic risk factor for the development of Parkinson disease (PD) is the presence of a glucocerebrosidase gene (GBA) mutation.
OBJECTIVE
To evaluate longitudinally and clinically a GBA mutation-positive cohort and the evolution of the prodromal features of PD.
DESIGN, SETTING, AND PARTICIPANTS
Participants in a study of the etiology and prodrome of PD were reevaluated in this clinic-based 2-year follow-up report. Patients with type 1 Gaucher disease (GD) and heterozygous GBA mutation carriers were recruited in 2010 from the Lysosomal Storage Disorder Unit at the Royal Free Hospital, London, England. Thirty patients who previously received a diagnosis of type 1 GD, 28 heterozygous GBA mutation carriers, and 26 genetically unrelated controls were included. Exclusion criteria included a diagnosis of PD or dementia for both the patients with GD and the GBA mutation carriers and any existing neurological disease for the controls.
MAIN OUTCOMES AND MEASURES
Assessment was performed for clinical markers using standardized scales for hyposmia, rapid eye movement sleep behavior disorder, depression, autonomic dysfunction, cognitive function, and parkinsonian motor signs (using the Unified Parkinson's Disease Rating Scale motor subscale [UPDRS part III]).
RESULTS
Over 2 years, depression scores were significantly worse for heterozygous carriers (mean baseline, 0.65; mean follow-up, 2.88; P = .01), rapid eye movement sleep behavior disorder scores were significantly worse for patients with GD (mean baseline, 0.93; mean follow-up, 2.93; P < .001) and heterozygotes (mean baseline, 0.10; mean follow-up, 2.30; P < .001), and UPDRS part III scores were significantly worse for patients with GD (mean baseline, 4.29; mean follow-up, 7.82; P < .001) and heterozygotes (mean baseline, 1.97; mean follow-up, 4.50; P < .001). For controls, there was a small but significant deterioration in the UPDRS part II (activities of daily living) score (mean baseline, 0.00; mean follow-up, 0.58; P = .006). At 2 years, olfactory and cognitive assessment scores were lower in patients with GD and heterozygotes compared with controls, but they did not differ significantly from baseline. When the results from the patients with GD and the heterozygotes were combined, a significant deterioration from baseline was observed, as reflected in the Rapid Eye Movement Sleep Behaviour Disorder Questionnaire (mean baseline, 0.51; mean follow-up, 2.63; P < .001), Beck Depression Inventory (mean baseline, 1.72; mean follow-up, 4.44; P = .002), and UPDRS part II (mean baseline, 0.88; mean follow-up, 2.01; P < .001) and part III scores (mean baseline, 3.09; mean follow-up, 6.10; P < .001) (all P < .01), and at 2 years, significant differences in University of Pennsylvania Smell Identification Test, Unified Multiple System Atrophy Rating Scale, Mini-Mental State Examination, Montreal Cognitive Assessment, and UPDRS part II and part III scores were observed between patients with GD/heterozygotes and controls (all P < .05).
CONCLUSIONS AND RELEVANCE
This study indicates that, as a group, GBA mutation-positive individuals show a deterioration in clinical markers consistent with the prodrome of PD. Within this group of individual, 10% appear to be evolving at a more rapid rate.
Topics: Aged; Biomarkers; Disease Progression; Female; Gaucher Disease; Glucosylceramidase; Heterozygote; Humans; Longitudinal Studies; Male; Middle Aged; Mutation; Parkinson Disease; Prodromal Symptoms; Severity of Illness Index
PubMed: 25506732
DOI: 10.1001/jamaneurol.2014.2950 -
Entropy (Basel, Switzerland) Apr 2021We give bounds on the difference between the weighted arithmetic mean and the weighted geometric mean. These imply refined Young inequalities and the reverses of the...
We give bounds on the difference between the weighted arithmetic mean and the weighted geometric mean. These imply refined Young inequalities and the reverses of the Young inequality. We also studied some properties on the difference between the weighted arithmetic mean and the weighted geometric mean. Applying the newly obtained inequalities, we show some results on the Tsallis divergence, the Rényi divergence, the Jeffreys-Tsallis divergence and the Jensen-Shannon-Tsallis divergence.
