-
Deutsche Medizinische Wochenschrift... Aug 1993
Topics: Adolescent; Adult; Child; Female; Humans; Male; Mebendazole; Oxyuriasis
PubMed: 8354142
DOI: No ID Found -
Biopolymers 2002A diffuse reflectance IR Fourier transform IR spectrometry (DRIFTS) method was developed for the rapid, direct measurement of mebendazole in drugs. Conventional KBr... (Comparative Study)
Comparative Study
A diffuse reflectance IR Fourier transform IR spectrometry (DRIFTS) method was developed for the rapid, direct measurement of mebendazole in drugs. Conventional KBr spectra and DRIFTS spectra were compared for the best determination of the active substance in the drug formulations. Two chemometric approaches were used in the data processing: multicomponent partial least squares (PLS2) and principal component regression. The best results were obtained with the PLS2 method.
Topics: Antinematodal Agents; Least-Squares Analysis; Mebendazole; Reference Standards; Spectroscopy, Fourier Transform Infrared; Tablets
PubMed: 11842414
DOI: 10.1002/bip.10041 -
The West Indian Medical Journal Feb 2013
Topics: Antiparasitic Agents; Giardia lamblia; Giardiasis; Humans; Mebendazole
PubMed: 24564073
DOI: No ID Found -
Transactions of the Royal Society of... 1991
Topics: Adolescent; Child; Child, Preschool; Giardiasis; Humans; Mebendazole
PubMed: 1755078
DOI: 10.1016/0035-9203(91)90264-y -
Journal of Veterinary Pharmacology and... Dec 2017Mebendazole is approved for use in aquatic animals and is widely used in Chinese aquaculture. We developed a pharmacokinetic and residue analysis for mebendazole levels...
Mebendazole is approved for use in aquatic animals and is widely used in Chinese aquaculture. We developed a pharmacokinetic and residue analysis for mebendazole levels in the goldfish (Carassius auratus). Plasma and muscle samples of C. auratus were taken after oral administration of 10 mg/kg mebendazole. The maximal drug plasma concentration of 0.55 mg/L was achieved at 48 hr and then declined with the elimination half-life (T ) of 7.99 hr. Administration of 10 mg/kg by oral gavage for 5 successive days resulted in a peak mebendazole concentration of 0.70 mg/kg in muscle at 96 hr after the last dose. The drug was then eliminated at a relatively slow rate from muscle with T of 68.41 hr. There was no detectable mebendazole in any muscle samples at 24 days postadministration. The AUC in plasma and muscle was 19.42 and 105.33 mg hr/L, respectively. These data provide information for dosage recommendations and withdrawal time determinations for mebendazole use in aquariums.
Topics: Administration, Oral; Animals; Antinematodal Agents; Goldfish; Half-Life; Mebendazole; Muscle, Skeletal
PubMed: 28401566
DOI: 10.1111/jvp.12398 -
American Journal of Obstetrics and... Jan 2003
Topics: Abnormalities, Drug-Induced; Anthelmintics; Female; Humans; Maternal-Fetal Exchange; Mebendazole; Pregnancy; Pregnancy Complications, Parasitic
PubMed: 12548188
DOI: 10.1067/mob.2003.78 -
The American Journal of Tropical... Jul 1997Preliminary studies indicated that single-dose (500 mg) mebendazole gave disappointing results in the treatment of hookworm infections (Necator americanus) in Mali. A... (Clinical Trial)
Clinical Trial Randomized Controlled Trial
Preliminary studies indicated that single-dose (500 mg) mebendazole gave disappointing results in the treatment of hookworm infections (Necator americanus) in Mali. A placebo-controlled, randomized trial conducted with the participation of 103 infected subjects (background hookworm prevalence > 50%) confirmed that mebendazole (Vermox) did not reduce parasite burdens significantly, as assessed through fecal egg counts. In contrast, a group of subjects treated with pyrantel (Combantrin) experienced a significant reduction in fecal worm egg counts (overall, both sexes combined showed a 75% reduction). Male subjects carried significantly more intense infections compared with females, but there was no gender difference in response to treatment. A standard egg hatch assay showed that N. americanus from our subjects in Mali was more resistant to benzimidazoles compared with a laboratory-maintained strain that had not been exposed to anthelmintics in more than 100 generations (50% effective dose = 0.12 and 0.07 microg/ml of thiabendazole, respectively), suggesting that, among other possibilities, the development of resistance to the benzimidazoles by N. americanus may have contributed to the drug failure. Whatever the underlying explanation, our results indicate that single-dose treatment with mebendazole is an ineffective treatment for hookworm infections and despite its relatively cheap cost and wide availability, mebendazole should not be considered a drug of choice in the mass treatment of hookworm infections in this region of Mali.
Topics: Adolescent; Adult; Aged; Animals; Antinematodal Agents; Child; Child, Preschool; Double-Blind Method; Drug Administration Schedule; Drug Resistance; Feces; Female; Humans; Male; Mali; Mebendazole; Middle Aged; Necator americanus; Necatoriasis; Parasite Egg Count; Treatment Outcome
PubMed: 9242313
DOI: 10.4269/ajtmh.1997.57.25 -
British Medical Journal Apr 1980
Topics: Benzimidazoles; Echinococcosis; Humans; Mebendazole
PubMed: 7407472
DOI: 10.1136/bmj.280.6220.1055-a -
British Medical Journal Mar 1980
Topics: Benzimidazoles; Echinococcosis; Humans; Mebendazole
PubMed: 7370670
DOI: 10.1136/bmj.280.6216.796 -
The Veterinary Record May 1979
Topics: Animals; Benzimidazoles; Bird Diseases; Birds; Mebendazole
PubMed: 473569
DOI: 10.1136/vr.104.21.490