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Acta Tropica Apr 2020The soil transmitted whipworm, Trichuris trichiura affects about half a billion people globally. Diagnosis is based on identification of characteristic lemon-shaped eggs...
The soil transmitted whipworm, Trichuris trichiura affects about half a billion people globally. Diagnosis is based on identification of characteristic lemon-shaped eggs in stool samples. Occasionally large Trichuris eggs have been reported and have been ascribed to variation within T. trichiura or zoonotic infection with T. vulpis from dogs. We observed that the egg size profile changed markedly after anthelmintic treatment, and remained so, in a human individual self-infected with T. trichiura. The large eggs were detected with two standard diagnostic methods, Kato-Katz thick smear and salt-flotation (McMaster) method. It is therefore important to bear in mind that the morphology of parasite eggs may vary, e.g. in response to previous drug treatment. Large Trichuris eggs in human stool samples should not be diagnosed as T. vulpis infection without confirmation by other means.
Topics: Adult; Animals; Anthelmintics; Feces; Humans; Male; Mebendazole; Parasite Egg Count; Trichuriasis; Trichuris; Zoonoses
PubMed: 31954684
DOI: 10.1016/j.actatropica.2020.105347 -
The American Journal of Tropical... Jul 1975In a controlled field trial of treatment for dracontiasis, mebendazole (Vermox) was found to be effective in eliminating the adult worm and preventing clinical relapses,... (Clinical Trial)
Clinical Trial Randomized Controlled Trial
In a controlled field trial of treatment for dracontiasis, mebendazole (Vermox) was found to be effective in eliminating the adult worm and preventing clinical relapses, but it did not achieve significant amelioration of symptoms, subsidence of inflammation, or healing of ulcers. The failure is attributed to poor absorption and lack of anti-inflammatory action of the drug. Mebendazole was well tolerated and although two patients reported mild gastrointestinal disturbances, which may be attributed to the drug, the study confirms that mebendazole is one of the safest anthelmintics in current use and is in that respect ideal for mass therapy.
Topics: Administration, Oral; Adolescent; Adult; Aged; Benzimidazoles; Child; Child, Preschool; Clinical Trials as Topic; Dracunculiasis; Dracunculus Nematode; Drug Evaluation; Female; Humans; Male; Mebendazole; Middle Aged; Recurrence; Skin Ulcer; Wound Healing; Yeast, Dried
PubMed: 125552
DOI: 10.4269/ajtmh.1975.24.600 -
Science (New York, N.Y.) Mar 1980Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the invasive and encystment...
Mebendazole was highly effective against the helminth parasite Trichinella spiralis in mice subjected to a 3-day course of treatment during the invasive and encystment phases of experimental trichinellosis. When treatment began either 2 or 4 weeks after the mice were inoculated with parasites, the number of larvae developing in the host musculature was greatly reduced by twice-daily oral administration of 3.125, 6.25, or 12.5 milligrams of mebendazole per kilogram of body weight.
Topics: Administration, Oral; Animals; Benzimidazoles; Disease Models, Animal; Dose-Response Relationship, Drug; Larva; Male; Mebendazole; Mice; Muscles; Trichinella; Trichinellosis
PubMed: 7355285
DOI: 10.1126/science.7355285 -
PloS One 2014Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a...
Mebendazole is an antihelminthic drug that exerts its effects via interference with microtubule function in parasites. To determine the utility of mebendazole as a potential treatment for vascular diseases involving proliferation of vascular smooth muscle cells, the effects of mebendazole on vascular smooth muscle cell proliferation were tested in vitro and in a mouse model of arterial injury. In vitro, mebendazole inhibited proliferation and migration of murine vascular smooth muscle cells and this was associated with altered intracellular microtubule organization. To determine in vivo effects of mebendazole following vascular injury, femoral arterial wire injury was induced in wild-type mice treated with either mebendazole or placebo control. Compared with placebo-treated mice, mebendazole-treated mice formed less neointima at the site of injury. Mebendazole is effective at inhibiting vascular smooth muscle cell proliferation and migration, and neointimal formation following arterial injury in mice.
Topics: Animals; Apoptosis; Cell Movement; Cell Proliferation; Disease Models, Animal; Hyperplasia; Male; Mebendazole; Mice; Muscle, Smooth, Vascular; Myocytes, Smooth Muscle; Neointima; Vascular System Injuries
PubMed: 24587248
DOI: 10.1371/journal.pone.0090146 -
Drugs in R&D Sep 2016Mebendazole is an effective drug widely used in the treatment of parasitic infections. Although theoretically considered as safe during lactation, no studies have...
INTRODUCTION
Mebendazole is an effective drug widely used in the treatment of parasitic infections. Although theoretically considered as safe during lactation, no studies have evaluated its potential adverse effects in infants of breastfeeding mothers.
OBJECTIVES
We aimed to evaluate the safety of mebendazole in infants of lactating women treated with the drug.