PubMed: 33922636
DOI: 10.3390/e23050514 -
Operative Neurosurgery (Hagerstown, Md.) Aug 2021As endoscopic endonasal skull base surgery (EESBS) for sellar pathology has become routine, there is increasing awareness of quality-of-life (QOL) outcomes related to...
BACKGROUND
As endoscopic endonasal skull base surgery (EESBS) for sellar pathology has become routine, there is increasing awareness of quality-of-life (QOL) outcomes related to this approach. Similarly, there is a growing interest in postoperative chemosensory function, with notable emphasis on olfaction and the corresponding psychosocial implications of olfactory dysfunction. Meanwhile, there has been minimal direct investigation into gustatory outcomes, and the association between these 2 chemosensory functions remains poorly understood.
OBJECTIVE
To investigate patient-reported chemosensory function and rhinologic-specific QOL following EESBS for routine sellar pathologies.
METHODS
Comprehensive clinical characteristics and sinonasal QOL assessments, measured using Anterior Skull Base Nasal Inventory-12 (ASK Nasal-12), were collected from 46 patients undergoing EESBS for sellar pathology.
RESULTS
Forty-six patients were included: 65.2% female, average age 52.8 yr (range: 27-89). The most common pathology was nonfunctioning pituitary adenoma (n = 28). Preoperative ASK Nasal-12 scores (mean = 0.81) demonstrated postoperative worsening at 2 wk (mean = 2.52, P < .0001) and 1 mo (mean = 1.33, P = .0031), with no difference at 3 mo postoperatively (mean = 0.89, P = .92). Meanwhile, there was significant worsening of preoperative subjective smell (mean = 0.62) and taste function (mean = 0.42) at 2 wk (mean = 3.48, P < .0001; mean = 2.69, P < .0001) and 1 mo (mean = 2.40, P < .0001; mean = 2.03, P < .0001) postoperatively, which persisted at approximately 3 mo postoperatively (mean = 1.26, P = .04; mean = 1.15, P = .0059).
CONCLUSION
Patients undergoing EESBS for sellar pathologies experience anticipated, temporary disruptions in sinonasal QOL but may have longer lasting perturbations in subjective olfaction and gustation. Given the increasing use of the endoscopic endonasal corridor, further investigation in postoperative chemosensory function is essential.
Topics: Female; Humans; Male; Middle Aged; Quality of Life; Skull Base; Smell; Taste; Treatment Outcome
PubMed: 33956975
DOI: 10.1093/ons/opab137 -
European Journal of Ophthalmology 2008To evaluate basal serum prolactin levels in patients with HLA-B27-associated uveitis. (Clinical Trial)
Clinical Trial Comparative Study
PURPOSE
To evaluate basal serum prolactin levels in patients with HLA-B27-associated uveitis.
METHODS
Prospective, nonrandomized comparative trial. Thirty-three patients with HLAB27- associated uveitis and 30 age- and sex-matched healthy control subjects were included. Age, systemic disease, treatment, and uveitis activity were recorded for comparative analysis between groups. Fourteen out of 23 patients with arthritic disease had ankylosing spondylitis. Basal serum prolactin levels were determined by electrochemiluminescence immunoassay on a Modular Analytics E170 analyzer.
RESULTS
Prolactinemia was significantly higher (mean=15.84 ng/mL) in patients vs controls (mean=11.50 ng/mL) (p=0.026). Subgroup analysis revealed prolactinemia in arthritic disease patients (mean=17.21 ng/mL) significantly higher than controls (mean=11.50 ng/mL) (p=0.009) and in ankylosing spondylitis (mean=17.65 ng/mL) vs controls (mean=11.50 ng/mL) (p=0.006). No correlation was found between prolactinemia and systemic treatment. Prolactinemia did not correlate with disease activity. Autoimmunity features also correlated with higher prolactinemia (mean=17.26 ng/mL) vs controls (mean=11.50 ng/mL) (p=0.015).
CONCLUSIONS
These results suggest the role of serum prolactin levels in HLA-B27-associated uveitis pathogenesis and its subgroups. There was no correlation with disease activity.
Topics: Adolescent; Adult; Aged; Aged, 80 and over; Child; Female; HLA-B27 Antigen; Humans; Luminescent Measurements; Male; Middle Aged; Prolactin; Prospective Studies; Spondylitis, Ankylosing; Uveitis, Anterior
PubMed: 18988164
DOI: 10.1177/112067210801800612