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Hematology/oncology Clinics of North... Oct 1995The two major topical treatment modalities for cutaneous T-cell lymphoma (CTCL) are mechlorethamine (nitrogen mustard) and topical carmustine (BCNU). Topical... (Review)
Review
The two major topical treatment modalities for cutaneous T-cell lymphoma (CTCL) are mechlorethamine (nitrogen mustard) and topical carmustine (BCNU). Topical mechorethamine hydrochloride has been used since the late 1950s as therapy for CTCL. Topical BCNU solution is a highly effective treatment for early stage mycosis fungoides. This article describes these two modalities.
Topics: Administration, Topical; Antineoplastic Agents, Alkylating; Carmustine; History, 20th Century; Humans; Lymphoma, T-Cell, Cutaneous; Mechlorethamine; Skin Neoplasms
PubMed: 8522483
DOI: No ID Found -
Archives of Dermatology Feb 1983Two adult patients with skin lesions typical of histiocytosis X were treated topically with mechlorethamine hydrochloride. In the patient whose disease was limited to...
Two adult patients with skin lesions typical of histiocytosis X were treated topically with mechlorethamine hydrochloride. In the patient whose disease was limited to the skin, a sustained remission was induced, but in the patient with extensive systemic disease, cutaneous remission lasted only six weeks.
Topics: Administration, Topical; Adult; Aged; Female; Histiocytosis, Langerhans-Cell; Humans; Ilium; Male; Mechlorethamine; Osteolysis; Radiography, Thoracic; Skin Diseases
PubMed: 6600596
DOI: No ID Found -
Skin Therapy Letter Mar 2023Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL), representing almost 50% of all lymphomas arising in the skin. There is an unmet need...
Mycosis fungoides (MF) is the most common type of cutaneous T-cell lymphoma (CTCL), representing almost 50% of all lymphomas arising in the skin. There is an unmet need in the treatment of MF in Canada, as current available therapies for early-stage MF are limited, without topical agents previously indicated. Chlormethine gel is a topical antineoplastic agent with phase II clinical trial and real-world data demonstrating safety and efficacy as a treatment option for adults with MF. Skin-related side effects such as dermatitis can be managed through appropriate strategies. The use of chlormethine gel can be considered for patients with stage IA and IB MF-CTCL as it provides an easily administered, skin-directed treatment option that fills an unmet need in Canada.
Topics: Adult; Humans; Mechlorethamine; Skin Neoplasms; Mycosis Fungoides; Lymphoma, T-Cell, Cutaneous; Skin
PubMed: 37054720
DOI: No ID Found -
Journal Der Deutschen Dermatologischen... Jul 2021
Topics: Humans; Lymphoma, Non-Hodgkin; Mechlorethamine; Mycosis Fungoides; Neoplasms, Connective Tissue; Skin Neoplasms
PubMed: 33942508
DOI: 10.1111/ddg.14462 -
Journal of the American Academy of... Jul 2022
Topics: Gels; Humans; Mechlorethamine; Mycosis Fungoides; Skin Neoplasms
PubMed: 34333079
DOI: 10.1016/j.jaad.2021.06.896 -
CMAJ : Canadian Medical Association... Feb 2017
Topics: Antineoplastic Agents; Chemical Warfare Agents; Drug Discovery; History, 20th Century; Humans; Mechlorethamine; Mustard Gas; World War I; World War II
PubMed: 28246228
DOI: 10.1503/cmaj.161032 -
Military Medicine Oct 1990Much mustard agent research has focused on mustard/DNA interactions. Mustard also interacts with proteins, however, and to reach the DNA any agent must first pass...
Much mustard agent research has focused on mustard/DNA interactions. Mustard also interacts with proteins, however, and to reach the DNA any agent must first pass through the cytoplasm. We hypothesized that the cell's proteins would covalently bind mustard, and thereby limit its access to the DNA. Keratinocyte proteins were radiolabeled with [14C]mechlorethamine and separated by electrophoresis. The banding patterns that resulted were made visible on x-ray films, then compared with control patterns. A correspondence of almost one-to-one was observed, which supports the hypothesis that many cellular proteins are susceptible to mustard alkylation. It follows that some mustard symptoms probably result from effects on existing proteins.
Topics: Carbon Radioisotopes; Cells, Cultured; Electrophoresis, Polyacrylamide Gel; Humans; Keratinocytes; Mechlorethamine; Protein Binding
PubMed: 2122288
DOI: No ID Found -
Tidsskrift For Den Norske Laegeforening... Nov 1977
Topics: Administration, Topical; Adult; Aged; Dermatitis, Contact; Humans; Mechlorethamine; Middle Aged; Mycosis Fungoides; Photochemotherapy; Skin; Skin Neoplasms; Ultraviolet Therapy
PubMed: 594965
DOI: No ID Found -
Annales de Dermatologie Et de... 1987
Topics: Administration, Topical; Humans; Mechlorethamine; Mycosis Fungoides; Psoriasis; Time Factors
PubMed: 3579129
DOI: No ID Found -
Vie Medicale (Paris, France : 1920) Dec 1954
Topics: Mechlorethamine; Nitrogen Mustard Compounds
PubMed: 14359671
DOI: No ID Found