METHODS
Women referred for consultation regarding mebendazole use were invited to participate in the study. Overall 45 lactating women treated with various protocols of mebendazole were recruited in this case series study.
RESULTS
Regardless of the treatment protocol used (single or repeated doses) mebendazole was well tolerated and was not associated with any adverse effects in infants of lactating mothers. There was mild GI irritability in two treated women.
CONCLUSION
This study provides first evidence in humans as to the safety of mebendazole in breastfeeding.
Topics: Adult; Breast Feeding; Female; Humans; Infant; Infant, Newborn; Mebendazole; No-Observed-Adverse-Effect Level; Parasitic Diseases
PubMed: 27623793
DOI: 10.1007/s40268-016-0142-z -
Zeitschrift Fur Gastroenterologie Dec 1983
Topics: Benzimidazoles; Drug Hypersensitivity; Echinococcosis; Female; Hepatitis; Humans; Kupffer Cells; Liver; Mebendazole; Middle Aged; Transaminases
PubMed: 6666188
DOI: No ID Found -
Transactions of the Royal Society of... 1991
Topics: Dracunculiasis; Humans; Mebendazole; Prognosis
PubMed: 1832247
DOI: 10.1016/0035-9203(91)90056-5 -
Transactions of the Royal Society of... 1990
Clinical Trial Comparative Study Randomized Controlled Trial
Topics: Adolescent; Adult; Child; Child, Preschool; Female; Giardiasis; Humans; Male; Mebendazole; Metronidazole; Middle Aged
PubMed: 2278074
DOI: 10.1016/0035-9203(90)90150-d -
Molecular Oncology Dec 2020The concept of polypharmacology involves the interaction of drug molecules with multiple molecular targets. It provides a unique opportunity for the repurposing of...
The concept of polypharmacology involves the interaction of drug molecules with multiple molecular targets. It provides a unique opportunity for the repurposing of already-approved drugs to target key factors involved in human diseases. Herein, we used an in silico target prediction algorithm to investigate the mechanism of action of mebendazole, an antihelminthic drug, currently repurposed in the treatment of brain tumors. First, we confirmed that mebendazole decreased the viability of glioblastoma cells in vitro (IC values ranging from 288 nm to 2.1 µm). Our in silico approach unveiled 21 putative molecular targets for mebendazole, including 12 proteins significantly upregulated at the gene level in glioblastoma as compared to normal brain tissue (fold change > 1.5; P < 0.0001). Validation experiments were performed on three major kinases involved in cancer biology: ABL1, MAPK1/ERK2, and MAPK14/p38α. Mebendazole could inhibit the activity of these kinases in vitro in a dose-dependent manner, with a high potency against MAPK14 (IC = 104 ± 46 nm). Its direct binding to MAPK14 was further validated in vitro, and inhibition of MAPK14 kinase activity was confirmed in live glioblastoma cells. Consistent with biophysical data, molecular modeling suggested that mebendazole was able to bind to the catalytic site of MAPK14. Finally, gene silencing demonstrated that MAPK14 is involved in glioblastoma tumor spheroid growth and response to mebendazole treatment. This study thus highlighted the role of MAPK14 in the anticancer mechanism of action of mebendazole and provides further rationale for the pharmacological targeting of MAPK14 in brain tumors. It also opens new avenues for the development of novel MAPK14/p38α inhibitors to treat human diseases.
Topics: Brain Neoplasms; Cell Line, Tumor; Cell Proliferation; Cell Survival; Computer Simulation; Glioblastoma; Humans; Inhibitory Concentration 50; Mebendazole; Mitogen-Activated Protein Kinase 14; Models, Molecular; Molecular Targeted Therapy; Protein Kinase Inhibitors
PubMed: 33021050
DOI: 10.1002/1878-0261.12810 -
Canadian Medical Association Journal Oct 1976Mebendazole, a new broad-spectrum anthelmintic, was used to treat patients with nematode infections--ascariasis, trichuriasis and hookworm. The dosage for adults was 100...
Mebendazole, a new broad-spectrum anthelmintic, was used to treat patients with nematode infections--ascariasis, trichuriasis and hookworm. The dosage for adults was 100 mg twice daily for 3 days and for children, 50 mg twice daily for 3 days. Pretreatment and post-treatment egg counts on stool specimens showed that after mebendazole there was a reduction of over 99% in egg count per gram of stool in all three types of infection. The overall cure rates for the infections were as follows: Ascaris lumbricoides, 86.8% (59/68); Trichuris trichiura, 86.0% (37/43); and hookworm, 85.7% (24/28). The drug was equally effective in light and heavy infections. No important side effect was noted with this drug. It is suggested that mebendazole is the drug of choice for trichuriasis and mixed nematode infection.
Topics: Adult; Ascariasis; Benzimidazoles; Child; Feces; Female; Helminthiasis; Hookworm Infections; Humans; Male; Mebendazole; Parasite Egg Count; Trichuriasis
PubMed: 974969
DOI: No ID Found